Contezolid Harbored Equivalent Efficacy to Linezolid in Tuberculosis Treatment in a Prospective and Randomized Early Bactericidal Activity Study by Jiang G, Liu R, Xue Y, Ge Q, Nie L, Lv Z, Kong Z, Shi J, Chen H, Li H, Wu X, Xie L, Song Y, Huang H, Gao M

“…In this study, we evaluated the early bactericidal activity (EBA) of CZD compared to LZD, with LZD serving as a control.Methods: Naive, smear-positive pulmonary TB patients were enrolled and randomly assigned to receive either a 14-day monotherapy regimen of 600 mg LZD once daily (QD) or 800 mg CZD twice daily (BID). …”
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Feasibility and Outcomes of Vessel-Sparing Surgery for Soft Tissue Sarcoma of the Thigh Adjacent to Femoral Vessels by Yang ZM, Qu H, Wang KY, Wu JD, Liu B, Jin LB, Huang X, Lin N, Tao HM, Ye ZM

“…A comparison was made with cases where the tumor was not adjacent to the femoral vessels, focusing on recurrence rates, survival prognosis, and the viability of vessel-sparing surgical techniques.Methods: A retrospective analysis was conducted on 211 cases. …”
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Knowledge Mapping of COVID-19 and Asthma/Allergic Rhinitis: A Visual and Bibliometric Analysis by Chen Y, Song C, Wang J, Cao Y, Lu Y, Han X

“…This study aims to fill that gap by systematically exploring how asthma and AR interact with COVID-19.Methods: By using the Web of Science Core Collection, we selected publications from January 2020 to October 2024 that related to COVID-19 and asthma/AR. …”
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Saikosaponin-d Attenuates Irinotecan-Induced Intestinal Toxicity via TAK1/NF-κB Pathway and Enhances Antitumor Efficacy by Zheng P, Ma R, Liu X, Song L, Ma B, Zou G

“…This study investigates the therapeutic potential and mechanisms of SSD against irinotecan (IRI)-induced intestinal mucositis.Methods: Using a CT26 colorectal cancer Syngeneic mouse model (BALB/c mice), we evaluated the synergistic antitumor efficacy of SSD combined with IRI. …”
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Assessment of Anxiety and Depression in the Perioperative Period in Women of Reproductive Age During Regional Anesthesia by O. A. Chernykh, R. E. Lakhin, A. V. Shchegolev

“…Prediction, early detection and effective treatment of these disorders are important for the well-being of women and their offspring.Aim of study To evaluate the effect of anesthesia and surgery on the level of anxiety, depression, short-term memory, and concentration in pregnant and nonpregnant women.Material and methods The observational prospective study included 120 patients who were divided into two equal groups — pregnant (n=60) and nonpregnant (n=60) women. …”
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Impacts of Avoiding Emergency Department Visits During the COVID-19 Pandemic Among Patients With Acute Ischemic Heart Events by Sung TC, Wang YC, Hsu HC, Huang YT, Shih HI

“…This study investigated how the pandemic influenced medical avoidance in such cases and assessed potential collateral damage and adverse outcomes in an ED that managed limited COVID-19 instances during this period.Methods: An observational cross-sectional study was conducted on adult ED visits at a tertiary hospital from January 2017 to December 2020, focusing on symptoms associated with acute ischemic heart events and complications. …”
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Impact of Comorbid Asthma on Life Quality of Patients with Chronic Rhinosinusitis and Nasal Polyps by Wu PW, Chang PH, Huang CC, Lee TJ, Fan YH, Huang CC

“…Pei-Wen Wu,1,2,* Po-Hung Chang,1,* Chi-Che Huang,1,2 Ta-Jen Lee,1– 3 Yu-Hsi Fan,1 Chien-Chia Huang1,2 1Division of Rhinology, Department of Otolaryngology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan; 2School of Medicine, Chang Gung University, Taoyuan, Taiwan; 3Department of Otolaryngology, Xiamen Chang Gung Hospital, Xiamen, People’s Republic of China*These authors contributed equally to this workCorrespondence: Chien-Chia Huang, Division of Rhinology, Department of Otolaryngology, Chang Gung Memorial Hospital, Linkou Branch, No. 5, Fu-Shin Street, Kweishan, Taoyuan, 333, Taiwan, Tel +886-3-3281200 ext. 8466, Fax +886-3-3979361, Email agar@cgmh.org.twObjective: This study aimed to characterize the clinical features of patients with comorbid asthma and chronic rhinosinusitis with nasal polyps and to evaluate the impact of comorbid asthma on the quality of life of these patients.Methods: Adult patients with bilateral chronic rhinosinusitis with nasal polyps scheduled for sinus surgery were prospectively enrolled. …”
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Knowledge, Attitude, and Practice of Palliative Care Among Physicians and Nurses in Intensive Care Units in Shanghai, China by He X, Cai H, Zhang J, Chen W, Zhu B

