N4BP3 Activates TLR4-NF-κB Pathway in Inflammatory Bowel Disease by Promoting K48-Linked IκBα Ubiquitination by Jiang W, Yin J, Han M, He W, Zhao Y, Hu J, Wang M, Wang S, Xu J, Deng C, Li J, Gong X, Shen Y

“…It is crucial to investigate whether N4BP3 regulates inflammatory bowel disease (IBD) through the TLR4 signaling pathway and to elucidate the underlying mechanisms.Methods: Lipopolysaccharides (LPS) were used to activate the TLR4 pathway in THP-1/Caco-2 cells. …”
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From Reductionist Skills to Meaningful Learning: Trust and Humility in Bedside Cardiac Assessment by Meisel JL, Navedo DD, Opole IO, Cohen GM, Bernard SA, Carmona H, Nahas AH, Eiduson CM, Papps N

“…We explored how an original bedside cardiac assessment (BCA) curriculum that supported professional attitudes, knowledge, and skills scaffolded clinical learning in a cohort of internal medicine clerkship students.Methods: The curriculum urged students to hear patients’ perspectives with humility and as key to diagnostic reasoning. …”
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Seroprevalence and Risk Factors for Toxoplasma gondii Infection in People Living with HIV: A Cross-Sectional Study from Maputo Central Hospital, Mozambique by Manuel L, Comia IR, Miambo RD, Sousa IM, Cuboia N, Carimo A, Massuanganhe SJ, Buene TP, Banze LR, Paraque BP, Nhancupe N, Schooley RT, Santos-Gomes GM, Noormahomed EV, Benson CA

“…Additionally, it aimed to assess the prevalence of neurological and psychiatric disorders (NPD) among study participants and its possible association with toxoplasmosis seropositivity.Methods: We conducted a descriptive, cross-sectional study of 200 patients aged > 18 years who were admitted to Maputo Central Hospital, Maputo, Mozambique, between March 2020 and October 2021. …”
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Risk of exacerbations, hospitalisation, and mortality in adults with physician-diagnosed chronic obstructive pulmonary disease with normal spirometry and adults with preserved rati... by Oskar Wallström, Caroline Stridsman, Helena Backman, Sigrid Vikjord, Anne Lindberg, Fredrik Nyberg, Lowie E.G.W. Vanfleteren

“…We aimed to identify and characterize patients with dnsCOPD, PRISm and spirometrically confirmed COPD (sCOPD) from dCOPD patients in SNAR, stratify them further according to symptoms and exacerbations risk using the Global Initiative for Chronic Obstructive Lung Disease (GOLD) A/B/E classification, and assess differences in risk for exacerbations, cause-specific hospitalisations and mortality. Methods: We enrolled patients aged ≥30 years with dCOPD in the SNAR from 1 January 2014 to 30 June 2022 with complete spirometry i.e., postbronchodilator values for both forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) (index date). …”
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Monitoring the Ecological Security of Esfahan with an Ecosystem Service Approach by Mostafa Keshtkar, Romina Sayahnia

“…The per capita ecological deficit in the city of Esfahan is equal to -3.5. In addition, the rate of resource using raises the potential concerns at this level. …”
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Ordovician conodonts of the Katkoyeh formation in the Kuh-e-Bonorg section, Kalmard Horst (west of Tabas) by Mohammad Nezhadabbas, Abbas Ghaderi, Hadi Jahangir, Ali Reza Ashouri

“…In the current research we have looked for the succession Katkoyeh formation in a section at the south of Kuh-e-Bonorg, eastern flank of the Kalmard anticline, from the age dating view, based on the conodont contents.   Material & Methods In the Kuh-e-Bonorg section, 80 rock samples were collected bed by bed for conodont content while only seven of them were productive. …”
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Interprofessional education in geriatric medicine: towards best practice. A controlled before–after study of medical and nursing students by Sanja Thompson, Kiloran Metcalfe, Katy Boncey, Clair Merriman, Lorna Catherine Flynn, Gaggandeep Singh Alg, Harriet Bothwell, Carol Forde-Johnston, Elizabeth Puffett, Caroline Hardy, Liz Wright, James Beale

