Construction and Validation of a Hospital Mortality Risk Model for Advanced Elderly Patients with Heart Failure Based on Machine Learning by Shang S, Wei M, Lv H, Liang X, Lu Y, Tang B

“…Shuai Shang,1,2,* Meng Wei,1,2,* Huasheng Lv,1,2,* Xiaoyan Liang,1,2 Yanmei Lu,1,2 Baopeng Tang1,2 1Department of Cardiac Pacing and Electrophysiology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, People’s Republic of China; 2Xinjiang Key Laboratory of Cardiac Electrophysiology and Remodeling, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, People’s Republic of China*These authors contributed equally to this workCorrespondence: Baopeng Tang, Department of Cardiac Pacing and Electrophysiology, Xinjiang Key Laboratory of Cardiac Electrophysiology and Remodeling, The First Affiliated Hospital of Xinjiang Medical University, No. 137, South Liyushan Road, Xinshi Zone, Urumqi, People’s Republic of China, Email tangbaopeng1111@163.com Yanmei Lu, Department of Cardiac Pacing and Electrophysiology, Xinjiang Key Laboratory of Cardiac Electrophysiology and Remodeling, The First Affiliated Hospital of Xinjiang Medical University, No. 137, South Liyushan Road, Xinshi Zone, Urumqi, People’s Republic of China, Email gracy@189.cnPurpose: This study aimed to develop and validate a model based on machine learning algorithms to predict the risk of in-hospital death among advanced elderly patients with Heart Failure (HF).Methods: A total of 4580 advanced elderly patients who were admitted to the hospital and diagnosed with HF from May 2012 to September 2023 were included in this study, among whom 552 cases (12.5%) died. …”
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Mapping Connection and Direction Among Symptoms of Sleep Disturbance and Perceived Stress in Firefighters: Embracing the Network Analysis Perspective by Liu B, Zou M, Liu L, Wu Z, Jin Y, Feng Y, Jia Q, Li M, Ren L, Yang Q

“…Hence, this study aimed to elucidate the relationship between sleep disturbances and perceived stress in firefighters through network analysis approaches.Methods: A total of 786 Chinese firefighters were included in this study. …”
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The Diagnostic Value of Bile Acids and Amino Acids in Differentiating Acute Coronary Syndromes by Yu Q, Zhao F, Wang S, Jia X, Shen S, Zhao X, Li Y, Song J, Sun M, Liu X, Liu Z

“…This study evaluates serum bile acids (BAs) and amino acids (AAs) as potential predictors of AMI in UA patients.Patients and Methods: A total of 72 Non-Coronary Artery Disease (NCAD) patients, 157 UA patients, and 79 AMI patients were analyzed. …”
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Alterations on Microcirculation of Optic Nerve Head Before and After OSA Surgery by Lin PW, Chiu LW, Lin CW, Chang CT, Lin HC

“…We conducted the first study to assess whether OSA surgery will change the optic nerve microcirculation in patients with OSA.Study Design: Prospective single-blind study.Setting: Tertiary medical center.Methods: The enrolled patients were completed for overnight polysomnography (PSG) and comprehensive ophthalmologic evaluation, including laser speckle flowgraphy (LSFG) for microcirculation of optic nerve head (ONH) before and 3 months after OSA surgery. …”
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Role of mitophagy in pancreatic cancer cachexia-induced muscle atrophy by WANG Yijie, LI Jianjun, WANG Xuesong

“…Objective‍　‍To explore the role of mitophagy in pancreatic cancer cachexia-induced muscle atrophy and its underlying mechanism. Methods‍　‍Six male C57BL/6J mice (8 weeks old, weighing 20~30 g) were equally and randomly divided into a control group (intrapancreatic injection of normal saline) and a cachexia group (orthotopic pancreatic injection of KPC1199 cells). …”
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Molecular Assessment of Traditional Mongolian Medicine Tongola-5 in Lactulose Induced Diarrhea: An in vivo Study by Ma C, Buren Q, Eerde M, Qing M, Bao X, Zhao L, Cao L, Zhang X, Bai Q, Chen M, Hong M, Bao Y, Lian H

