Effects of miR-204-3p inhibitor on epithelial-mesenchymal transition and silicosis fibrosis in silicon dioxide-induced alveolar epithelial cells by Fang CHEN, Jing YU, Wenxuan HU, Yangyang PI, Xi ZHANG, Luning WANG, Ping ZHAO, Faxuan WANG

“…ObjectiveTo investigate the effect of miR-204-3p inhibitor on the epithelial-mesenchymal transition (EMT) process and silicosis fibrosis in silicon dioxide dust-induced alveolar epithelial cells. MethodsA co-culture model of macrophages and epithelial cells was established using a Transwell chamber. …”
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Research Influence оf Nitrogen оn Formation Condensate Loss During the Development оf the Chayandinskoye Field by R. K. Dobrolyubova, E. I. Inyakina, I. I. Krasnov

“…The analysis of the performed studies confirmed that nitrogen affects the solubility of the condensate in gases to varying degrees and that the methane-type condensates of the Chayandinskoye field have better solubility, all other things being equal.Materials and methods of research. The works [2-9] consider laboratory studies and analytical calculations of the fluid-dynamic properties of gas condensate mixtures in the presence of nitrogen in the system, as well as other non-hydrocarbon components that affect the loss of hydrocarbons in the deposit. …”
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Post-registration experience of nivolumab in advanced hepatocellular carcinoma: an international study by Dominik Bettinger, Bo Yu, David Szafron, Yinghong Wang, Mahvish Muzaffar, Thomas Marron, Uqba Khan, Yi-Hsiang Huang, David J Pinato, Ahmed Kaseb, Anwaar Saeed, Tomi Jun, Sirish Dharmapuri, Musharraf Navaid, ChiehJu Lee, Anushi Bulumulle, Sonal Paul, Petros Fessas, Neil Nimkar, Hannah Hildebrand, Tiziana Pressiani, Yehia I Abugabal, Nicola Personeni, Lorenza Rimassa, Celina Ang, Abdul Rafeh Naqash, Francesca Benevento

“…Post-registration data of treatment in a real-world setting is lacking.Patients and methods We performed an international, multicenter observational study to confirm safety and efficacy of nivolumab in 233 patients treated outside clinical trials from eight centers in North America, Europe and Asia.Results Patients received nivolumab for Barcelona Clinic Liver Cancer stage C (n=191, 92.0%) and Child-Pugh (CP) A (n=158, 67.8%) or B (n=75, 32.2%) HCC as first (n=85, 36.5%) or second to fourth systemic therapy line (n=148, 63.5%). …”
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Intravascular lithotripsy vs. rotational atherectomy on coronary microcirculation: a retrospective multicenter propensity-matched multicenter study by Xi Zhang, Xi Zhang, Xi Zhang, Peijian Wang, Chenguang Li, Tao Zhao, Tao Zhao, Tao Zhao, Jiaji He, Jiaji He, Jiaji He, Bin Liu, Qing Jin, Qing Jin, Qing Jin, Pin Gan, Pin Gan, Pin Gan, Jilei Zhang, Jilei Zhang, Jilei Zhang, Qiang Xue, Qiang Xue, Qiang Xue

“…However, the impact of intravascular lithotripsy (IVL) on CMD remains unclear, and no studies have directly compared IVL and rotational atherectomy (RA) in the context of CMD.ObjectiveThis study aimed to evaluate CMD, as indicated by angiographic microvascular resistance (AMR), in patients undergoing IVL- or RA-assisted PCI for heavily calcified coronary lesions.MethodsThis multicenter retrospective cohort study enrolled patients underwent either RA- or IVL-assisted percutaneous coronary intervention (PCI) at three centers. …”
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Study on the risk factors for colorectal polyp recurrence: a cross-sectional retrospective cohort study by Fang Li, Fang Li, Mengge Lu, Mengge Lu, Bo Xu, Zheng Xiang, Zheng Xiang, Yuan Zhang, Yuan Zhang, Boran Cao, Xuewei Li, Xuewei Li, Yanan Wu, Yanan Wu, Rongrong Zheng, Rongrong Zheng, Qin Cai, Qin Cai, Jun Shen, Pengfei Xin, Pengfei Xin, Lianbo Xiao, Lianbo Xiao, Yanqin Bian, Yanqin Bian

