Evaluation of multidrug-resistant bacteria and their molecular mechanisms found in small animal veterinary practices in Portugal by Joana Moreira da Silva, Joana Moreira da Silva, Juliana Menezes, Juliana Menezes, Juliana Menezes, Laura Fernandes, Laura Fernandes, Cátia Marques, Cátia Marques, Cátia Marques, Sofia Santos Costa, Dorina Timofte, Andreia J. Amaral, Andreia J. Amaral, Andreia J. Amaral, Constança Pomba, Constança Pomba, Constança Pomba

“…The goal of our work was to evaluate the environmental contamination and staff carriage by MDROs in veterinary practices across Portugal.MethodsFourteen SAVPs were enrolled. Environmental samples were collected from critical areas such as operating room, wards and pre-operative area. …”
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Prospective study of continuous rhythm monitoring in patients with early post-infarction systolic dysfunction: clinical impact of arrhythmias detected by an implantable cardiac mon... by Jesus Hernandez-Hernandez, Ana Martin-Garcia, Javier Jimenez-Candil, Pedro L Sanchez, Carlos González-Juanatey, Javier García-Fernández, Alba Cruz-Galban, Olga Duran-Bobin, Javier Garcia-Seara, Teba Gonzalez-Ferrero, Jose Morinigo, Manuel Sanchez-Garcia, Gonzalo Fernandez-Palacios, Jose Seijas-Amigo, Juliana Elices, Javier Portales-Fernandez, Francisco Martin-Herrero, Ana García-Campos, Jose A Perez-Rivera, Marta Alonso-Fernandez-Gatta, Alfonso Macías, Paloma Perez-Espejo

“…Among patients with post-infarction left ventricular dysfunction, modern implantable cardiac monitoring devices (ICM) allow a unique opportunity to determine in real-time the burden of non-sustained ventricular tachycardias and their relationship to the subsequent occurrence of sustained or symptomatic events.Methods and analysis Approximately 200 patients with left ventricular ejection fraction (LVEF) equal to or less than 40% after acute myocardial infarction will be included in the study. …”
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Maltreatment and parenting in youth with primary and secondary callous‐unemotional traits: Anxiety matters by Jessica J. Todorov, Gregor Kohls, Ruth Pauli, Jack Rogers, Anka Bernhard, Katharina Ackermann, Nora M. Raschle, Jules R. Dugre, Aranzazu Fernandez‐Rivas, Miguel Angel Gonzalez‐Torres, Amaia Hervas, Areti Smaragdi, Karen Gonzalez, Ágnes Vetró, Dimitris Dikeos, Arne Popma, Christina Stadler, Kerstin Konrad, Christine M. Freitag, Graeme Fairchild, Rory T. Devine, Stephane A. De Brito

“…Youth with primary and secondary CU traits were equally high on levels of abuse, neglect, and maladaptive parenting (all p values >0.05). …”
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Impact of multidimensional assessment on anti-fracture treatment decisions in patients with fragility hip fractures within a Fracture Liaison Service by Chiara Ceolin, Stefania Sella, Cristina Simonato, Ester Bukli, Giulia Bano, Valentina Camozzi, Anna Bertocco, Marco Onofrio Torres, Alberta Cecchinato, Martin Diogo, Mor Peleg Falb, Francesca Guidolin, Maria Grazia Rodà, Michele Cannito, Antonio Berizzi, Andrea Venturin, Vito Cianci, Elisa Pala, Mariachiara Cerchiaro, Deris Gianni Boemo, Maria Vittoria Nesoti, Gaetano Paride Arcidiacono, Paolo Simioni, Pietro Ruggieri, Giuseppe Sergi, Sandro Giannini, Marina De Rui, on behalf of the Hip-POS working group

“…This study aimed to identify the primary factors influencing anti-fracture therapy decisions in older patients with fragility fractures, using a multidimensional geriatric assessment approach integrated into our FLS program. Methods A retrospective analysis was conducted on patients aged 65 and above with hip fractures admitted to Azienda Ospedale-Università Padova. …”
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A Multicenter Randomized Double-Blind Vehicle-Controlled Parallel Group Phase 2 Study Evaluating the Efficacy and Safety of GN-037 Cream in Patients with Mild-to-Moderate Plaque Ps... by Burhan Engin, Müge Güler Özden, Özge Sevil Karstarlı Bakay, Selda Pelin Kartal, İlkin Zindancı, Salih Levent Çınar, Recep Dursun, Gizem Pehlivan Ulutaş, Tuğba Özkök Özkök Akbulut, Fatma Aslı Hapa, Emel Bülbül Başkan, Mehmet Melikoğlu, Algün Polat Ekinci, Neslihan Demirel Öğüt, Pelin Hızlı, Zafer Türkoğlu, Özlem Su Küçük, Zeynep Topkarcı, Ümit Türsen, Filiz Canpolat, Hanife Uçgun, Şirin Yaşar, Selami Aykut Temiz, Asena Çiğdem Doğramacı, Sedat Altuğ, Serhat Kozlu, Nadir Ulu, Server Serdaroğlu