“…Chunli Ma,1,* Qiqige Buren,1,* Mutu Eerde,2,* Ming Qing,3 Xiufang Bao,4 Linyun Zhao,1 Lili Cao,1 Xin Zhang,1 Qigeqi Bai,4 Meiling Chen,4 Mei Hong,1 Yulong Bao,1 Hua Lian4 1School of Basic Medicine, Inner Mongolia Medical University, Hohhot, Inner Mongolia, 010110, People’s Republic of China; 2Medical Innovation Center for Nationalities, Inner Mongolia Medical University, Hohhot, Inner Mongolia, 010110, People’s Republic of China; 3International Mongolian Hospital of Inner Mongolia, Hohhot, Inner Mongolia, 010065, People’s Republic of China; 4College of Mongolian Medicine, Inner Mongolia Medical University, Hohhot, Inner Mongolia, 010110, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yulong Bao; Hua Lian, Chilechuan Dairy Economic Development Zone, Hohhot, Inner Mongolia Autonomous Region, 010110, People’s Republic of China, Tel +86 18698451017 ; +86 13171029769, Email yulongbao@immu.edu.cn; lianhua81521@163.comPropose: To elucidate the mechanisms underlying the therapeutic effects of Tonglaga-5 (TLG5) in the treatment of chronic diarrhea.Methods: The chemical compositions of TLG5 in both in vitro and systemic circulation were analyzed using UPLC-Q/TOF MSE. …”
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Complementary Strategy of Maternal Immunization with RSVpreF Vaccine and Monoclonal Antibodies for the Prevention of Respiratory Syncytial Virus Among Italian Infants: A Cost-Effec... by Barbara Polistena, Fabio Midulla, Giovanni Sotgiu, Daniela d’Angela, Roberto Di Virgilio, Federico Spandonaro

“…The objective of the study is providing an estimation of the efficiency of complementary strategy RSVpreF and monoclonal antibodies for the prevention of RSV among Italian infants. Methods Using a model (with a cohort framework and a Markov-type process) specifically adapted to the Italian context, the study provided cost-effectiveness and cost-utility assessment of prevention strategies adding the maternal vaccination to the existing immunization opportunities with palivizumab or nirsevimab administered to high risk and unprotected infants. …”
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Ginsenoside Reshapes Intestinal Microecology to Alleviate Microgravity Stress by Wang Y, Chen T, Shi Z, Dong L, Li M, Peng B, Li Q, Pan R, Xiao S, Yang Q, Jiang N, Liu X, Hu Q, Chen Y

“…This study focused on the regulation of GTSs in intestinal homeostasis imbalance caused by microgravity.Methods: A hindlimb suspension (HLS) rat model was established to evaluate the intestinal protective effects of GTSs. …”
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Artesunate Mitigates Sepsis-Induced Acute Kidney Injury via Lactate/AMPK/mTOR-Regulated Autophagy Based on Multi-Omics by Chen H, Du P, Guo R, Li X, Zhang L, Duan J, Chen M, Guo J, Li Y, Jiang T

“…However, the precise regulatory mechanisms remain to be fully elucidated.Methods: This study investigates the impact of ART on renal function in a sepsis mouse model and its effect on LPS-induced cytotoxicity in HK-2 cells, aiming to clarify the potential therapeutic mechanisms underlying ART’s efficacy in S-AKI. …”
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A Hospital-Based, Single-Center, Cross-Sectional Study to Investigate the Status Quo of Hyperuricaemia in a Booming Seaside City with Young Population from 2020 to 2021 in China by Li C, Sun J, Wei Q, Yue J, Wang X, Zhang Q, Peng S, Liao X, Zeng H, Asakawa T

“…Chunyan Li,1,* Jiajia Sun,1,2,* Qifeng Wei,3,* Jianrong Yue,1 Xuefei Wang,1 Qin Zhang,1 Shiping Peng,1 Xiujuan Liao,1 Hui Zeng,4 Tetsuya Asakawa5 1Department of Health Management, National Clinical Research Center for Infectious Diseases, Shenzhen Third People’s Hospital, Shenzhen, Guangdong Province, People’s Republic of China; 2Faculty of Medicine, Macau University of Science and Technology, Macao, People’s Republic of China; 3Department of Orthopedics, National Clinical Research Center for Infectious Diseases, Shenzhen Third People’s Hospital, Shenzhen, Guangdong Province, People’s Republic of China; 4Department of Health Services Section, National Clinical Research Center for Infectious Diseases, Shenzhen Third People’s Hospital, Shenzhen, Guangdong Province, People’s Republic of China; 5Institute of Neurology, National Clinical Research Center for Infectious Diseases, Shenzhen Third People’s Hospital, Shenzhen, Guangdong Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Tetsuya Asakawa, Institute of Neurology, National Clinical Research Center for Infectious Diseases, Shenzhen Third People’s Hospital, 29 Bulan Road, Shenzhen, Guangdong Province, 518112, People’s Republic of China, Email asakawat1971@gmail.com Hui Zeng, Department of Health Services Section, National Clinical Research Center for Infectious Diseases, Shenzhen Third People’s Hospital, 29 Bulan Road, Shenzhen, Guangdong Province, 518112, People’s Republic of China, Email 24178743@qq.comBackground: This is a hospital-based, single-center, cross-sectional study to investigate the status quo of hyperuricaemia (HUA) in general adults in Shenzhen, a booming seaside city in the South China.Methods: All health adults (≥ 18 years old) undergoing health examination from 2020 Oct 1 to 2021 September 30 in a general hospital were enrolled. …”
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Evaluating the Diagnostic and Prognostic Value of Peripheral Immune Markers in Glioma Patients: A Prospective Multi-Institutional Cohort Study of 1282 Patients by Lu J, Zhang ZY, Zhong S, Deng D, Yang WZ, Wu SW, Cheng Y, Bai Y, Mou YG