“…ObjectiveTo investigate the factors associated with the recurrence of colorectal polyps.MethodsData on polyp recurrence and related factors, including gender, age, BMI, family history, smoking history, alcohol consumption history, gallbladder disease history, food allergy, polyp size, number, and pathological classification, Helicobacter pylori (Hp) infection, parathyroid hormone, gastrin, and blood lipid levels, were collected as exposure factors. …”
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CREATING THE KULTUK POLYGON FOR EARTHQUAKE PREDICTION: VARIATIONS OF (234U/238U) AND 87SR/86SR IN GROUNDWATER FROM ACTIVE FAULTS AT THE WESTERN SHORE OF LAKE BAIKAL by S. V. Rasskazov, E. P. Chebykin, A. M. Ilyasova, E. N. Vodneva, I. S. Chuvashova, S. A. Bornyakov, A. K. Seminsky, S. V. Snopkov, V. V. Chechel'nitsky, N. A. Gileva

“…In 1970s and 1980s, only quite laborious methods were available for measuring uranium isotopic ratios. …”
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The Magnetic Field in Quiescent Star-forming Filament G16.96+0.27 by Qi-Lao Gu, Tie Liu, Zhi-Qiang Shen, Sihan Jiao, Julien Montillaud, Mika Juvela, Xing Lu, Chang Won Lee, Junhao Liu, Pak Shing Li, Xunchuan Liu, Doug Johnstone, Woojin Kwon, Kee-Tae Kim, Ken’ichi Tatematsu, Patricio Sanhueza, Isabelle Ristorcelli, Patrick Koch, Qizhou Zhang, Kate Pattle, Naomi Hirano, Dana Alina, James Di Francesco

“…The estimated plane-of-sky magnetic field strength is ∼96 μ G and ∼60 μ G using two variants of the Davis–Chandrasekhar–Fermi methods. We calculate the virial and magnetic critical parameters to evaluate the relative importance of gravity, the magnetic field, and turbulence. …”
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The actuator farm model for large eddy simulation (LES) of wind-farm-induced atmospheric gravity waves and farm–farm interaction by S. Stipa, A. Ajay, J. Brinkerhoff

“…</p> <p>Finally, combining the AFM with a domain nesting method allows us to conduct simulations of two aligned wind farms in a fully neutral ABL and of wind-farm-induced atmospheric gravity waves under a conventionally neutral ABL, obtaining excellent agreement with ADM simulations but with much lower computational cost. …”
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Randomised trial comparing weight loss through lifestyle and GLP-1 receptor agonist therapy in people with MASLD by Ahmad Moolla, Toryn Poolman, Nantia Othonos, Jiawen Dong, Kieran Smith, Thomas Cornfield, Sarah White, David W. Ray, Sofia Mouchti, Ferenc E. Mózes, Helena Thomaides-Brears, Stefan Neubauer, Jeremy F. Cobbold, Leanne Hodson, Jeremy W. Tomlinson

“…To dissect the mechanisms underpinning their benefits, we conducted a prospective, randomised, experimental medicine study in people with MASLD, comparing GLP-1RA treatment (liraglutide) to matched lifestyle-induced weight loss and assessed the impact of treatment withdrawal. Methods: Twenty-nine participants with MASLD, without type 2 diabetes underwent metabolic phenotyping including measurement de novo lipogenesis (DNL), liver magnetic resonance imaging, body composition, adipose tissue RNA sequencing, circulating proteome, and stool microbiome analysis. …”
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Can serum metabolic signatures inform on the relationship between healthy lifestyle and colon cancer risk? by Komodo Matta, Vivian Viallon, Anastasia Chrysovalantou Chatziioannou, Nivonirina Robinot, Roland Wedekind, Christina C. Dahm, Agnetha Linn Rostgaard-Hansen, Anne Tjønneland, Therese Truong, Chloé Marques, Pauline Frenoy, Rudolf Kaaks, Renée Turzanski Fortner, Matthias B. Schulze, Sabrina Sieri, Mario Fordellone, Rosario Tumino, Fulvio Ricceri, Tonje Braaten, Therese Haugdahl Nøst, Maria-Jose Sánchez, Olatz Mokoroa-Carollo, Sandra Colorado-Yohar, Camino Trobajo-Sanmartín, Keren Papier, Rhea Harewood, Kostas Tsilidis, Salvatore Vaccarella, Mattias Johansson, Elisabete Weiderpass, Cyrille Delpierre, Sebastien Lamy, Kristin Benjaminsen Borch, Pekka Keski-Rahkonen, Elio Riboli, Heinz Freisling, Marc Gunter, Pietro Ferrari

