A Comparison of in-vitro Pharmacokinetics and Pharmacodynamics of Branded and Its Locally Produced Cefuroxime Sodium Against Staphylococcus and Escherichia Escherichia coli by Du M, Sun T, Wang X, Chi X, Xiao Y

“…Mengjiao Du,1,2,* Tingting Sun,1,2,* Xueting Wang,3,4 Xiaohui Chi,5 Yonghong Xiao2– 4 1Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, People’s Republic of China; 2Jinan Microecological Biomedicine Shandong Laboratory, Jinan, Shandong, People’s Republic of China; 3Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, People’s Republic of China; 4Research Units of Infectious Disease and Microecology, Chinese Academy of Medical Sciences, Hangzhou, Zhejiang, People’s Republic of China; 5Department of Medical Laboratory, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaohui Chi, Department of Medical Laboratory, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong, People’s Republic of China, Email 15684003984@163.com Yonghong Xiao, Jinan Microecological Biomedicine Shandong Laboratory, Jinan, Shandong, People’s Republic of China, Email xiao-yonghong@163.comPurpose: To compare the in-vitro antibacterial effects of branded and its locally produced cefuroxime sodium against Staphylococcus ATCC29213, clinical strains of methicillin-sensitive Staphylococcus aureus (MSSA) 164342 and methicillin-sensitive coagulase-negative staphylococci (MSCNS) 117933, and Escherichia coli ATCC25922, and to provide a reference for their clinical use.Methods: An in-vitro antibacterial susceptibility test, time-kill curve and pharmacokinetics and pharmacodynamics (PK/PD) modeling was used in the comparison.Results: The minimum inhibitory concentrations (MIC) of the two types of cefuroxime sodium were identical against four bacterial strains; both types of cefuroxime sodium had MICs of 0.5 μg/mL, 8 μg/mL, 0.5 μg/mL, and 0.25 μg/mL against ATCC 29213, ATCC 25922, M164342 and MSCNS117933, respectively. …”
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Novel Loop-Structure-Based CD19/CD22 Dual-Target CAR-T Therapy for High-Risk Diffuse Large B-Cell Lymphoma Presenting with Hemophagocytic Lymphohistiocytosis: A Case Report by Ye Y, Li S, Guo Z, Zhao L, Zhou H, Zhong N, He M, Cao YJ, Liu L

“…Yuan Ye,1,* Shuhong Li,2,* Zhi Guo,1,* Lijun Zhao,2 Huanhuan Zhou,1 Nan Zhong,1 Mingxin He,1 Yu J Cao,2 Liqiong Liu1 1Department of Hematology, Affiliated Nanshan Hospital of Shenzhen University, Shenzhen, Guangdong, 518052, People’s Republic of China; 2State Key Laboratory of Chemical Oncogenomics, Shenzhen Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen, Guangdong, 518055, People’s Republic of China*These authors contributed equally to this workCorrespondence: Liqiong Liu, Department of Hematology, Affiliated Nanshan Hospital of Shenzhen University, Shenzhen, Guangdong, 518052, People’s Republic of China, Email llqwsp@hotmail.com Yu J Cao, State Key Laboratory of Chemical Oncogenomics, Shenzhen Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen, Guangdong, 518055, People’s Republic of China, Email joshuacao@pku.edu.cnObjective: To investigate the efficacy and safety of novel loop-structure-based CD19/CD22 dual-target chimeric antigen receptor T-cell (CD19/CD22 BS LoopCAR-T) therapy in high-risk diffuse large B-cell lymphoma (DLBCL) presenting with hemophagocytic lymphohistiocytosis (HLH).Methods: We analyzed the clinical data of a high-risk DLBCL patient presenting with HLH treated with CD19/CD22 BS LoopCAR-T at the Affiliated Nanshan Hospital of Shenzhen University in December 2023.Results: The patient, a 59-year-old female, was diagnosed with myelodysplastic syndromes with multilineage dysplasia in October 2022. …”
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Impact of HIV Pretreatment Drug Resistance on Secondary Transmission Through Treatment Dropout: A Prospective Population-Based Study in Southwestern China by Chen Y, Xu X, Chen H, Zhang X, Zhu Q, Liang S, Xing H, Liao L, Feng Y, Shao Y, Ruan Y, Lan G, Li J