“…The study aims to assess the KAP of palliative care ICU physicians and nurses and identify influencing factors.Patients and Methods: A cross-sectional survey was conducted among ICU physicians and nurses at three Shanghai hospitals. …”
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РЕЗУЛЬТАТЫ ОБЪЕКТИВНОЙ АККОМОДОМЕТРИИ ПРИ СОДРУЖЕСТВЕННОМ КОСОГЛАЗИИ by E. P. Tarutta, N. A. Aklaeva, T. Yu. Larina, N. A. Tarasova, T. Z. Khvedelidze, N. Yu. Kushnarevich

“…Highly amblyopic eyes had equal and drastically decreased BAR and MAR (average of -0.16 ± 0.07 D); in the fellow eyes, BAR and MAR were higher -1.08 ± 0.14 and -1.0 ± 0.14 D, respectively. …”
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Development of a Diagnostic Model for Focal Segmental Glomerulosclerosis: Integrating Machine Learning on Activated Pathways and Clinical Validation by Ge Y, Liu X, Shu J, Jiang X, Wu Y

“…This study seeks to enhance the diagnostic accuracy of FSGS by integrating machine learning approaches to identify activated pathways, complemented by robust clinical validation.Methods: We analyzed data from 163 FSGS patients and 42 living donors across multiple GEO cohorts via the ComBat algorithm to address batch effects and ensure the comparability of gene expression profiles. …”
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Two-year Results of Bronchoscopic Lung Volume Reduction Using One-Way Endobronchial Valves: Real-World Single Center Data by Bivort D, Blondeel A, Geysen H, Vandervelde CM, Coolen J, Ceulemans LJ, Dooms C, Janssens W, Everaerts S

“…While several randomized controlled trials have demonstrated improvements in lung function, exercise performance, and quality of life, information on long-term outcomes of BLVR outside clinical trial settings are limited.Objective: This study provides real-world data with a follow-up of up to two years, incorporating the BODE index (Body-Mass Index, Airflow Obstruction, Dyspnea, and Exercise Capacity Index), as part of the follow-up assessments.Methods: Data were collected for all patients treated with BLVR at the University Hospitals of Leuven, Belgium, including lung function parameters, 6-minute walking distance, respiratory questionnaires, and the BODE index at intervals of 3, 6, 12, and 24 months. …”
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Identification and Validation of Key Genes Involved in the Coupling of Mitochondria-Associated Endoplasmic Reticulum Membrane in Hemorrhoidal Disease by Mao L, Rao Z, Wang Y, Yang J, He J, Zheng Z, Chen L

“…This study aims to identify key genes linked to MAM in HD and to provide novel therapeutic targets.Methods: Transcriptome data and MAM-related genes (MAM-RGs) were obtained from the Gene Expression Omnibus (GEO) database and relevant literature. …”
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Integrated Profiling Delineated KIF18A as a Significant Biomarker Associated with Both Prognostic Outcomes and Immune Response in Pancreatic Cancer by Nan K, Zhang L, Zou Y, Geng Z, Huang J, Peng Y, Yin S, Zhang M

“…However, its role in pancreatic adenocarcinoma (PAAD) remains unclear.Methods: To evaluate that role, RNA sequencing datasets, complemented by pertinent clinical metadata, were procured from the Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) repositories. …”
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Effects of saline drinking water on growth performance, carcass traits, and blood biochemistry in crossbred Muscovy ducks by Le Thanh Phuong, Nguyen Thi Thuy, Nguyen Thiet

“…This study aimed to investigate the effects of saline drinking water on the growth performance, carcass traits, and blood biochemistry of crossbred Muscovy ducks (Cairina moschata). Materials and Methods: A completely randomized design was used, including five treatments with five replications per treatment. …”
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Association of Vegetable and Fruit Consumption Patterns with Cognitive Function in Older People with Different BMI Ranges: Findings from China by Huang L, Hong Z, Guo Y, Song W, Huang J, Cao W, Cao C, Chen R, Bai Z