“…Metabolomics offers potential to uncover biological mechanisms linking lifestyle and colon cancer. Methods Lifestyle and untargeted metabolomic data were available from a nested case–control study within the European Prospective Investigation into Cancer and Nutrition (EPIC), including 1,067 colon cancer cases and 1,067 controls matched on age, sex, study centre, and blood collection time. …”
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Assessment of the thoracic aorta after aortic root replacement and/or ascending aortic surgery using 3D relaxation-enhanced angiography without contrast and triggering by Carsten Gietzen, Jan Paul Janssen, Juliana Tristram, Burak Cagman, Kenan Kaya, Robert Terzis, Roman Gertz, Thorsten Gietzen, Henry Pennig, Alexander C. Bunck, David Maintz, Thorsten Persigehl, Navid Mader, Kilian Weiss, Lenhard Pennig

“…The purpose of this study was to evaluate the performance of REACT after surgery of the aortic root and/or ascending aorta by performing an intraindividual comparison to CE-MRA.Material and methodsThis retrospective single center study included 58 MRI studies of 34 patients [mean age at first examination 45.64 ± 11.13 years, 31 (53.44%) female] after ascending aortic surgery. …”
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Early detection to improve outcome in people with undiagnosed psoriatic arthritis: the PROMPT research programme including RCT by Neil McHugh, Laura Bojke, Mel Brooke Turfrey, Rachel Charlton, Myka Ransom, Laura C Coates, Howard Collier, Claire Davies, Emma Dures, Philip Helliwell, Jana James, Anya Lissina, Vishnu B Madhok, Alison L Nightingale, Jonathan Packham, Catherine Smith, Eldon Spackman, Cerys Tassinari, William Tillett, Sarah T Brown

“…BN models may be a useful method to identify clusters of symptoms that predict PsA with reasonable accuracy. …”
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Acupuncture as adjunctive therapy for acute cerebral infarction: a randomized clinical trial by Jiang-Peng Cao, Jiang-Peng Cao, Jiang-Peng Cao, Xin-Yue Du, Xiao-Xi Liu, Xiao-Xi Liu, Meng-Han Li, Meng-Han Li, Man Zhang, Sheng-Xuan Guo, Sheng-Xuan Guo, Qiu-Han Cai, Qiu-Han Cai, Jia-Xin Zhang, Jia-Xin Zhang, Jia-Xin Zhang, Shan-Shan Sun, Shan-Shan Sun, Shan-Shan Sun, Jia-Wei Han, Lin-Ling Chen, Na Zheng, Lan-Yu Jia, Gui-Ping Li, Gui-Ping Li, Yuan-Hao Du, Yuan-Hao Du

“…We aimed to investigate the efficacy and safety of acupuncture as adjunctive therapy to improve neurological function in patients with ACI.MethodsThe multicenter, sham-controlled, patient- and assessor-blinded randomized controlled trial was conducted in 4 tertiary hospitals in China from January to September 2024. …”
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Improving health-promoting workplaces through interdisciplinary approaches. The example of WISEWORK-C, a cluster of five work and health projects within Horizon-Europe by Deborah De Moortel, Michelle C Turner, Ella Arensman, Alex Binh Vinh Duc Nguyen, Víctor Gonzalez

“…The project is a collaboration between five countries (Austria, Belgium, Greece, the UK, and Sweden) and entails a cross-national mixed-methods intervention study with an embedded process and impact evaluation. …”
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H2FPEF and HFA‐PEFF scores for heart failure risk stratification in hypertrophic cardiomyopathy patients by Yi‐Peng Gao, Hong‐Yun Liu, Xiao‐Jun Bi, Jie Sun, Ying Zhu, Wei Zhou, Ya‐Ting Fan, Xue‐Qing Cheng, Pei‐Na Huang, Ya‐Ni Liu, You‐Bin Deng

“…This study aimed to explore the value of the H2FPEF and HFA‐PEFF scores for HF risk stratification in patients with hypertrophic cardiomyopathy (HCM). Methods and results In this cohort study, 1068 HCM patients were included. …”
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Antimicrobial efficacy of methylene blue-functionalized graphene oxide-mediated photodynamic therapy against Enterococcus faecalis in root canal disinfection by Rizwan Jouhar, FCPS, Mohamad Syahrizal Halim, M.Rest.Dent, Sayed A. Quadri, MD, Muhammad Adeel Ahmed, PhD, Faheem Shah, PhD

