Adenovirus Nanoparticles Displaying RBD Induce a Protective Immune Response Against BA.5 in Mice by Mo C, Wang Z, Liu D, Yang X, Zhang Q, Ye L, Yuan S, Deng S, Lai Z, Huang D, Yang Y, Xu D, Yuan J, Zhu Y, Liu H, Zhou C, Liao X, Li X, Liu W, Zhou R, Tian X

“…Hexon is the major capsid protein, and multiple hypervariable regions (HVRs) have been used for displaying exogenous antigens and inducing a strong antibody responses.Methods: We utilized SpyCatcher/SpyTag technology to incorporate SpyTag into HVR2, 4, and 7 of the hexon of the bivalent vaccine strain rAd3/7, respectively, to construct recombinant Ad, rAd3/7-SpyTag. …”
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Prognostic Implications of Red Blood Cell Distribution Width to Albumin Ratio in Myelofibrosis: A 10-Year Multicenter and Retrospective Study by Zeng T, Zheng Z, Qian H, Liu L, Shi X, Shao Y, Huang Z, Li R, Wen B, Han Q, Feng Q, Tu L, Bao X, Tong H, Jin J, Huang J

“…The red cell distribution width to albumin ratio (RAR), a novel biomarker indicative of inflammation, has emerged as a strong prognostic indicator in the general population but remains unexplored in MF.Methods: We retrospectively enrolled 504 consecutive MF patients from 7 hematological centers over a 10-year period. …”
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Abstract 062: N20 Potential And Imaging Biomarkers Of Functional Recovery In Acute Ischemic Stroke Patients And EVT by Alicia Martinez Piñeiro, Giuseppe Lucente, María Hernandez‐Perez, Jordi Cortés, Andrea Arbex, Meritxell Gomis Cortina, Laura Dorado Bouix, Natalia Pérez de la Ossa, Alba Ramos‐Fransi, Miriam Almendrote, Carlos Castaño, Sebastián Remollo, Maria Rosa García Sort, Patricia Cuadras Collsamata, Mónica Millán, Antoni Dávalos

“…This secondary study aims to describe the association between the N20 response and imaging biomarkers of ischemic penumbra, infarct volume and collateral flow. Methods Presence and amplitude of the N20 response was recorded before EVT. …”
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Evaluation of Environmental Effects of Applied Pesticides on Canola (Brassica napus L.), Sugar Beet (Beta vulgaris L.), and Potato (Solanum tuberosum L.) Fields in Ali Abad Katool... by Zahra Deilam, Hossein Kazemi, Maral Niazmoradi, Javid Gherekhloo

“…This study investigated the environmental effects of pesticides used in canola, sugar beet, and potato fields in Aliabad Katool County (Golestan province), during 2021-2022.Materials and MethodsFor this purpose, 21 canola fields, six potato fields, and five sugar beet fields were randomly selected and information related to pesticide spraying, field area, crop rotation, and crop yield with continuous monitoring, face-to-face interviews, and completed questionnaires was collected from farmers. …”
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Mechanism of magnesium sulfate suppressing vascular calcification in rats with chronic renal failure through TLR4/NF-κB pathway by Dong Li-ming, Li Yin-hui, Li Li

“…ObjectiveTo explore the effect of magnesium sulfate on vascular calcification （VC） in rats with chronic renal failure （CRF） through the pathway of Toll-like receptor 4 （TLR4）/nuclear transcription factor-κB （NF-κB）.MethodsA total of 50 Sprague-Dawley （SD） rats were randomized into five groups of control， model， magnesium sulfate-L （25% magnesium sulfate， 2 mL）， magnesium sulfate-H （25% magnesium sulfate， 4 mL） and magnesium sulfate-H+PDTC （25% magnesium sulfate， 4 mL+NF-κB inhibitor PDTC， 100 mg/kg） （<italic>n</italic>=10 each）. …”
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Specific features of cognitive skill development in athletes of situational sports by Vyacheslav Romanenko, Yrui Tropin, Leonid Podrigalo, Natalya Boychenko, Anatoly Abdula, Nataliia Sereda, Yaroslav Yatsiv

