A Cost-Effectiveness Analysis of Mosunetuzumab vs Tisagenlecleucel for Treatment of Third- or Higher-Line (3L+) Relapsed or Refractory (R/R) Follicular Lymphoma (FL) in Italy by Luminari S, Pinto A, Puccini B, D’Arpino A, Omodeo Salè E, Bellone M, Pradelli L, Sabinot A

“…Pascale’, Naples, Italy; 4Hematology, Careggi Hospital and University, Florence, Italy; 5Pharmacy Unit, Santa Maria Della Misericordia Hospital, Perugia, Italy; 6Division of Pharmacy, IEO European Institute of Oncology IRCCS, Milan, Italy; 7Department of Health Economics and Outcome Research, AdRes Health Economics and Outcome Research, Turin, Italy*These authors contributed equally to this workCorrespondence: Marco Bellone, Department of Health Economics and Outcome Research, AdRes Health Economics and Outcome Research, Via Vittorio Alfieri, 17, Turin, 10121, Italy, Tel +39 011 7651239, Email m.bellone@adreshe.comPurpose: To compare the cost-effectiveness of mosunetuzumab with tisagenlecleucel for treating patients with relapsed or refractory follicular lymphoma (R/R FL 3L+) from the perspective of the Italian National Health Service (NHS).Patients and Methods: The analysis employs a weekly cycle partitioned survival model (PSM) with a lifetime horizon. …”
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Metagenomics Analysis of Altered Gut Microbiome in Psoriasis and the Mediation Analysis: A Case-Control Study by Xiao Y, Jing D, Xiao H, Mao M, Kuang Y, Shen M, Lv C, Jian X, Peng C, Chen X

“…However, the mechanisms underlying gut microbiome changes caused by dietary habits in psoriasis remain unclear.Patients and Methods: We performed a case-control study including 64 psoriasis patients and 64 age-, sex-, and body mass index (BMI)-matched controls. …”
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Clinical Characteristics and Seizure Outcomes in Antibody-Positive Autoimmune Limbic Encephalitis by Song H, Xu S, Du BQ, Lai QL, Cai MT, Li H, Hu Y, Ding Y, Ding MP, Zhang YX, Shen CH

“…We aimed to investigate the clinical characteristics and seizure outcomes in a cohort with antibody-positive ALE.Methods: We consecutively recruited patients with antibody-positive ALE and new-onset seizures between July 2014 and February 2024. …”
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Cornus officinalis Protects Against Steroid-Induced Osteonecrosis of the Femoral Head Through Inhibiting Inflammatory Responses and Apoptosis via Network Pharmacology and Experimen... by Wang Y, Fan Y, Li M, Song Z, Wang P, Xie F, Miao Y, Wang Y, Zhang P, Zhan Q

“…This study is to investigate the mechanisms of SZY against SONFH via network pharmacology and experimental validation analysis.Methods: The active components and related targets of SZY and related-SONFH targets were collected from public databases. …”
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cAMP/PKA/CREB/GLT1 signaling involved in the antidepressant-like effects of phosphodiesterase 4D inhibitor (GEBR-7b) in rats by Liu X, Guo H, Sayed MDSM, Lu Y, Yang T, Zhou D, Chen Z, Wang H, Wang C, Xu J

“…Next, we also investigated the alterations of cyclic adenosine monophosphate (cAMP), protein kinase A (PKA) catalytic subunit (PKAca), cAMP response element-binding (CREB), and glutamate transporter 1 (GLT1) levels produced by GEBR-7b in the rats model of depression.Methods: Effects of GEBR-7b on CUS (35 days)-induced depression-like behaviors were examined by measuring immobility time in the forced swimming test (FST). …”
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Psychometric validation of the Chronic Ocular Pain Questionnaire (COP-Q) by Amy Findley, Brigitte J. Sloesen, Nicola Hodson, Agkreta Leventi, Ben Pascoe, Rob Arbuckle, Paul O’Brien, Christel Naujoks, Michela Montecchi-Palmer, Diana Plaza, Paul M. Karpecki, Pedram Hamrah

“…Both 4-hour and 24-hour Symptom Module recall period versions are likely to yield consistent results and are equally robust.…”
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Recurrence Prediction by Multi-Omics in the Patient with Colorectal Peritoneal Metastases After Cytoreductive Surgery: A Prospective Biomarker Study by Chen C, Gong Z, Zhang Z, Gu H, Zhu A, Peng D, Li B, Wang J, Hu Y, Wang D, Sun L

