Sodium-glucose co-transporter-2 inhibitors in patients with chronic kidney disease with or without type 2 diabetes: systematic review and meta-analysis by Gordon Guyatt, Arnav Agarwal, Thomas Agoritsas, Haoming Tian, Sheyu Li, Chang Xu, Ping Fu, Qingyang Shi, Xiaoxi Zeng, Per Olav Vandvik, Xinyu Zou, Yunhe Mao, Qinbo Yang, Xianghang Luo, Belen Ponte

Get full text

HMGB1 Inhibition Alleviates Chronic Nonbacterial Prostatitis by Suppressing M1 Polarization of Macrophages by Zhou J, Ding L, Chen J, Chen C, Jiang P, Mei Z, Jiang Q, Hua X

“…This study aimed to investigate HMGB1’s potential contributions to the pathogenesis of CP/CPPS, offering new perspectives for innovative treatments.Materials and Methods: We have successfully extracted prostate antigens from Sprague–Dawley rat prostate tissue and established an experimental autoimmune prostatitis (EAP) mouse model in non-obese diabetic (NOD) mice. …”
Get full text

Identification of Single-Nucleotide Polymorphisms in B3GAT2, CPQ, and HPSE Genes in the Liver Tissue of Arian Broilers with Ascites using RNA-seq Data by Somayeh Hassnvand, Ayoub Farhadi, Elham Yonesi, Ghodrat Rahimimianji, Karim Hasan Pur

“…The present study aimed to identify single-nucleotide polymorphisms (SNPs) in CPQ, B3AGT2, and HPSE genes in the liver tissue of Arain broiler chickens with ascites syndrome using RNA-seq data. Methods: This research was conducted in two phases, including the first phase (ascites induction) and the second phase (normal rearing conditions). …”
Get full text

Alcohol intake and pancreatic cancer risk: An analysis from 30 prospective studies across Asia, Australia, Europe, and North America. by Sabine Naudin, Molin Wang, Niki Dimou, Elmira Ebrahimi, Jeanine Genkinger, Hans-Olov Adami, Demetrius Albanes, Ana Babic, Matt Barnett, David Bogumil, Hui Cai, Chu Chen, A Heather Eliassen, Jo L Freudenheim, Gretchen Gierach, Edward L Giovannucci, Marc J Gunter, Niclas Håkansson, Mayo Hirabayashi, Tao Hou, Brian Z Huang, Wen-Yi Huang, Harindra Jayasekara, Michael E Jones, Verena A Katzke, Woon-Puay Koh, James V Lacey, Ylva Trolle Lagerros, Susanna C Larsson, Linda M Liao, Kenneth Lo, Erikka Loftfield, Robert J MacInnis, Satu Männistö, Marjorie L McCullough, Anthony Miller, Roger L Milne, Steven C Moore, Lorelei A Mucci, Marian L Neuhouser, Alpa V Patel, Elizabeth A Platz, Anna Prizment, Kim Robien, Thomas E Rohan, Carlotta Sacerdote, Sven Sandin, Norie Sawada, Minouk Schoemaker, Xiao-Ou Shu, Rashmi Sinha, Linda Snetselaar, Meir J Stampfer, Rachael Stolzenberg-Solomon, Cynthia A Thomson, Anne Tjønneland, Caroline Y Um, Piet A van den Brandt, Kala Visvanathan, Sophia S Wang, Renwei Wang, Elisabete Weiderpass, Stephanie J Weinstein, Emily White, Walter Willett, Alicja Woslk, Brian M Wolpin, Shiaw-Shyuan S Yaun, Chen Yuan, Jian-Min Yuan, Wei Zheng, Paul Brennan, Stephanie A Smith-Warner, Pietro Ferrari

“…We examined the association between alcohol intake and pancreatic cancer risk in a large consortium of prospective studies.<h4>Methods and findings</h4>Population-based individual-level data was pooled from 30 cohorts across four continents, including Asia, Australia, Europe, and North America. …”
Get full text