“…This study aimed to identify the peculiarities of cognitive skill formation in athletes participating in situational sports. Material and Methods. The study involved 97 participants, including 80 qualified male athletes with 5 to 9 years of training experience, representing three sports: football (n = 26, age 15.3 ± 0.49 years), judo (n = 31, age 16.6 ± 2.83 years), and taekwondo (n = 23, age 16.5 ± 1.90 years), and 17 boys (age 8.71 ± 1.16 years) who were not engaged in organized sports but expressed interest in doing so. …”
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Problematic Social Media Use, Self-Objectification, and Body Image Disturbance: The Moderating Roles of Physical Activity and Diet Intensity by Çınaroğlu M, Yılmazer E

“…It also explores the psychological outcomes of depression and anxiety.Methods: A cross-sectional study was conducted with 594 women aged 18– 65 in Istanbul, Türkiye. …”
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The Role of L-Sorbose Metabolism in Enhancing Fitness and Virulence in Escherichia coli Under Acidic Conditions by Qiu T, Chen X, Deng X, Zhang G, Wen S, Wu J, Sun D, Li T, Yan B, Dai M, Zhong LL, Tian GB

“…While metabolic flexibility is critical for E. coli fitness to host environments, the role of secondary carbon sources like L-Sorbose remains poorly characterized.Methods: The functional importance of L-Sorbose metabolism in E. coli CFT073 was investigated under acidic conditions simulating gastrointestinal and urinary tract environments. …”
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Transcriptomic Changes and Pathological Mechanisms in Familial and Sporadic Idiopathic Restless Legs Syndrome: Implications for Inflammation and Cell Adhesion Molecules by He XR, Song JM, Zhao JP, Zhang J, Feng JT, Chen SQ, Zhou ZY, Wang HM, Zhang Y, Feng Y, Wu YC, Zhu XY

“…The study aims to investigate transcriptomic changes and underlying pathological mechanisms in familial and sporadic idiopathic RLS to uncover potential contributors to its pathogenesis.Patients and Methods: This study included 37 RLS patients, 39 unrelated healthy controls and 19 healthy relatives of RLS patients with a positive family history. …”
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A Nomogram for Diagnosing Ventilator-Associated Pneumonia Using Circulating Inflammation Indicators in ICU Patients by Yang J, Bao W, Wang H, Zhou J, Hu Q, Wang Y, Li Y

“…Jiajia Yang,1,&ast; Weiyuan Bao,2,&ast; Hongmei Wang,1 Jie Zhou,3 Qiang Hu,4 Ying Wang,1 Yuancheng Li5 1Department of Infection Management, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, 215008, People’s Republic of China; 2Department of Logistics Support, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, 215008, People’s Republic of China; 3Intensive care unit, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, 215008, People’s Republic of China; 4Department of Respiratory and Critical Care Medicine, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, 215008, People’s Republic of China; 5Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, 210042, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Ying Wang, Department of Infection Management, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, No. 242, Guangji Road, Suzhou, 215008, People’s Republic of China, Email wangy830224@sina.com Yuancheng Li, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, Jiangsu, 210042, People’s Republic of China, Email ycli@pumcderm.cams.cnPurpose: To construct a risk nomogram model of ventilator-associated pneumonia (VAP) patients with mechanical ventilation in the intensive care unit (ICU) based on peripheral blood inflammatory indicators and to evaluate its diagnostic value.Patients and Methods: A matched 1:2 case: control study was conducted. …”
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Intravoxel Incoherent Motion Improves the Accuracy of Preoperative Prediction of Vessels Encapsulating Tumor Clusters in Hepatocellular Carcinoma by Li M, Zhang G, Li J, Ren Y, Jin X, Ke Q, Guo C, Lv J, Lu H, Xu Y, Liang W, Quan X, Li X

