Combination of Essential Oils and Extracts Enriched with Tocopherols in Diet of Holstein Steers and Its Effect on Ruminal Fermentation, Antioxidant and Anti-Inflammatory Response,... by João Gustavo Weschenfelder Wandscheer, Natalia Turcatto, Guilherme Luiz Deolindo, Mateus Henrique Signor, Alexandro Fritzen, Marcelo Vedovatto, Camila Ten Kathen Jung, Gilberto Vilmar Kozloski, Ana Carolina Hadlich Xavier, Roger Wagner, Bianca Fagan Bissacotti, Priscila Marquezan Copetti, Aleksandro Schafer da Silva

“…Background: This experiment evaluated whether the combination of essential oils (thyme, rosemary, orange) with extracts of <i>Cinnamomum</i> and <i>Quillaja saponaria</i> (enriched with tocopherols) in steers’ diet has positive effects on the health, digestibility, growth, oxidative stress, and fatty acid profile of meat. Methods: The experiment included 24 Holstein steers, divided into two groups, randomly divided (treated = phytogenic mixture (n = 12); control = monensin (n = 12)), undergoing a growth phase of 120 days and 90 days of finishing in individual pens, with a monthly collection of blood, rumen fluid, feces, and feed. …”
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Normal tissue complication probability modeling for late rectal bleeding after conventional or hypofractionated radiotherapy for prostate cancer by Christian A.M. Jongen, Ben J.M. Heijmen, Wilco Schillemans, Andras Zolnay, Marnix G. Witte, Floris J. Pos, Ben Vanneste, Ludwig J. Dubois, David van Klaveren, Luca Incrocci, Wilma D. Heemsbergen

“…Purpose: To develop a single NTCP model for grade ≥ 2 late rectal bleeding (G2 LRB) after conventional or hypofractionated radiotherapy for prostate cancer. Methods and Materials: The development dataset consisted of prostate cancer patients (n = 656) previously randomized to conventional (39 x 2 Gy) or hypofractionated (19 x 3.4 Gy) external beam radiotherapy with N = 89 G2 LRB cases. …”
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Abnormal Brain Functional Connectivity in Patients with Chronic Obstructive Pulmonary Disease and Correlations with Clinical and Cognitive Parameters by Han KI, Yeo Y, Jo HJ, Jo MJ, Park Y, Park TS, Jung SJ, Bae JH, Jang SH, Choi J, Park DW, Kim TH

“…In this study, we used resting-state functional magnetic resonance imaging to investigate brain functional connectivity (FC) abnormalities in patients with COPD and explored the correlation between abnormal FC and COPD-related clinical parameters.Methods: Forty-one patients with COPD, without a definite diagnosis of cognitive impairment or depression, and 30 age- and sex-matched controls were recruited. …”
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Human Mesenchymal Stem Cell-Derived Exosomes as Engineering Vehicles of Daunorubicin for Targeted c-Mpl+ AML Therapy by Li C, Wen Y, Wang J, Li L, He Y, Cheng Y, Chen J, Huang J, Ouyang C, Liu Y, Zhou R, Chen H, Li F, Guo Q, Chen Y, Chen C, Zhang Q

“…This study aimed to develop a type of targeted exosomes (Exos) capable of delivering anticancer drugs directly to c-Mpl+ AML cells.Methods: Human umbilical cord mesenchymal stem cells (hUCMSCs) were isolated as the source of Exos. …”
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MRI Features and Neutrophil-to-Lymphocyte Ratio (NLR)-Based Nomogram to Predict Prognosis of Microvascular Invasion-Negative Hepatocellular Carcinoma by Wei Y, Huang X, Pei W, Zhao Y, Liao H