“…Therefore, this study aims to explore their relationship, with a special focus on gender differences.Patients and Methods: A cross-sectional survey was conducted in Anhui Province, China, between July and September 2019, and information was collected from 6211 participants regarding socio-demographics, the frequency of vegetable and fruit consumption per week, and cognitive function. …”
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Is diagnostics of Benign Paroxysmal Positional Vertigo with a mechanical rotation chair superior to traditional manual diagnostics? A randomized controlled crossover study by Malene Hentze, Malene Hentze, Dan Dupont Hougaard, Dan Dupont Hougaard, Herman Kingma, Herman Kingma

“…While both modalities detected unilateral posterior canal BPPV equally good (p = 0.51), traditional MD underperformed for non-posterior BPPV (significantly) and in subgroups referred by ENTs (trend) or with impaired cooperation during traditional MD (significantly).ConclusionTraditional manual BPPV diagnostics remains a valuable first-line approach for most patients. …”
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The Clinical Value of Systemic Immune Inflammatory Index in Predicting the Prognosis of Patients with Bloodstream Infection by Ou S, Lu H, Qu R, Cui X, Xiong Z, Fan F, Yu X, Hasi C

“…Shuheng Ou,1,* Hong Lu,2,* Rui Qu,3 Xiaolong Cui,3 Zhou Xiong,4 Fangfang Fan,5 Xiao Yu,5 Chaolu Hasi2 1Academy of Medical Sciences, Shanxi Medical University School, Taiyuan, People’s Republic of China; 2Department of Laboratory Medicine, First Hospital of Shanxi Medical University, Taiyuan, People’s Republic of China; 3First Clinical Medical College, First Hospital of Shanxi Medical University, Taiyuan, People’s Republic of China; 4School of Public Health, Anhui Medical University, Hefei, People’s Republic of China; 5NHC Key Laboratory of pneumoconiosis, Shanxi Key Laboratory of respiratory diseases, Department of pulmonary and critical care medicine, First Hospital of Shanxi Medical University, Taiyuan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Chaolu Hasi, Email hasichaolu1967@163.comIntroduction: We analyzed the correlation between systemic immune inflammatory index (SII), systemic inflammatory response index (SIRI), systemic inflammatory index (AISI), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR) and mortality in patients with bloodstream infection to determine their application potential in predicting the prognosis of bloodstream infection.Methods: We calculated SII, SIRI, AISI, NLR, PLR, and MLR in 469 patients with bloodstream infections. …”
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Comparison of breastfeeding practice among Iranian and Afghan refugee mothers: a prospective cohort study in Iran by Zohreh Heidary, Mostafa Saeedinia, Haniyeh Fathi, Shima Rafiee, Zohre Khalajinia, Parvaneh Sadeghimoghadam, Mohammadamin Parsaei

“…Abstract Background Breastfeeding is a critical health equalizer and predictor of significant maternal and infant health outcomes, profoundly influenced by the socioeconomic and cultural status of mothers. …”
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The GLP-1 receptor agonist liraglutide inhibits necroptosis and neuroinflammation in a mouse model of Parkinson’s disease with diabetes co-morbidity by Xiaomin Zhang, Pengyang Du, Bo Bai, Peng Feng, Xia Lian, Christian Hölscher, Yongqing Wang, Guofang Xue

“…ObjectiveTo investigate the effects of the glucagon-like peptide-1 (GLP-1) receptor agonist liraglutide on motor function, necroptosis, and neuroinflammation in the brain in mice with diabetic Parkinson’s disease (PD) and its possible mechanism.MethodsWe prepared a diabetic model with streptozotocin, followed by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced diabetic PD model, along with liraglutide or saline intervention, and the control group with equal volume saline. …”
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Refining Intra-Arterial Therapy Selection for Large Hepatocellular Carcinoma: A Deep Learning Approach Based on Covariate Interaction Analysis by An C, Li L, Luo Y, Zuo M, Liu W, Li C, Wu P

“…However, optimizing IAT selection for large HCC remains challenging due to tumor heterogeneity and varying patient responses.Aim: To develop and validate a deep learning (DL) model for guidance of decision-making between TACE and HAIC for unresectable HCC.Methods: We conducted a retrospective, multi-center study involving 900 patients with large HCC treated with IATs. …”
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