“…Therefore, this study used preoperative IVIM to predict VETC pattern in HCC and performed preoperative noninvasive recurrence risk stratification.Patients and Methods: Patients with suspicious HCC were included prospectively. …”
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Fu-Fang-Qi-Di-Hua-Yu-Tang Improves Diabetic Macrovascular Disease via PI3K/AKT Pathway Regulation by Zhang S, Yan M, Liang P, Zhang Y, Liu J, Huang H, Li G, Wu H

“…Shizhao Zhang,1,&amp;ast; Mei Yan,2,&amp;ast; Pengpeng Liang,1 Ye Zhang,3 Jiamin Liu,1 Hai Huang,1 Guiyun Li,1 Hongyan Wu1,2 1Shenzhen Hospital, Shanghai University of Traditional Chinese Medicine, Shenzhen, 518000, People’s Republic of China; 2School of Clinical Medicine, Jiangxi University of Chinese Medicine, Nanchang, 330000, People’s Republic of China; 3Pediatrics (TCM), Shenzhen Maternity and Child Healthcare Hospital Co-Construction Hospital, Shenzhen, 518000, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Hongyan Wu, Email wu.hy@163.comObjective: This study aimed to investigate the active ingredients and mechanisms of Fu-Fang-Qi-Di-Hua-Yu-Tang (FFQD) in alleviating atherosclerosis and insulin resistance in diabetic macrovascular disease (DMD) mice.Methods: Chemical profiling of FFQD was performed using UPLC-Q-TOF-MS. …”
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Long Non-Coding RNA lncTAF15:1-1 Promotes CCL5 Secretion and Cell Migration of Monocyte-Derived Dendritic Cells via PI3K/AKT/mTOR Pathway in Systemic Lupus Erythematosus by Xiang M, Sun Z, Ge Y, Zhang Z, Zheng C, Gao Z, Wang J, Xu J, Liang J, Wang Y

“…Hence, this study tried to reveal the underlying roles of one lncRNA, lncTAF15:1– 1, in modulating DC functions and its involvement with CCL5 secretion in SLE pathogenesis.Methods: The expression levels of lncTAF15:1– 1 were measured using qPCR in cultivated monocyte-derived dendritic cells (moDCs). …”
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CD8+ T Cell-Derived Perforin Exacerbates Dysbiosis and Inflammatory Bowel Disease via &amp;beta;-Hydroxybutyrate Suppression in Mouse Colonic Epithelium by Huang S, Pan L, Li M, Pang S, Tian Y, Shi W, Zong Y, Zhang D, Tian D

“…However, the exact mechanisms remain unclear.Methods: We applied a DSS-induced colitis model in wild-type and perforin-deficient (Prf1−/−) mice. …”
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Association Between Neutrophil Percentage to-Albumin Ratio, Neutrophil to-Lymphocyte Ratio, Platelet-to Lymphocyte Ratio and in-Hospital Mortality in Elder Patients with Bloodstrea... by Yu Z, Liu C, Gong M, Zhang P, Pei C, Liu X, Han X, Zhu P, Xu G, Du Y

“…This study aimed to investigate the association and the predictive value of NPAR, NLR and PLR with in-hospital mortality.Methods: This study included older patients with BSI who were hospitalized in a large healthcare center in Beijing from December 2011 to January 2024. …”
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Reduced Thioredoxin Regulates IL-1&amp;beta; Secretion via NLRP3 of IL-1&amp;beta;+ Alveolar Macrophages in COPD by Wang L, Shi R, Li Z, Ma R, Wang C, Xu C, Guo R, Xiao C, Du X, Yang W

“…The aim of this paper is to investigate the changes in the redox protein thioredoxin (TRX) in COPD and the role TRX plays in IL-1β release.Methods: We analyzed data from single-cell RNA sequencing (scRNA-seq) of COPD lung tissue in the GEO database. …”
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Triphasic CT Radiomics Model for Preoperative Prediction of Hepatocellular Carcinoma Pathological Grading by Huang H, Pan X, Zhang Y, Yang J, Chen L, Zhao Q, Huang L, Lu W, Deng Y, Huang Y, Ding K

