Prognostic Impact of Anemia in Patients with Significant Mitral Regurgitation: A Multicenter Cohort Study by Lv J, Lu Q, Li Z, Ye Y, Zhang B, Wang W, Zhao Q, Zhang H, Zhao Z, Wang B, Liu Q, Guo S, Yu Z, Duan Z, Zhao Y, Gao R, Xu H, Ge J, Wu Y

“…This study sought to investigate the prevalence of anemia in patients with significant mitral regurgitation (MR), as well as its association with outcomes.Methods: A total of 4339 patients with moderate or greater MR in the China Valvular Heart Disease study were included in this analysis. …”
Get full text

Development and Validation of a Prognostic Molecular Phenotype and Clinical Characterization in Grade III Diffuse Gliomas Treatment with Radio-Chemotherapy by Gu W, Tang J, Liu P, Gan J, Lai J, Xu J, Deng J, Liu C, Wang Y, Zhang G, Yu F, Shi C, Fang K, Qiu F

“…Weiguo Gu,1,2,* Jiaming Tang,2,* Penghui Liu,1 Jinyu Gan,1 Jianfei Lai,1 Jinbiao Xu,2 Jianxiong Deng,2 Chaoxing Liu,1 Yuhua Wang,2 Guohua Zhang,3 Feng Yu,1,2 Chao Shi,2,3 Ke Fang,2 Feng Qiu2,3 1Department of Oncology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, People’s Republic of China; 2Department of Oncology, Gaoxin Branch of the First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, People’s Republic of China; 3Nanchang Key Laboratory of Tumor Gene Diagnosis and Innovative Treatment Research, Gaoxin Branch of the First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Jiangxi, People’s Republic of China*These authors contributed equally to this workCorrespondence: Feng Qiu, Department of Oncology, Gaoxin Branch of the First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, People’s Republic of China, Email ndyfy01149@ncu.edu.cn Ke Fang, Department of Oncology, Gaoxin Branch of the First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Jiangxi, People’s Republic of China, Email fangkeqq88@163.comBackground: The relationship between molecular phenotype and prognosis in high-grade gliomas (WHO III and IV, HGG) treated with radiotherapy and chemotherapy is not fully understood and needs further exploration.Methods: The HGG patients following surgery and treatment with radiotherapy and chemotherapy. …”
Get full text

Diagnostic Accuracy of Non-Invasive Diagnostic Tests for Nonalcoholic Fatty Liver Disease: A Systematic Review and Network Meta-Analysis by Sun Y, Hu D, Yu M, Liang SB, Zheng Y, Wang X, Tong G

“…We aimed to assess and compare the diagnostic accuracy of various NITs for NAFLD using network meta-analysis (NMA).Materials and Methods: We conducted a systematic search in seven databases up to April 2024 to identify studies evaluating the diagnostic values of NITs, with liver biopsy as the gold standard. …”
Get full text

Associations between the Chinese Visceral Adiposity Index and the Self-Reported Menopausal Status: Results from Two Nationally Representative Population-Based Studies by Dong C, Ma D, Gu K, Lin Y, Song J, Wang Y, Yu J, Zhou Y

“…This study explores the Chinese visceral adiposity index (CVAI) as a potential indicator of menopausal status to aid in disease prevention.Patients and Methods: A cohort of 404 premenopausal Chinese women aged 45 years and above, from the China Health and Retirement Longitudinal Study (CHARLS), was included. …”
Get full text

Serum Folic Acid Predicted Pre-Operative Aortic Rupture in Symptomatic Aortic Aneurysm Dissection: A Prospective, Single-Center, Observational Study by Song F, Chen Z, Yang Z, Zou G, Liu B, Li W, Hong Y, Meng J, Zhao G, Bellou A, Li X

“…The aim of this study was to evaluate the predictive value of serum folic acid level for pre-operative adverse events in patients with symptomatic aortic aneurysm/aortic dissection.Methods and Results: Patients with symptomatic aortic aneurysm/aortic dissection, presenting to the emergency department (ED), were enrolled in the study. …”
Get full text

PREDICATIVE ARRANGEMENT OF NATIONAL ANTHEM TEXTS IN ENGLISH- AND GERMAN- SPEAKING COMMUNITIES by Anatoliy M. Prykhodko, Nataliia V. Lazebna

“…The indicative and imperative moods are almost equally represented, whereas the conditional mood is underrepresented. …”
Get full text