“…The optimal learner group size was determined. The equal numbers of participants from each profession for successful IPE are not necessary. …”
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Cultural influences on fidelity components in recovery colleges: a study across 28 countries and territories by Charlotte Hanlon, Lisa Brophy, Peter Bates, Samson Tse, Claire Henderson, Ioannis Bakolis, Mike Slade, Michio Murakami, Julie Cooper, Vicky Stergiopoulos, Michael Ryan, Susana Ochoa, Daniel Hayes, Amy Ronaldson, Bernd Puschner, Ashleigh Charles, Ramona Hiltensperger, Yasuhiro Kotera, Wouter Vanderplasschen, Julie Repper, Simran Takhi, Simon Felix, Mariam Namasaba, Simon Lawrence, Vanessa Kellermann, Agnieszka Kapka, Danielle Dunnett, Tesnime Jebara, Sara Meddings, Clara De Ruysscher, Lene Eplov, Charlotte Toernes, Dagmar Narusson, Yuki Miyamoto, Stynke Castelein, Trude Gøril Klevan, Hannah Morland-Jones, Edith Moore, Gianfranco Zuaboni, Laura Asher, Jonna Tolonen, Mário Andrade, Daniel Elton, Jason Grant

“…The 12-item Recovery Colleges Characterisation and Testing (RECOLLECT) Fidelity Measure (RFM) evaluates the operational fidelity of RCs based on 12 components, but cultural influences on these components remain underexplored.Aims To assess associations between Hofstede’s cultural dimensions and RFM items to identify cultural influences on fidelity components.Methods A cross-sectional survey of RC managers was conducted across all 221 RCs. …”
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Artificial intelligence contouring in radiotherapy for organs-at-risk and lymph node areas by Céline Meyer, Sandrine Huger, Marie Bruand, Thomas Leroy, Jérémy Palisson, Paul Rétif, Thomas Sarrade, Anais Barateau, Sophie Renard, Maria Jolnerovski, Nicolas Demogeot, Johann Marcel, Nicolas Martz, Anaïs Stefani, Selima Sellami, Juliette Jacques, Emma Agnoux, William Gehin, Ida Trampetti, Agathe Margulies, Constance Golfier, Yassir Khattabi, Olivier Cravéreau, Alizée Renan, Jean-François Py, Jean-Christophe Faivre

“…The objective of this study is to compare eight available AI software programs in terms of technical aspects and accuracy for contouring organs-at-risk and lymph node areas with current international contouring recommendations. Material and methods From January–July 2023, we performed a blinded study of the contour scoring of the organs-at-risk and lymph node areas by eight self-contouring AI programs by 20 radiation oncologists. …”
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Neoadjuvant sintilimab and chemotherapy followed by transoral surgery for HPV-positive resectable oropharyngeal cancer: a single-arm, two-centre, phase 2 trialResearch in context by Shida Yan, Xing Zhang, Fengjiao Li, Ankui Yang, Hui Li, Wanming Hu, Qiaohong Lin, Xiyuan Li, Mingyuan Du, Jingtao Chen, Guodong Man, Jianwei Zhang, Xuemei Fang, Li Ning, Shiting Zhang, Lili Han, Yanmei Ma, Jun Wang, Shuwei Chen, Ming Song

“…We aimed to explore the efficacy and safety of neoadjuvant immunochemotherapy and the feasibility of sequential transoral surgery in patients with resectable HPV+OPSCC. Methods: In this single-arm, two-centre, phase 2 trial, patients with resectable HPV+OPSCC (clinical stage T2-4N0-3M0) were recruited and received two cycles of neoadjuvant sintilimab, cisplatin, and nab-paclitaxel every three weeks, followed by transoral surgery, including transoral robotic surgery (TORS). …”
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Inhibition of Ferroptosis by Adipose Stem Cell-Derived Apoptotic Vesicles Enhances Angiogenesis and Accelerates Diabetic Wound Healing by Zhang J, Kuang J, Gong S, Wang H, Ding F, Zhao L, Shi L, Liu S, Zhao Y, Liu J, Dou G

“…This study aims to investigate whether adipose stem cell-derived apoptotic vesicles (ASCs-apoVs) promote angiogenesis and accelerate diabetic wound healing by inhibiting endothelial cell ferroptosis.Methods: Diabetic mice model was established by feeding with high-fat diet (HFD) for 3 months followed by full-thickness skin wound preparation. …”
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Análise de lesões musculoesqueléticas em praticantes de musculação e corrida (Analisis de lesión musculoesquelética em practicantes de musculación y de las carreras) (Analysis of... by Flavio Boechat de Oliveira, Wallin do Couto Conceição, Rafael Barreto, Igor Carvalho, Giovanne Moraes de L. Ribeiro, Rodrigo Gomes de Souza Vale

