Self-Management Intervention for Reducing Epilepsy Burden Among Adult Ugandans with Epilepsy (SMART-U): Randomised Clinical Trial Protocol by Mbalinda SN, Kaddumukasa M, Najjuma JN, Birungi DR, Kaddumukasa MN, Levin JB, Still CH, Burant CJ, Modi AC, Katabira ET, Sajatovic M

“…The purpose of this 2-site randomised controlled experiment is to investigate this further, based on encouraging preliminary evidence.Methods: A total of 188 adult people with epilepsy (PWE) attending the neurology clinics at Mulago and Mbarara hospitals and consent to participate in the study will be recruited. …”
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Houttuynia cordata-Derived Exosome-Like Nanoparticles Mitigate Colitis in Mice via Inhibition of the NLRP3 Signaling Pathway and Modulation of the Gut Microbiota by Li JH, Xu J, Huang C, Hu JX, Xu HM, Guo X, Zhang Y, Xu JK, Peng Y, Zhang Y, Zhu MZ, Zhou YL, Nie YQ

“…This study aims to evaluate the efficacy of HELNs in treating colitis in mice and investigate its potential mechanisms.Methods: HELNs were isolated from H. cordata for characterization, and their safety and stability were evaluated. …”
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The Future of Hospital Medicine in Japan: Lessons From the United States Hospital Medicine System by Suzuki T, Katayama K, Houchens N, Hartley S, Tokuda Y, Watari T

“…Marianna University School of Medicine, Kanagawa, Japan; 3Medicine Service, Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, MI, USA; 4Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA; 5Muribushi Okinawa Center for Teaching Hospitals, Urasoe, Okinawa, Japan; 6Tokyo Foundation for Policy Research, Tokyo, Japan; 7Kyoto University Hospital, Integrated Clinical Education Center, Kyoto, Japan; 8General Medicine Center, Shimane University Hospital, Shimane, Japan*These authors contributed equally to this workCorrespondence: Takashi Watari, Shimane University Hospital, General Medicine Center, 89-1 Enya, Izumo city, Shimane prefecture, Shimane, Japan, Email wataritari@gmail.comPurpose: To compare hospitalist roles and training systems between the United States (US) and Japan, identifying strengths and challenges to guide development of Japan’s emerging hospital medicine program.Methods: A qualitative, descriptive narrative study was conducted during a 10-day observational site visit to the Veterans Affairs Ann Arbor Healthcare System and University of Michigan Hospital in October 2022. …”
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From medical school to global health leadership: 35-year career outcomes and gender disparities from the Aga Khan University Medical College by Adil H. Haider, Maham Vaqar, Asma Altaf Hussain Merchant, Sharjeel Ahmad, Komal Abdul Rahim, Namra Qadeer Shaikh, Noreen Afzal, Shayan Shah, Anum Rahim, Saad Bin Zafar Mahmood, Saqib Kamran Bakhshi, Sadaf Khan, Muhammad Tariq

“…After the exclusion of missing data, 862 responses were analyzed. Both genders were equally represented (49.8%). Most participants had completed residency (82.0%) and fellowship (56.0%) training. …”
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Effectiveness of a Care Plan Based on the Multi-Theory Model in Reducing Fear of Disease Progression and Improving Quality of Life in Breast Cancer Patients: A Randomized Controlle... by Zhang J, Zhuang J, Chen X, Chu T, Zhang Q, Ma L, Zhou H, Wu Y, Chen L

“…Our research aimed to evaluate the effectiveness of a care plan based on the Multi-Theory Model of health behavior change in reducing fear of progression in breast cancer patients undergoing adjuvant chemotherapy.Patients and Methods: This randomized controlled trial enrolled 108 eligible participants receiving adjuvant chemotherapy at Jiangnan University Affiliated Hospital between May and December 2024. …”
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Strategies to Enhance Health Communication Participation Among Medical Students in Chinese Universities: A Cross-Sectional Study by Jiang N, Chen M, Yan T, Liu Q, Shu Q, Liang X, Tao Z, Nie W, Yang X, Guo Y, Li X, Zhu DJ, Fu Y, Li L

“…This study aimed to explore the current status and influencing factors of medical students’ participation in health communication and offer specific suggestions.Methods: In this cross-sectional study, an online self-designed questionnaire was distributed to medical students during August 2022 to September 2022. …”
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The Association Between Specific Oral Behaviors and the Number of Temporomandibular Disorder Symptoms in the General Population: A Cross-Sectional Study by Tian Y, Tan Y, Yang M, Lv X, Zheng Y, Zhang Q, Sun Y, Wang J, Xiong X

