Engineered Biomimetic Nanoparticles-Mediated Targeting Delivery of Allicin Against Myocardial Ischemia-Reperfusion Injury by Inhibiting Ferroptosis by Li M, Wu J, Yang T, Zhao Y, Ren P, Chang L, Shi P, Yang J, Liu Y, Li X, Wang P, Cao Y

“…Here, inspired by the natural interaction between neutrophils and inflamed cardiac microvascular endothelial cells (CMECs), a neutrophil membrane-camouflaged nanoparticle for non-invasive active-targeting therapy for IR injury by improving drug delivery to the injured heart is constructed.Methods: In this study, we engineered mesoporous silica nanoparticles (MSNs) coated with a neutrophil membrane to act as a drug delivery system, encapsulating AL. …”
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Association of the Monocyte-to-High Density Lipoprotein Ratio with the FRS and as a Predictor of Cardiovascular Risk in Individuals with Psoriasis Vulgaris by Gu X, Shen H, Jiang J, Gu P, Liu P, Zhao Z, Ge J

“…This retrospective study aimed to investigate the relationship between MHR and the Framingham risk score (FRS) and assess the prognostic significance of this relationship for mid- to high-risk CVD in individuals with psoriasis vulgaris (PsV).Methods: A total of 128 PsV patients and 120 healthy controls were included. …”
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Predictive Value of Bone Metabolism Marker PINP in the Risk of Diabetic Retinopathy: A Cross-Sectional Study by Chen G, Zhang Y, Wang W, Jing Y

“…Guanhua Chen,1,2,* Yuan Zhang,1,2,* Weimin Wang,2,3,* Yali Jing1,2,* 1Department of Endocrinology, Endocrine and Metabolic Disease Medical Center, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, People’s Republic of China; 2Branch of National Clinical Research Centre for Metabolic Diseases, Nanjing, People’s Republic of China; 3Department of Endocrinology, Endocrine and Metabolic Disease Medical Center, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yali Jing, Department of Endocrinology, Endocrine and Metabolic Disease Medical Center, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, 210008, People’s Republic of China, Email jingyalidr@163.comBackground: Given the association between diabetic microvascular disease and bone metabolism, we aimed to investigate the correlation between the concentration of the serum bone turnover marker procollagen type I N-terminal propeptide (PINP) and diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM) in this study.Methods: This was a cross-sectional study. …”
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SGLT-2 inhibitors in the management of acute decompensated heart failure by Anastasia E. Poskakalova, Svetlana N. Nasonova, Igor V. Zhirov, Sergey N. Tereshchenko

“…Evaluation of the six-month efficacy of early dapagliflozin administration in patients with ADHF with a reduced left ventricular ejection fraction (LVEF) in comparison with standard therapy. Materials and methods. The results of the six-month follow-up of 122 patients with ADHF with a reduced LVEF (28±6%), who were divided equally into 2 groups: the standard therapy (group 1) and the sodium-glucose cotransporter-2 inhibitor – dapagliflozin (group 2). …”
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Comparative Morphometric and Histometric Evaluation of Power-Dependent Tissue Ablation Using Fractional Carbon Dioxide Laser by Ryu HG, Park J, Kim H, Kim W, Lee HR, Ko J, Cho SB

“…Although clinical outcomes vary with the energy and pulse settings, comparative morphometric and histometric data on power-dependent tissue interactions are limited.Objective: To evaluate and compare fractional CO2 laser-induced microscopic thermal zones (MTZs) ablation characteristics at peak powers of 30 W and 40 W using an ex vivo porcine skin model.Methods: Ex vivo porcine skin was treated with a fractional CO2 laser at energy levels ranging from 40 to 240 mJ under 30 W and 40 W settings. …”
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Direct and Indirect Effects of Risk Perception and Risk Information on PTSD in Frontline Healthcare Workers by Wu L, Geng S, Zhou Y, Jiao R, Ouyang H, Cheng S, Shang Z, Yan W, Wang J, Jia Y, Li X, Liu W

“…The PTSD checklist for DSM-5 (PCL-5), risk information questionnaire, and risk perception questionnaire are utilized to collect data.Methods: Bivariate correlation analysis and structural equation modelling are performed to analyze the mediating role of risk perception in the relationship between risk information and PTSD.Results: The estimated prevalence of PTSD among frontline healthcare workers is 28.2%. …”
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Auto-Immune Glial Fibrillary Acidic Protein Astrocytopathy with Active Intrathecal Epstein-Barr Virus: A Single-Center Case Series Report by Yu X, Zou Y, Li M, Wang L, Feng W, Wei L, Yang L, He J, Bu H, Li Y