“…Yunyun Wei,1,2,&ast; Xuegang Huang,3,&ast; Wei Pei,1,2,&ast; Yang Zhao,1,2 Hai Liao1,2 1Department of Medical Imaging Center, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, 530021, People’s Republic of China; 2Guangxi Key Clinical Specialty (Medical Imaging Department), Nanning, Guangxi, 530021, People’s Republic of China; 3Department of Infectious Diseases, The First People’s Hospital of Fangchenggang City, Fangchenggang, Guangxi, 538021, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Hai Liao, Department of Medical Imaging Center, Guangxi Medical University Cancer Hospital, No. 71 hedi Road, Nanning, Guangxi, 530021, People’s Republic of China, Tel +86-771-5334951, Email 42442427@qq.comPurpose: This study aimed to develop a novel nomogram to predict recurrence-free survival (RFS) for microvascular invasion (MVI)-negative hepatocellular carcinoma (HCC) patients after curative resection.Patients and Methods: A total of 143 pathologically confirmed MVI-negative HCC patients were analyzed retrospectively. …”
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Proposal and Verification of New Revised Criteria for ABPA/ABPM Diagnosis by Cai R, Ge H, Liu B, Tang Y, Wang J, Chen X, Liu B, Hu X, Deng S, Li H, Dai L, Tang J, Wu C, Gong X, Wang G, Li X, Feng J

“…In 2021, Asano et al introduced new diagnostic criteria for allergic bronchopulmonary mycosis (ABPM), which were found to improve diagnostic sensitivity compared to existing criteria, but the specificity was lower.Methods: To develop revised scoring criteria for ABPA/ABPM diagnosis, delphi surveys were conducted with two rounds in 14 experts. …”
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Outcome Following Chest Tube Removal with Respect to Phase of Respiration in Chest Trauma Patients: A Randomised Controlled Trial by Ritesh Kumar, Sandeep Chauhan, Mahavir Singh, Mohammed Faiz, Deepak, Gaurav Sharma, Manish Kumar Yadav, Sanjay Marwah

“…After evacuation of pleural contents, removal of chest tube is equally important since its careless removal can cause serious complications like Recurrent Pneumothorax (RP) and even lung collapse. …”
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Berberine Intervention Mitigates Myocardial Ischemia-Reperfusion Injury in a Rat Model: Mechanistic Insights via miR-184 Signaling by Yang H, Cao G, Li X, Zhao Z, Wang Y, Xu F

“…Additionally, the study explored the role of the miR-184/NOTCH1 signaling pathway in mediating these effects.Methods: Male Wistar rats were randomly assigned to five groups: sham-operated control, I/R injury, I/R treated with berberine, I/R treated with inhibitor NC and I/R treated with a miR-184 inhibitor. …”
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The role of the control of “life’s essential 8” for prevention on heart failure and all-cause mortality in patients with hypertension: the Kailuan cohort study by Jing Wang, Shuilin Wu, Liuxin Li, Jing Wu, Shiqiu Meng, Xueying Qin, Xin Chen, Shoulin Wu, Jie Shi, Yanping Bao, Feng Wang

“…However, evidence on the beneficial effects and necessity of LE8 control is still lacking, especially for hypertension. Methods The study population was drawn from the Kailuan cohort, hypertensive population at baseline with the non-hypertensive population matched 1:1 according to age and sex were involved in this analysis. …”
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Epidemiology of Overweight and Obesity in Early Childhood in China and Associated Factors by Li H, Xiang W, Yi Y, Huang X, Luo H, Cai Y, Liu L, Li H, Huang Y, Luo Q, Fan L, Lin Q

“…Hongai Li,1,&amp;ast; Wei Xiang,1,2,&amp;ast; Yajun Yi,3 Xiaoyan Huang,1 Hailing Luo,1 Yuhua Cai,1 Li Liu,1 Haidan Li,1 Yan Huang,1 Qing Luo,1 Lichun Fan,1 Qiuyu Lin1 1Department of Pediatrics, Hainan Women and Children’s Medical Center (Children’s Hospital Affiliated to Hainan Medical University), Haikou, 570206, People’s Republic of China; 2National Health Commission (NHC) Key Laboratory of Control of Tropical Diseases, Hainan Medical University, Haikou, 571199, People’s Republic of China; 3Department of Medicine, Vanderbilt University Medical School, Nashville, TN, 37212, USA&amp;ast;These authors contributed equally to this workCorrespondence: Qiuyu Lin, Department of Pediatrics, Hainan Women and Children’s Medical Center (Children’s Hospital Affiliated to Hainan Medical University), Haikou, People’s Republic of China, Tel +8615595779936, Fax +86089836689190, Email 45024711@qq.com Lichun Fan, Department of Pediatrics, Hainan Women and Children’s Medical Center (Children’s Hospital Affiliated to Hainan Medical University), Haikou, People’s Republic of China, Tel +8618689852199, Email 285562830@qq.comObjective: To evaluate the epidemiological landscape and identify the risk factors associated with overweight and obesity in early childhood in China.Methods: We collected measurements of weight and height and calculated the body mass index (BMI) for preschool children. …”
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Modified Zuo Gui Wan Ameliorates Ovariectomy-Induced Osteoporosis in Rats by Regulating the SCFA-GPR41-p38MAPK Signaling Pathway by Song C, Yan Q, Ma Y, Li P, Yang Y, Wang Y, Li W, Wan X, Li Y, Zhu R, Liu H, Zhang Z

