Prognostic Significance of Circulating Immune Subset Counts in Nasopharyngeal Carcinoma by Xie H, Zhang L, Chen L, Zhou W, Zhang L, Su Y, Li B, Ding P, Xiao Y, Lu T, Gong X, Li J

“…Honghui Xie,1– 3,* Lin Zhang,1,3,4,* Lizhi Chen,5,* Wenchao Zhou,1,6 Lijuan Zhang,1,3 Yong Su,1– 3 Bocheng Li,1,6 Peng Ding,1,6 Yun Xiao,1– 3 Tianzhu Lu,1,2,4,7 Xiaochang Gong,1,2,4,7 Jingao Li1,2,4,7 1NHC Key Laboratory of Personalized Diagnosis and Treatment of Nasopharyngeal Carcinoma, Jiangxi Cancer Hospital, Nanchang, Jiangxi, 330029, People’s Republic of China; 2Department of Radiation Oncology, Jiangxi Cancer Hospital, Nanchang, Jiangxi, 330029, People’s Republic of China; 3Jiangxi Clinical Research Center for Cancer, Jiangxi Cancer Hospital & Institute, The Second Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, 330029, People’s Republic of China; 4JXHC Key Laboratory of Tumour Metastasis, Jiangxi Cancer Hospital, Nanchang, Jiangxi, 330029, People’s Republic of China; 5Department of Oncology, Shangrao People’s Hospital, Shangrao, Jiangxi, 334000, People’s Republic of China; 6Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330064, People’s Republic of China; 7JXHC Key Laboratory of Tumor Microenvironment and Immunoregulation, Jiangxi Cancer Hospital, Nanchang, Jiangxi, 330029, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaochang Gong, NHC Key Laboratory of Personalized Diagnosis and Treatment of Nasopharyngeal Carcinoma, Jiangxi Cancer Hospital, No. 519, Beijing East Road, Nanchang, Jiangxi, 330029, People’s Republic of China, Email gxcanddw@163.com Jingao Li, NHC Key Laboratory of Personalized Diagnosis and Treatment of Nasopharyngeal Carcinoma, Jiangxi Cancer Hospital, No. 519, Beijing East Road, Nanchang, Jiangxi, 330029, People’s Republic of China, Email lijingao@hotmail.comPurpose: This study aimed to assess the prognostic value of circulating immune cells in newly diagnosed, non-metastatic nasopharyngeal carcinoma (NPC) and to develop a nomogram combining immune cell counts with clinical characteristics.Methods: In this retrospective study, patients with non-metastatic NPC treated between January 2015 and December 2018 were included. …”
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PEG-Coated Ceria-Zirconia Nanoparticle Prevent Weight Gain and Obesity-Related Organ Damage Through Autophagy Flux Activation and ROS Scavenging by Kim EK, Hong SE, Choi YS, Yu SL, Kang J, Park CG, Lee HY, Lee SK, Lee DC, Hwang WM, Yun SR, Park Y, Park MH, Lee J, Yoon KR, Lerman LO, Yoon SH

“…In this study, we examined the therapeutic efficacy of PEG-CZNPs against obesity-induced organ complications and investigated the associated intracellular mechanisms.Methods: Palmitate was used to establish a cellular model of obesity in HK-2 cells. …”
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Triple Therapy with Interventional Treatment, Donafenib, and Anti-PD-1 Antibodies in Unresectable Hepatocellular Carcinoma: A Retrospective Real-World Study in China by Ye Q, Song Z, Yu T, Li Y, Ai L, Yang G, Su K, Chen D, Zhao W, Ding R, Zha Y, Li G

