The Influence of Emphysema on Treatment Response to Biologic Therapy in Severe Asthma by Biener L, Morobeid H, Pizarro C, Kuetting D, Nickenig G, Skowasch D

“…Our aim was to examine the effects of emphysema on biologic treatment response in SA in this retrospective cohort study.Methods: Pulmonary emphysema was examined using computed tomography. …”
Get full text

Activation of the Reelin/GSK-3β/p-Tau Signaling Pathway in the Hippocampus of Patients with Temporal Lobe Epilepsy by Lin J, Lin X, Fu YJ, Li X, Li X, Wang Y, Zhao L, Yu S, Piao YS

“…Juan Lin,1,2,* Xinyu Lin,1,* Yong-Juan Fu,1 Xuran Li,3 Xin Li,3 Yujiao Wang,1,4 Lihong Zhao,1 Shun Yu,3 Yue-Shan Piao1,5,6 1Department of Pathology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, People’s Republic of China; 2Department of Pathology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510120, People’s Republic of China; 3Department of Neurobiology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, People’s Republic of China; 4Department of Pathology, Shanxi Provincial People’s Hospital, Affiliated People’s Hospital of Shanxi Medical University, Taiyuan, 030012, People’s Republic of China; 5Clinical Research Center for Epilepsy, Capital Medical University, Beijing, 100053, People’s Republic of China; 6National Center for Neurological Disorders, Beijing, 100053, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yue-Shan Piao, Email yueshanpiao@126.com; Shun Yu, Email yushun103@163.comPurpose: In this study, we evaluated the presence of tau deposition and protein expression of Reelin/GSK-3β/p-Tau signaling pathway in the hippocampus of patients with temporal lobe epilepsy (TLE).Methods: A total of 37 cases of TLE with and without hippocampal sclerosis (HS) were selected histopathologically for our study with 5 autopsy cases as the control group. …”
Get full text

Lysyl Oxidase-Like 1 (LOXL1) Up-Regulation in Chondrocytes Promotes M1 Macrophage Activation in Osteoarthritis via NF-κB and STAT3 Signaling by Jiang Y, Wang S, Zhu W, Liu X, Yang Y, Huo L, Ye J, Ma Y, Zhou Y, Yang Z, Mao J, Wang X

“…There is still a lack of biomarkers for OA, so it cannot be intervened in time.Methods: OA biomarkers were identified from human cartilage datasets using LASSO and SVM-RFE, followed by ROC analysis. …”
Get full text

Effect of Imeglimin, a Novel Anti-Diabetic Agent, on Insulin Secretion and Glycemic Variability in Type 2 Diabetes Treated with DPP-4 Inhibitor: A 16-Week, Open Label, Pilot Study by Itsukaichi A, Yoshikawa F, Fuchigami A, Iwata Y, Sato G, Miyagi M, Hirose T, Uchino H

“…This study aimed to investigate the efficacy of combining imeglimin with dipeptidyl peptidase-4 inhibitor (DPP-4i), the most frequently prescribed first-line treatment for patients with type 2 diabetes (T2D) in Japan, to improve glycemic control.Patients and Methods: Eleven patients with T2D treated with DPP-4i alone (6.5% ≤ hemoglobin A1C [HbA1c] < 10%) received 1000 mg imeglimin twice daily for 16 weeks. …”
Get full text

FoxO1 as a Hub in Immunosenescence Induced by Hepatocellular Carcinoma and the Effect of Yangyin Fuzheng Jiedu Prescription by Xie Y, Yan F, Liu X, Yu L, Yan H, Shang Z, Kong Y, Yang Z

“…The objective of this study is to clarify the mechanism of action of YFJP in treating HCC.Methods: By constructing networks, the active components and molecular targets of YFJP in the treatment of HCC were explored. …”
Get full text

Comparative Evaluation of Enamel Surface Abrasion Produced by Three Different Types of Toothbrush Bristle Designs: An In-vitro Study by Akanksha Mohan Karale, Pramod Waghmare, Vidya Dodwad, Pooja pharne, Akshay Karale

“…In this test, a p-value less than or equal to 0.05 was considered statistically significant. …”
Get full text

Global Burden of Kidney Cancer Attributable to High Body Mass Index in Adults Aged 60 and Older from 1990 to 2021 and Projections to 2040: A Systematic Analysis for the Global Burd... by Lin J, Zhang Z, Meng X, Yin X, Pu L, Xiang C, Yang J

“…This study analyzes the burden of kidney cancer attributable to high BMI in those aged ≥ 60, clarifying causes and future trends.Methods: Using Global Burden of Disease (GBD) 2021 study, we assessed kidney cancer burden due to high BMI in population aged ≥ 60 from 1990 to 2021, comparing deaths, disability-adjusted life years (DALYs), age-standardized rate (ASR) of DALYs (ASDR), and mortality (ASMR). …”
Get full text