“…We aimed to validate the anti-OP effect of MZGW and explore its underlying mechanism.Methods: An ovariectomy (OVX) rat model in vivo and a RANKL-induced osteoclasts (OCs) model in vitro were established. …”
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The Predictive Effects of Atherogenic Indices and Remnant Cholesterol on Gestational Diabetes Mellitus Risk by Cheng Y, Song J, Zhao L, Yin J, Lu X, Zhao Y, Sun G

“…Yao Cheng,1,&amp;ast; Jieping Song,2,&amp;ast; Lei Zhao,1,&amp;ast; Jieyun Yin,3 Xinfeng Lu,4 Yun Zhao,1 Guoqiang Sun1 1Obstetrics Department, Maternal and Child Health Hospital of Hubei Province, Wuhan, Hubei, People’s Republic of China; 2Medical Genetics Center, Maternal and Child Health Hospital of Hubei Province, Wuhan, Hubei, People’s Republic of China; 3Department of Epidemiology and Health Statistics, School of Public Health, Medical College of Soochow University, Suzhou, Jiangsu, People’s Republic of China; 4Medical Record Department, Maternal and Child Health Hospital of Hubei Province, Wuhan, Hubei, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Guoqiang Sun, Obstetrics Department, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuluo Road No. 745, Hongshan District, Wuhan, 430070, People’s Republic of China, Email sunguoqiang@hbfy.com Yun Zhao, Obstetrics Department, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuluo Road No. 745, Hongshan District, Wuhan, 430070, People’s Republic of China, Email zhao020060@163.comPurpose: This study aimed to investigate the predictive effects of atherogenic indices and remnant cholesterol on the risk of GDM.Patients and Methods: This observational study was conducted based on the Hospital’s clinical information system. …”
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Analysis of the results of treatment of patients with malignant tumors of the salivary glands by V. T. Vayradyan, A. M. Mudunov, V. D. Ermilova, R. I. Azizyan, I. A. Zaderenko, S. B. Aliyeva, E. L. Dronova

“…Objective: improve results of the treatment of patients with malignant salivary gland neoplasm (MSGN).Materials and methods. Analysis of 417 patients suffering from MSGN treated in the Federal State Budgetary Institution “N.N. …”
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Diagnostic Accuracy of the Alice NightOne Single-Belt Monitor for Obstructive Sleep Apnea and Reliability of Wireless Data Transfer by Peng M, Zhang Y, Zhao R, Li J, Zhang X, Deng L, Zhao L, Zhou B, Wang X, Dong X, Han F

“…MaoHuan Peng,1,&amp;ast; YuanYuan Zhang,2,&amp;ast; Rui Zhao,3 Jing Li,1 XueLi Zhang,1 LiHua Deng,4 Long Zhao,1 Bing Zhou,1 XinRu Wang,1 XiaoSong Dong,1 Fang Han1 1Department of Sleep Medicine, Peking University People’s Hospital, Beijing, People’s Republic of China; 2Department of General Practice, Peking University People’s Hospital, Beijing, People’s Republic of China; 3Department of Pulmonary and Critical Care Medicine, Peking University People’s Hospital, Beijing, People’s Republic of China; 4Department of Geriatrics, Peking University People’s Hospital, Beijing, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: XiaoSong Dong, Department of Sleep Medicine, Peking University People’s Hospital, Beijing, 100044, People’s Republic of China, 100044, Email dongxiaosong@pkuph.edu.cnObjective: To validate the performance of a single-belt type 3 portable monitor Alice NightOne for diagnosis of obstructive sleep apnea and its reliability in remote data transmission.Methods: Our study included two parts: in-laboratory Alice NightOne (ANO) monitoring (ANOlab) and home sleep apnea testing (HSAT) using ANO (ANOhome). …”
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Biodegradable Electrospun PLGA Nanofibers-Encapsulated Trichinella Spiralis Antigens Protect from Relapsing Experimental Autoimmune Encephalomyelitis and Related Gut Microbiota Dys... by Sabljić L, Radulović N, Đokić J, Stojanovic DB, Radojević D, Glamočlija S, Dinić M, Golić N, Vasilev S, Uskoković P, Sofronić-Milosavljević L, Gruden-Movsesijan A, Tomić S