“…This study evaluated tumor tissue biomarkers and combined circulating tumor DNA (ctDNA) and methylation analysis via ultra-deep next-generation sequencing (NGS) for recurrence prediction.Methods: CRCPM patients undergoing surgery were enrolled (n=21). …”
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The Practices of Public Hospital Registered Nurses Regarding Post-Stroke Dysphagia, in China by Lu QY, Bu MR, Zhu Y, Huang ZY, Gao SH, Yuan C

“…A multi-center descriptive cross-sectional design was utilized.Participants and Methods: From March 2 to April 18, 2024, 1010 nurses from 14 provinces in China completed an online questionnaire through convenient sampling. …”
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ADL and Cognitive Function in Chinese Elderly: Mediating Role of Social Participation and Moderating Role of Intergenerational Support by Li W, Xin D, Feng X, Li Y, Zhu W, Xu J, Yin S

“…Wanling Li,1,2,* Dinuo Xin,2,* Xiaofang Feng,2 Yueqin Li,2 Wenjuan Zhu,2 Jiajia Xu,2 Shiyu Yin1 1Department of Nursing, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of China; 2Department of Nursing, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, 030032, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shiyu Yin, Department of Nursing, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, Hubei, 430030, People’s Republic of China, Tel/Fax +86-18834896110, Email 1538746173@qq.com Jiajia Xu, Department of Nursing, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, 030032, People’s Republic of China, Tel/Fax +86-351-8379512, Email xujiajia392@163.comPurpose: This study aimed to explore the relationship between activities of daily living (ADL) and cognitive function in Chinese elderly, and to analyze in depth the mediating and moderating roles of social participation and children’s intergenerational support in this relationship, in order to provide a reference basis for delaying cognitive decline in the elderly.Patients and Methods: Based on data from the 2020 wave of China Health and Retirement Longitudinal Survey (CHARLS 2020), this study included 5612 subjects aged 60 years and older, and extracted main variables such as demographic information, ADL, social participation, cognitive function, and children’s intergenerational support. …”
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The CT-Imaging Location of Lumbar 3 Sympathetic Radiofrequency Thermocoagulation for Sympathetic-Related Diseases Therapy by Wang R, Gao Z, Ma L

“…Ruxiang Wang,1,* Zhuoyue Gao,2,* Ling Ma1 1Department of Anesthesiology and Pain Medicine, Affiliated Hospital of Jiaxing University, Jiaxing, People’s Republic of China; 2Department of Anesthesiology, Daqing Oilfield General Hospital, Daqing, 163001, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ling Ma, Email 1319108@qq.comPurpose: The location characteristic of the lumbar 3 sympathetic trunk under Computed Tomography (CT) was discovered through 106 cases, imaging analysis after successful lumbar 3 sympathetic radiofrequency thermocoagulation operations serving the clinic and reducing the operation time.Methods: There are 113 patients underwent bilateral L3 lumbar sympathetic thermal radiofrequency procedures in our hospital from January 2017 to January 2021, with 106 cases of successful procedure. …”
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IL-8 Downregulation Mediates the Beneficial Effects of Infection-Induced Fever on Breast Cancer Prognosis by Li H, Liang X, Ma J, Liu Q, Lin Y, Tang J, Ren Z, Liang Z

“…However, the key cytokines and the underlying mechanisms through which fever exerts its anti-tumor effects remain unclear.Patients and Methods: A total of 794 breast cancer patients were recruited between 2008 and 2017, with follow-up extending until October 31st, 2023. …”
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MiRNAs and Neutrophil-Related Membrane Proteins from Plasma-Derived Extracellular Vesicles for Early Prediction of Organ Dysfunction and Prognosis in Septic Patients by Ye R, Wei Y, Li J, Xu M, Xie H, Huang J, Deng L, Li C

“…We sought to investigate the profile of extracellular vesicles (EVs)-mediated communication between plasma and polymorphonuclear neutrophils (PMNs) in sepsis, and to elucidate whether miRNAs and PMN-related membrane proteins from plasma-derived EVs (plasma-EVs) are associated with sepsis-induced organ dysfunction and prognosis.Methods: PMN-derived EVs (PMN-EVs) were isolated from the blood samples of healthy controls (N=3) and patients with septic shock (N=3) after ICU admission. …”
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Hypoxia-induced genome-wide DNA demethylation by DNMT3A and EMT of cancer cells by Biswanath Chatterjee, Pritha Majumder, Chun-Chang Chen, Jing-Ping Wang, Po-Hsuan Su, Hung-Cheng Lai, Ching-Chen Liu, Hsin-Nan Lin, Chen-Hsin A. Yu, Hanna S. Yuan, Che-Kun James Shen

