Performance of specific CMIP6 GCMs for simulating the historical rainfall and temperature climatology of Lake Tana sub-basin, Ethiopia by Tadele Melese Lebeza, Temesgen Gashaw, Haimanote Kebede Bayabil, Pieter R. van Oel, Abeyou W. Worqlul, Yihun T. Dile, Abebe Demissie Chukalla

“…Through wide-ranging evaluation methods using the Comprehensive Rating Index (CRI) and Taylor diagram, our study contributes by highlighting the top performing GCMs across different temporal scales for precipitation, Tmax and Tmin separately. …”
Get full text

The Joint Association of Sleep Quality and Outdoor Activity with Asthma and Allergic Rhinitis in Children: A Cross-Sectional Study in Shanghai by Lu R, Zhang Y, Chen Y, Lyu J, Li R, Kang W, Zhao A, Ning Z, Hu Y, Lin X, Tong S, Lu Z, Li S

“…Ruoyu Lu,1,* Ye Zhang,1,* Yiting Chen,1 Jiajun Lyu,1 Rong Li,1 Wenhui Kang,1 Anda Zhao,1,2 Zidi Ning,1 Yabin Hu,3 Xiaya Lin,4 Shilu Tong,3 Zhaohui Lu,3 Shenghui Li1,5 1School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 2Huadong Hospital, Fudan University, Shanghai, People’s Republic of China; 3National Children’s Medical Center, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, People’s Republic of China; 4Hainan Branch, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Sanya, Hainan Province, People’s Republic of China; 5MOE-Shanghai Key Laboratory of Children’s Environmental Health, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhaohui Lu, National Children’s Medical Center; Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, 1678 Dongfang Road, Pudong District, Shanghai, 200127, People’s Republic of China, Tel +86-18930830796, Email luzhaohui@sjtu.edu.cn Shenghui Li, School of Public Health, Shanghai Jiao Tong University School of Medicine, 227 South Chongqing Road, Huangpu District, Shanghai, 200025, People’s Republic of China, Tel +86-21-63846590, Email lsh9907@163.com; submission9907@163.comPurpose: Aiming to investigate the combined association of sleep quality and outdoor activity with the risk of asthma and allergic rhinitis in children.Patients and Methods: 16,936 children from kindergartens and primary schools in 13 administrative districts of Shanghai, China were involved in the analyses. …”
Get full text

Identification of Ferroptosis -Related Genes in MAFLD/MASH and HQHF Validation by Liu S, Zhang L, Xu J, Zhao Q, Shang D, Liu X, Zhang Q, Liu M, Zhao W

“…This study aims to identify differentially expressed genes (DEGs) associated with MAFLD/MASH and explore their potential link to ferroptosis, a form of regulated cell death.Methods: We conducted differential expression analysis using two datasets from the GEO database. …”
Get full text

Impact of Relaxation and Music Intervention on Psychological and Gastrointestinal Health in Military Recruits: A Prospective Study by Liu J, Liu T, Lu H, Zhao X, Ma S, Song F, Qiao N, Cheng W, Qi X

“…This prospective before-after study aimed to explore whether progressive muscular relaxation training combined with music intervention, which is potentially beneficial for psychological conditions, can improve gastrointestinal symptoms.Methods: A total of 623 recruits’ effective questionnaires before and after intervention were collected. …”
Get full text

Unveiling the Temporal Dynamics and Molecular Regulation Profiles of Neutrophil Extracellular Traps Following Spinal Cord Injury by Li J, Chang C, Li Y, Cui S, Bai J, Zhang C, Wang X, Li K, Jian F

“…This study aimed to explore the temporal dynamics and key regulatory genes of NET formation in SCI to identify therapeutic targets.Methods: We integrated two transcriptomic datasets from the GEO database to identify differentially expressed NETs-related genes (NRGs) in SCI. …”
Get full text

Prognostic Value of Spontaneous Potential in Left Atrial Posterior Wall Isolation and Radiofrequency Ablation for Non-Paroxysmal Atrial Fibrillation by Chen ZY, Zhong YH, Gong KZ, Chen XH, Xu Z, Zhang FL