“…Objective: To characterize and analyze the prevalence of musculoskeletal injuries in bodybuilders and runners. Methods: The sample consisted of 30 bodybuilders and runners with more than 12 months of practice. …”
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Measuring what matters: Building impact pathways to actionable information for the weADAPT platform by S. Bharwani, K. Williamson, R. Butterfield

“…This study addresses this gap by assessing the usability and impact of the weADAPT online platform through a mixed-methods approach, combining a user survey and semi-structured interviews. …”
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Patient buy-in to social prescribing through link workers as part of person-centred care: a realist evaluation by Stephanie Tierney, Geoffrey Wong, Debra Westlake, Amadea Turk, Steven Markham, Jordan Gorenberg, Joanne Reeve, Caroline Mitchell, Kerryn Husk, Sabi Redwood, Tony Meacock, Catherine Pope, Beccy Baird, Kamal R Mahtani

“…Setting Patients engaging with link workers in seven different parts of England were involved. Methods As part of data collection, we observed link workers interacting with 35 patients. …”
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Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study. by Bram P Prins, Ali Abbasi, Anson Wong, Ahmad Vaez, Ilja Nolte, Nora Franceschini, Philip E Stuart, Javier Guterriez Achury, Vanisha Mistry, Jonathan P Bradfield, Ana M Valdes, Jose Bras, Aleksey Shatunov, PAGE Consortium, International Stroke Genetics Consortium, Systemic Sclerosis consortium, Treat OA consortium, DIAGRAM Consortium, CARDIoGRAMplusC4D Consortium, ALS consortium, International Parkinson’s Disease Genomics Consortium, Autism Spectrum Disorder Working Group of the Psychiatric Genomics Consortium, CKDGen consortium, GERAD1 Consortium, International Consortium for Blood Pressure, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Inflammation Working Group of the CHARGE Consortium, Chen Lu, Buhm Han, Soumya Raychaudhuri, Steve Bevan, Maureen D Mayes, Lam C Tsoi, Evangelos Evangelou, Rajan P Nair, Struan F A Grant, Constantin Polychronakos, Timothy R D Radstake, David A van Heel, Melanie L Dunstan, Nicholas W Wood, Ammar Al-Chalabi, Abbas Dehghan, Hakon Hakonarson, Hugh S Markus, James T Elder, Jo Knight, Dan E Arking, Timothy D Spector, Bobby P C Koeleman, Cornelia M van Duijn, Javier Martin, Andrew P Morris, Rinse K Weersma, Cisca Wijmenga, Patricia B Munroe, John R B Perry, Jennie G Pouget, Yalda Jamshidi, Harold Snieder, Behrooz Z Alizadeh

“…Yet it is inconclusive whether these associations are causal.<h4>Methods and findings</h4>We performed Mendelian randomization (MR) analyses using two genetic risk scores (GRSs) as instrumental variables (IVs). …”
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Role and mechanism of action of nuclear receptor coactivator 4 in the development of acquired resis-tance to targeted inhibitors in pancreatic cancer with KRAS G12C mutation by CHANG Hao, WANG Ya'nan, LIU Shihai, WANG Jing

“…Objective To investigate the role and mechanism of action of nuclear receptor coactivator 4 (NCOA4) in acquired resistance to targeted inhibitors in pancreatic cancer with KRAS G12C mutation. Methods Human pancreatic cancer cell lines CFPAC-1, PANC-1, and MIA-PaCa-2 were cultured in vitro. …”
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Genomic analysis of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) causing infections in children—a Spanish multicenter study by Silvia García-Cobos, Silvia García-Cobos, Natalia Seco Alberca, Blanca Bravo-Queipo-de-Llano, Verónica Casquero-García, Eva Ramírez de Arellano, Eva Ramírez de Arellano, Cristina Calvo, Cristina Calvo, Guillermo Ruíz-Carrascoso, Guillermo Ruíz-Carrascoso, Iker Falces-Romero, Iker Falces-Romero, Nieves Larrosa Escartín, Nieves Larrosa Escartín, Nieves Larrosa Escartín, Belén Viñado-Perez, Belén Viñado-Perez, Miguel Ángel Martínez-López, Susana Melendo Pérez, Enrique Ruíz de Gopegui, Enrique Ruíz de Gopegui, Santiago Pérez Vázquez, Jaime Carrasco-Colom, Belén Aracil García, Belén Aracil García, María Pérez-Vázquez, María Pérez-Vázquez, Ana Méndez-Echevarría, Ana Méndez-Echevarría, Jesús Oteo Iglesias, Jesús Oteo Iglesias

