GALNT14 Genetic Variants Harbor Differential Prognostic Values Linking to Distinct Macrophage Cell Types in Hepatocellular Carcinoma by Chu YD, Ho PH, Chen WT, Shih YL, Lai MW, Hsu CW, Yeh CT

“…This study aims to identify an SNP panel to improve prognosis prediction and explore its role in modulating tumor-infiltrating immune cells (TIICs).Patients and Methods: We included 345 HCC patients underwent surgical resection: 15 in the exploration cohort and 330 in the validation cohort. …”
Get full text

Triglycerides and HDL Cholesterol Mediate the Association Between Waist Circumference and Hyperuricemia in Normal-Weight Men by Cui WX, Wang SW, Gao L, Mu DH, Li N, Pan FH, Zhou WH, Hu Y

“…The aim of this research was to explore the mediating roles of TG and HDL-C in the association between WC and hyperuricemia in normal-weight men.Methods: A retrospective observational study was conducted among normal-weight men (18.5 ≤ BMI < 24 kg/m2) aged ≥ 18 years who underwent health checkups in Nanjing from 2021– 2023. …”
Get full text

Epidemiology and Molecular Drug-Resistance Patterns of Tuberculosis in Non-Elderly Patients in Luoyang, China, 2019-2023 by Wang Z, Xu L, Guo T, Liu J, Jin J, Zhang Q, Jiang T, Zhao Z, Xue Y

“…This study aimed to analyze TB transmission and molecular resistance profiles among non-elderly patients (&lt; 60 years) in Luoyang City.Patients and Methods: From 2019– 2023, 24,706 non-duplicate sputum samples from 10 TB-designated hospitals were tested for Mycobacterium tuberculosis complex (MTBC) via IS6110-targeted real-time PCR. …”
Get full text

The study of the elemental composition of peppermint (Mentha piperita) by K. V. Andrianov, Yu. A. Fedchenkova, O. P. Khvorost

“…Studying qualitative structure and quantitative content of macro - and microelements in leaf of 3 samples of peppermint became the purpose of our research. Materials and methods of research The peppermint leaves of 3 samples were the object of our research. …”
Get full text

The Effects of M2 Macrophages-Derived Exosomes on Urethral Fibrosis and Stricture in Scar Formation by Ren X, Wang Z, Wang J, Li X, Wei H, Liu C, Liu S, Zhu Y, Feng C, Yin Y, Tian Y, Wu M, Zeng X

“…This study aimed to investigate the possible effects of M-Exos on the initiation and development of urethral fibrosis and stricture after injury, and to elucidate the underlying mechanisms.Methods: In this study, we used time-tracking immunofluorescence staining for M1 and M2 macrophage markers to characterize sequential properties in the site of injured urethra. …”
Get full text

Challenges to creating primary care teams in a public sector health centre: a co-operative inquiry by Bob Mash, Pat Mayers, Hoffie Conradie, Abraham Orayn, Marjan Kuiper, Joey Marais, Bennie Cornelissen, Shaamelah Titus

“…The teams depended on effective collaboration between the doctors and the CNPs. Methods: A co-operative inquiry group, consisting of two facility managers, an administrator, and medical and nursing staff, met over a period of nine months and completed three cycles of planning, action, observation and reflection. …”
Get full text

Association Between Systemic Immune-Inflammation Index in Early Pregnancy and Preeclampsia: A Multicenter Cohort Study by Li Q, Li M, Zhao C, Chen X, Zhang C, Li Y, Chen Y, Yue C

“…The development of preeclampsia (PE) may be attributed to an excessive systemic inflammatory response in pregnant women, however, the relationship between SII and PE remains unclear.Methods: This study included 47,480 singleton pregnant women from three hospitals, comprising 2489 PE patients and 34,835 healthy controls. …”
Get full text

Heart Rate Variability in Young Adults with Bronchial Asthma with and without Previous COVID-19 Infection: A Cross-sectional Study by Gunaseelan Deivendran, Thamarai Selvi Kanagaraj, Bhavisha Sreenivasan Leelabai, Nalini Jayanthi, Saravanan Ayyavoo

“…Aim: To compare HRV parameters between young adult bronchial asthma patients with and without a history of COVID-19, and assess the extent of autonomic dysfunction attributable to COVID-19. Materials and Methods: This cross-sectional study included 100 bronchial asthma patients aged 20-40 years, equally divided into two groups based on COVID-19 history. …”
Get full text

