The Role of Circulating Fatty Acids in Mediating the Effect of Insomnia on Heart Failure: A Two-Step, Two-Sample Mendelian Randomization Study by Zuo B, Yu B, Wang P, Zhang C, Zhao C, Sun Y, Ai S

“…This study aims to investigate the mediating role of fatty acids in the association between insomnia and heart failure.Methods: We performed two-step, two-sample Mendelian randomization analysis by applying SNPs as genetic instruments for exposures, mediators and outcomes. …”
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European civil procedure: current status within the legal system of the European Union and its member states by V. Terekhov

“…In order to guarantee an equal level of judicial protection everywhere in the EU a procedural “bill of rights” is required, and it needs to be adopted at the “highest level” of the system.Conclusions. …”
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Competition Between Protein and DNA for Binding to Natural Sepiolite Nanofibers by Adame Brooks D, Piétrement O, Dardillac E, Castro Smirnov FA, Aranda P, Ruiz-Hitzky E, Lopez BS

“…In this study, we analyzed the adsorption of DNA and proteins to sepiolite by analyzing the competition among these biomolecules during the adsorption process.Methods: To determine the binding of sepiolite to proteins, we used BSA and a monoclonal antibody (mAb) against the CD4 membrane antigen as a model. …”
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Impact of IL-17A Inhibitors on Serum Uric Acid Levels in Psoriatic Patients with Hyperuricemia: A Prospective Observational Study by Wu C, He C, Wang H, Wang W, Jin H

“…It also explored the risk factors for hyperuricemia in psoriatic patients and the effectiveness of IL-17A inhibitors for the skin lesions of psoriatic patients with hyperuricemia.Methods: Patients aged ≥ 18 years with moderate to severe plaque psoriasis along with concomitant hyperuricemia (defined as an SUA level > 416 μmol/L in men and > 357 μmol/L in women) at baseline were treated with either secukinumab or ixekizumab. …”
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Cow’s Milk Allergy and Associated Factors Among Children in Abha City, Saudi Arabia – A Retrospective Case Control Study by Alqurashi NK, Mahmood SE, Alsabaani A, Ahmad A, Khan MS, Shati AA

“…Therefore, this study was undertaken to determine the factors associated with CMA among children in Abha city and to explore the knowledge and practice regarding CMA among parents in Abha city.Methods: This retrospective one-year case control study was conducted amongst children with CMA (cases) and healthy children without CMA (controls) and their parents attending Abha Maternity and Children Hospital, Saudi Arabia. …”
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Effects of Acupuncture Combined with Conventional Rehabilitation Training for Patients with Post-Stroke Dysphagia: A Randomized Controlled Trial by Xu F, Zhang Y, Su X, Dai F, Ye Y, Ling M, Hu P, Cheng H

“…This study aimed to examine the effects of acupuncture combined with conventional rehabilitation training (CRT) on swallowing function, neurotransmitter levels, nutritional status, and swallowing-related quality of life in patients with PSD.Methods: Following screening, 90 patients with PSD were randomly assigned to either the intervention group (receiving acupuncture combined with CRT) or the control group (receiving CRT only). …”
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Low Impact Development-Based Drainage Design in Residential Areas: A Case Study of Mastrip Housing by Yangga Purnagusti, Entin Hidayah, Audiananti Meganandi Kartini

“…Therefore, infiltration LID methods can be considered to improve the effectiveness of reduction. …”
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Integrated Multi-Omics Analyses Reveal Innovative Diagnostic and Therapeutic Targets Associated with Atopic Dermatitis by Chen X, Cao B, Tan Z, Li X, Xu W, Liu Y, Gong F

“…Identifying novel, reliable biomarkers is crucial to enhance diagnostic accuracy, reduce healthcare costs, and aid in developing new treatments.Methods: Data from the Gene Expression Omnibus database were used to identify potential AD biomarkers through Weighted Gene Co-expression Network Analysis and machine-learning. …”
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Exploring the publication gap in pediatric randomized clinical trials: completed vs. uncompleted pediatric clinical trials by Katerina Nebeska, Katerina Nebeska, Lenka Souckova, Lenka Souckova, Lenka Souckova, Lenka Souckova, Radka Stepanova, Regina Demlova, Regina Demlova

“…The publication of RCTs’ results is equally crucial, yet not all completed RCTs share their findings, contributing to publication bias. …”
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Exploration of Epigenetic Mechanisms and Biomarkers Among Patients with Very-Late-Onset Schizophrenia-Like Psychosis by Gan Y, Yue W, Sun J, Yang D, Fang C, Zhou Z, Yin J, Zhou H