“…The study aimed to assess the relationship between pretreatment drug resistance (PDR) and ART dropout, as well as the relationship between HIV treatment dropout and HIV secondary transmission.Methods: This study included all eligible participants from a local surveillance database in southwestern China between 2014 and 2021. …”
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Forecasting Hospitalization for Adult Asthma Patients in Emergency Departments Based on Multiple Environmental and Clinical Factors by Xi H, Zhang Y, Li W, Zhang C, Sun Y, Ji H, He Z, Chang C

“…Assessing the need for hospitalization of patients with complex comorbidities remains a significant challenge.Research Question: This study aims to develop models that integrate various environmental and clinical factors to predict the hospitalization of adult asthma patients in EDs and to interpret these models.Study Design and Methods: A retrospective analysis was conducted utilizing data from asthma patients at a single ED from 2016 to 2023; the data included demographics, vital signs, illness severity, laboratory test results, and comorbidities, along with environmental variables. …”
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Mechanism of the Traditional Chinese Medicine Simiao Biejia Decoction Improves the Diabetes Mellitus-Induced Erectile Dysfunction in Rats by Liu Y, Sun D, Xing D, Rui Y, Jin Y, Wang P, Cai B, Li C, Gao C, Cui Y, Jin B

“…This study aimed to investigate the effects and mechanisms of SMBJ in a rat model of DMED using network pharmacology, proteomics, and molecular docking.Methods: A rat model of DMED was established, and SMBJ granules were administered (0, 7.1, 14.2, and 28.4 mg/kg/d, respectively) for 4 weeks. …”
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O ESPAÇO VERDE DO BAIRRO ESTÁ ASSOCIADO AO AUMENTO DA CONEXÃO À NATUREZA EM ADULTOS E IDOSOS by Helena Moreira, Luís Quaresma, Graça Pinto, José Martinho, Ronaldo Gabriel, Andreia Teixeira

“…Purpose: The current study examines the associations between residential green space, PA, and CN in subjects between the ages of 18 and 75 years. Methods: The sample included 194 individuals, 61 men (41.42±15.37 years) and 133 women (39.93±15.60 years). …”
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Community-Based Approaches to Healthy Aging: Lessons from Japanese Blue Zones by Hiroko Oe, Kai Weeks, Sitsada Sartamorn

“…The study employed qualitative fieldwork methods including semi-structured interviews with 60 residents aged 65 and above, equally divided between the two study sites. …”
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Comprehensive Analysis of Programmed Cell Death-Related Genes in Diagnosis and Synovitis During Osteoarthritis Development: Based on Bulk and Single-Cell RNA Sequencing Data by Zhou J, Jiao S, Huang J, Dai T, Xu Y, Xia D, Feng Z, Chen J, Li Z, Hu L, Meng Q

“…Diverse programmed cell death (PCD) pathways are closely linked to the pathogenesis of OA, but few studies have explored the relationship between PCD-related genes and synovitis.Methods: The transcriptome expression profiles of OA synovial samples were obtained from the Gene Expression Omnibus (GEO) database. …”
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The Adjunctive Effect of Quercetin on Postoperative Pain Management Following Cesarean Section: A Randomized Controlled Study by Mohamed Elmokadem E, Khaled Abou El Fadl D, Bassiouny AM, Mahmoud MMAE, Samy M, El Said NO

“…This study aimed to assess the efficacy of preoperative Quercetin administration on acute post-operative pain following cesarean section.Patients and Methods:  In this prospective, double-blinded, randomized controlled trial, 80 patients undergoing elective cesarean section under spinal anaesthesia were randomly allocated to receive either 500 mg oral Quercetin (n=40) or matching placebo (n=40) one hour before surgery. …”
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Risk factors for complicated community-acquired pneumonia in Egyptian children: a hospital-based 6-month study by Abla S. Mostafa, Amr Mahmoud Abdel Khaleq, Yasser Hassan Mohammed, Erini Farid Fawzy

