Patient and public involvement and engagement with underserved communities in dementia research: Reporting on a partnership to co‐design a website for postdiagnostic dementia suppo... by Claudio Di Lorito, Sarah Griffiths, Marie Poole, Chandrika Kaviraj, Martin Robertson, Neil Cutler, Jane Wilcock

“…These seven members of the public undertook the role of partners in the study. They all equally contributed to the study design, recruitment of participants, development and revision of topic guides for the interviews and development of the website. …”
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Long-term results of lymphedema treatment with Combined lymph node transfer and collagen scaffolds: An Observational Study by Dimitrios Dionyssiou, Antonios Tsimponis, Eleni Georgiadou, Konstantina Mamaligka, Efterpi Demiri

“…Our observational study aimed to examine the hypothesis that nanofibrillar collagen scaffolds (NCS) combined with VLNT can provide guided lymphagiogenesis creating long-lasting lymphatic pathways. Methods: Twenty-four patients (21 female, 3 male) underwent a lymphatic microsurgery for upper (n = 11) or lower (n = 13) limb secondary lymphedema and completed at least 18 months follow-up were selected and equally divided in 2 groups; Group-A underwent VLNT, Group-B underwent combined VLNT and NCS procedure. …”
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Deciphering Immunometabolic Landscape in Rheumatoid Arthritis: Integrative Multiomics, Explainable Machine Learning and Experimental Validation by Dong Q, Wu J, Zhang H, Chen X, Xu X, Chen J, Shi C, Luo L, Zhang D

“…This study explores the complex immunometabolic landscape of RA to identify potential therapeutic targets.Patients and Methods: We integrated genome-wide association study (GWAS) data involving 1,400 plasma metabolites, 731 immune cell traits, and RA outcomes from over 58,000 participants. …”
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Effectiveness of Finnish SISU training in enhancing prehospital personnels’ work performance: A randomised controlled pilot study by Hanna Vihonen, Janne Karvonen, Harri Gustafsberg, Juha-Matti Huhta, Heidi Kangasniemi, Timo Jama, Sanna Hoppu

“…The sample comprised 16 paramedics, divided equally between the intervention and control groups. …”
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Design, Synthesis, and Biological Evaluation of Novel Hydroxytyrosol Derivatives as Protectors for Vascular Endothelium Against Lipid Overload by Hou XX, Wang S, Ma XX, Wen Y, Li ZJ, Liu XY, Zhang X, Zhang Y, Qin XY

“…The aim of the study was to design and synthesize novel hybrid molecules to improve HT’s biological efficiency.Materials and Methods: A pharmacophore connection strategy was used to design and synthesize novel hybrid molecules by combining HT or its analogues with adamantane (ADM). …”
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Working time distribution and administrative burden in Austrian community health nursing: A cross-sectional survey by Raimund M. Kovacevic, Doris A. Behrens, Walter Hyll

“…Participants: Out of the N = 220 eligible community health nurses, 121 (55%) nurses answered the questions relevant to working time analysis and 115 (52%) for studying regional disparity of service delivery. Methods: The analysis used descriptive statistics, statistical tests, and regression analysis, employing Excel®, Stata® and R. …”
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Bidirectional Relationship Between Hypoalbuminemia and Postoperative Pneumonia in Elderly Hip Fracture Patients: A Retrospective Cohort Study by Wang J, Yu H, Xu X, Guo J

“…However, their bidirectional relationship in elderly HF patients remains underexplored.Methods: This retrospective cohort study was conducted in China enrolling elderly patients (≥ 65 years) with HFs between Mar 2020 and Feb 2023. …”
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Opaganib Promotes Weight Loss and Suppresses High-Fat Diet-Induced Obesity and Glucose Intolerance by Maines LW, Keller SN, Smith RA, Smith CD

“…Additionally, opaganib and semaglutide were equally effective in promoting body weight loss and improving glucose tolerance in obese mice. …”
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A CDKN2B-Associated Immune Prognostic Model for Predicting Immune Cell Infiltration and Prognosis in Esophageal Carcinoma by Peng X, Han J, Huang J, Zhou L, Chen X, Zhou W