“…Zhi-Yang Chen,1,2,* Yu-Hong Zhong,1,3,* Ke-Zeng Gong,1 Xue-Hai Chen,1 Zhe Xu,1 Fei-Long Zhang1 1Department of Cardiology, Fujian Medical University Union Hospital; Fujian Heart Medical Center, Fujian Institute of Coronary Heart Disease; Fujian Clinical Medical Research Center for Heart and Macrovascular Disease, Fuzhou, 350001, People’s Republic of China; 2Department of Cardiology, Zhangzhou Yuanshan Hospital, Zhangzhou, 363100, People’s Republic of China; 3Department of Cardiology, Huian County Hospital, Quanzhou, 362100, People’s Republic of China*These authors contributed equally to this workCorrespondence: Fei-Long Zhang, Department of Cardiology, Fujian Medical University Union Hospital; Fujian Heart Medical Center, Fujian Institute of Coronary Heart Disease; Fujian Clinical Medical Research Center for Heart and Macrovascular Disease, No. 29 Xinquan Road, Gulou District, Fuzhou, 350001, People’s Republic of China, Tel +86 10 8888888, Fax +86 10 6666666, Email cardizhang@163.comObjective: This study aimed to examine the long-term effects of left atrial posterior wall spontaneous potential (SP) in patients with non-paroxysmal atrial fibrillation (AF) who underwent pulmonary vein isolation (PVI) combined with left atrial posterior wall isolation (PVI+BOX) ablation.Methods: Clinical data were retrospectively collected from 140 patients with symptomatic non-paroxysmal atrial fibrillation (NPAF) who underwent first-time radiofrequency ablation between 2022 and 2023. …”
Get full text

Correlations Between TyG-Related Indices and Bone Health: A Cross-Sectional Study of Osteoporosis in a Rural Chinese Population by Jia F, Lu Y, Wen H, Tu J, Ning X, Wang J, Li P

“…This study aimed to explore the association between TyG indices and OP in a low-income rural Chinese population.Methods: This cross-sectional study was conducted in rural Tianjin, China, in 2020. …”
Get full text

Compare the Effects of 0 mg/kg, 0.1 mg/kg, 0.3 mg/kg and 0.5 mg/kg Esketamine on Emergence Agitation After Tonsillectomy and Adenoidectomy in Children: A Randomized Control Trial by Jiang P, Liu W, Peng Q, Feng Y, Wang D, Luo K, Huang S

“…This study investigated the effects of pre-anesthesia sedation of esketamine at 0mg/kg (Control group), 0.1mg/kg, 0.3mg/kg and 0.5mg/kg on EA in children.Methods: 164 children aged 3– 10 years, with American Society of Anesthesiologists (ASA) class I–II were included. …”
Get full text

Clinical Value of Complement C3a, C5a, and sC5b-9 in Evaluating the Severity of Patients with Severe Fever with Thrombocytopenia Syndrome by Chen T, Liu Y, Liu Y, Hu N, Dai Y, Zhu C, Han Y, Jin K, Li J

“…This article aims to evaluate the validity of complement C3a, C5a, and sC5b-9 in predicting the severity and clinical outcomes in SFTS.Patients and Methods: Patients diagnosed with SFTS at the First Affiliated Hospital with Nanjing Medical University from March to November 2021 were enrolled in this retrospective analysis. …”
Get full text

Exploring the Mechanism of Qinzhuliangxue Mixture for Treating Skin Lesions in Atopic Dermatitis: Insights from Network Pharmacology and Experimental Validation by Qiao Y, Yin H, Zhang H, He Q, Li Y, Sun L, Wang J, Li X, Koh WX, Pottakorn A, Chu Z, Xiang Y

“…The hospital preparation-Qinzhuliangxue mixture (QZLX) has shown potential in alleviating skin lesions in AD patients; however, its underlying mechanisms remain largely unexplored.Methods: QZLX’s key compounds and their targets in AD skin lesions were screened by network pharmacology, and gene enrichment analysis was performed. …”
Get full text

Comparative Effectiveness of Different Frequencies of Spinal Cord Stimulation for the Treatment of Patients with Failed Back Surgery Syndrome: Systematic Review and Network Meta-An... by Qin YY, Zhang CP, Tang SS, Wu JP, Zhu LX, Li YH, Xu F

“…This first network meta-analysis (NMA) compared the effectiveness and superiority of different SCS frequencies for FBSS.Material and Methods: Adhering to PRISMA guidelines, we searched PubMed, Web of Science, Embase, and CENTRAL for RCTs. …”
Get full text