Pulmonary and Physical Virtual Reality Exercises for Patients With Blunt Chest Trauma: Randomized Clinical Trial by Tjitske D Groenveld, Indy GM Smits, Naomi Scholten, Marjan de Vries, Harry van Goor, Vincent MA Stirler

“…ObjectiveThis study aimed to assess the effectivity of breathing and physical exercises using VR on the pulmonary recovery of patients with blunt chest trauma at the ward. MethodsA pilot randomized controlled trial was performed. …”
Get full text

The Role of Dectin-1-Akt-RNF146 Pathway in &beta;-Glucan Induced Immune Trained State of Monocyte in Sepsis by Guo C, Xu P, Luo W, Zhang J, Sun X, Hoang H, Ma D, Wu D, Zhong J, Miao C

“…However, the role of trained immunity in sepsis has not been fully understood.Methods: We profiled the characteristics of peripheral blood mononuclear cells from septic patients using single-cell RNA sequencing (scRNA-seq) analyses. …”
Get full text

Water-Sediment Characteristics and Flow-Sediment Diversion Patterns in Typical Bifurcated Channels in the Middle Reaches of Huaihe River by ZHANG Hui, NI Jin, BEN Peng, WANG Jiu-sheng

“…The sediment concentration ratios of each bifurcated channel were approximately equal to the ratios of their respective flow sediment transport capacity. …”
Get full text

HSPA4 Expression is Correlated with Melanoma Cell Proliferation, Prognosis, and Immune Regulation by Wang X, Li Z, Xu J, Wang J, Li Y, Li Q, Niu J, Yang R

“…However, its function in cutaneous malignant melanoma (CMM) remains uncertain.Patients and Methods: The gene and protein expression level of HSPA4 in CMM was investigated with public databases. …”
Get full text

Mechanism of a Novel Complex: Zinc Oxide Nanoparticles-Luteolin to Promote Ferroptosis in Human Acute Myeloid Leukemia Cells in Vitro by Wang W, Li Z, Lyu C, Wang T, Han C, Cui S, Wang J, Xu R

“…In this study, we synthesized a new complex: zinc oxide nanoparticles-luteolin (ZnONPs-Lut) and aimed to investigate its effects on cell death in the AML cell line (MOLM-13) in vitro and to elucidate the underlying mechanisms.Methods: We assessed cell viability, quantified changes in gene expression using real-time quantitative PCR (qRT-PCR), and measured changes in ferrous (Fe2+) content, glutathione (GSH) content, malondialdehyde (MDA) content, reactive oxygen species (ROS), and mitochondrial membrane potential (MMP) levels following treatment with different concentrations of MOLM-13 cells with different concentrations of ZnONPs-Lut. …”
Get full text

Correlation Between Systemic Immune Inflammation Index(Sll) and Outcome After Occlusion in Patients with Post-Infarction Ventricular Septal Rupture by Hou Q, Zhao Y, Lin Z, Chen T, Di X, Wang X, Cheng J, Guo X, Chen C, Hu D, Liu C, Jiang Y, Liu Y, Li Y, Su M, Liu Y

“…This study aims to determine the association between SII and prognosis following occlusion in patients with post-infarction ventricular septal rupture (PIVSR).Methods: A total of 130 patients admitted to Fuwai Central China Cardiovascular Hospital between 2018 and 2023 were included in this retrospective study. …”
Get full text

Brain development using a multicomponent intravenous lipid emulsion in preterm infants by Katherine M. Ottolini, Julius Ngwa, Sudeepta K. Basu, Kushal Kapse, Melissa Liggett, Jonathan Murnick, Catherine Limperopoulos, Nickie Andescavage

“…The primary aim of this study was to assess extrauterine third trimester brain growth in very preterm infants supported with soybean oil-only compared to fish-oil containing multicomponent lipid emulsions; white matter development and neurobehavioral regulation at term were also investigated. Methods Human milk-fed very preterm infants (born less than or equal to 32 weeks’ gestation) receiving either soybean oil-only (before 2019) or multicomponent (after 2019) lipid emulsions underwent quantitative brain MRI (volumetric growth and white matter development) and neurodevelopmental assessment (Neonatal Intensive Care Unit Network Neurobehavioral Scale) at term-equivalent age. …”
Get full text

Investigating the Use of Generative Adversarial Networks-Based Deep Learning for Reducing Motion Artifacts in Cardiac Magnetic Resonance by Ma ZP, Zhu YM, Zhang XD, Zhao YX, Zheng W, Yuan SR, Li GY, Zhang TL