“…This study explored the association between CDKN2B deletion, immunophenotype, and the prognosis of EC.Methods: We investigated CDKN2B status and RNA expression, identified differentially expressed immune-associated genes between wild-type CDKN2B (CDKN2BWT) and deleted CDKN2B (CDKN2Bdeletion) in Cancer Genome Atlas (TCGA) EC samples. …”
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Rethinking Language by Gastor Mapunda, Tracey Costley, Hannah Gibson, Nancy Kula, Colin Reilly

“…We view these pedagogies as an essential factor in teacher training which is linked to wider notions of access and equality, but which is currently being overlooked.   …”
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Cerebrospinal Fluid Leakage Combined with Blood Biomarkers Predicts Poor Wound Healing After Posterior Lumbar Spinal Fusion: A Machine Learning Analysis by Pang Z, Ou Y, Liang J, Huang S, Chen J, Huang S, Wei Q, Liu Y, Qin H, Chen Y

“…Thus, our primary aim is to using machine learning identify these risk factors and construct a clinical risk prediction model.Methods: We retrospectively reviewed 2516 patients who underwent posterior lumbar spinal fusion at Guangxi Medical University’s Second Affiliated Hospital between August 2021 and August 2023. …”
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Impact of Antimicrobial Stewardship and Infection Prevention and Control Programmes on Antibiotic Usage and A. baumannii resistance: A 2016–2023 Multicentre Prospective Study by Liu L, Liu B, Li L, Li Y, Zhou X, Li Q

“…Lei Liu,1,2,* Bin Liu,1,2,* Liang Li,1,2 Yu Li,3 Xiangdong Zhou,1,2 Qi Li1,2 1Department of Respiratory Medicine, The First Affiliated Hospital, Hainan Medical University, Haikou, Hainan, People’s Republic of China; 2Hainan Province Clinical Medical Center of Respiratory Disease, Haikou, Hainan, People’s Republic of China; 3Department of Respiratory Medicine, The Fourth Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qi Li, Email lqlq198210@sina.comObjective: This study assesses the efficacy of antimicrobial stewardship (AMS) and infection prevention and control programmes (IPCP) in guiding the use of antibiotics and the control of A. baumannii (AB) resistance at multiple medical centres.Methods: We evaluated the effectiveness of the policy on antibiotic consumption and AB resistance by determining the relationship between the defined daily doses (DDD) for antibiotics – or alcohol-based hand gel (ABHG) consumption – and the incidence of carbapenem-resistant AB (CR-AB), multidrug-resistant AB (MDR-AB) and extensively drug-resistant AB (XDR-AB) at two medical centers from 2016– 2023.Results: In total, 4057 AB isolates were collected; 64.95% of the AB isolates were CR, 59.48% were MDR and 1.41% were XDR. …”
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Digital outdoor exercise program for obese patients with type 2 diabetes mellitus: a non-inferiority randomized controlled trial by Jian Cui, Qiang Liu, Lihua Huang, Haoyan Yu

“…Adherence and cost-effectiveness were also assessed.MethodsWe conducted a randomized controlled noninferiority trial at a single tertiary center. …”
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Factors associated with malaria in pregnancy among antenatal care mothers at Gulu Regional Referral Hospital in northern Uganda by Solomon Oguta, Brian Serumaga, Lameck Odongo, Donald Otika, Jackline Ayikoru, Raymond Otim, Jimmyy Opee, Baifa Arwinyo, Francis Pebolo Pebalo, Vincentina Achora, Sande Ojara, Benard Abola, Silvia Awor

“…This study aimed to assess the factors associated with malaria in pregnancy among antenatal care mothers at Gulu Regional Referral Hospital. Methods This was a cross-sectional study at Gulu Regional Referral Hospital antenatal clinic from July to August 2023. …”
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Seroprevalence and Clinical Insights of Ocular Herpesvirus Infections: A Cross-Sectional Study Evaluating ELISA as a Diagnostic Tool by Chen S, Peng Q, Wang H, Xie J, Cao H, Xu X

