Association between serum albumin and severe impairment of activities of daily living in patients with stroke: a cross-sectional study by Ranran Bi, Yupeng Shi, Manrong Li, Xiaochen Liu, Zhenchao Ma, Yiqing Huang, Bingyin Liang, Fang Cui

“…This study aims to provide further results.Materials and methodsThis study examined cross-sectional data from patients aged 18 years or older with a diagnosis of stroke confirmed by cranial CT or MRI within 24 h of admission, gathered from January 2020 to August 2022. …”
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Effect of Telemedicine-Supported Structured Exercise Program in Patients with Chronic Low Back Pain: Study Protocol for a Randomized Controlled Trial by Feng Y, Jia C, Liu H, Bao T, Wang C, Wang Z, Huang J, Jiang Y, Wang X, Zhang R, Zhang Y, Zhang S, Zhu S, He C

“…Consequently, further research is warranted to clarify the impact of telemedicine-supported structured exercise programs on patients with CLBP.Patients and Methods: This randomized controlled trial will include patients with CLBP who have not received exercise therapy in the past three months. …”
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Human Neural Stem Cells Reduce Hypoxia-Ischemic Neurological Impairment Through the Regulation of Inflammatory M1/M2 Microglias in Rats by Ding YB, Zhao Y, Chen BY, Wang Q, Wang ZY, Luan Z, Yi B

“…Ya-Bing Ding,1,2,* Yuan Zhao,1– 3,* Bing-Yu Chen,1 Qian Wang,1 Zhao-Yan Wang,1 Zuo Luan,1,2 Bin Yi4 1Department of Pediatrics, The Sixth Medical Center of PLA General Hospital, Beijing, People’s Republic of China; 2Department of Pediatrics, The Second School of Clinical Medicine, Southern Medical University, Guangzhou, People’s Republic of China; 3Department of Neonatology, Children’s Hospital of Shanxi, Women Health Centre of Shanxi, Taiyuan, People’s Republic of China; 4Department of Pediatrics, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zuo Luan, Department of Peadiatric, The Sixth Medical Center of PLA General Hospital, Beijing, 100048, People’s Republic of China, Tel +86-18600310270, Fax +86-1066958303, Email luanzuodoctor@126.com Bin Yi, Gansu Provincial Maternity and Child-care Hospital, Lanzhou, Gansu, 730000, People’s Republic of China, Email www.0931@163.comObjective: This study aims to investigate the therapeutic efficacy and migration of human neural stem cell (hNSC) therapy in a rat model of moderate to severe Hypoxic-ischemic encephalopathy (HIE).Methods: hNSCs were transplanted into the brain ventricle of HIE-induced rats. …”
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Effect of cervical traction on cervicogenic headache in patients with cervical radiculopathy: a preliminary randomized controlled trial by Anis Jellad, Amine Kalai, Amr Chaabeni, Cyrine Ben Nasrallah, Atef Ben Nsir, Mahbouba Jguirim, Asma Belguith Sriha, Zohra Ben Salah Frih, Mohamed Hedi Bedoui

“…The purpose of the study was to make a preliminary estimate of efficacy of adding MICT to conventional rehabilitation on CGH in patients with cervical radiculopathy. Methods A total of 36 CR patients with CGH were randomly allocated to 3 equally sized groups (A, B and C). …”
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The Mechanism of Sijunzi Decoction Suppresses Gastric Cancer Metastasis via the m6A Methyltransferase METTL14 Based on Untargeted Metabolomics Studies and Network Pharmacology Anal... by Li X, Zhao L, Wang J, Ma T, Zhou J, Bian Y, Guo J

“…However, additional research is necessary to comprehend the mechanisms beneath the therapeutic potential of SJZ in gastric cancer.Objective: This research endeavored to analyze how SJZ treats gastric cancer using network pharmacology and experimental validation.Methods: Liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) and network pharmacology were applied to systemically clarify the mechanism of SJZ against gastric cancer. …”
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Aggregation of Stress Granules Induced by Hypoxia and Lipopolysaccharide via PKR-p-eIF2α Pathway and 4EBP1 Pathway Inhibits the Inflammatory Response in Peri-Implantitis by Li S, Ma C, Fan C, Liu Y, Li J, Yin B, Zhong L, Bai N, Li Z