Unveiling the antiurolithiatic potentiality of two benzene sulfonamide derivatives against ethylene glycol-induced renal calculi by Ahmed M. Elgendy, Mohamed S. Nafie, Zohour I. Nabil, Nahla S. El-Shenawy, Heba N. Gad El-Hak

“…The study aimed to reveal the antiurolithiatic potential of two benzene sulfonamide derivatives (SBCl and SBF; A and B, respectively) against ethylene glycol-induced kidney stones. Methods: The rats were divided into two main groups: the first group consisted of 20 rats with induced kidney stones, and the second group included 15 control rats. …”
Get full text

Characterizing ECOPD Phenotypes: Associations with In-Hospital Outcomes and Immunoinflammatory Mechanisms by Wang Q, Wang L, Zhang L, Zhao C, Liu Y, Liu L, Yuan L, Feng M, Wang G, Li L, Zhang S, Yuan Y, Kang D, Zhang X

“…We sought to explore the underlying mechanisms that contribute to the relationship between ECOPD phenotypes and these outcomes.Methods: A k-means cluster analysis was conducted on 20,890 recruited patients hospitalized for ECOPD. …”
Get full text

The Hydrocephalus Association Patient-Powered Interactive Engagement Registry (HAPPIER): Design and Initial Baseline Report by Jakopin NE, Lanjewar SN, Garzon A, Gross P, Holubkov R, Moghekar A, Preston J, Romanoski M, Shannon CN, Tamber MS, Van der Willigen T, Sloan M, Chau MJ, Koschnitzky JE

“…This publication introduces the registry by highlighting the demographics, etiology, treatments, symptom profiles, and diagnosed comorbidities of the participants.Methods: The Hydrocephalus Association and a 10-member steering committee developed HAPPIER. …”
Get full text

DS-Modified Paeoniflorin pH-Responsive Lipid&amp;ndash;Polymer Hybrid Nanoparticles for Targeted Macrophage Polarization in a Rat Model of Rheumatoid Arthritis by Zhang J, Yang J, Yu Z, Bai H, Wang Y, Wang R

“…Simultaneously, dextran sulfate serves as a ligand to actively target Scavenger receptor class A type I overexpressed on activated macrophages in RA synovium, achieving dual-targeted delivery via environmental responsiveness and ligand-receptor interaction.Methods: We developed dextran sulfate-modified Pae–PPNPs–DS, which exhibits dual capabilities of active macrophage targeting and pH-triggered drug release, to deliver paeoniflorin to macrophages and improve drug delivery at the joint inflammation site. …”
Get full text

Evaluating Digital Rehabilitation Outcomes in Chronic Musculoskeletal Conditions Across Non-Obesity, Obesity, and Severe Obesity by Pereira AP, Janela D, Areias AC, Molinos M, Tong X, Bento V, Yanamadala V, Cohen SP, Correia FD, Costa F

“…The rising prevalence of obesity calls for scalable solutions to address MSK conditions in this population, given their complex clinical profile and barriers to accessing care.Purpose: To evaluate the engagement and clinical outcomes of a fully remote digital care program in patients with MSK conditions, focusing on those with and without comorbid obesity.Patients and Methods: A post-hoc analysis of a prospective, longitudinal, single-arm observational home-based study conducted between August, 2023, and August, 2024. …”
Get full text

Safety and efficacy of low-dose esketamine weakly opioidized anesthesia in elderly patients with lumbar spinal stenosis undergoing surgery: a prospective, double-blind randomized c... by Ni-Na Hou, Meng-Yun Zhang, Yu-Wei Zhang, Hong-Jing Wu, Hong Luo, Heng Yang

“…We aimed to evaluate the intraoperative safety and efficacy of weak opioidized anesthesia with low-dose esketamine in the treatment of elderly patients with lumbar spinal stenosis undergoing total laminectomy with complete decompression and interbody implant fusion. Methods In total, 90 elderly patients were randomized into three groups: the esketamine HS group (0.2 mg/kg induction, 0.25 mg/(kg·h) infusion), the esketamine LS group (0.2 mg/kg induction, 0.125 mg/(kg·h) infusion), and the control group (group C receiving an equal volume of saline). …”
Get full text