“…This study reports a case series of auto-immune GFAP astrocytosis with positive cerebrospinal fluid (CSF) EBV DNA, describing its clinical manifestations and treatment experience.Patients and Methods: In the serial case study, we reported six patients diagnosed with GFAP astrocytopathy having intrathecal EBV.Results: The significant signs included headache, fever and urination disorder, ataxia, limb weakness, numbness, consciousness disorder, psychological disorder, and blindness, among others. …”
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Dynamic Nomogram for Predicting the Fall Risk of Stroke Patients: An Observational Study by Wu Y, Jiang X, Wang D, Xu L, Sun H, Xie B, Tan S, Chai Y, Wang T

“…The study aimed to develop and verify a dynamic nomogram model for predicting the falls risk in stroke patients during rehabilitation.Methods: An observational study design was adopted, 488 stroke patients were treated in a tertiary hospital from March to September 2022 were investigated for fall risk factors and related functional tests. …”
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Case Reports: Chemokine and Cytokine Profiling in Patients with Herpetic Uveitis by Nguyen NV, Linderman SL, Fashina T, Devine M, Conrady CD, Shantha JG, Ahmed R, Yeh S

“…Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, Nebraska, USA, Tel +1 402 559-2020, Email syeh@unmc.eduPurpose: To report cytokine/chemokine profiles of ocular fluid in two patients with herpetic uveitis.Methods: Cytokine and chemokine profiling of ocular fluid was performed in two patients with herpetic uveitis. …”
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Does Seasonality Affect Peptic Ulcer Perforation? A Single-Center Retrospective Study by Iva Krajnović, Zenon Pogorelić, Iva Perić, Marija Ćavar, Matija Borić

“…Gastric and duodenal perforations were nearly equally observed (51% vs. 49%). A statistically significant difference in overall perforation rates by gender was observed (<i>p</i> = 0.009), though not between ulcer sites (<i>p</i> = 0.628 and <i>p</i> = 0.739). …”
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A Multifunctional Low-Temperature Photothermal Nanomedicine for Melanoma Treatment via the Oxidative Stress Pathway Therapy by Zhang D, Liu X, Li X, Cai X, Diao Z, Qiu L, Chen X, Liu Y, Sun J, Cui D, Ye Q, Yin T

“…The main objective of this study was to construct a multifunctional nanomedicine (GNR@PEG-Qu) to investigate its therapeutic effect on melanoma from the oxidative stress pathway.Methods: First, the nanomedicine GNR@PEG-Qu was synthesized and characterized, and its photothermal and antioxidant properties were confirmed. …”
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Comparison of Efficacy and Safety Outcomes of Different Doses Schedules of Thalidomide for Treating Moderate-to-Severe &beta;-Thalassemia Patients by Yang WJ, Shi LD, Liang Y, Liang LM, Zhang H, Wang L, Zhou Q

“…Wei-Jia Yang,1,&ast; Lian-dong Shi,2,&ast; Ye Liang,3,&ast; Li-ming Liang,4,&ast; Hao Zhang,5 Li Wang,2 Qian Zhou1 1Department of Eugenics and Genetics, Guilin People’s Hospital, Guilin, Guangxi Zhuang Autonomous Region, 541002, People’s Republic of China; 2Department of Ultrasound, Guilin People’s Hospital, Guilin, Guangxi Zhuang Autonomous Region, 541002, People’s Republic of China; 3Department of Cardiology, The People’s Hospital of Guangxi Zhuang Autonomous Region, and Institute of Cardiovascular Diseases, Guangxi Academy of Medical Sciences, Nanning, 530000, People’s Republic of China; 4Department of Genetic Metabolism Center Laboratory, Guilin Women and Children’s Hospital, Guilin, Guangxi Zhuang Autonomous Region, 541001, People’s Republic of China; 5Department of Pharmacy, Guilin People’s Hospital, Guilin, Guangxi Zhuang Autonomous Region, 541002, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Wei-Jia Yang, Department of Eugenics and Genetics, Guilin People’s Hospital, No. 12 of Wenming Road, Xiangshan District, Guilin, Guangxi Zhuang Autonomous Region, 541002, People’s Republic of China, Tel +86 18977300052, Fax +86 07732881579, Email weijiayangywj@126.comObjective: In this study, we evaluated the effectiveness and safety of thalidomide by clinically observing 48 individuals with β-thalassemia who have been administered thalidomide in small and medium doses over a period of two years.Methods: Thalidomide’s efficacy was gauged by tracking hemoglobin (Hb) level alterations post its administration. …”
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Comparative Effectiveness of Bariatric Surgery Versus GLP‐1 Receptor Agonists in Reducing the Risk of New‐Onset of NASH: A Retrospective Multinational Cohort Study From North Ameri... by Abdallah Hussein, Ameer Awashra, Islam Rajab, Mohammad Bdair, Dawoud Hamdan, Ahmad Nouri, Elaf Khatib, Ghiras Khatib, Nyan Latt