“…Conclusions Altogether, this study has provided the first demonstration of a physiological function of the active DNA demethylation activity of the DNMTs. Equally important, our findings have revealed a missing link between the HIF-1α pathway and the O2-sensing KDM pathway both of which are known to be essential for a wide set of normal and disease-associated cellular processes. …”
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Autonomic Nervous Regulation was Associated with Sleep Quality Among Peritoneal Dialysis Patients by Huang B, Qian Y, Gao Y, Chen Z, Zhang L, Mao H, Xing C, Ren H, Wang J

“…However, the relationship between autonomic nervous system activity and sleep remains inadequately elucidated.Methods: This cross-sectional study enrolled adult maintenance PD patients in our center. …”
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Integration of single-cell sequencing and drug sensitivity profiling reveals an 11-gene prognostic model for liver cancer by Qunfang Zhou, Jingqiang Wu, Jiaxin Bei, Zixuan Zhai, Xiuzhen Chen, Wei Liang, Jing Meng, Mingyu Liu

“…However, the characteristics of tumor cells themselves are equally important for patient prognosis and treatment. …”
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Identification of Epigenetic Alteration of the IFI44L Gene in B Cells of Sjogren’s Syndrome as a Clinical Biomarker and Molecular Significance by Zhang K, Luo Z, Yao X, Lu D, Hong T, Zhu X, Chen M, Wang X

“…This study investigated gene expression and epigenetic changes in IFI44L, analyzing its correlation with disease activity and clinical indicators.Methods: Differentially expressed genes (DEGs) were identified from the GSE199868 dataset, while IFN-I-related genes were collected from GeneCards. …”
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High BMP7 Expression May Worsen Airway Disease in COPD by Altering Epithelial Cell Behavior by Dong W, Xie M, Ming C, Li H, Xu X, Cui L, Wang W, Li Y

“…Previous research has shown that BMP7 is highly expressed in the airway epithelia of patients with COPD, but its role in airway disease has not been fully elucidated.Methods: A lung tissue cohort and a sputum cohort were included in the study. …”
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Cinobufagin Suppresses Lipid Peroxidation and Inflammation in Osteoporotic Mice by Promoting the Delivery of miR-3102-5p by Macrophage-Derived Exosomes by Geng Z, Sun T, Yu J, Wang N, Jiang Q, Wang P, Yang G, Li Y, Ding Y, Zhang J, Lin G, Zhao Y

“…This research aims to ascertain the bone-protective properties of cinobufagin and investigate underlying mechanisms.Methods: Mice were ovariectomized to establish an osteoporosis model, followed by intraperitoneal injections of cinobufagin and cinobufagin-treated RAW.264.7-derived exosomes for therapy. …”
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Gubi Decoction Ameliorates Porous Cartilage Endplate in an Intervertebral Disc Degeneration Model Mouse Through Inhibition of NF-κB Activity and Pyroptosis by Yao S, Li Y, Ruan H, Wu L, Zeng H

“…Our prior studies have highlighted the therapeutic potential of Gubi decoction (GBD) in alleviating knee osteoarthritis, however, but the specific mechanism of GBD in treating IVDD is not clear.Objective: To ascertain the clear mechanism of GBD for enhancing its therapeutic efficacy in treating lVDD, through comparison of its effects across different doses of GBD and clinical positive control drugs using a mouse IVDD model.Methods: In this study, 8-week-old male mice were treated with lumbar spine instability (LSI) surgery to construct IVDD model mice. …”
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Downregulation of EB1 impedes Cx43 localization and cardiac conduction after hypothermic ischemia-reperfusion in rats by Chunlei Wen, Rongfeng Yang, Jing Yi, Ying Cao, Yuting Song, Li An, Zijun Wang, Hong Gao

“…This study aims to investigate the role and mechanisms of EB1 in hypothermic ischemia-reperfusion arrhythmia. Methods 4–6 week old male Sprague-Dawley (SD) rats were randomly assigned to four groups with a control group receiving no treatment. …”
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