“…This study investigated the molecular traits of community-associated methicillin-resistant S. aureus (CA-MRSA) isolates causing infections in children in Spain.MethodsAntibiotic susceptibility testing and whole-genome sequencing were performed in 98 CA-MRSA isolates (4.2 median age, 52% males). …”
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Development and validation of a risk prediction model for premenopausal breast cancer in 19 cohorts by Kristen D. Brantley, Michael E. Jones, Rulla M. Tamimi, Bernard A. Rosner, Peter Kraft, Hazel B. Nichols, Katie M. O’Brien, Hans-Olov Adami, Amaia Aizpurua, Amy Berrington de González, William J. Blot, Tonje Braaten, Yu Chen, Jessica Clague DeHart, Laure Dossus, Sjoerd Elias, Renée T. Fortner, Montserrat Garcia-Closas, Inger T. Gram, Niclas Håkansson, Susan E. Hankinson, Cari M. Kitahara, Woon-Puay Koh, Martha S. Linet, Robert J. MacInnis, Giovanna Masala, Lene Mellemkjær, Roger L. Milne, David C. Muller, Hannah Lui Park, Kathryn J. Ruddy, Sven Sandin, Xiao-Ou Shu, Sandar Tin Tin, Thérèse Truong, Celine M. Vachon, Lars J. Vatten, Kala Visvanathan, Elisabete Weiderpass, Walter Willett, Alicja Wolk, Jian-Min Yuan, Wei Zheng, Dale P. Sandler, Minouk J. Schoemaker, Anthony J. Swerdlow, A. Heather Eliassen

“…Abstract Background Incidence of premenopausal breast cancer (BC) has risen in recent years, though most existing BC prediction models are not generalizable to young women due to underrepresentation of this age group in model development. Methods Using questionnaire-based data from 19 prospective studies harmonized within the Premenopausal Breast Cancer Collaborative Group (PBCCG), representing 783,830 women, we developed a premenopausal BC risk prediction model. …”
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Gender Influence on Bimekizumab Response in Patients with Psoriasis: Results of a Real-World Multicenter Retrospective Study—IL PSO (Italian Landscape PSOriasis) by Helena Gioacchini, Agnese Rossi, Maria Esposito, Emanuele Vagnozzi, Maria Concetta Fargnoli, Paolo Gisondi, Francesco Bellinato, Chiara Assorgi, Pina Brianti, Santo Raffaele Mercuri, Martina Burlando, Emanuele Cozzani, Giovanna Brunasso, Stefano Caccavale, Anna Balato, Giacomo Caldarola, Clara De Simone, Elena Campione, Alessandro Giunta, Francesco Tonon, Marina Venturini, Carlo Giovanni Carrera, Angelo Valerio Marzano, Andrea Carugno, Paolo Sena, Antonio Costanzo, Alessandra Narcisi, Francesco Cusano, Paolo Dapavo, Pietro Quaglino, Annunziata Dattola, Antonio Giovanni Richetta, Francesca Gaiani, Piergiorgio Malagoli, Matteo Megna, Luca Potestio, Edoardo Mortato, Francesco Loconsole, Francesca Romano, Andrea Faragalli, Rosaria Gesuita, Tommaso Bianchelli, Federico Diotallevi, Diego Orsini, Anna Campanati

“…Notably, no studies have specifically investigated bimekizumab, a humanized, full-length IgG1 monoclonal antibody that acts as a dual inhibitor of interleukin (IL)-17A and IL-17F. Methods This was a cross-sectional, observational, retrospective, multicenter analysis. …”
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Connectivity guided intermittent theta burst stimulation versus repetitive transcranial magnetic stimulation in moderately severe treatment resistant depression by Richard Morriss, Lucy Webster, Luke Ingram, Mohamed Abdelghani, Adriana Anton, Shaun Barber, Peter Bates, Paul Briley, Clement Boutry, Cassandra Brookes, Edward Cox, Beth Hall, Marilyn James, Matthew Keane, Micheal Kurkar, Sudheer Lankappa, Peter Liddle, Hamish McAllister-Williams, Hyerin Oh, Alexander O’Neill-Kerr, Jehill Parikh, Stefan Pszczolkowski, Ana Suazo Di Paola, Louise Thomson, Yvette Walters, Dorothee Auer

“…Magnetic resonance imaging neuronavigation personalised repetitive transcranial magnetic stimulation or intermittent theta burst stimulation are acceptable methods to reduce depression symptoms over 26 weeks in treatment-resistant depression alongside other reasons for improvement. …”
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