“…Aim To identify and elucidate risk factors that predispose children diagnosed with community-acquired pneumonia (CAP) to develop local pulmonary complications (complicated community-acquired pneumonia) in our Egyptian community. Methods One-hundred pediatric cases with CAP were involved in a case–control study, where cases were classified into 2 groups depending on the absence (41 cases) or the presence (59 cases) of local pulmonary complications. …”
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Ultrasound and Clinicopathological Characteristics of Papillary Thyroid Carcinoma Predict the Coexistence of TERT Promoter and BRAFV600E Mutations by Yu M, Zhang C, Wang Z, Lv S, Sun Y, Zhao W, Li L, Kong Q, Liu K, Wang S

“…This study aimed to develop preoperative and postoperative predictive models for coexisting mutations based on ultrasound and clinicopathological characteristics to stratify prognostic risks and guide clinical decision-making.Methods: Retrospective analysis of the ultrasound and clinicopathological characteristics of 120 patients with a surgical pathology of PTC with TERT promoter and BRAFV600E gene testing results in the Affiliated Hospital of Jining Medical University from December 2020 to December 2023. …”
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Predicting In-Hospital Mortality in Myocardial Infarction: A Nomogram-Based Retrospective Analysis of the MIMIC-IV Database by Peng S, Chen Q, Ke W, Wu Y

“…We aimed to develop and validate a predictive model for in-hospital mortality in myocardial infarction patients.Methods: LASSO regression analysis, univariate analysis, and multivariate logistic analysis were used to construct the nomogram in the training set, followed by model comparison, internal validation, and sensitivity analysis.Results: The analysis comprised 4688 patients in total. …”
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Systemic Lupus Erythematosus Stimulates Chondrocyte Pyroptosis to Aggravate Arthritis via Suppression of NRF-2/KEAP-1 and NF-κB Pathway by Shen S, Fang X, Zhang H, Lang T, Fu F, Du Y, Xu T, Jin H, Tong P, Wu C, Hu C, Ruan H

“…The study aimed to investigate the impact of SLE exacerbation on arthritis using the MRL/lpr mouse model, which closely mimics human SLE manifestations.Methods: In the present study, we evaluated the impact of SLE onset on knee joint degeneration by comparing arthritic phenotype and complex molecular alterations between 6 female 14-week-old MRL/lpr mice, which manifest SLE, and MRL/MpJ mice, which remain unaffected.Results: Our results demonstrated that MRL/lpr mice exhibited a more severe arthritic phenotype compared to MRL/MpJ mice, characterized by elevated Osteoarthritis Research Society International (OARSI) scores (P < 0.01), disrupted extracellular matrix metabolism, impaired chondrocyte proliferation and increased apoptosis. …”
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Interleukin-1 Receptor-Associated Kinase-3 Aggravates Neuroinflammatory Injury After Intracerebral Hemorrhage via Activation NF-&kappa;B/IL-17A Pathway in Mice by Wang J, Li Y, Tan C, Shao J, Tang W, Kong Q, Sheng W, Ding Z, Li F, Piao J, Lv D, Hu L, Wang Q, Jiang X

“…Although previous studies have shown that IRAK3 is involved in immune responses, the potential effects of IRAK3 on ICH remain unclear.Methods: Collagenase IV–induced ICH mouse model. Western blotting was used to determine the expression of IRAK3 at different time points following ICH. …”
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The Application of Multifunctional Endoscope Transport Carts in Bedside Endoscopy in Intensive Care Unit Patients by Zhang M, Du J, Zhang Q, Qiao F, Ye L, Hu B, Tao S

“…Miao Zhang,1,2,&amp;ast; Jiang Du,1,2,&amp;ast; Qiongying Zhang,1,2 Fu Qiao,3 Liansong Ye,1,4 Bing Hu,1,4 Siyuan Tao3 1Department of Gastroenterology and Hepatology, West China Hospital, Sichuan University, Chengdu, Sichuan, People’s Republic of China; 2West China School of Nursing, Sichuan University, Chengdu, Sichuan, People’s Republic of China; 3Department of Infection Control, West China Hospital, Sichuan University, Chengdu, Sichuan, People’s Republic of China; 4Digestive Endoscopy Medical Engineering Research Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Qiongying Zhang, Department of Gastroenterology and Hepatology, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Wuhou District, Chengdu, Sichuan, 610041, People’s Republic of China, Email hxnjzqy@163.com Fu Qiao, Department of Infection Control, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Wuhou District, Chengdu, Sichuan, 610041, People’s Republic of China, Email qiaofu2005@scu.edu.cnBackground: This study aimed to investigate whether the application of multifunctional endoscope transport carts, in bedside endoscopy in intensive care unit (ICU) patients, can improve the cleaning quality of the endoscopes.Methods: A total of 175 endoscopes, used for bedside endoscopy in ICU patients in a hospital in China during November 2023 to January 2024, were randomly classified into the control group (n=88) and the experimental group (n=87). …”
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A Health Literate Healthcare Organization Index System for China: Based on CiteSpace and Qualitative Analysis by Zhao S, Chen Y, Xia X, Zhou J, Wang X, Sun Q, Chang J, Ge J, Hu L, Lu R