“…However, the diagnostic and prognostic value of nSII in glioma remains unknown.Methods: From October 2006 to April 2022, 1282 patients with primary glioma were enrolled. …”
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Retrospective Multicentre Real-Life Study Evaluating the Efficacy of Atezolizumab Combined with Bevacizumab for the Treatment of Metastatic Hepatocellular Carcinoma: HIREAL Study by Barbe-Richaud JB, Moinard-Butot F, Husson-Wetzel S, Bolliet M, Chiappa P, Belletier C, Ribeiro M, Poprawa E, Bigot C, Abergel A, Ben Abdelghani M

“…The secondary objective was to conduct subgroup analyses to further examine how the effects of the combination treatment differ based on Child‒Pugh scores, prior local treatment, and alpha-fetoprotein (AFP) levels.Methods: We conducted a multicentric retrospective study. …”
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Dysbiosis of Gut Microbiota in Ankylosing Spondylitis Patients by Yang L, Wang K, Liu B, Chen T, Ma T, Cui Z, Zhang D, Zhang S, Liu X, Shen J, Lu H

“…This study aimed to investigate the gut microbiota profiles of AS patients from Southern China and explore the relationship between gut microbiota and the occurrence and development of AS.Patients and Methods: We enrolled 30 AS patients and 25 healthy controls from the Fifth Affiliated Hospital of Sun Yat-sen University. …”
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Clinical Outcomes of AFP-Negative Patients with Advanced HCC: A Propensity-Matched Analysis from a Retrospective Cohort Study by Liu X, Zhuang L, Yang F, Liu P, Xia Z, Guo Y, Dong P, Chen C, Li Z

“…The aim of this study is to analyze the prognosis of advanced HCC with negative (< 20 ng/mL) AFP at baseline following systemic drug treatment.Methods: In this study, 91 patients with AFP-negative advanced HCC who received systemic drug treatment in Nanjing Jinling Hospital from February 2011 to September 2023 were collected, and 213 patients with AFP-positive advanced HCC were collected as the control group. …”
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Predictive Role of Blood Cell-Derived Inflammatory Markers for the Risk of Asymptomatic Cerebral Infarction in Essential Hypertension: A Population-Based Cross-Sectional Study in C... by Zhang Q, Wang M, Du H, Qu H, Liu K, Dong W, Kong D, Tian D, Zhao X, Hao Y, Liu M

“…Qinghui Zhang,1,* Menglin Wang,1,* Huiyu Du,1 Huiyun Qu,2 Kai Liu,1 Wenyong Dong,1 Dehui Kong,1 Dandan Tian,1 Xiaojian Zhao,1 Yibin Hao,1 Min Liu1 1Department of Hypertension, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, Zhengzhou, Henan, People’s Republic of China; 2Department of Hypertension, Henan Provincial People’s Hospital, People’s Hospital of Henan University, Zhengzhou, Henan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yibin Hao, Department of Hypertension, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, Zhengzhou, Henan, People’s Republic of China, Email haoyibin0708@163.com Min Liu, Department of Hypertension, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, Zhengzhou, Henan, People’s Republic of China, Email liumin136@126.comObjective: This study aimed to investigate the relationship between ACI and blood cell-derived inflammatory markers including platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), systemic immune inflammation index (SII) and systemic inflammation response index (SIRI) in an essential hypertensive (EH) cohort, and assess the predictive value of these inflammatory markers for ACI risk in this population.Methods: A total of 583 EH patients were included and categorized into ACI (123 patients) and non-ACI (NACI) (460 patients) groups. …”
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Effect of Haplo-Allogeneic Hematopoietic Stem Cell Transplantation Timing on Patients with Severe Aplastic Anemia Without Histocompatible Matched Sibling Donor by Fan D, Xiao F, Zhao J, Yan XQ, Liu Q, Liu L, Wang WQ, Qin WW

“…To evaluate the effects of different transplantation timing on patient survival, the incidence of graft-versus-host disease (GVHD), and the risk of infection on the outcomes of patients with SAA.Methods: This retrospective study included 82 SAA patients who underwent haplo-HSCT using the “Beijing protocol”. …”
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Role of autophagy in lipid aggregation in lipid-induced renal tubular epithelial damage by WANG Rui, ZHANG Ning