“…Yansha Gan,1,* Weihua Yue,2,* JiaoJiao Sun,1 DanTing Yang,1 ChunXia Fang,1 Zhenhe Zhou,1 JiaJun Yin,1 Hongliang Zhou3 1The Affiliated Mental Health Center of Jiangnan University, Wuxi, Jiangsu, 214151, People’s Republic of China; 2National Clinical Research Center for Mental Disorders, Peking University Sixth Hospital, Beijing, 100191, People’s Republic of China; 3Department of Psychology, The Affiliated Hospital of Jiangnan University, Wuxi City, Jiangsu, 214100, People’s Republic of China*These authors contributed equally to this workCorrespondence: JiaJun Yin, The Affiliated Mental Health Center of Jiangnan University, Wuxi, Jiangsu, 214151, People’s Republic of China, Email yinjiajun@jiangnan.edu.cn Hongliang Zhou, Department of Psychology, The Affiliated Hospital of Jiangnan University, No. 200, Huihe Road, Binhu District, Wuxi City, Jiangsu Province, People’s Republic of China, Email Hongliangzh2022@hotmail.comObjective: This study aimed to identify DNA methylation patterns associated with Very Late-Onset Schizophrenia-like Psychosis (VLOSLP) and to develop methylation-based biomarkers that differentiate VLOSLP from Schizophrenia (SCZ) and Alzheimer’s Disease (AD).Methods: We analyzed methylation microarray datasets (n = 1218) from SCZ and AD patients obtained from the GEO database. …”
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Association Between Vitamin A and D Status and the Risk of COVID-19 in the Elderly Population: A Single-Center Experience by Li T, Cui X, Li X, Yang J, Wang H, Yang J, Jin Z

“…Thus, the aim of this study was to explore the association between vitamin A and D status and the risk of COVID-19 in the elderly population.Methods: From April 1st to September 20th, 2023, 32 COVID-19 patients who tested positive for severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection through polymerase chain reaction (PCR) were enrolled in this study. …”
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A Comparative Study of Esketamine-Propofol and Sufentanil-Propofol for Analgesia and Sedation During Breast Minimally Invasive Rotary Resection with Local Anesthesia: A Randomized... by Li N, Qi X, Bao J, Gu Y, Zhou X, Wang T, Jiang N, Wang Y, Ye Q

“…This study aims to compare the safety and efficacy of esketamine versus sufentanil as adjuncts to propofol for analgesia and sedation during breast MIRR.Patients and Methods: A total of 90 patients undergoing elective breast MIRR were randomly assigned to receive either sufentanil-propofol or esketamine-propofol for analgesia and sedation. …”
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Impact of Echinococcus granulosus Cyst Fluid on the Phenotypic Dynamics and Degranulation of RBL-2H3 Mast Cells by Yue Z, Zhou JR, Wang CS, Pu XL, Parehati G, Cao LW, Bayina B, Ye JR

“…Zhen Yue,1,2,* Jing-Ru Zhou,3,* Chun-Sheng Wang,1 Xue-Li Pu,1 Guligeiya Parehati,1 Li-Wei Cao,1 Batesurong Bayina,1 Jian-Rong Ye1 1Department of Anesthesiology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, People’s Republic of China; 2Department of Anesthesiology, Changji People’s Hospital, Changji, 831100, People’s Republic of China; 3Department of Anesthesiology, The Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi, 830063, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jian-Rong Ye, Department of Anesthesiology, The First Affiliated Hospital of Xinjiang Medical University, No. 137, Liyushan South Road, Urumqi, 830054, People’s Republic of China, Tel +86 18999938777, Email ywjianrongym@126.comObjective: This study aimed to evaluate the effects of Echinococcus granulosus cyst fluid (EgCF) on the phenotypic characteristics and degranulation activity of mast cells during echinococcosis-associated hypersensitivity reactions, using the RBL-2H3 rat basophilic leukemia cell line as an in vitro model.Methods: The cytotoxic effects of EgCF on RBL-2H3 cells were assessed using the Cell Counting Kit-8 assay. …”
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Prognostic Value of Apolipoprotein E in Predicting One-year Mortality in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease by Li Y, Wu Q, Li Z, Xiao Y, Wei L