“…Shenyu Zhao,1,&amp;ast; Yang Chen,2,&amp;ast; Xiyang Xia,2 Jing Zhou,2 Xiaoyu Wang,2 Qing Sun,1 Jiaqian Chang,2 Jiaying Ge,2 Lingmin Hu,2 Renjie Lu1,3 1Changzhou Third People’s Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, Jiangsu, People’s Republic of China; 2Department of Reproduction, Changzhou Maternity and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, Jiangsu, People’s Republic of China; 3Changzhou Institute for Advanced Study of Public Health, Nanjing Medical University, Changzhou, Jiangsu, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Renjie Lu, Changzhou Third People’s Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, Jiangsu, 213000, People’s Republic of China, Email renjie_lu@126.com Lingmin Hu, Department of Reproduction, Changzhou Maternity and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, Jiangsu, 213000, People’s Republic of China, Email hulingmin1986@126.comObjective: This study aims to analyze the current status and development trends of health literate healthcare organization (HLHO) worldwide, and preliminarily construct an index system suitable for HLHO in China.Methods: This study first utilized CiteSpace for bibliometric analysis to explore global research hotspots and trends in HLHO. …”
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Impact of the COVID-19 pandemic on hospital-based heart failure care in New South Wales, Australia: a linked data cohort study by Daniel McIntyre, Desi Quintans, Samia Kazi, Haeri Min, Wen-Qiang He, Simone Marschner, Rohan Khera, Natasha Nassar, Clara K. Chow

“…This study aimed to examine heart failure care during the pandemic in New South Wales (NSW). Methods Analysis of hospital utilisation among patients aged ≥ 18 years with a primary diagnosis of heart failure conducted using linked administrative health records from hospital admission, emergency department, non-admitted services, and mortality data collections. …”
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Clinical efficacy of 177Lu-DOTATATE peptide receptor radionuclide therapy in thyroglobulin-elevated negative iodine scintigraphy: A “not-so-promising” result compared to GEP-NETs... by Sandip Basu, Rahul Parghane, Chinna Naik

“…The selected patients were analyzed for the following parameters: (i) the patient characteristics, (ii) the metastatic burden, (iii) study of PRRT cycles and activity, (iv) response assessment (undertaken by three-parameter scale: symptomatic including Karnofsky/Lansky Performance scoring, biochemical and scan features) employing predefined criteria (detailed in methods), and (v) Grade III/IV hematological or renal toxicity. …”
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Understanding Mental Health Service Perceptions in Chinese Americans with Type 2 Diabetes and Co-Occurring Mental Health Challenges Living in New York City: A Qualitative Study by Liu J, Cao J, Shi Y, Jiang Y, Ruan J, Wu B, Tsai W, Hu L

“…This study aimed to provide an in-depth exploration of mental health care perceptions in this population.Patients and Methods: Two focus group discussions involving 12 participants were conducted in Mandarin. …”
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The Association Between Medication Adherence and Health-Related Quality of Life in Patients with COPD: A Cross-Sectional Study by Saja MF, Younis AS, Alzahrani LA, Alkhlassi IN, Aldakhil LS, Albayyat RM, Alnasser NA, Alokla KS, Alghamdi LA, Rashed AN, Azer SA

“…This study aimed to measure medication adherence and its impact on HRQoL in patients with COPD.Patients and Methods: This cross-sectional observational study included patients with COPD from two health centers in Riyadh, Saudi Arabia. …”
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