“…This study evaluates the comparative effectiveness of BS and GLP‐1 RAs in reducing the incidence of new‐onset NASH and related hepatic complications. Methods This was a large, population‐based, retrospective cohort using data from the TriNetX platform. …”
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Abstract 265: A Curious Case Of Acute Binocular Diplopia, Ischemic Stroke Of The Interstitial Nucleus Of Cajal by Hamza M. Ahmed, Ahmad Al‐Awwad

“…Neurological exam significant for left hypertropia and exotropia in primary gaze, equal in right/left gaze and right/left head tilt, as well as large amplitude medium frequency (see‐saw) nystagmus characterized by upbeat nystagmus with intorsion on the right, and downbeat nystagmus with extorsion left. …”
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Bioinformatic Analysis of Apoptosis-Related Genes in Preeclampsia Using Public Transcriptomic and Single-Cell RNA Sequencing Datasets by Liu L, Li X, Yang H, Xu F, Dong X

“…We used transcriptomics and single-cell RNA sequencing (scRNA-seq) to explore apoptosis-related genes (ARGs) and their cellular mechanisms as potential PE biomarkers.Patients and Methods: All the data included in this study were sourced from public databases. …”
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The Effect of Vitamin E, &amp;Bgr;-Carotene, and Acidophilus Probiotics on The Salivary Gland Flow Rate in Streptozotocin-Induced Diabetes in Rats: An in-vivo Study by Felemban MF, Bin Mubayrik AF, Alotaibi O

“…This study aimed to evaluate the effects of the effect of vitamin E, β-carotene, and probiotics blend on the salivary glands of rats with Streptozotocin (STZ)-induced diabetes, addressing gaps in current research.Methods: Eighty rats were induced with diabetes using a single intraperitoneal injection of STZ (60 mg/kg). …”
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Effect of soft tissue volume on midfacial gingival margin alterations following immediate implant placement in the esthetic zone: a 1-year randomized clinical and volumetric trial by Ahmed Ibrahim Aboul Fettouh, Noha Ayman Ghallab, Khaled Abdel Ghaffar, Azza Ezz Elarab, Nourhan Gamal Abdel-Aziz, Nael Adel Mina, Nesma Mohamed Shemais, Omnia Aboul Dahab

“…Participants were randomly assigned into three equal group; IIP + Bonegraft (Control), IIP + CTG and IIP + CHA. …”
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Scalable camera traps for measuring the attractiveness of sugar baits for controlling malaria and dengue vectors by Felician C. Meza, Frank C. Tenywa, Simon Ashall, Fredros O. Okumu, Sarah J. Moore, Frederic Tripet

“…We integrated them into a rugged ATSB monitoring station for day and nighttime recording of mosquitoes landing on the bait. Methods The camera traps were evaluated in a semifield system and then in the field in rural Tanzania. …”
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Quick Systemic Lupus Activity Questionnaire (Q-SLAQ): a simplified version of SLAQ for patient-reported disease activity by Susanne Pettersson, Iva Gunnarsson, Andreas Jönsen, Christopher Sjöwall, Dag Leonard, Vera Illescas-Bäckelin, Estelle Trysberg

“…Bivariate correlations between Q-SLAQ and SLAQ were good (ρ=0.82–0.96).Conclusions Q-SLAQ and the original SLAQ performed equally well, demonstrating that the shorter Q-SLAQ can safely be used to monitor patients’ perception of disease impact/activity. …”
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Candida albicans-Derived &beta;-Glucan as a Novel Modulator of Tumor Microenvironment: Targeting Macrophage Polarization and Inducing Ferroptosis in Lung Cancer by He X, Ran Q, Li X, Xiong A, Zhang L, Jiang M, Bai L, Peng D, Wang J, Sun B, Li G

“…This study investigates the inhibitory effects of β-glucan extracted from Candida albicans on lung cancer progression, focusing on its impact on TAM polarization and the induction of ferroptosis, a form of regulated cell death.Methods: Utilizing both in vivo animal models and in vitro cellular assays, we assessed the impact of β-glucan on tumor growth, cellular proliferation, and migration. …”
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