Anti-PS IgG Immune Complexes Impair Macrophage Phagocytosis in SLE via LOX-Dependent Oxidative Stress by Guan H, Huang L, Liu Y, Zhu E, Chen L, Li W, Wu H, Zhang X, Qin R, Zheng J, Mo Y, Zhong M, Xu B, Dai X, Wei Q, Chen Y, Wang Q, Zheng Z, Ma K, Tang C

“…In this study, we aimed to explore the effector mechanisms of PS immune-complex during lupus development.Patients and Methods: Serological profiles of immune-complexes in SLE patients were analyzed. …”
Get full text

Studying Spatiotemporal Changeability of Oak Forests in Zagros in Response to Rainfall Variation by Zahra Alirezai, Amir Gandomkar, Morteza khodagholi, Alireza Abbasi

“…Borhan et al., 2015). 2-Materials and Methods In this study, two categories of data were used. …”
Get full text

Social Media Behavior Guidelines for Healthcare Professionals: An American Society of Pain and Neuroscience NEURON Project by Giuffrida A, Saia-Owenby C, Andriano C, Beall D, Bailey-Classen A, Buchanan P, Budwany R, Desai MJ, Comer A, Dudas A, Tieppo Francio V, Grace W, Gill B, Grunch B, Goldblum A, Garcia RA, Lee DW, Lavender C, Lawandy M, Mandell L, Mata R, Rabii M, Patel K, Patel RG, Patel AA, Sayed D, Singh G, Strand N, Tate J, Schatman ME, Deer T

“…As part of the broader initiatives on Spine and Nerve practice, the executive board of ASPN has decided it would be beneficial to include comprehensive guidance for healthcare providers when engaging on social media.Methods: A panel of experts was chosen based on expertise, publications, diversity, and their social media presence. …”
Get full text

A caffeine and theacrine combination improves cognitive performance in tactical personnel under physically fatiguing conditions by Blaine S. Lints, Adam T. Harrison, Sten O. Stray-Gundersen, Gianna F. Mastrofini, Riccardo F. Romersi, Noah K. Nakagawa, Mackenzie B. Yoder, Chimaobim E. Martin-Diala, Alexa J. Chandler, R. Davis Moore, Shawn M. Arent

“…Theacrine, a purine alkaloid similar in structure to caffeine but with a longer half-life, less habituation, and fewer side effects, is proposed as a caffeine-alternative to enhance cognitive resilience.Methods Tactically trained participants (n = 20; F = 5; M = 16; age = 21.5 ± 3.8 y) completed one baseline and three experimental visits. …”
Get full text

The effectiveness of psychosocial interventions for reducing problematic substance use, mental ill health, and housing instability in people experiencing homelessness in high incom... by Chris O'Leary, Esther Coren, Sandor Gellen, Anton Roberts, Harry Armitage

“…Objectives To summarise the existing evidence of whether psychosocial interventions work in reducing problematic substance use, mental ill health, and housing instability for adults experiencing homelessness in high income countries. Search Methods We used searches undertaken for the Homelessness Effectiveness Evidence and Gap Map (EGM) 5th edition. …”
Get full text

Comparison of Clinical Outcomes between the Fourth Day and the Fifth Day Embryo Transfer in IVF/ICSI Cycles: A Retrospective Cohort Study before and after PSM by Yasong Geng, Fangfang Dai, Meiyang Du, Linlin Tao, Haoyang Dai, Bo Zheng, Shusong Wang

“…It is important to explore whether the fourth day morulae could be a widely used alternative transplantation option to replace the fifth day blastocysts. Methods: This study involved 1167 patients undergoing their first in in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) cycles. …”
Get full text

Serum LCAT as a Gender-Neutral Biomarker for Early Osteoporosis: A Multicenter Cohort Validation Study by Wen Y, Cheng S, Gou L, Zhou W, Li Y, Wang R, Wu J, Dai X, Gao M, Wang L, Xue B, Wang Y