“…Triple therapy combining interventional treatments, donafenib, and anti-PD-1 monoclonal antibodies has shown promise in recent studies, but real-world data remain limited.Objective: To evaluate the real-world efficacy and safety of triple therapy with interventional treatment, donafenib, and anti-PD-1 monoclonal antibodies in patients with uHCC.Methods: This retrospective study included 89 patients with uHCC who received donafenib, anti-PD-1 monoclonal antibodies (tislelizumab or sintilimab), and interventional therapies (TACE and/or HAIC) between March 2022 and December 2023. …”
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Influence of Socio-Demographic, Occupational and Lifestyle Variables on Sleep Time by Dutheil F, Saint-Arroman C, Clinchamps M, Flaudias V, Fantini ML, Pereira B, Berthon M, Laporte C, Baker JS, Charkhabi M, Cocco P, Lecca R, Puligheddu M, Figorilli M, Zak M, Ugbolue UC, Ubago-Guisado E, Gracia-Marco L, Bouillon-Minois JB, Vialatte L

“…Therefore, we aimed to evaluate the influence of those variables on sleep time, and to study risk factors of being a short sleeper.Methods: The COVISTRESS international study is an online questionnaire using the secure REDCap® software. …”
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Characteristics and Quality of Life of Patients with COPD with Different Degrees of Exercise-Induced Desaturation on Six-minute Walk Test by Gao B, Wang S, Zhao L, Liao H, Qumu S, Wang P, Yang T, Jiang S

“…Beiyao Gao,1,* Siyuan Wang,1,* Li Zhao,2– 5,* Hongbin Liao,6 Shiwei Qumu,4,5,7 Peijian Wang,1 Ting Yang,4,5,7 Shan Jiang1 1Department of Rehabilitation Medicine, China-Japan Friendship Hospital, Beijing, People’s Republic of China; 2Department of Lung Transplantation, China-Japan Friendship Hospital, Beijing, People’s Republic of China; 3National Center for Respiratory Medicine, China-Japan Friendship Hospital, Beijing, People’s Republic of China; 4National Clinical Research Center for Respiratory Diseases, Beijing, People’s Republic of China; 5Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, China; 6Department of Clinical Medicine, Peking University, Beijing, People’s Republic of China; 7Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shan Jiang, Email landjiang@126.com Ting Yang, Email zryyyangting@163.comObjective: To identify predictive factors for different exercise-induced desaturation (EID) severities and evaluate health-related quality of life six months later in chronic obstructive pulmonary disease (COPD) patients.Methods: This retrospective study consecutively analyzed 116 COPD outpatients (male: 82.8% [96/116]; age: 63.48 ± 7.48 years; disease severity distribution: GOLD 1/2/3/4 = 55.8%/34.6%/7.7%/1.9%). …”
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European Beech (Fagus sylvatica L.): Quasi-Virgin Forest Stand of the Gorgany Mts.: Structure, Vascular Plants Diversity, Health Conditions by Yuriy Shparyk, Ivan Danylyk, Oleksandr Kuzyarin, Ivan Senchak, Nazar Kruk

“…The studies were carried out using traditional forest inventory methods in permanent and temporary experimental plots. …”
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Grinding power model for flute grinding of solid tools based on equivalent chip thickness by Lei REN, Jiangtao PAN, Daohui XIANG, Junjin MA, Xiaobin CUI

“…A grinding power model for flute grinding of solid tools is proposed based on equivalent chip thickness, aiming to achieve precise prediction and control of grinding power for flute grinding.MethodsA kinematic model for flute grinding is established using homogeneous coordinate transformation. …”
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Oxygen-Generating Biomimetic Nano-Herb System for Synergistic Therapy & Pain Relief in Triple-Negative Breast Cancer via HIF-1α/VEGF Pathway by Cao DC, Liang Y, Guo Y, Wu DY, Wang NN, Li YM, Sun HF, Wang Q, Zhang X, Chi YL, Sun PP, Li YJ, Wang RR, Wang PY, Xie SY, Xie N