Comprehensive Bioinformatics Analyses and Experimental Validation of the Cell Cycle Related Protein SAPCD2 as a New Biomarker and Potential Therapeutic Target in Pancreatic Cancer by Liu Y, Li B, Ke L, Luo T, Wu H, Lin J, Deng Y, Huang X, Xu L, Liu Y, Qi J

“…However, no comprehensive study has explored its expression and regulation, discussed its role in tumor prognosis and immune modulation, along with therapy response in pan-cancer until now.Methods: SAPCD2 expression was analyzed using data from The Cancer Genome Atlas database (TCGA) and Human Protein Atlas (HPA) database. …”
Get full text

Clinical Characteristics and Risk Factors for Blood Culture-Positive Klebsiella pneumoniae Liver Abscess: A Retrospective Study by Zhang HF, Chen JW, Li SS, Wu SW, Li S, Liu CY, Cai C, Lu MQ

“…This study aimed to investigate the clinical characteristics of patients with blood culture-positive KPLA and identify potential predictive indicators.Methods: We performed a retrospective analysis of clinical data from 263 KPLA patients diagnosed at our hospital between January 2019 and December 2023. …”
Get full text

Whole Transcriptome-Based ceRNA Regulatory Network Analysis of Radiation-Induced Esophageal Epithelial Cell Injury by Lin H, Feng Y, Liu H, Zhang J, Zhang X, Ying X, Shi Y, Tan H, Tu W

“…This study aimed to investigate the effects of ionizing radiation on human esophageal epithelial cells and explore the role of the ceRNA network in this injury.Methods: Cellular phenotype experiments assessed the effects of ionizing radiation on human esophageal epithelial cells. …”
Get full text

Anatomical and morphological features of the heart of a domestic dog (Canis Lupus Familiaris L., 1758) by M. R. Ragulya, L. P. Goralskyi, I. M. Sokulskyi, N. L. Kolesnik, B. V. Gutyj

“…For the work, complex morphological research methods were used: anatomical, histological, organo-, histo- and cytometric, statistical, thanks to which new data on the peculiarities of the macro-, histo- and cytomorphometric characteristics of the morphological structures of the heart in the studied animals were presented. …”
Get full text

Biospeckle Optical Coherence Tomography in Visualizing the Heat Response of Skin: Age-Related Differences by Ryosuke Nakasako, Jun Yamada, Takahiro Kono, Hirofumi Kadono, Uma Maheswari Rajagopalan

“…Currently, research related to the visualization of cutaneous vascular changes to heat stress depending on age and gender is limited to methods such as laser Doppler flowmetry and plethysmography, which do not provide any spatially resolved information at high resolution. …”
Get full text

Effects of Prophylactic Infusion of Equivalent Doses of Norepinephrine and Phenylephrine in Preventing Spinal Anesthesia-Induced Hypotension During Cesarean Delivery on Fetal and M... by Mao J, Lin K, Liu X, Liu J, Liang G, Sheng Z

“…We aimed to compare the effects of norepinephrine and phenylephrine at equivalent doses on fetal and maternal outcomes, and assess their efficacy at the 90% effective dose (ED90).Methods: A total of 100 parturients scheduled for cesarean delivery were randomly allocated to receive either 0.10&amp;nbsp;&amp;mu;g/kg/min norepinephrine (Group NE) or 0.60&amp;nbsp;&amp;mu;g/kg/min phenylephrine (Group PE) to prevent spinal anesthesia-induced hypotension. …”
Get full text

A Nomogram Based on Fibrinogen-to-Neutrophil Ratio as a Novel Predictor of Lymph Node Metastasis in Patients with Cervical Cancer and Type 2 Diabetes Mellitus by Kuang H, Yang D, Lin R, Tang Y, Luo Y, Wang S, Xia T, Lou G, Chen H

“…In this regard, we propose the fibrinogen-to-neutrophil ratio (FNR) as an innovative and promising biomarker for evaluating pelvic lymph node metastasis in cervical cancer patients with type 2 diabetes.Methods: The study was conducted on 141 patients diagnosed with cervical cancer and concomitant type 2 diabetes, who were treated at the First Affiliated Hospital of Xiamen University. …”
Get full text

Gender-Related Characterization of Acne in Chinese: A Multiple-Center Cross-Sectional Survey on 13085 Cases by Zhu T, Ge Y, Zhang J, Chen Y, Zhong H, Yang L, Zhang J, Li K, Yang S