“…Yihong Tian,1,2,* Yanyue Tan,3,* Ming Yang,1 Xiayang Lv,3 Yunhao Zheng,1 Qiang Zhang,4 Yanyu Sun,1 Jun Wang,1,2 Xin Xiong1,2 1State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chengdu, Sichuan, People’s Republic of China; 2Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, People’s Republic of China; 3Department of Nursing, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, People’s Republic of China; 4Department of Orthodontics, Affiliated Hospital of Qingdao University, Qingdao, Shandong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jun Wang; Xin Xiong, West China Hospital of Stomatology, Sichuan University, No. 14 section 3, Renmin South Road, Chengdu, 610041, People’s Republic of China, Email wangjunv@scu.edu.cn; drxiongxin@scu.edu.cnObjective: This study aimed to thoroughly explore the relationship between individual oral behavior and the differing numbers of temporomandibular disorder (TMD) symptom in the general population.Methods: A total of 565 participants were recruited and completed a questionnaire containing demographic characteristics, eight specific oral behaviors, and five major TMD symptoms (5Ts) checklist. …”
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Assessment of Birth Preparedness and Complication Readiness among Pregnant Women: A Cross-sectional Study by T Elamathi, K Ananthi, Rimi Singh

“…Patients with American Society of Anaesthesiologists (ASA) I/II status were randomly allocated into two equal groups of 20 each. Group-R received 0.75% hyperbaric ropivacaine 3.5 mL+0.1 mL normal saline (total 3.6 mL) and Group-L received 0.5% hyperbaric levobupivacaine 3.5 mL+0.1 mL normal saline (total 3.6 mL). …”
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Estimated glucose disposal rate outperforms other insulin resistance surrogates in predicting incident cardiovascular diseases in cardiovascular-kidney-metabolic syndrome stages 0–... by Bingtian Dong, Yuping Chen, Xiaocen Yang, Zhengdong Chen, Hua Zhang, Yuan Gao, Enfa Zhao, Chaoxue Zhang

“…The incorporation of the eGDR index into predictive models significantly improved prediction performance for CVD events, with the area under the ROC and PR curves equal to or exceeding 0.90 in both the training and testing sets. …”
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Ultra-low dose dual-layer detector spectral CT for pulmonary nodule screening: image quality and diagnostic performance by Li Ding, Mingwang Chen, Xiaomei Li, Yuting Wu, Jingxu Li, Shuting Deng, Yikai Xu, Zhao Chen, Chenggong Yan

“…Abstract Objectives To investigate the image quality and diagnostic performance with ultra-low dose dual-layer detector spectral CT (DLSCT) by various reconstruction techniques for evaluation of pulmonary nodules. Materials and methods Between April 2023 and December 2023, patients with suspected pulmonary nodules were prospectively enrolled and underwent regular-dose chest CT (RDCT; 120 kVp/automatic tube current) and ultra-low dose CT (ULDCT; 100 kVp/10 mAs) on a DLSCT scanner. …”
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Alfentanil Enhanced the Sedation of Remimazolam During Anaesthesia Induction in Patients Undergoing Urological Day Surgery: A Randomised Controlled Trial by Lin Y, Chen Q, Liao Y, Xu B, Zhang C, Luo J, Liu S, Wu X, Guan X

“…The aim is to investigate whether alfentanil enhances sedative effects of remimazolam during anaesthesia induction in patients undergoing urological day surgery.Methods: This was a single-centre, single-blinded, randomised clinical trial. …”
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Inhibition of renal interstitial fibrosis by mulberry leaf alkaloids in rats with diabetic nephropathy by Feng Wu, Li Wei

“…ObjectiveTo explore whether or not mulberry leaf alkaloids can inhibit renal interstitial fibrosis in diabetic nephropathy （DN） rats.MethodsDN rat model was established by a high-fat diet and a tail vein injection of streptozotocin （STZ） in 50 Sprague-Dawley （SD） rats. …”
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The Comprehensive Analysis of Weighted Gene Co-Expression Network Analysis and Machine Learning Revealed Diagnostic Biomarkers for Breast Implant Illness Complicated with Breast Ca... by Huang Z, Wang H, Pang H, Zeng M, Zhang G, Liu F

“…This study aimed to identify the crosstalk genes between BII and BC and explored their clinical value and molecular mechanism initially.Methods: We retrieved the data from Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA), and identified the differentially expressed genes (DEG) as well as module genes using Limma and weighted gene co-expression network analysis (WGCNA). …”
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Labdane Diterpenoids from <i>Leonotis ocymifolia</i> with Selective Cytotoxic Activity Against HCC70 Breast Cancer Cell Line by Jane Busisiwe Ncongwane, Vuyelwa Jacqueline Tembu, Comfort Mduduzi Nkambule, Douglas Kemboi, Gerda Fouche, Nyeleti Vukea, Jo-Anne de la Mare

“…Of the compounds extracted, 13<i>S</i>-nepetaefolin demonstrated the greatest cytotoxic activity with an IC₅₀ of 24.65 µM (SI = 1.08) against HCC70 cells; however, it was equally cytotoxic to non-tumorigenic MCF-12A breast cells (IC₅₀ of 26.55 µM), whereas its isomer (<b>2</b>) showed no activity. …”
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Core Outcome Sets for Pain Disorders: A Systematic Review of Research and Reporting Quality by Cui Y, Li B, Jiang S, Li Y, Wang S