“…Dian-Chao Cao,1– 3,* Yan Liang,1,4,* Yang Guo,1 Dong-Yang Wu,1 Na-Na Wang,1 Yan-Mei Li,5 Hong-Fang Sun,1 Qin Wang,1 Xia Zhang,1 Yong-Liang Chi,6 Pei-Pei Sun,4 You-Jie Li,1 Ran-Ran Wang,7 Ping-Yu Wang,1,8 Shu-Yang Xie,1– 3 Ning Xie9 1Department of Biochemistry and Molecular Biology, Binzhou Medical University, Yantai, Shandong, 264003, People’s Republic of China; 2Department of General Surgery, the second Medical College, Yantai Affiliated Hospital, Binzhou Medical University, Yantai, Shandong, 264003, People’s Republic of China; 3Shandong Laboratory of Advanced Materials and Green Manufacturing, Yantai, Shandong, 264000, People’s Republic of China; 4Department of Oncology, Binzhou Medical University Affiliated Hospital of Traditional Chinese Medicine, Binzhou, Shandong, 256600, People’s Republic of China; 5Department of Immune Rheumatism, Yantaishan Hospital, Yantai, Shandong, 264000, People’s Republic of China; 6Department of Anesthesiology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250011, People’s Republic of China; 7Department of Rehabilitation Engineering, Institute of Rehabilitation Medicine, School of Rehabilitation Medicine, Binzhou Medical University, Yantai, Shandong, 264003, People’s Republic of China; 8Department of Epidemiology, Binzhou Medical University, Yantai, Shandong, 264003, People’s Republic of China; 9Department of Chest Surgery, Binzhou Medical University Affiliated Yantaishan Hospital, Yantai, Shandong, 264000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ning Xie, Department of Chest Surgery, Binzhou Medical University Affiliated Yantaishan Hospital, Yantai, Shandong, 264000, People’s Republic of China, Tel +86-0535-6913211, Fax +86 0535 6913163, Email sunnyvvv@163.com Shu-Yang Xie, Department of Biochemistry and Molecular Biology, Binzhou Medical University, Yantai, Shandong, 264003, People’s Republic of China, Tel +86 0535 6913211, Fax +86 0535 6913163, Email xieshuyang@bzmc.edu.cnPurpose: This study aims to develop an innovative delivery system, (Q+M/MnOx)@Clip, to enhance the bioavailability and therapeutic efficacy of quercetin both in tumor treatment and pain alleviation.Methods: The (Q+M/MnOx)@Clip system was evaluated to enhance the release of quercetin, investigate its ability to target cancer cells, alleviate tumor hypoxia, and improve the efficacy of chemodynamic therapy (CDT). …”
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Comparison of the Performance Between the Montbiliard × Holstein Crossbred and Holstein Calves in Hot and Humid Areas by Pirouz Shakeri, Hassan Khamisabadi, Mehdi Bahrami Yekdangi, Mahdi Abasy Firouzjaei, Amir Ali Shakeri

“…The calves were fed two times daily in equal portions at 8:00 and 16:00 with a total mixed ration. …”
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Comparison of Hyperbaric 0.5% Levobupivacaine and Hyperbaric 0.75% Ropivacaine for Intrathecal Use in Infraumbilical Surgeries: A Randomised Clinical Study by Tejash H Sharma, Jagrati Jain, Priya Kishnani, Richa Tailor, Sara Mary Thomas

“…Aim: To compare the sensory and motor blockade, time of two-segment regression, time for rescue analgesia, haemodynamic effects and sedative effects between hyperbaric 0.5% levobupivacaine and hyperbaric 0.75% ropivacaine. Materials and Methods: This prospective, double-blinded and randomised clinical study was conducted in the Department of Anaesthesiology, Shrimati Bhikhiben Kanjibhai Shah Medical Institute and Research Centre (a tertiary care institute), Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara, Gujarat, India, from September 2023 to July 2024, with a sample size of 40 patients. …”
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Characteristics of Pollen Concentration Changes in Xi’an and Their Correlation with Allergy-Related Diseases by Zhan Q, Lyu H, He Z, Zhang X, Wang C, Gao Y, Guo Q, Zhang N, Liu C, Shi Y, Lei Y, Xu B, Mi Y, Gao T, Zhu K, Ren X, Ouyang Y, Chen J