“…Objective To investigate the role of autophagy in lipid aggregation in lipid-induced renal tubular epithelial damage.Methods Renal tubular epithelial cells(HK-2) were incubated with low density lipoprotein(LDL) at different concentrations(0,20 μg/ml,50 fig/ml,and 100 μg/ml)for 24 h.Lipid deposition in HK-2 cells was evaluated by oil red O stain.Autophagosomes were observed by transmission electron microscopy.The LC3-GFP fusion protein was observed by fluorescence microscope.LC3 Ⅰ/Ⅱ protein was assessed by Western blotting.Results(1)LDL stimulate HK-2 cell for 24 h at the concentration in range from 0—100 μg/ml,and we detected lipid deposition in HK-2 cell stain by oil red O.The result showed that lipid deposition increasing caused by LDL stimulating in HK-2 cell performed in a time-dependent manner.(2) Autophagosome were observed in nomal HK-2 cell by transmission electron microscopy.However,after LDL stimulation HK-2 cell,autophagosome was increased in a dose-dependent manner with the LDL at the concentration from 0 to 50 μg/ml.But,autophagosome decreased rapidly at LDL 100 μg/ml concentration.(3) Few LC3-GFP dots were present in nomal HK-2 cell in basal condition,which were detected by fluorescence microscope.However,after LDL stimulation HK-2 cell,LC3-GFP dots was increased in a dose-dependent manner with the LDL at the concentration from 0 to 50 μg/ml(P<0.05).But,LC3-GFP dots decreased rapidly at LDL 100 μg/ml concentratioa(4)Both LC3- I and LC3-Ⅱ expressed in HK-2 cell,but LC3- I expression was dominant in normal cell.After LDL at concentration range from 0—50 μg/ml stimulated HK-2 cell,both LC3-Ⅰ and LC3-Ⅱ increased gradully,but LC3-Ⅱ increased more obviously.The expression of LC3- Ⅰ in 50 μg/ml LDL treated group was 2 times as that in 0 μg/ml LDL treated group(P<0.05).But the expression of LC3-Ⅱ in 50 μg/ml LDL treated group was 3 times as that in0 μg/ml LDL treated group(P<0.05).Thus,LC3-Ⅱ/LC3-I ratio increased in a dose-dependent manner at LDL concentration range from 0 to 50 μg/ml.However,when LDL concentration increased at 100 μg/ml,both LC3- Ⅰ and LC3-Ⅱ were drastically reduced.The expression of LC3- I in 100μg/ml LDL treated group was almost equally with that in 0 μg/ml LDL treated group(P>0.05).The expression of LC3- Ⅱ in 100 μg/ml LDL treated group dropped and it is only 1.5 times as that in 0 μg/ml LDL treated group(P<0.05).LC3-II/LC3-I ratio were also declined sharply.Conclusions Autophagy may be involved in lipid-induced renal tubular epithelial damage in lipid aggregation.…”
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Indications and outcomes of rivaroxaban use in cats by Ella Yarsley, Claire R. Sharp, Claire R. Sharp, Corrin J. Boyd, Joonbum Seo, Joonbum Seo, Erin Mooney

“…The study objective was to describe the use of rivaroxaban in a large population of hospitalised cats.MethodsCases were retrospectively identified from June 2017 to July 2024 at seven veterinary specialty hospitals. …”
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Novel AP39-Loaded Liposomes Sustain the Release of Hydrogen Sulphide, Enhance Blood-Brain Barrier Permeation, and Abrogate Oxidative Stress-Induced Mitochondrial Dysfunction in Bra... by Al Tahan MA, Marwah MK, Dhaliwal M, Diaz Sanchez L, Shokr H, Kaur M, Ahmad S, Badhan RK, Dias IH, Sanchez-Aranguren L

“…However, its clinical application is limited due to poor stability and rapid release, necessitating a drug delivery system to enhance therapeutic efficacy.Purpose: This study aimed to develop a novel AP39-loaded liposomal formulation to provide controlled H2S release, facilitate AP39 permeation across the blood-brain barrier (BBB), and assess functional effects in mitigating oxidative stress and preserving mitochondrial function.Methods: AP39-loaded unilamellar liposomes were prepared via ethanol injection and characterised for size, polydispersity, and zeta potential. …”
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Predicting ICU Admission in Patients with Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy by Su XH, Li WP, Xu XF, Su XL, Liu J, Feng SY, Liu JY, Dong RQ, Ngai IK, Yang L, Xu L, Li ZQ, Li DC, Jiang Y, Peng FH

“…This study aimed to develop and validate predictive models to identify A-GFAP-A patients at increased risk for ICU admission.Methods: We retrospectively analyzed 107 patients (January 2021 - August 2024), randomly assigned to training and validation cohorts (7:3). …”
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