A Survey of Physicians and Patients in Pakistan Assessing the Improvement of Visualization of the Cervix, Ease of Use, and Patient Comfort Using a Newly Designed Vaginal Speculum:... by Khan S, Waters-Kellar L, Barsh E, Shannon A, Clark S, Ryznar RJ, Trawick A, Payton M, Bouquet J

“…This study aimed to evaluate three of these limitations (visualization of the cervix, ease of use, and relative comfort) using a newly designed vaginal speculum that was hypothesized to overcome these limitations.Methods: This pilot prospective observational clinical study was conducted at five hospitals in Karachi, Pakistan. …”
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Increased CD163+ Macrophage Activation and High Expression of CD163 Promote Granulosa Cell Apoptosis in Polycystic Ovary Syndrome by Ye J, Wang S, Wang Z, Jiang Y, Jia J, Yang Y, Huo L, Liu X, Zhou Y, Yang Z, Mao J, Ma Y, Wang X

“…However, the precise mechanisms by which inflammation influences granulosa cell function remain poorly understood.Methods: Differentially expressed genes (DEGs) were identified from the GSE34526 dataset, with the inflammatory marker CD163 selected for further investigation due to its upregulation in ovarian granulosa cells in PCOS. …”
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Incidence of malignant brain and other central nervous system tumors (С70–C72) in Siberia and the Russian Far East by L. D. Zhuikova, E. L. Choynzonov, O. A. Ananina, L. V. Pikalova, I. N. Odintsova, G. A. Kononova

“…Malignant brain and other central nervous system tumors show a statistically significant increased incidence worldwide (GLOBOCAN, 2018).The study objective – to estimate the incidence of malignant brain and other central nervous system tumors in Siberia and the Russian Far East.Materials and methods. Using data from the population-based cancer registry in Siberia and the Russian Far East, we calculated the cancer incidence rates, the age-standardized incidence rates (ASIR), the index accuracy (the ratio of the number of cancer-related deaths to the number of new cases) of malignant brain and other central nervous system tumors during the period 2010 to 2019.Results. …”
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Jacmel, entre rêve et réalité by Jean Davoigneau, Isabelle Duhau

“…The local commercial bourgeoisie rebuilt their houses and warehouses using imported construction methods and materials. The Bord de Mer neighbourhood, the seaside neighbourhood, acquired a new appearance with structures in brick, in moulded cast iron, in riveted steel and in wrought iron. …”
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Respiratory bacterial and viral pathogen spectrum among influenza-positive and influenza-negative patients by Jing Shi, Shi Han, Yating Zhang, Xiaohua Lu, Yunxia Gan, Narenqimuge Tong, Lu Ma, Hang Zhuan, Ying Dai, Yaqi Ji, Guoming Li, Dan Chen, Lu Yang

“…This study aims to gain insights into the pathogenesis, epidemiology, and clinical implications of co-infections, facilitating the development of preventive and targeted interventions. Methods A total of 1,596 oropharyngeal swabs from influenza-like cases were collected from 2021 to 2023 and analyzed using real-time PCR. …”
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The Impact of Microwave Ablation on Recurrence and Metastasis of Hepatocellular Carcinoma: Insights From Animal Studies and Cytokine Profiling by Wang Y, Tan H, Wen C, Chen S, Zheng G, Qi H, Xie L, Shen L, Cao F, Fan W

“…The role of cytokine alterations in this post-ablation inflammatory microenvironment is crucial for understanding how MWA impacts tumor behavior.Purpose: This study aims to investigate the impact of post-ablation inflammatory responses on HCC recurrence and metastasis through animal experiments and cytokine profiling, with the goal of identifying potential biomarkers or therapeutic targets.Materials and Methods: This study involved 35 male C57BL/6 mice (6– 8 weeks old) to establish metastatic and orthotopic cancer models. …”
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Functional Brain Activity Alterations in Type 1 Narcolepsy Patients with Anxiety and Depression: A 7-Tesla Resting State-Functional Magnetic Resonance Imaging Study by Chen Y, Ye J, Chen J, Zhen Z, Tang C, Ren S, Han Q, Gao D