“…This study investigates the correlation between airborne pollen dynamics and allergic rhinitis (AR) incidence in Xi’an (2020– 2023) and compared with 1984 data for informing evidence-based prevention strategies.Methods: The species and concentration of daily pollen in Xi’an were monitored for 4 consecutive years (2020– 2023). …”
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TRACE Model: Predicting Treatment Response to Transarterial Chemoembolization in Unresectable Hepatocellular Carcinoma by Wang W, Zhang Q, Cui Y, Zhang S, Li B, Xia T, Song Y, Zhou S, Ye F, Xiao W, Cao K, Chi Y, Qu J, Zhou G, Chen Z, Zhang T, Chen X, Ju S, Wang YC

“…Weilang Wang,1,* Qi Zhang,2,* Ying Cui,1,* Shuhang Zhang,1 Binrong Li,1 Tianyi Xia,1 Yang Song,3 Shuwei Zhou,1 Feng Ye,4 Wenbo Xiao,5 Kun Cao,6 Yuan Chi,7 Jinrong Qu,8 Guofeng Zhou,9,10 Zhao Chen,11 Teng Zhang,12 Xunjun Chen,13 Shenghong Ju,1 Yuan-Cheng Wang1 1Department of Radiology, Zhongda Hospital, Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology, School of Medicine, Southeast University, Nanjing, 210009, People’s Republic of China; 2Center of Interventional Radiology and Vascular Surgery, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, Nanjing, People’s Republic of China; 3MR Scientific Marketing, Siemens Healthineers Ltd, Shanghai, People’s Republic of China; 4Department of Diagnostic Radiology, National Cancer Center/National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China; 5Department of Radiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People’s Republic of China; 6Department of Radiology, Peking University Cancer Hospital and Institute, Beijing, People’s Republic of China; 7Department of Radiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, People’s Republic of China; 8Department of Radiology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, Henan, People’s Republic of China; 9Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China; 10Shanghai Institute of Medical Imaging, Shanghai, People’s Republic of China; 11Department of Radiology, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China; 12Institute for Artificial Intelligence in Medicine, School of Artificial Intelligence, Nanjing University of Information Science and Technology, Nanjing, People’s Republic of China; 13Department of Radiology, The People’s Hospital of Xuyi County, Huaian, Jiangsu, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yuan-Cheng Wang, Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology, Department of Radiology, Zhongda Hospital, School of Medicine, Southeast University, 87 Ding Jia Qiao Road, Nanjing, Jiangsu, 210009, People’s Republic of China, Tel +086 25 83272121, Fax +086 25 83311083, Email yuancheng_wang@seu.edu.cnPurpose: To develop and validate a predictive model for predicting six-month outcome by integrating pretreatment MRI features and one-month treatment response after TACE.Methods: A total of 108 patients with 160 hCCs from a single-arm, multicenter clinical trial (NCT03113955) were analyzed and served as the training cohort. …”
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Remimazolam attenuates intestinal ischemia-reperfusion injury in mice by regulating ferroptosis through CX43 by KONG Lingguo, KONG Lingguo, LENG Yufang, LENG Yufang, MA Xiaojie

“…Objective‍　‍To investigate whether remimazolam attenuates intestinal ischemia-reperfusion (I/R) injury in mice by regulating ferroptosis through connexin-43 (CX43). Methods‍　‍Molecular docking was applied to predict the binding affinity of remimazolam to CX43. …”
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Amentoflavone Impedes NF-κB Activation and Mediates Apoptosis Induction in Lung Cancer Cells: An in vitro and in silico exploration by Faiyaz SSM, Ahmad A, Fatima D, Shahid SMA, Kaushik G, Verma C, Tiwari RK, Kumar V

“…Amentoflavone (AMF) is a biflavonoid with intrinsic ability to modulate key signaling pathways associated with homeostatic and non-homeostatic conditions impels its exploration as therapeutic candidate against non-small cell lung carcinoma (NSCLC) A549 cells.Objective: This study investigates the anticancer potential of AMF in A549 cells, focusing on its unique dual role in NF-κB suppression and apoptosis induction, and compares its efficacy to the standard drug doxorubicin.Materials and Methods: A549 cells were treated with varying concentrations of AMF for 24 h. …”
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The Efficacy of Sodium Bicarbonate Ringer’s Solution and Lactate Ringer’s Solution in Patients Undergoing Long-Term Abdominal Open Surgery: A Multicenter Prospe... by Zhou S, Zhao K, Liu C, Luo H, Shi J, Liu C, Li X, Gao F, Wu X, Shen Q, Yuan W, Chai X, Wei X