Predicting Short-Term Risk of Cardiovascular Events in the Elderly Population: A Retrospective Study in Shanghai, China by Zhu W, Tan S, Zhou Z, Zhao M, Wang Y, Li Q, Zheng Y, Shi J

“…This study aimed to develop a short-term risk prediction model for CVD events among individuals aged ≥ 60 years in Shanghai, China.Methods: Stratified random sampling recruited elderly individuals. …”
Get full text

Association Between Pain and Frailty in Middle-Aged and Older Patients: The Mediating Roles of Sleep and Mood by Wang HP, Wang T, Ye HT, Dong YY, Zhao SJ, Liu QR, Hu XY, Ji MH, Yang JJ

“…This study aimed to investigate the association between pain and frailty, with a particular focus on the mediating roles of sleep and mood.Patients and Methods: A cross-sectional study was conducted involving 244 middle-aged and older participants in local hospital. …”
Get full text

Plasma Aldosterone Elevation in Hypertensive Patients and Association with Urinary Stone Formation: A Large-Scale Population Study from Northwest China by Song S, Li N, Shen D, Hu J, Cai X, Zhu Q, Zhang Y, Ma R, Zhou P, Zhang Z, Jiang W, Hong J

“…Therefore, this study aimed to investigate the relationship between PAC levels and urinary stones, including their subtypes, in patients with hypertension.Methods: This large-scale study included a total of 35161 hypertensive patients. …”
Get full text

Effects of Dexmedetomidine as an Adjuvant in Preoperative Ultrasound-Guided Internal Branch of Superior Laryngeal Nerve Block on Postoperative Sore Throat and Hemodynamics in Patie... by Chen Z, Zhang L, Lu G, Zhang Y, Zhao D, Zhao S, Zhang H, Jin Y, Zhao X, Jin Y

“…In this first randomized controlled trial to date, we aimed to investigate the effects of US-guided iSLNB, with or without perineural dexmedetomidine, on the incidence and severity of POST following DLTs.Methods: A total of 159 patients were randomly assigned to three groups: control, bilateral US-guided iSLNB (2 mL 0.20% ropivacaine + 1 mL saline on each side), and bilateral US-guided iSLNB combined with perineural dexmedetomidine group (2 mL 0.20% ropivacaine + 1 mL 0.5 μg·kg− 1 dexmedetomidine on each side). …”
Get full text

Reflecting on the Implementation of United Kingdom (UK) General Practitioner Training Models in China: Highlights From a Train-the-Trainer Pilot Program by Luo F, Chen M, Chen Y, Huang H, Zhan W, Chen L, Xu D, Lv B

“…This program aims to reflect on the effective implementation of innovative training models in the context of Chinese GPs training system, ultimately aiming to improve the trainers’ capability in training the future Chinese general practitioners.Methods: This study was a cross-sectional survey with an online questionnaire seeking feedback from the GP teachers and trainers who attended the train-the-trainer program featuring co-designed online and offline teaching.Results: All participants were general practitioners; average age 42.5± 5.41 years, including 65% female, 65% consultant general practitioners, 60% general practitioners with PhD, average years of clinical practice being 17.7± 6.96, average years of teaching being 6.0± 1.41, average hours of teaching weekly being 2.1± 0.85, and average number of residents trained being 39.6± 51.87. …”
Get full text

Efficacy and Safety of Eravacycline Combination Therapy for Carbapenem-Resistant Acinetobacter baumannii Pneumonia in ICU Patients: A Retrospective Study by Guo Q, Wei Y, Zhao Q, Zhang W, Lv P, Zhou Z, Wang S

“…This study compares eravacycline with tigecycline for CRAB pneumonia in ICU patients.Methods: This retrospective study analyzed 65 ICU patients with CRAB pneumonia treated at Henan Provincial People’s Hospital from September 2023 to March 2024; the clinical efficacy and adverse reactions of eravacycline and tigecycline as target therapies were compared.Results: Both CRAB pneumonia cohorts exhibited more than 50% co-infection rates, predominantly Aspergillus and Klebsiella pneumoniae. …”
Get full text

Inflammatory Burden Index: A Superior Prognostic Biomarker of Systemic Inflammation in Patients on Peritoneal Dialysis by Chen J, Tang R, Tian N, Deng J, Ao S, Peng F, Zhan X, Wen Y, Wang X, Feng X, Su N, Tang X, Wu X, Zhou Q, Xu Q

“…The purpose of this study was to evaluate the prognostic value of various systemic inflammation biomarkers and to identify the optimal one in PD patients.Patients and Methods: This longitudinal study involved 3,225 patients undergoing PD across China. …”
Get full text