“…This study aimed to investigate the seroprevalence of HSV and VZV infections in patients with suspected ocular infections and to evaluate associated risk factors.Methods: We conducted a cross-sectional study using enzyme-linked immunosorbent assay (ELISA) to detect antibodies against HSV and VZV in patients with ocular symptoms. …”
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Gait Characteristics and Neuroanatomical Alterations in Obstructive Sleep Apnea–Hypopnea Syndrome by Jiang J, Mo Y, Abuduwaili Z, Mao C, Fang S, Ke Z, Hu Z, Huang L, Xu S, Yang D, Xiong R, Xie P, Zhu X, Xu Y

“…Recently, it has been found to contribute to gait disorders, but there is limited information regarding how various indicators of OSAHS affect gait patterns.Methods: A total of 136 subjects recruited from Nanjing Drum Tower Hospital were categorized based on apnea hypopnea index (AHI) and oxygen saturation (SpO2), respectively. …”
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Open donor nephrectomy via singular pararectal extraperitoneal mini-incision: single-center experience with 425 consecutive cases by Philipp Tessmer, Oliver Beetz, Anna Meyer, Clara A. Weigle, Simon Stoerzer, Gunilla Einecke, Wilfried Gwinner, Florian W. R. Vondran, Felix Oldhafer, Moritz Schmelzle, Nicolas Richter

“…Conclusions Unlike the endoscopic technique, SPEM is equally suitable for right- and left-sided nephrectomy. …”
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Innovative Cardiac Rehabilitation: Effects of Adaptive Postural Balance Exercise on Coronary Artery Disease and Type 2 Diabetes by Qin D, Liu G, Zhang J, Lin S, Liu X, Zhao J, Zhang Q, Ma M, Wang S

“…Specifically, we compared the efficacy of APBCRE with aerobic exercise (AE) alone and irregular exercise (IE).Patients and Methods: This randomized controlled trial included 348 patients with CAD, comprising 261 patients with T2DM and 87 non-diabetic CAD patients as a control group. …”
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The Effect of Minimal-Dose S-Ketamine Administration Post-Surgery on Opioids Consumption and Functional Rehabilitation Exercises in Patients Undergoing Minimally Invasive Radical R... by Xie J, Shen F, Wang X, Yao J, Zhou L, Huang L, Sun J

“…Jue Xie,1 Fangming Shen,1 Xingming Wang,2 Juan Yao,1 Lingzhen Zhou,3 Luxin Huang,1 Jie Sun1 1Department of Anesthesiology, Surgery and Pain Management & Key Laboratory of Clinical Science and Research, Zhongda Hospital Southeast University, Southeast University School of Medicine, Nanjing, Jiangsu, People’s Republic of China; 2Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, People’s Republic of China; 3Department of Thoracic Surgery, Zhongda Hospital Southeast University, Southeast University School of Medicine, Nanjing, Jiangsu, People’s Republic of ChinaCorrespondence: Jie Sun, Email dgsunjie@hotmail.comStudy Objective: To examine the impact of minimal-dose S-ketamine on postoperative analgesia in patients undergoing minimally invasive radical resection for esophageal cancer, with a focus on reducing opioid consumption, enhancing analgesic quality, and facilitating postoperative recovery.Methods: A total of 216 patients undergoing minimally invasive radical resection of esophageal cancer under general anesthesia were randomly assigned into two groups (S-ketamine and control group), receiving intravenous S-ketamine (0.015 mg/kg/h) or an equal volume of saline for 48 h postoperatively. …”
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The Predictive Value of Soluble Fms-Like Tyrosine Kinase-1 for Prognosis in COVID-19 Patients by Lai C, Wang Y, Shi F, Geng N, Liu Z, Pan W, Shi H, Ma Y, Liu B

“…This study aimed to investigate the prognostic value of soluble fms-like tyrosine kinase-1 (sFlt-1) in COVID-19 patients.Methods: A prospective cohort study was conducted involving 154 COVID-19 patients, with comprehensive clinical data and laboratory parameters analyzed to evaluate the effectiveness of sFlt-1 in determining disease severity and prognosis.Results: The results revealed that sFlt-1 levels correlated significantly with disease severity, showing higher levels in severe/critical cases compared to mild cases (P< 0.05). …”
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