“…However, whether timely controlled delivery of ESL1 antigens in vivo, as in natural infections, could enhance its therapeutic potential for MS is still unknown.Methods: To test this, we encapsulated ESL1 antigens into biodegradable poly (lactide-co-glycolic) acid (PLGA) nanofibers by emulsion electrospinning as a delivery system and assessed their release dynamics in vitro, and in an animal MS model, experimental autoimmune encephalomyelitis (EAE), induced 7 days after PLGA/ESL1 subcutaneous implantation. …”
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Knowledge, attitudes, and factors associated with the utilization of youth-friendly sexual and reproductive health services among teenagers and young adults in Kigali City, Rwanda by Julienne Nyirarukundo, Venuste Musugire, Boniface Nsengiyumva, Joella Mukashyaka, Zephanie Nzeyimana

“…Results This study revealed that out of the 850 TYAs included in the study, both sexes were nearly equally represented: 49.4% females versus 50.6% males. …”
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Clinical Outcomes of Hospitalized Immunocompromised Patients With COVID-19 and the Impact of Hyperinflammation: A Retrospective Cohort Study by Zhang X, Han X, Li C, Cui J, Yuan X, Meng J, Han Z, Han X, Chen W, Xiong J, Xie W, Xie L

“…We aimed to illustrate the inflammation profile and clinical outcomes of hospitalized immunocompromised patients with COVID-19.Methods: We conducted a retrospective study using a multicenter database and included adult hospitalized patients with Corona virus disease 2019 (COVID-19) in China’s late 2022 COVID-19 wave. …”
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Identification of EARS2 as a Potential Biomarker with Diagnostic, Prognostic, and Therapeutic Implications in Colorectal Cancer by Wang L, Deng X, Tang J, Gong Y, Bu S, Li Z, Liao B, Ding Y, Dai T, Liao Y, Li Y

“…This study identifies key genes associated with lactic acid metabolism and explore their impact on CRC.Patients and Methods: This study utilized data from The Cancer Genome Atlas, Gene Expression Omnibus, other public databases, and our institutional resources. …”
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A Phase I Study to Evaluate the Safety, Tolerability, Pharmacokinetics of BGT-002, a Novel ATP-Citrate Lyase Inhibitor, in Healthy Chinese Subjects by Liu Y, Yu C, Zhang Y, Xie Z, Wang Y, Qian H, Liang L, Liu Y, Chen Q, Jia J, Yan S, Lai X, Li W, Li J, Zhang Y, Nan F, Yu C

“…., Shanghai, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Fajun Nan; Chen Yu, Email fjnan@simm.ac.cn; cyu@shxh-centerlab.comObjective: This Phase I study evaluated the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of BGT-002, a novel ATP-citrate lyase (ACLY) inhibitor, in healthy Chinese adults.Methods: This study included three parts: Part I (single-ascending-dose study), Part II (multiple-ascending-dose study), and Part III (food effect study). …”
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LianChuang ZhiXue Liquid Enema Modulates the Macrophage Polarization of Ulcerative Colitis via Inhibiting the Jagged-1/Notch1 Signaling Pathway by Zhang Y, Liu J, Zhang D, Qian H

“…However, its specific molecular mechanism has not been clarified to explore the underlying macular mechanism of LCZXL enema effect on UC, based on Jagged-1/Notch1 signaling pathway and the macrophage polarization.Methods: After modeling of UC mice, the experiment was conducted in two parts: Experiment I: Control, Model, Mesalazine, Low dose of LCZXL (LCZXL-L), High dose of LCZXL (LCZXL-H); Weight and Disease Activity Index (DAI) scores were recorded on days 1, 3, 5, 7, 9, 11, and 13. …”
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