“…Shuang Li,1,2,* Chunling Ma,3,* Chun Fan,4 Yanshan Liu,5 Jian Li,2,6 Baoheng Yin,1,2 Lingmei Zhong,7 Na Bai,1,2 Zhiyuan Li3 1Department of Prosthodontics, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, People’s Republic of China; 2School of Stomatology, Qingdao University, Qingdao, Shandong, People’s Republic of China; 3Medical Research Center, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, People’s Republic of China; 4Department of Periodontology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, People’s Republic of China; 5Department of Maxillofacial Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, People’s Republic of China; 6Department of Oral Implantology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, People’s Republic of China; 7Department of Pulmonary and Critical Care Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhiyuan Li, Email zyli0120@163.com Na Bai, Email na.bai@qdu.edu.cnObjective: To investigate whether stress granules (SGs) exist in peri-implantitis (PI) and to explore the formation mechanism and role of SGs in the response of human gingival fibroblasts (hGFs) to hypoxia or LPS.Methods: Gingival tissues were collected from patients with PI and from healthy individuals. …”
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Growth Differentiation Factor-15 as a Potential Biomarker for Renal Involvement in POEMS Syndrome by Huang Y, Chen J, Yao Y, Zhang L, Li Y, Li J

“…Growth differentiation factor-15 (GDF-15) is related with renal function, but few studies have focused on it in renal impairment of POEMS syndrome.Objective: To evaluate the potential of circulating GDF-15 concentration as a biomarker for renal function in POEMS syndrome.Methods: 150 Chinese patients, diagnosed with POMES syndrome, were enrolled and divided into three subgroups according to their chemotherapy stage. …”
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Development and Validation of Predictive Models for Inflammatory Bowel Disease Diagnosis: A Machine Learning and Nomogram-Based Approach by Dong R, Wang Y, Yao H, Chen T, Zhou Q, Zhao B, Xu J

“…This study aimed to develop predictive models for diagnosing IBD, Crohn’s disease (CD), and Ulcerative colitis (UC) by combining two approaches: machine learning (ML) and traditional nomogram models.Methods:  Cohorts 1 and 2 comprised data from the UK Biobank (UKB), and the First Hospital of Jilin University, respectively, which represented the initial laboratory tests upon admission for 1135 and 237 CD patients, 2192 and 326 UC patients, and 1798 and 298 non-IBD patients. …”
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Low sensitivity of the fourth‐generation antigen/antibody HIV rapid diagnostic test Determine™ HIV Early Detect for detection of acute HIV infection at the point of care in rural E... by Iza Ciglenecki, Nombuso Ntshalintshali, Esther Mukooza, Skinner Lekelem, Mpumelelo Mavimbela, Sindisiwe Dlamini, Lenhle Dube, Nomvuyo Mabuza, Melat Haile, Tom Ellman, Antonio Flores, Olivia Keiser, Sindy Matse, Roberto de laTour, Alexandra Calmy, Bernhard Kerschberger

“…We nested a diagnostic accuracy study within a larger study of the burden of sexually transmitted infections in rural Eswatini. Methods Adults were enrolled at six routine HIV testing sites (HTS) in the Shiselweni region between June 2022 and April 2023. …”
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A comparison of applicant and accepted student characteristics to research training programs with implications for recruitment and selection strategy by Young-Hee Cho, Young-Hee Cho, Chi-Ah Chun, Chi-Ah Chun, Hector Ramos, Paul Buonora, Paul Buonora, Paul Buonora, Vasanthy Narayanaswami, Vasanthy Narayanaswami, Kim-Phuong L. Vu, Kim-Phuong L. Vu