Low-dose Esketamine combined with Propofol in microscopic pediatric strabismus surgery: a randomized controlled study by Yaping Shen, Bo Shi, Yu Mo, Junhe Wu, Zhentao Sun

“…Group C was pre-treated with an equal volume of saline, and propofol 2.5 mg/kg was administered slowly after one minute. …”
Get full text

Machine Learning and Experimental Validation Reveal MYH11 as a Novel Prognostic Biomarker and Therapeutic Target in Bladder Cancer by Tan Z, Chen X, Fu S, Huang Y, Li H, Gong C, Lv D, Yang C, Wang J, Ding M, Wang H

“…This study aimed to explore the potential molecular mechanisms of BCa using multi-omics and single-cell analysis.Methods: First, differential analysis of transcriptome data related to BCa from public databases was performed, and a risk model was then developed using 101 different machine learning algorithms to determine prognostic genes, followed by independent prognostic analysis to construct a nomogram. …”
Get full text

Chaihu-Shugan-San Ameliorated Osteoporosis of Mice with Depressive Behavior Caused by Chronic Unpredictable Mild Stress via Repressing Neuroinflammation and HPA Activity by He MC, Xia SH, Pan H, Zhou TT, Wang XL, Li JM, Li XM, Zhang Y

“…This study aimed to explore the development of osteoporosis in depressive mice model and investigate the beneficial effects of the classical herbal formula Chaihu-Shugan-San (CHSG) on the brain and bone.Methods: CHSG powder was prepared by spray-drying following extraction with water. …”
Get full text

Factors Associated with Nursing Intention of Discharged Patients With Drainage Tubes During Transitional Care: a Case–Control Study by Ding X, Jiao W, Gong X, Sun Y, Sang L, Yu M

“…Xiaoying Ding,* Weijie Jiao,* Xue Gong, Yuanyuan Sun, Lin Sang, Ming Yu Department of Ultrasound, Xijing Hospital, The Fourth Military Medical University, Xi’an, Shaanxi, 710032, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ming Yu, Department of Ultrasound, Xijing Hospital, The Fourth Military Medical University, No. 127 Changle West Road, Xi’an, Shaanxi, 710032, People’s Republic of China, Email yumingfmmu@126.comPurpose: This study aimed to assess the crucial factors that contribute to the self-nursing intention of discharged patients with drainage tubes, with a specific emphasis on percutaneous surgeries.Patients and Methods: A case–control study was conducted in accordance with the EQUATOR-STROBE statement. …”
Get full text

NRF2 Deficiency in Bladder Epithelial Cells Owing to Ubiquitination by N6-Methyladenosine-Modified TRIM21 Induces Oxidative Stress and Inflammation to Aggravate IC/BPS by Fan Z, Ge Q, Ni B, Zhang J, Du T, Xu H, Duan Z, Zhang S, Wang C, Xue J, Ling F, Chen Z, Shen B, Wei Z

“…This study aimed to investigate the effects of nuclear factor erythroid 2-related factor 2 (NRF2) on IC/BPS and the potential molecular mechanisms.Methods: Bladder mucosal biopsies from IC/BPS patients were subjected to RT-qPCR and immunoblotting to quantify NRF2 mRNA/protein expression. …”
Get full text

AI in Home Care—Evaluation of Large Language Models for Future Training of Informal Caregivers: Observational Comparative Case Study by Clara Pérez-Esteve, Mercedes Guilabert, Valerie Matarredona, Einav Srulovici, Susanna Tella, Reinhard Strametz, José Joaquín Mira

“…Furthermore, it seeks to identify specific domains where LLMs show the most promise and where improvements are necessary to optimize their reliability for caregiver training. MethodsAn observational, comparative case study evaluated 3 LLMs—GPT-3.5, GPT-4o, and Microsoft Copilot—in 10 home care scenarios. …”
Get full text

The impact of the universities closure on physical activity and academic performance in physical education in university students during the COVID-19 pandemic by Aleksander Yu. Osipov, Tatyana I. Ratmanskaya, Elena A. Zemba, Vladimir Potop, Mikhail D. Kudryavtsev, Roman S. Nagovitsyn

“…The purpose of the research was to assess overall and sport/fitness PA level and academic performance in PE in a sample of university students pre- to post-cancellation of face-to-face PE classes due to the COVID-19 pandemic. Material and Methods. Participants (n=209) – university students (19-20 years old). …”
Get full text