“…Yang Chen,1,2,* Jingyi Ye,3,* Jiafei Chen,4 Zhiming Zhen,4 Chenglin Tang,2 Shuancheng Ren,5 Qi Han,4 Dong Gao3 1College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, People’s Republic of China; 2College of Acupuncture and Tuina, Chongqing College of Traditional Chinese Medicine, Chongqing, People’s Republic of China; 3Department of Sleep and Psychology, Chongqing University Affiliated Renji Hospital, the Fifth People’s Hospital of Chongqing, Chongqing, People’s Republic of China; 4 7T Magnetic Resonance Imaging Translational Medical Center, Department of Radiology, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, People’s Republic of China; 5Department of Physiology, College of Basic Medical Sciences, Army Medical University (Third Military Medical University), Chongqing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Dong Gao, Email gaodong1973@163.com Qi Han, Email hanqi1227@tmmu.edu.cnPurpose: This study aimed to investigate abnormal changes in brain region functional activity in type 1 narcolepsy (NT1) patients comorbid with anxiety and depression.Methods: Twenty NT1 patients and 20 healthy controls (HCs) underwent subjective/objective sleep assessments (polysomnography, SAS, SDS) and 7T rs-fMRI to analyze regional homogeneity (ReHo) and fractional amplitude of low-frequency fluctuations (fALFF).Results: Compared with the HCs group, NT1 patients had higher SAS and SDS scores. …”
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Endothelial cells nurture stem cell-like characteristics of osteosarcoma cells in a perivascular niche by CXCL12/CXCR4 pathway by CAO Ya, LIU Yang, WANG Yang

“…Objective‍　‍To investigate the effect of endothelial cells in the perivascular niche on the stem cell-like characteristics of osteosarcoma cells and primarily explore the possible molecular mechanism. Methods‍　‍A co-culture model was established in vitro using SV40T- human umbilical vein endothelial cells (HUVEC-T1) and osteosarcoma stem cells (OSCs) derived from the human osteosarcoma cell line 143B. …”
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SERUM LncRNA SNHG16: A Biomarker for Diagnosing Childhood Obesity and Predicting Its Progression to Metabolic Syndrome by Hu J, Zheng Z, Liang D, Zhang Y, Chen J, Zhou C, You C, Liu Q

“…This study explores the expression and clinical significance of long non-coding RNA SNHG16 (SNHG16) in childhood obesity and its complications with MS (obesity-MS).Patients and Methods: Healthy controls and obese children (categorized as those with simple obesity or obesity-MS) were enrolled. …”
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Effect of Intraoperative Intravenous Infusion of Esketamine Combined with Dexmedetomidine on Postoperative Sleep Disturbance in Patients Undergoing Radical Mastectomy by Geng X, Pu Y, Hu Z, Zhang H, Wang M, Fang C, Lv G, Li W, Zhang X, Fan X, Liu S, Chen X, Wu J

“…We investigated the effects of intraoperative esketamine combined with intravenous dexmedetomidine on the incidence of POSD and postoperative sleep architecture.Methods: A single-center, randomized, double-blind controlled trial was conducted. …”
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Insight into Antiviral Activity of Ag/TiO2 Nanocomposites Against Influenza H1N1 Virus and Its Antiviral Mechanism by Ma Y, Xiao X, Wang Y, Sun J, Tang P, Li J, Sun X, Xu D, Yang Z, Chen S, Liu X

“…Yihe Ma,1– 3,* Xiaojun Xiao,2,* Yutao Wang,3,* Jie Sun,4 Ping Tang,5 Jing Li,3 Xizhuo Sun,5 Damo Xu,1,2 Zifeng Yang,3 Shiguo Chen,4 Xiaoyu Liu2 1Department of Respiratory and Allergy, Third Affiliated Hospital of Shenzhen University, Shenzhen, People’s Republic of China; 2State Key Laboratory of Respiratory Disease for Allergy at Shenzhen University, Shenzhen Key Laboratory of Allergy & Immunology, School of Medicine, Shenzhen University, Shenzhen, People’s Republic of China; 3State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People’s Republic of China; 4Nanshan District Key Laboratory for Biopolymers and Safety Evaluation, Shenzhen Key Laboratory of Polymer Science and Technology, Guangdong Research Center for Interfacial Engineering of Functional Materials, College of Materials Science and Engineering, Shenzhen University, Shenzhen, People’s Republic of China; 5Department of General Practice, Third Affiliated Hospital of Shenzhen University, Shenzhen, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaoyu Liu, State Key Laboratory of Respiratory Disease for Allergy at Shenzhen University, Shenzhen Key Laboratory of Allergy & Immunology, School of Medicine, Shenzhen University, Shenzhen, People’s Republic of China, Email lxy0901@szu.edu.cnPurpose: Synthesis and characterization of silver (Ag)/titanium dioxide (TiO2) nanocomposite (ATA) to investigate its antiviral activity against the H1N1 influenza virus and antiviral mechanisms.Materials and Methods: A water-dispersible ATA was prepared by a photocatalytic reduction process from AgNO3 and TiO2. …”
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Impact of Plasmapheresis on the Time Course of Changes in Cytokines After Operations on the Heart and Great Vessels by A. A. Yeremenko, A. A. Ragimov, S. A. Poreshina, M. A. Babayev, L. I. Vinnitsky, I. N. Solovyeva

“…To assess the impact of plasmapheresis on the time course of changes in pro- and anti-inflammatory interleukins and the results of treatment in patients after complicated operations on the heart and great vessels.Material and methods. 44 patients were examined. In 33 patients, the intra- and postoperative period was complicated by a prolonged extracorporeal circulation (EC), massive blood loss, acute hemolysis, the development of disseminated intravascular coagulation. …”
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Research Status and Direction of Chronic Obstructive Pulmonary Disease Complicated with Coronary Heart Disease: A Bibliometric Analysis from 2005 to 2024 by Bian H, Zhu S, Xing W, Qi L, Xue J, Peng X, Jin Z, Zhao H