“…Its second aim was to investigate whether applicants who were accepted to the programs using a holistic selection process differed in academic discipline, demographics, and psychosocial characteristics from applicants who were not accepted.MethodsInformation on students’ majors, race/ethnicity, and gender was obtained from the university records or applications submitted by students. …”
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Whole-body and site specific [18F]FDG uptake patterns on PET/CT have limited value in differentiating between polymyalgia rheumatica and other inflammatory diseases: two cohorts of... by Andreas Wiggers Nielsen, Gijs D. van Praagh, Kornelis S. M. van der Geest, Ib Tønder Hansen, Berit Dalsgaard Nielsen, Søren Geill Kjær, Jesper Blegvad-Nissen, Kate Rewers, Christian Møller Sørensen, Elisabeth Brouwer, Ellen-Margrethe Hauge, Lars Christian Gormsen, Riemer H. J. A. Slart, Kresten Krarup Keller

“…Therefore, this study aimed to investigate both the overall whole-body [18F]FDG-uptake patterns and the specific uptake patterns at individual sites in patients suspected of having PMR. Methods Two distinct cohorts of patients with suspected PMR from Denmark and the Netherlands were prospectively included, encompassing 66/27 and 36/21 PMR/non-PMR patients, respectively. …”
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Domestic violence and its determinants among reproductive-age women in Sub-saharan Africa: a multilevel analysis of 2019–2024 demographic and health survey data by Girum Nakie, Gebresilassie Tadesse, Setegn Fentahun, Gidey Rtbey, Fantahun Andualem, Getasew Kibralew, Mulualem Kelebie, Mamaru Melkam, Techilo Tinsae, Mulat Awoke Kassa, Tekletsadik Tekleslassie Alemayehu, Muluken Yigezu, Tigist Kifle Tsegaw, Tesfaye Segon, Yilkal Abebaw Wassie

“…It violates human rights, hinders gender equality, and requires a multifaceted approach. Studies in sub-Saharan Africa (SSA) reveal significant disparities across nations. …”
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Modifying exercise and physical therapy in medical rehabilitation to promote a physically active lifestyle: Protocol for a multicenter controlled hybrid type 2 effectiveness-implem... by Eva Grüne, Johannes Carl, Wolfgang Geidl, Johanna Popp, David Victor Fiedler, Natalie Boss, Regina Brinkmann, Juliane von dem Bussche, Gabi Eichner, Kathrin Kleinert, Christoph Löhr, Florian Mex, Paul Schwanitz von Keitz, Till Richter, Joachim Schmidt, Rainer Tischendorf, Gorden Sudeck, Klaus Pfeifer

“…The objectives of the STABEKO study are A) to evaluate the implementation of modified exercise and physical therapy and to identify influencing factors for development and implementation, and B) to determine the short- and long-term effectiveness of the modified therapy on PAHCO and physical activity of the persons undergoing rehabilitation. Methods As part of the STABEKO study, we will use cooperative planning as a co-creation approach for planning, developing, and implementing actions to modify exercise and physical therapy by engaging relevant actors from practice, policy, and research in an equal decision-making process. …”
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Association of autoantibodies with the IFN signature and NETosis in patients with systemic lupus erythematosus by Ellen D. Kaan, Tammo E. Brunekreef, Julia Drylewicz, Lucas L. van den Hoogen, Maarten van der Linden, Helen L. Leavis, Jacob M. van Laar, Michiel van der Vlist, Henny G. Otten, Maarten Limper

“…Here we studied the association between autoantibodies, the IFN signature, NET release, and clinical manifestations in patients with SLE. Methods: We performed principal component analysis (PCA) and hierarchical clustering of 57 SLE-related autoantibodies in 25 patients with SLE. …”
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Time to endovascular thrombectomy for acute ischaemic stroke in language other than English (LOTE) communities in South-Western Sydney by Dennis Cordato, Peter Thomas, Alan McDougall, Cecilia Cappelen-Smith, Christopher Blair, Nathan Manning, Jing ji, Longting Lin, Mark Parsons, Andrew K Cheung, Daniel Wardman, Chushuang Chen, Suzanne J Hodgkinson, Helen Badge, Vivek Pidugun, Timmy Pham

“…Patients requiring interpreters equally exhibited shorter ATP times (152 vs 170 min; p=0.01) and higher stroke severity. …”
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Effect of vitamin D on proteinuria, lipid status, glicoregulation and C-reactive protein in patients with type-2 diabetes mellitus by Petrović Marijana, Dragović Tamara, Petrović Stanko, Obrenčević Katarina, Rančić Nemanja, Đurašinović Tatjana, Petrović Dejan, Ignjatović Ljiljana, Rabrenović Violeta, Nenezić Nemanja, Marinković Dejan, Maksić Đoko