“…Ze-Peng Ma,1,2,&ast; Yue-Ming Zhu,3,&ast; Xiao-Dan Zhang,4 Yong-Xia Zhao,1 Wei Zheng,3 Shuang-Rui Yuan,1 Gao-Yang Li,1 Tian-Le Zhang1 1Department of Radiology, Affiliated Hospital of Hebei University/ Clinical Medical College, Hebei University, Baoding, 071000, People’s Republic of China; 2Hebei Key Laboratory of Precise Imaging of inflammation Tumors, Baoding, Hebei Province, 071000, People’s Republic of China; 3College of Electronic and Information Engineering, Hebei University, Baoding, Hebei Province, 071002, People’s Republic of China; 4Department of Ultrasound, Affiliated Hospital of Hebei University, Baoding, Hebei Province, 071000, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Xiao-Dan Zhang, Department of Ultrasound, Affiliated Hospital of Hebei University, No. 212 of Yuhua East Road, Lianchi District, Baoding, 071000, People’s Republic of China, Tel +86 17325535302, Email xiaodanzhangzxd@126.comObjective: To evaluate the effectiveness of deep learning technology based on generative adversarial networks (GANs) in reducing motion artifacts in cardiac magnetic resonance (CMR) cine sequences.Methods: The training and testing datasets consisted of 2000 and 200 pairs of clear and blurry images, respectively, acquired through simulated motion artifacts in CMR cine sequences. …”
Get full text

Evaluating the Efficacy of Pre-Emptive Peribulbar Blocks with Different Local Anesthetics or Paracetamol Using the Adequacy of Anesthesia Guidance for Vitreoretinal Surgeries: A Pr... by Michał Jan Stasiowski, Anita Lyssek-Boroń, Katarzyna Krysik, Dominika Majer, Nikola Zmarzły, Beniamin Oskar Grabarek

“…The aim was to analyze the utility of PBBs compared with intravenous paracetamol added to AoA-guided GA on the incidence of IPPP and hemodynamic stability in patients undergoing VRS. Methods: A total of 185 patients undergoing vitreoretinal surgery (VRS) were randomly assigned to one of several anesthesia protocols: general anesthesia (GA) with analgesia optimized through AoA-guided intraoperative remifentanil opioid analgesia (IROA) combined with a preemptive single dose of 1 g of paracetamol (P group), or PBB using one of the following options: 7 mL of an equal mixture of 2% lidocaine and 0.5% bupivacaine (BL group), 7 mL of 0.5% bupivacaine (BPV group), or 7 mL of 0.75% ropivacaine (RPV group). …”
Get full text

Novel SLC16A2 Frameshift Mutation as a Cause of Allan-Herndon-Dudley Syndrome and its Implications for Carrier Screening by Lin P, Liu H, Lou J, Lyu G, Li Y, He P, Fu Y, Zhang R, Zhang Y, Yan T

“…This case report describes the genetic cause of AHDS in a male proband and to expanding the mutation spectrum of the SLC16A2 gene.Methods: A blood specimen was collected from a one-year-old child with delayed development and abnormal thyroid function and this was followed by whole-exome sequencing (WES) was performed on the proband to identify potential genetic mutations. …”
Get full text

Misconceptions on COVID-19 Risk Among Ugandan Men: Results From a Rapid Exploratory Survey, April 2020 by Keneth Iceland, Kasozi, MacLeod, Ewan, Ssempijja, Fred, Mahero, Michael W., Matama, Kevin, Musoke, Grace Henry, Bardosh, Kevin, Ssebuufu, Robinson, Wakoko-Studstil, Florence, Echoru, Isaac, Tiyo Ayikobua, Emmanuel, Mujinya, Regan, Nambuya, Grace, Onohuean, Hope, Zirintunda, Gerald, Ekou, Justine, Welburn, Susan Christina

“…The aim of the study was to identify possible misconceptions among males and females toward COVID-19 in Uganda using a rapid online survey distributed via social media. Methods: A cross-sectional survey carried out in early April 2020 was conducted with 161 Ugandans, who purposively participated in the online questionnaire that assessed understandings of COVID-19 risk and infection. …”
Get full text

Isolation of Murine Pancreatic Stellate Cells and the Establishment of a New ex-vivo Activation Model by Wang X, Li M, Liu X, Sun G, Zhang D, Sun L, Yin Y, Zhang W, Hao J

“…Currently, there is a lack of methods for isolating activated PSCs that are unaffected by cell attachment. …”
Get full text

Unveiling the Mechanisms and Therapeutic Effects of Xiaoyao Sanjie Decoction in Triple-Negative Breast Cancer: A Network Pharmacology and Experimental Validation Approach by Qi Y, Xu B, He J, Jiang B, Yan L, Zhou H, Chen S

“…Network pharmacological methods identified 206 targets for anti-TNBC. Bioinformatics analysis suggests that the EZH2/AKT1 signaling pathway might play an important role in the effects of XYSJD against TNBC. …”
Get full text