“…This study sought to investigate the correlation between the levels of ApoE and all-cause mortality over one year in individuals who are diagnosed with acute exacerbations of chronic obstructive pulmonary disease (AECOPD).Methods: In this study, we checked serum ApoE concentrations of AECOPD patients on admission and collected the patients’ laboratory and clinical information. …”
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Evaluation of Streptococcus faecalis, Clostridium butyricum, Bacillus mesentericus, Lactobacillus sporogenes, Saccharomyces Boulardi multistrain probiotic formulation in acute gast... by Bhavna Darshan Patel, Girish Kulkarni, Swagata Chowdhuri, Animesh Arya, Kaithayil Mammen John, Ashwini Suyog Patki Doshi, Rathish Nair, Krishnaprasad Korukonda

“…This study evaluates the safety and efficacy of a novel multistrain probiotic formulation in managing AGE and antibiotic-associated diarrhea (AAD). Methods This observational, real-world study included 683 patients from 239 sites across India, assessing the effects of a multistrain probiotic formulation in AGE and AAD. …”
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Exogenous GABA Alleviates Tourette Syndrome-Like Behavior in Sprague-Dawley Rats by Altering Gut Microbiota and Striatum Metabolism by Xu Y, Li LN, He XJ, Wang S, Li X, Feng H, Zhang HF, Song L, Shi HS, Tian XY

“…However, the effect of exogenous GABA administration on tic alleviation remains unreported.Objective: In this study, we aim to investigate the therapeutic effects of exogenous GABA on TS-like behaviors in Sprague-Dawley rats and explore its potential mechanisms, including gut microbiota regulation, oxidative stress mitigation, and restoration of GABA-glutamate balance, to provide insights into TS pathogenesis and alternative treatment strategies.Materials and Methods: A TS model rat was established through intraperitoneal administration of 3,3-Iminodipropionitrile (150 mg/kg/day), followed by GABA (20 mg/kg/day) administration by gavage. 15 minutes of behavioral testing (stereotypical behavior and head twitching behavior) was then conducted. 16S rRNA sequencing identified microbiome changes, and LC-MS assessed striatal metabolite changes.Results: The results showed that a 4-week GABA treatment alleviated TS-like behavior in rats. …”
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Effectiveness and Safety of Acupuncture as an Adjunctive Therapy for Post-Stroke Depression: An Overview of Systematic Reviews by Liu X, Zhu F, Zhang JL, He ZX, Yin S, Wu RH, He YY, Zeng F

“…Acupuncture as an adjuvant therapy shows promise, though current systematic reviews exhibit significant discrepancies in effectiveness/safety evidence with insufficient methodological rigor.Purpose: To evaluate systematic reviews assessing acupuncture as an adjuvant therapy for PSD.Methods: Electronic searches were conducted across eight databases from their inception to March 2024. …”
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Immune Subtypes in Sepsis: A Retrospective Cohort Study Utilizing Clustering Methodology by Zhao J, Dai R, Zhao Y, Tan J, Hao D, Ren J, Wang X, Chen Y, Peng H, Zhuang Y, Zhou S, Chen Y

“…Identifying distinct clinical phenotypes may enable more targeted therapeutic interventions and improve patient care.Objective: This study aims to use clustering analysis techniques to identify different immune subtypes in sepsis patients and explore their clinical relevance and prognosis.Methods: The study included 236 patients from the EICU at Shanghai Tenth People’s Hospital, who met the Sepsis 3.0 diagnostic criteria. …”
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How to Choose Treatment Regimens for Idiopathic Membranous Nephropathy Patients with PLA2R-Negative: A Single-Center Retrospective Cohort Study by Zhou Z, Zou Y, Ke B, Shen W

“…This study aimed to evaluate the efficacy and adverse events of these three treatment regimens in IMN patients with PLA2R-negative.Methods: This study included 46 PLA2R-negative IMN patients confirmed by renal biopsy and immunofluorescence from the Department of Nephrology, the Second Affiliated Hospital of Nanchang University between September 2021 and October 2023. …”
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Dynamical lymphadenectomy as a component of multidisciplinary approach while doing operative interventions for pancreatic cancer by O. Yu. Usenko, M. Yu. Nychytailo, M. S. Zagriichuk, V. V. Kropelnytskyi, N. E. Klochkova, Yu. V. Nezhentseva, Ya V. Romaniv, O. O. Pidopryhora, D. M. Skrypka

“…To improve the results of treatment of pancreatic cancer, using modification of volumes of lymphadenectomy and application of multidisciplinary approach. Materials and methods. Into the investigation 16 patients, suffering a moderately differentiated (G2) adenocarcinoma of the pancreatic gland head (II stage of the disease) were included. …”
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