“…Abstract: Objective: This study assessed the antimicrobial efficacy of photodynamic therapy (PDT) using functionalized graphene oxide with methylene blue (MB/rGO) to achieve root canal disinfection against Enterococcus faecalis. Methods: In this in vitro study, E. faecalis biofilms were developed on 105 single-rooted teeth after decoronation over 21 days. …”
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Delivery of miR-26a-5p by Subcutaneous Adipose Tissue-Derived Extracellular Vesicles Alleviates Acute Lung Injury in Mice Through CHUK/NF-&amp;kappa;B Pathway by Xie Y, Ran L, Yue C, Wang C, Chen F, Su Y, Qin Y, Zhang Q, Liu J, Du N, Zhang L, Jiang Y, Liu G

“…This study aimed to elucidate the immunomodulatory roles and underlying mechanisms of adipose tissue-derived EVs in the pathogenesis of ARDS.Methods: Subcutaneous adipose tissue extracellular vesicles (SAT-EVs) were collected from the mice via ultracentrifugation. …”
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Genetic Variants of UGP2 and FBP2 in the Glycolysis Pathway Independently Predict Survival of Patients with HBV-Related Hepatocellular Carcinoma by Gong R, Qiu M, Liu Y, Cao J, Zhou Z, Lin Q, Jiang Y, Liang X, Wei Y, Wen Q, Chen P, Wei X, Wei J, Zhan S, Zhang R, Ye D, Yu H

“…However, the effect of genetic variants in glycolysis pathway genes in survival of patients with hepatitis B virus-related hepatocellular carcinoma (HBV-HCC) remains unclear.Methods: We employed multivariable Cox proportional hazards regression analyses to estimate associations between genetic variants in 240 glycolysis pathway genes and overall survival (OS) of 866 patients with HBV-HCC, and we also used false positive report probability for multiple testing corrections.Results: We found that UGP2 rs4293553 G allele was significantly associated with a better OS of HBV-HCC patients [hazards ratio (HR) = 0.73, 95% confidence interval (CI) = 0.62– 0.86, P &lt; 0.001], and that FBP2 rs635087 G allele was significantly associated with a worse OS in these patients (HR = 1.38, 95% CI = 1.18– 1.61, P &lt; 0.001). …”
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IL-17A as a Key Mediator of Pulmonary-Intestinal Immune Interactions in a Mouse Model of Asthma and Colitis by Wu C, Hu X, Mo Z, Meng Y, Du Y, Duan Y, Zeng Z, Shan J, Li J, Zhang N, Ma Y, Wang H, Liu C, Zhang G, Foster PS, Xu H, Li F, Yang M

“…While IL-17A has been implicated in both asthma and colitis independently, its role in coordinating systemic immune responses across tissue compartments is not well defined.Methods: In this study, we developed a combined house dust mite-induced asthma model and dextran sulfate sodium-induced colitis model to investigate the role of IL-17A in driving inflammation in both the lungs and the intestines.Results: Our findings demonstrate that IL-17A neutralization markedly reduced airway and intestinal inflammation, attenuated mucus hypersecretion, downregulated pro-inflammatory cytokine expression, and alleviated colitis severity. …”
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Radiation-Based Multi-Modal Therapy Combining with Immunotherapy to Develop a Vaccine-Like Effective Treatment for Triple-Negative Breast Cancer by Dai M, Tian Z, Xu F, Yao B, Liang H, Li D, Wang J, Rong J, Liu T, Tang H, Lu H, Zhang W

“…Current treatments like chemotherapy and immunotherapy face challenges due to chemotherapy side effects, limited immunotherapy applicability, and TNBC&amp;rsquo;s immunosuppressive microenvironment.Purpose: To achieve a more effective treatment for TNBC, a novel therapeutic strategy has been developed, which uses X-ray excited photodynamic therapy (X-PDT) to activate the tumor immune microenvironment following with the immunotherapy of Anti-CTLA4.Methods: Base on the 4T1 tumor mouse model, this study initially investigated the regulatory effects of X-PDT on the tumor immune microenvironment. …”
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