“…The aim of this study was to examine the influence of vitamin D supplementation on proteinuria, cholesterol, triglycerides, C-reactive protein (CRP) and hemoglobin A1c in patients with type-2 DM and vitamin D insufficiency/ deficiency. Methods. This prospective, cohort study included 90 patients with type-2 DM and vitamin D insufficiency/ deficiency divided into 3 equal groups: with normal proteinura, with microproteinuria and with macroproteinuria. …”
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Serum taurine affects lung cancer progression by regulating tumor immune escape mediated by the immune microenvironment by Tu-Liang Liang, Hu-Dan Pan, Pei-Yu Yan, Jia-Ning Mi, Xiao-Cui Liu, Wei-Qian Bao, Li-Rong Lian, Cui-Fen Zhang, Ying Chen, Jing-Rong Wang, Ying Xie, Hua Zhou, Xiao-Jun Yao, Pawlec Graham, Elaine Lai-Han Leung, Liang Liu, Run-Ze Li

“…Objectives: Our study aimed to systematically investigate the role of taurine in lung cancer, with the ultimate goal of contributing novel strategies for lung cancer treatment. Methods: Lung cancer C57 and nude mice models, RNA sequencing, and stable transfection were applied to explored the effects and mechanisms of taurine on lung cancer. …”
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Variables associated with cognitive function: an exposome-wide and mendelian randomization analysis by Yong-Li Zhao, Yi-Ning Hao, Yi-Jun Ge, Yi Zhang, Lang-Yu Huang, Yan Fu, Dan-Dan Zhang, Ya-Nan Ou, Xi-Peng Cao, Jian-Feng Feng, Wei Cheng, Lan Tan, Jin-Tai Yu

“…We performed univariate analyses to identify variables significantly associated with each cognitive function in two equal-sized split discovery and replication datasets. …”
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Evaluation of multidrug-resistant bacteria and their molecular mechanisms found in small animal veterinary practices in Portugal by Joana Moreira da Silva, Joana Moreira da Silva, Juliana Menezes, Juliana Menezes, Juliana Menezes, Laura Fernandes, Laura Fernandes, Cátia Marques, Cátia Marques, Cátia Marques, Sofia Santos Costa, Dorina Timofte, Andreia J. Amaral, Andreia J. Amaral, Andreia J. Amaral, Constança Pomba, Constança Pomba, Constança Pomba

“…The goal of our work was to evaluate the environmental contamination and staff carriage by MDROs in veterinary practices across Portugal.MethodsFourteen SAVPs were enrolled. Environmental samples were collected from critical areas such as operating room, wards and pre-operative area. …”
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Prospective study of continuous rhythm monitoring in patients with early post-infarction systolic dysfunction: clinical impact of arrhythmias detected by an implantable cardiac mon... by Jesus Hernandez-Hernandez, Ana Martin-Garcia, Javier Jimenez-Candil, Pedro L Sanchez, Carlos González-Juanatey, Javier García-Fernández, Alba Cruz-Galban, Olga Duran-Bobin, Javier Garcia-Seara, Teba Gonzalez-Ferrero, Jose Morinigo, Manuel Sanchez-Garcia, Gonzalo Fernandez-Palacios, Jose Seijas-Amigo, Juliana Elices, Javier Portales-Fernandez, Francisco Martin-Herrero, Ana García-Campos, Jose A Perez-Rivera, Marta Alonso-Fernandez-Gatta, Alfonso Macías, Paloma Perez-Espejo

“…Among patients with post-infarction left ventricular dysfunction, modern implantable cardiac monitoring devices (ICM) allow a unique opportunity to determine in real-time the burden of non-sustained ventricular tachycardias and their relationship to the subsequent occurrence of sustained or symptomatic events.Methods and analysis Approximately 200 patients with left ventricular ejection fraction (LVEF) equal to or less than 40% after acute myocardial infarction will be included in the study. …”
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