“…The aim is to investigate the effects of sodium bicarbonate Ringer’s solution on lactate metabolism, acid-base balance, and clinical outcomes in patients undergoing extended-duration open abdominal surgery, with the objective of refining fluid replacement strategies for this patient population.Patients and Methods: A multicenter randomized controlled trial was conducted involving 112 patients undergoing open abdominal surgery. …”
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Determination of Composition and Amount of Different Feeds to Produce Animal Products to Use in Agricultural Policy Studies in Iran by Seyed Majid Alimagham, Afshin Soltani, Behrouz Dastar, Taghi Ghoorchi

“…Extended Abstract Background: The value of water, energy, and food resources is such that access to and proper use of these resources are pillars of security, success, and equality worldwide. Today, governments are struggling to find solutions to a complex set of problems that, if left unresolved, could lead to the collapse of human civilization. …”
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Relationship Between Social Support, Symptom Burden, Dyspnea, Perceived Stress, Perceived Stigma, Coping Styles, and Psychological Distress in Patients with Stable COPD: A Structur... by Tian X, Yi L, Liu X, Zuo F, Shang H, Zhang J, Ren Y

“…This study aimed to explore how social support, symptom burden, dyspnea, perceived stress, perceived stigma, and coping styles impact psychological distress in stable COPD using a structural equation model (SEM).Methods: A convenience sample of 386 stable COPD patients was recruited from three tertiary hospitals in Chongqing, China. …”
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Probiotic Bifico Ameliorates Depression- and Anxiety-Like Behaviors Induced by Estrogen Deficiency via NLRP3 Inflammasome Inhibition by Yu X, Yu X, Yang Y, Cheng W, Shi M, Chen L, Zhang X, Xu Y

“…This study aims to investigate the effects of the probiotic Bifico on neuroinflammation and behaviors in ovariectomized (OVX) rats.Methods: After OVX rats were treated with Bifico for 6 weeks, depression- and anxiety-like behaviors were evaluated using the sucrose preference test, forced swimming test, open field test and elevated plus maze. …”
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Adverse Event Management in Patients with Platinum-Resistant Ovarian Cancer Treated with Niraparib and Anlotinib: Updates from the Phase II, Multi-Center ANNIE Study by Deng T, Yan L, Li J, Liu G, Yin A, Feng Y, Zheng M, Zhang C, Huang H, Huang Q, Lin A, Jiang J, Kong B, Liu J

“…We report updated overall survival (OS) and safety data and the management of key treatment-emergent adverse event (TEAE) from the ANNIE study.Methods: In the multi-center, single-arm, Phase 2 ANNIE study, enrolled patients received oral niraparib 200 mg or 300 mg (baseline bodyweight-directed) once daily and anlotinib 10 mg (12 mg before protocol amendment) once daily on days 1– 14 of each 21-day cycle. …”
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EFFICACY OF CARDIOVERTER-DEFIBRILLATORS IN PREVENTION OF SUDDEN DEATH AND OVERALL MORTALITY DECREASE IN PATIENTS WITH THE SYNDROME OF DILATION CARDIOMYOPATHY: DIFFERENTIAL APPROA... by O. V. Blagova, A. V. Nedostup, E. V. Zaklyazminskaya

“…To evaluate the exact efficacy of the implantable cardioverter-defibrillators (ICD) and combination devices (CRT-D), and to evaluate their influence on the rate of sudden death and overall mortality in patients with the dilation cardiomyopathy syndrome (DCMP), and to clarify the selection criteria for implantation.Material and methods. Totally, 220 DCMP patients investigated: 66 (30%) of them (mean age 48,5±12,8 y. o., 47 males) underwent implantation of ICD (n=37) and CRT-D (n=29), 154 (70%) patients were in comparison group (mean age 47,1±12,4 y. o., 104 males). …”
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