“…Yali Wen,1,&amp;ast; Shoujun Cheng,2,&amp;ast; Liming Gou,3,&amp;ast; Weihong Zhou,4,&amp;ast; Yishan Li,5 Ruoxuan Wang,6 Ji Wu,7 Xuening Dai,8 Ming Gao,9 Lei Wang,10 Bin Xue,3,11,12 Yinhe Wang1,13 1Department of Orthopedics, Nanjing Drum Tower Hospital, Clinical College of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, People’s Republic of China; 2Department of Clinical Laboratory, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, People’s Republic of China; 3Department of Translational Medicine Research Center, Children’s Hospital of Nanjing Medical University, Nanjing, People’s Republic of China; 4Department of Health Management Centre, Drum Tower Hospital Affiliated to Nanjing University Medical School, Nanjing, Jiangsu, People’s Republic of China; 5Department of Translation Studies, Army Engineering University of PLA, Nanjing, People’s Republic of China; 6Department of Clinical Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, People’s Republic of China; 7Department of Orthopedics, Sir Run Run Hospital, Nanjing, Jiangsu, People’s Republic of China; 8Department of Geriatrics, Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China; 9Department of Endocrinology, Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China; 10Department of Orthopedics, the First Affiliated Hospital of Nanjing Medical University, Nanjing, People’s Republic of China; 11Department of Jiangsu Key Laboratory of Early Development and Chronic Diseases Prevention in Children, Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China; 12Department of General Surgery, The Affiliated Changzhou Second People’s Hospital of Nanjing Medical University, Changzhou, People’s Republic of China; 13Department of Orthopedics, Clinical College, Nanjing Drum Tower Hospital, Nanjing, Jiangsu, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Yinhe Wang, Department of Orthopedics, Nanjing Drum Tower Hospital, Nanjing University of Chinese Medicine, Nanjing, 210000, People’s Republic of China, Email milkyway199@hotmail.com Bin Xue, Translational Medicine Research Center, Children’s Hospital of Nanjing Medical University, Nanjing, 210008, People’s Republic of China, Email xuebin@njmu.edu.cnPurpose: This study aims to identify a novel biomarker for the early detection and prevention of osteoporosis.Methods: A cross-sectional study (n=138, from 497 screened) was conducted at Nanjing Drum Tower Hospital (Sep 2023-Jun 2024). …”
Get full text

Efficacy and safety of doravirine/lamivudine/tenofovir disoproxil fumarate in HIV treatment: a real-world single-center study in China by Aixin Li, Letian Liu, Hongwei Zhang, Xi Wang, Zaicun Li, An Liu, Lili Dai, Jingji Zhang, Yue Gao, Jiangzhu Ye, Jianwei Li, Lijun Sun, Lijun Sun

“…This study presents real-world results of a retrospective analysis of patients who initiated DOR/3TC/TDF at a Chinese HIV center.MethodsThis retrospective analysis was carried out on patients who received DOR/3TC/TDF (initial or switch) at the outpatient clinic of the Infection Center in Beijing Youan Hospital in China. …”
Get full text

Immune Microenvironment Characterization and Machine Learning-Guided Identification of Diagnostic Biomarkers for Ulcerative Colitis by Zheng Q, Wang L, Zhang Y, Peng J, Hou J, Wang H, Ma Y, Tang P, Li Y, Li H, Chen Y, Li J, Chen Y

“…Current treatments often show limited efficacy, highlighting the need for novel diagnostic and therapeutic approaches.Methods: RNA-Seq data from 495 UC patients and 320 controls (training dataset) and 389 UC patients and 209 controls (testing dataset) were analyzed. …”
Get full text

Optimizing Treatment for Hospitalized Patients with COPD: A Study on the Impact of a LINE App-Based Multidisciplinary Team Approach Targeting Pharmacological Treatment, Lifestyle C... by Huang HY, Chen CL, Lin YL, Chen SC, Lee LC, Dai HM, Chiang CY, Chang YF, Lu H, Lee MR, Yang CC, Su CH, Chiang YZ, Yang MC, Shyu RY, Lan CC

“…This study explored the effectiveness of LINE-based MDT interventions in hospitalized patients with COPD.Methods: This retrospective analysis included patients with COPD admitted for exacerbations and compared their outcomes before and after the implementation of LINE-based MDT care. …”
Get full text