Prevalence, Risk Factors, and Clinical Outcomes with Advanced HIV Disease Among People with Newly Diagnosed HIV During the “Treat-All” Era: A Retrospective Coho... by Jin J, Pan S, Chen J, Yin J, Ba H, Hou H, Zhang Y, Ma K

“…This study investigated the prevalence, characteristics, risk factors, and clinical outcomes of advanced HIV disease (AHD) in newly diagnosed HIV-positive individuals in China during the “treat-all” period.Patients and methods: We performed a retrospective cohort study on newly diagnosed adult ART-naive people with HIV (PWH) in Xi’an from 2016 to 2022. …”
Get full text

The Interaction Between Family Functioning and the PCDH9 rs9540720 Polymorphism on Major Depressive Disorder in Chinese Freshmen by Qin Y, Hu S, Niu S, Zhang W, Sun H, Xu R, Li H, Mu F, Liu N, Wang J, Sun H, Zhang Y, Liu Y

“…This study examined the effects of the interaction between PCDH9 and family functioning on MDD in first-year university students.Methods: A cohort of 6985 first-year university students in China was established in 2018 and was followed for one year. …”
Get full text

Association of the Triglyceride-Glucose Index and Obesity Indicators with Multiple Chronic Diseases: A Longitudinal Cohort Study Based on CHARLS by Lan Y, Qi G, Li B, Sooranna SR, Chen D, Rao W, Lin Y, Pang Y

“…Yincai Lan,1,* Guangzi Qi,1,* Boya Li,1 Suren Rao Sooranna,2 Dongshun Chen,3 Wenlian Rao,3 Yinxia Lin,1 Yaqin Pang4– 7 1School of Public Health, Youjiang Medical University for Nationalities, Baise, Guangxi, 533000, People’s Republic of China; 2Life science and clinical research center, Youjiang Medical University for Nationalities, Baise 533000, Guangxi, China and Department of metabolism, digestion and reproduction, Imperial College London, Chelsea & Westminster Hospital, London, SW10 9NH, UK; 3School of Basic Medicine, Youjiang Medical University for Nationalities, Baise, Guangxi, 533000, People’s Republic of China; 4School of Medical Laboratory Medicine, Youjiang Medical University for Nationalities, Baise, Guangxi, 533000, People’s Republic of China; 5Key Laboratory of Environmental and Population Health Research, Ecological Aluminum Industrial Base of Guangxi Universities, Baise, Guangxi, 533000, People’s Republic of China; 6Key Laboratory for Environmental Pollution and Health Risk Assessment, Youjiang Medical University for Nationalities, Baise, Guangxi, 533000, People’s Republic of China; 7Modern Industrial College of Biomedicine and Great Health, Youjiang Medical University for Nationalities, Baise, Guangxi, 533000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yinxia Lin; Yaqin Pang, Email lin1837731@163.com; pangyaqin@126.comObjective: To explore the relationship between triglyceride glucose (TyG) and the obesity combined indexes and the occurrence of multiple chronic diseases (MCD), which will help to provide a basis for the prevention and treatment of this condition.Methods: 3037 participants in the China Health and Retirement Longitudinal Study, which was conducted from 2011 to 2015 were selected for this study. …”
Get full text

Atherogenic and Inflammatory Markers in Recent Small Subcortical Infarcts: Associations with Location, Morphology, and Short-Term Recurrence by Huang C, Geng J, Fan J, Tian B, Wang K, Zhang Y, Zhou X, Zhu X, Sun Z

“…This study aimed to investigate the associations between the atherogenic index of plasma (AIP), systemic immune-inflammation index (SII), and systemic inflammation response index (SIRI) with the occurrence and recurrence of RSSIs.Methods: Three hundred forty-two patients with RSSIs who met the eligibility criteria were included in the cross-sectional analysis. …”
Get full text

Early infantile epileptic encephalopathy type 16: the new clinical and genetic variant of TBC1D24 gene mutation by A. A. Kholin, I. D. Fedonyuk, O. P. Dovelman, N. N. Zavadenko, T. V. Kozhanova, E. A. Kholina, G. Sh. Khondkarian, E. S. Il`ina

“…Objective: to analyse the clinical and neurophysiological data from a case of early infantile epileptic encephalopathy type 16 in a child with homozygous mutation in TBC1D24 gene.Material and methods. Female child M. aged 1 year and 2 months, with identified mutations in TBC1D24 gene was examined. …”
Get full text