“…Other gender-related characteristics of acne have not been well elucidated yet.Objective: We compared characteristics of skin lesions, severity and risk factors of acne between males and females in Chinese.Methods: Investigator-administered questionnaire was used to collect demographic data, clinical feature and risk factors of acne from May 2020 to August 2021. …”
Get full text

A Pan-Cancer Analysis of Natriuretic Peptide Receptor 3 (NPR3) with Clinical Cohort and in vitro Validation by Liu Y, Liu J, Li Y, Zhao Z, Lyu D, Dong K, Wei M, Huang R, Lu B, Pan X

“…This study aimed to comprehensively analyze NPR3’s role across multiple cancers, focusing on its potential as a prognostic biomarker, particularly in kidney cancer.Methods: A comprehensive pan-cancer study of NPR3 was conducted using 20 different databases and datasets. …”
Get full text

Adeno‐Associated Virus 8 and 9 Myofibre Type/Size Tropism Profiling Reveals Therapeutic Effect of Microdystrophin in Canines by Matthew J. Burke, Braiden M. Blatt, James A. Teixeira, Dennis O. Pérez‐López, Yongping Yue, Xiufang Pan, Chady H. Hakim, Gang Yao, Roland W. Herzog, Dongsheng Duan

“…However, little is known about the fibre type and fibre size tropism of AAV in large mammals. Methods We evaluated fibre type‐ and size‐specific transduction properties of AAV8 and AAV9 in 17 dogs that received systemic gene transfer (dose 1.94 ± 0.52 × 1014 vg/kg; injected at 2.86 ± 0.30 months; harvested at 20.79 ± 3.30 months). …”
Get full text

The Mediation Role of Insulin Resistance and Chronic Systemic Inflammation in the Association Between Obesity and NAFLD: Two Cross-Sectional and a Mendelian Randomization Study by Huang X, Chen Q, Su Q, Gong J, Wu L, Xiang L, Li W, Chen J, Zhao H, Huang W, Du S, Ye W

“…Xiaoyin Huang,1,&ast; Qianni Chen,2,&ast; Qingling Su,1,&ast; Jiamin Gong,1 Liqin Wu,2 Liangguang Xiang,3 Wanxin Li,1 Jun Chen,1 Hongwei Zhao,4 Wuqing Huang,1 Shanshan Du,5 Weimin Ye1,5,6 1Department of Epidemiology and Health Statistics, Fujian Medical University, Fuzhou, People’s Republic of China; 2Department of Ultrasonography, Fuqing City Hospital Affiliated to Fujian Medical University, Fuqing, People’s Republic of China; 3Department of General Surgery, Fuqing City Hospital Affiliated to Fujian Medical University, Fuqing, People’s Republic of China; 4Division of Occupational and Environmental Health, University of Utah, Salt Lake City, UT, USA; 5Institute of Population Medicine, Fujian Medical University, Fuzhou, People’s Republic of China; 6Department of Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden&ast;These authors contributed equally to this workCorrespondence: Shanshan Du, Institute of Population Medicine, Fujian Medical University, Fuzhou, People’s Republic of China, Tel +86 591 2286 9594, Email dushanshan1007@163.com Weimin Ye, Department of Epidemiology and Health Statistics, Fujian Medical University, Fuzhou, People’s Republic of China, Tel +86 591 2286 2023, Fax +86 591 2286 2510, Email ywm@fjmu.edu.cnPurpose: We aimed to identify the association between obesity and nonalcoholic fatty liver disease (NAFLD) and to quantify the mediating effects of insulin resistance (IR) and chronic inflammation through observational studies and Mendelian randomization (MR).Patients and Methods: In the current study, three IR-related indicators and three indicators of inflammation were included. …”
Get full text

Synergistic Induction of Immunogenic Cell Death by Biomineralized Manganese and Bisphosphonates Enhances Anti-PD-L1 Therapy in Triple-Negative Breast Cancer by Zhang X, Liu N, Wei M, Yang C, Lin Y, Zeng Y, Li Y, Zhou L, Li T, Zheng Q, Yu H, Zhang J, Gu Y, Xia N, Li S

“…Strategies to synergistically enhance ICD induction and elucidate the underlying molecular mechanisms remain to be fully explored.Methods: We analyzed the mode of apoptosis and immunogenicity of cancer cells post-treatment using Western blotting, flow cytometry, and confocal microscopy. …”
Get full text