“…In this study, we provide valuable insights in the field by examining the evolution of the relationship between COPD and CHD over the past 20 years.Methods: A comprehensive computer search was conducted in the Web of Science (WOS) core dataset, covering literature on COPD combined with CHD from January 1, 2005, to August 20, 2024. …”
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DL-Tryptophan Alleviates Sepsis-Related Acute Liver Injury via AhR Activation by Li B, Wang Q, Hu L, Duan W, Chen Y, Wang Z, Liu C, Liao L

“…Baitian Li,1,* Qing Wang,2,3,* Lungui Hu,3 Wenying Duan,3 Yuxuan Chen,3 Zetian Wang,3 Chunzheng Liu,3 Lijun Liao3 1Department of Emergency Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230601, People’s Republic of China; 2Shanghai YangZhi Rehabilitation Hospital, Shanghai, 201619, People’s Republic of China; 3Department of Pain Management, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200433, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lijun Liao, Department of Pain Management, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, People’s Republic of China, Email liao@pan-support.com Chunzheng Liu, Department of Pain Management, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, People’s Republic of China, Email lcz980712@163.comIntroduction: This research sought to elucidate the extent to which DL-tryptophan may confer protection against sepsis-induced acute liver damage (SALI) and to investigate the underlying mechanisms, particularly emphasizing aryl hydrocarbon receptor (AhR) activation.Methods: Cecal ligation and puncture (CLP) was utilized to create a murine sepsis model. …”
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Exploration of the relationships between the information and communication technology (ICT) and the education system in Morocco by Abdelkarim Taam, Amine Amar, Brahim Hmedna, Khalid Benabbes, El Menzhi Kaoutar, Rachid Daoudi, Adil El Makrani

“…Consequently, countries have adapted several methods of teaching and learning and made continuous reforms for a better quality of education. …”
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Systemic hormonal contraception and risk of venous thromboembolism by Oskari Heikinheimo, Elena Toffol, Timo Partonen, Anna But, Antti Latvala, Jari Haukka

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Exploring the Association Between Immune Cell Phenotypes and Osteoporosis Mediated by Inflammatory Cytokines: Insights from GWAS and Single-Cell Transcriptomics by Kuang S, Ma X, Sun L, Wang C, Li Y, Wang G, Sun J, Zhou F, Zhang C

“…Despite established links between immune cell phenotypes and inflammatory cytokines and osteoporosis, the exact mechanism involved remains unclear, and further understanding is needed for effective prevention and treatment.Methods: Here, we performed a two-sample Mendelian randomization (MR) study to estimate the causal effects between 731 immune cell types, 91 and 41 inflammatory factors (which may have some overlap), and 5 types of osteoporosis. …”
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Mitophagy-Related Gene CHDH Predicts Prognosis and Immune Response and Inhibits Proliferation and Migration in vitro and in vivo of Oral Squamous Cell Carcinoma by Chen L, Zhou Z, Guo L, He Z, Luo W, Fu Y, Xiao Q, Liu B, Huang P

“…Mitophagy is a special type of cellular autophagy that plays an important role in tumors, but its role in OSCC is still unclear.Methods: Mitophagy-related genes (MRGs) were obtained from the GeneCards database. …”
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Injectable Nanocomposite Hydrogel for Accelerating Diabetic Wound Healing Through Inflammatory Microenvironment Regulation by Chen Y, Li Y, Song H, Liu X, Zhang H, Jiang J, Liu H, Zhuo R, Cheng G, Fang J, Xu L, Qi Y, Sun D

“…Employing zeolitic imidazolate framework-8 (ZIF-8) as a drug delivery platform, integrated within a temperature-sensitive injectable hydrogel, presents an intriguing strategy for the closure of various irregular wounds, modulation of inflammatory responses, and promotion of angiogenesis.Methods: Herein, ZIF-8 loaded with curcumin (Cur) combined with methylcellulose/carboxymethyl chitosan (MCC) thermosensitive hydrogel was described. …”
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Xingxiao Pill Suppressed the Progression of Non-Small Cell Lung Cancer by Targeting SREBP1/FASN–Induced Fatty Acid Biosynthesis via PI3K/AKT/mTOR Signaling Pathway by Zhou X, Hu X, Zhang Z, Lin S, Lin X, Zhou T, Bai Y, Hu K

“…This study aimed to evaluate the potential efficacy of XXP in treating NSCLC and to investigate how XXP regulates fatty acid biosynthesis in NSCLC.Methods: A lung carcinoma mouse model was created by transplanting Lewis lung carcinoma (LLC) cells into male C57BL/6 mice. …”
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