“…., Shanghai, 200232, People’s Republic of China; 3Department of Pathology, The Third Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530031, People’s Republic of China; 4Department of Radiology, The First People’s Hospital of Qinzhou, Qinzhou, Guangxi, 530550, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Ke Ding, Department of Radiology, The Third Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, 530031, People’s Republic of China, Email 272480365@qq.com Yingying Huang, Department of Radiology, The First People’s Hospital of Qinzhou, Qinzhou, Guangxi, 530031, People’s Republic of China, Email 273749105@qq.comObjective: This study aimed to develop and validate a triphasic CT-based radiomics model for the synchronous prediction of multiple critical pathological markers in hepatocellular carcinoma (HCC).Materials and Methods: This retrospective study analyzed 174 patients with 187 hepatocellular carcinoma (HCC) lesions. …”
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Preoperative radiological parameters correlated to hallux valgus recurrence after distal chevron metatarsal osteotomy by Y. Hernanz-González, J.C. Martínez-Ávila, E. Sánchez-Morata, A. Gómez-Sánchez, J.D. Serrano-Alonso, J. Vilá-Rico

“…Radiologic HV recurrence was defined by a final hallux valgus angle (HVA) equal or greater than 20 degrees. Conclusions: Greater age at time of surgical treatment and preoperative noncongruent I metatarsophalangeal joint were identified as predictors for HV recurrence. …”
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Mechanistic Insights into Shenzhuo Formula for Diabetic Retinopathy: Integrating UPLC-Q-TOF-MS/MS, Network Pharmacology, Single-Cell RNA Sequencing Data, and Experimental Validatio... by Zang X, Zhang L, Ma J, Wang A, Ding L, Wang Y, Sun J, Li J, Hang X, Li X, Zhao L

“…This study aims to investigate the underlying mechanisms of SZF to expand treatment strategies for DR.Methods: SZF components were analyzed using Ultra Performance Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometry/Mass Spectrometry (UPLC-Q-TOF-MS/MS). …”
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A Multi-Algorithm Machine Learning Model for Predicting the Risk of Preterm Birth in Patients with Early-Onset Preeclampsia by Xu Y, Zu Y, Zhang Y, Liang Z, Xu X, Yan J

“…Yanhong Xu,1,&amp;ast; Yizheng Zu,2,&amp;ast; Ying Zhang,1,&amp;ast; Zewei Liang,1 Xia Xu,1,3– 5 Jianying Yan1,3– 5 1College of Clinical Medicine for Obstetrics &amp; Gynecology and Pediatrics, Fujian Medical University Fujian Maternity and Child Health Hospital, Fuzhou, Fujian, People’s Republic of China; 2The Affiliated Changzhou Second People’s Hospital of Nanjing Medical University, Changzhou, Jiangsu, People’s Republic of China; 3Fujian Clinical Research Center for Maternal-Fetal Medicine, Fuzhou, Fujian, People’s Republic of China; 4Laboratory of Maternal-Fetal Medicine, Fujian Maternity and Child Health Hospital, Fuzhou, Fujian, People’s Republic of China; 5National Key Obstetric Clinical Specialty Construction Institution of China, Fuzhou, Fujian, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Xia Xu, College of Clinical Medicine for Obstetrics &amp; Gynecology and Pediatrics, Fujian Medical University Fujian Maternity and Child Health Hospital, No. 18 Daoshan Road, Gulou District, Fuzhou, Fujian, People’s Republic of China, Email xuxia0623@fjmu.edu.cn Jianying Yan, College of Clinical Medicine for Obstetrics &amp; Gynecology and Pediatrics, Fujian Medical University Fujian Maternity and Child Health Hospital, No. 18 Daoshan Road, Gulou District, Fuzhou, Fujian, People’s Republic of China, Email yanjy2019@fjmu.edu.cnPurpose: To analyze the risk factors for preterm birth in patients with early-onset preeclampsia (EOPE) based on multi-algorithm machine learning and to construct a predictive model to explore the predictive value of the model.Methods: A retrospective analysis was conducted on 442 EOPE patients from a single tertiary center, divided into preterm birth (&lt; 37 weeks, n=358) and term-born (≥ 37 weeks, n=84) groups. …”
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