Investigating the Role and Underlying Mechanisms of 18β-Glycyrrhetinic Acid in the Therapy of Ulcerative Colitis Through Modulation of the PPAR-γ/NF-κB... by Zhu A, Qiu Q, Xu Z, Zhang Q, Sun F, Liu Y, Chen Z, Zhang Y, Yao J

“…Aijing Zhu,1,* Qingqing Qiu,1,* Zhengguang Xu,1,* Qilian Zhang,2 Fang Sun,1,3 Yanzhan Liu,1 Zeang Chen,1 Yanan Zhang,4 Jing Yao1,3 1School of Basic Medicine, Jining Medical University, Jining, 272067, People’s Republic of China; 2People’s Hospital Affiliated to Shandong First Medical University, Jinan, 271100, People’s Republic of China; 3Jining Key Laboratory of Pharmacology, Jining Medical University, Jining, 272067, People’s Republic of China; 4Department of Obstetrics, Affiliated Hospital of Jining Medical University, Jining, Shandong, 272029, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jing Yao, Jining Medical University, School of Basic Medicine, Jining Medical University, Jining, 272067, People’s Republic of China, Tel +86 537-3616269, Email yjing_87@163.com Yanan Zhang, Affiliated Hospital of Jining Medical University, Department of Obstetrics, Affiliated Hospital of Jining Medical University, Jining, Shandong, 272029, People’s Republic of China, Tel +86 15153705143, Email yanan1202@163.comBackground: 18β-glycyrrhetinic acid (18β-GA), a triterpenoid saponin naturally occurring in Glycyrrhizae uralensis, has potent anti-inflammatory and antioxidant properties, but the therapeutic efficacy and precise mechanism of 18β-GA in ulcerative colitis (UC) remain unclear.Methods: To determine the therapeutic potential of 18β-GA, we constructed a dextran sodium sulfate (DSS)-induced UC model on a cohort of thirty-two female BALB/c mice and used mouse peritoneal macrophages to establish a co-culture system for in vitro experiments. …”
Get full text

Surgical Management of Anterior Urethral Stricture: A 23-year Single-Center Study by Guo Y, Ma N, Zhang J, Chen S, Liu P, Yang Z, Li Y

“…We conducted a 23-year single-center retrospective study to evaluate the long-term surgical outcomes of anterior urethral strictures with different clinical characteristics and to study factors that contribute to stricture recurrence.Methods: A retrospective study was conducted on 145 male patients diagnosed with anterior urethral stricture, who underwent meatotomy, anastomotic urethroplasty (AU), penile skin flap urethroplasty (PFU), single-stage buccal mucosa grafting (SSU), or multistage buccal mucosa grafting (MSU) between April 2000 and August 2023. …”
Get full text

Extracting Cognitive Impairment Assessment Information From Unstructured Notes in Electronic Health Records Using Natural Language Processing Tools: Validation with Clinical Assess... by Wang KY, Mahesri M, Novoa-Laurentiev J, Bessette LG, York C, Zakoul H, Lee SB, Ngan K, Zhou L, Kim DH, Lin KJ

“…Suite 3030, Boston, MA, 02120, USA, Tel +1 (617) 278-0930, Fax +1 (617) 232-8602, Email jklin@bwh.harvard.eduPurpose: We aimed to develop a Natural Language Processing (NLP) algorithm to extract cognitive scores from electronic health records (EHR) data and compare them with cognitive function recorded by Centers for Medicare & Medicaid Services (CMS)-mandated clinical assessments in nursing homes and home health visits.Patients and Methods: We identified a cohort of Medicare beneficiaries who had either the Minimum Data Set (MDS) or Outcome and Assessment Information Set (OASIS) linked to EHR data from the Research Patient Data Registry (Mass General Brigham, Boston, MA) from 2010 to 2019. …”
Get full text

Association Between Central Sleep Apnea and Left Atrial Enlargement in Snoring Patients with Preserved Ejection Fraction by Sun X, Wang Y, Wu C, Gao Y

“…However, the relationship between CSA and left atrial size in individuals with preserved EF remains underexplored.Objective: This study aims to examine the relationship between left atrial size and CSA in snoring patients with preserved EF.Methods: An observational study was conducted involving 341 consecutive snoring patients from a cardiology department who underwent overnight polysomnography (PSG) and echocardiography. …”
Get full text