“…Ying Cui,1– 3,&amp;ast; Bo Li,1– 3,&amp;ast; Shiyi Jiang,4 Yuxian Li,1– 3 Sixuan Wang1– 3 1Department of Acupuncture, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, People’s Republic of China; 2Department of Acupuncture, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, People’s Republic of China; 3Department of Acupuncture, Tianjin University of Traditional Chinese Medicine, Tianjin, People’s Republic of China; 4Department of Rehabilitation, Wuxi Xishan District Hospital of Traditional Chinese Medicine, Wuxi, Jiangsu, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Bo Li, Department of Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, No. 314, Anshan Xi Road, Nankai District, Tianjin, 300072, People’s Republic of China, Email ibou119@163.comPurpose: To systematically review the current research status of Core Outcome Sets (COS) for pain-related diseases and to evaluate the methodological quality of existing COS.Methods: Two researchers independently conducted a comprehensive search of both English and Chinese databases. …”
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4-Octyl Itaconate Modulates Dendritic Cells Function and Tumor Immunity via NRF2 Activation by Zhu B, Zhu L, Ge Z, Zheng S, Dai X, Feng D, Tan L, Sha P, Yao Y

“…In this study, we aimed to investigate the role of itaconate in regulating the maturation and function of DCs and its underlying molecular mechanism.Methods: Bone marrow-derived dendritic cells (BMDCs) were treated with 4-octyl itaconate (4OI). …”
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Machine Learning Strategies for Preoperative PJI Diagnosis: Integrative Analysis of Serum and Synovial Fluid Markers by Chen B, Yang Y, Zhou H, Li F, Shen Y, Cheng Q, Huang W, Qin L

“…This study aims to develop a new diagnostic model for the preoperative diagnosis of PJI based on serum and synovial fluid markers and further validate its effectiveness.Methods: We retrospectively collected data from patients admitted for joint revision surgery between January 2018 and October 2022, selecting serum and synovial fluid markers as variables for the study. …”
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Intranasal Dexmedetomidine for the Management of Preoperative Anxiety-Related Insomnia: A Randomized, Three-Blinded, Clinical Trial Compared with Lorazepam and Placebo by Yang WY, Huang K, Lin ZJ, Zeng W, Liu X, Liu HB, Zhong ML, Wei J, Liang WD, Wang LF, Chen L

“…Wen-yi Yang,1,&ast; Kuan Huang,2,3,&ast; Zhi-jian Lin,1 Wen Zeng,2,3 Xin Liu,2,3 Hong-bo Liu,1 Mao-lin Zhong,2,3 Jun Wei,2,3 Wei-dong Liang,2,3 Li-feng Wang,2,3 Li Chen2,3 1The First Clinical Medical College of Gannan Medical University, Ganzhou, Jiangxi, People’s Republic of China; 2Anesthesia Surgical Center, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, People’s Republic of China; 3Anesthesia Key Laboratory of Gannan Medical University, Ganzhou, Jiangxi, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Li Chen, Anesthesia Surgical Center, The First Affiliated Hospital of Gannan Medical University, 23 Qingnian Road, Zhanggong District, Ganzhou, People’s Republic of China, Tel +8615727752168, Email zgx8778@126.comPurpose: To evaluate the efficacy and safety of intranasal dexmedetomidine (Dex), oral lorazepam, and a placebo in managing preoperative anxiety-related insomnia.Patients and Methods: A total of 90 patients exhibiting symptoms of preoperative anxiety and insomnia were randomly assigned to three groups: Dex (receiving 2.5 μg/kg Dex intranasally and starch tablets orally), lorazepam (receiving saline intranasally and 2 mg lorazepam orally), and placebo (receiving saline intranasally and starch tablets orally). …”
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Association Between Locoregional Private Equity Investment in Retina Practices and Academic Vitreoretinal Caseload by Franco JJ, Pan WW, Mian SI, Wubben TJ

“…In particular, there remains a dearth of literature assessing the impact of PE acquisition on non-PE practices; herein, we assess the effect of locoregional PE investment on the rate of pars plana vitrectomy (PPV) for retinal detachment (RD) repair performed at a US academic center.Methods: Patients who underwent RD PPV (Current Procedural Terminology [CPT] codes 67108 or 67113) or routine PPV (reference group; CPT 67040, 67041, or 67042) at a single US academic center from 01/01/2013 to 12/31/2023 were identified. …”
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Detectability of Iodine in Mediastinal Lesions on Photon Counting CT: A Phantom Study by Joric R. Centen, Marcel J. W. Greuter, Mathias Prokop

“…<b>Conclusions:</b> Iodine detectability with PCCT is at least equal to CCT for simulated mediastinal lesions of 1–12 mm, even at a dose reduction of 66%. …”
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