“…The present multicenter randomized double-blind vehicle-controlled parallel group phase 2 study aimed to investigate the efficacy and safety of GN-037 in patients with mild-to-moderate plaque psoriasis (MMPP). Methods Patients (n = 190) were randomized (2:2:1) to receive GN-037 or CP or vehicle (V) cream twice daily to a selected target body lesion for 4 weeks. …”
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Optimizing treatment for depression in primary care using psychotherapy versus antidepressant medication in a low-resource setting: protocol for the OptimizeD randomized controlled... by Julia R. Pozuelo, Anuja Lahiri, Rahul S. P. Singh, Arvind Kushwah, Mimansa Khanduri, Akanksha Shukla, Azaz Khan, Sruthi G., Varun Shende, Yashika Parashar, Yashwant K. Mehra, Anant Bhan, Ronald C. Kessler, Daisy R. Singla, John A. Naslund, Karmel W. Choi, Pim Cuijpers, Robert DeRubeis, Mohammad M. Herzallah, Chunling Lu, Jordan W. Smoller, Tyler J. VanderWeele, Abhijit R. Rozatkar, Tamonud Modak, Michelle Melwyn Joel, Debasis Biswas, Shubham Atal, Umay Kulsum, Steven D. Hollon, Vikram Patel

“…The Optimizing Depression (OptimizeD) trial aims to explore whether different patients respond differently to behavioral activation therapy versus antidepressant medication and if providing each patient with their optimal treatment improves outcomes in primary care. Methods We plan to randomize 1,500 patients with moderate to severe depression (defined as a Patient Health Questionnaire [PHQ-9] score ≥ 10) from primary healthcare settings in Bhopal, India, with equal allocation either to a culturally adapted behavioral activation therapy delivered by trained counselors (Healthy Activity Program) or to antidepressant medication (fluoxetine). …”
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CCN estimations at a high-altitude remote site: role of organic aerosol variability and hygroscopicity by F. Rejano, F. Rejano, A. Casans, A. Casans, M. Via, J. A. Casquero-Vera, J. A. Casquero-Vera, S. Castillo, S. Castillo, H. Lyamani, A. Cazorla, A. Cazorla, E. Andrews, E. Andrews, D. Pérez-Ramírez, D. Pérez-Ramírez, A. Alastuey, F. J. Gómez-Moreno, L. Alados-Arboledas, L. Alados-Arboledas, F. J. Olmo, F. J. Olmo, G. Titos, G. Titos

“…To further evaluate the role of <span class="inline-formula"><i>κ</i>_OA</span> in CCN predictions, we established a new OA scheme that uses the OA oxidation level (parameterized by the <span class="inline-formula"><i>f</i>₄₄</span> factor) to calculate <span class="inline-formula"><i>κ</i>_OA</span> and predict CCN. This method also shows a large bias, especially during midday hours (up to 40 %), indicating that diurnal information about the oxygenation degree does not improve CCN predictions. …”
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Levels of total IgE versus specific IgE during childhood for defining and predicting T2-high asthma by Tamo Sultan, MD, Frederikke Skov, MD, Nicklas Brustad, MD, PhD, Nilo Vahman, MD, PhD, Jakob Stokholm, MD, PhD, Klaus Bønnelykke, MD, PhD, Ann-Marie Malby Schoos, MD, PhD, DMSc, Bo Chawes, MD, PhD, DMSc

“…Objective: To investigate the role of total and specific immunoglobulin E (tIgE/sIgE) for defining and predicting T2-high asthma in childhood as biomarkers of “allergy-driven”. Methods: We utilized data from the COPSAC2000 (n = 411) and COPSAC2010 (n = 700) mother-child cohorts with repeated measurements of tIgE, sIgE, b-eos and FeNO through childhood. …”
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The EORTC QLQ-F17 as a shortened version of the EORTC QLQ-C30 to assess self-reported functioning in cancer patients: investigating equivalence and psychometric properties in a ran... by Florian Zeman, Johannes M. Giesinger, Tobias Pukrop, Morten Aa Petersen, Mogens Groenvold, Sandra Nolte, Dagmara Kuliś, Sunil Shrestha, Laurence Leysen, Kim Cocks, Corneel Coens, Georgios Ioannidis, Cecilia Pompili, Michael Koller

“…The QLQ-F17 is conceived an equivalent to the functional part of the QLQ-C30, but to date there is no empirical evidence to support this rationale. Methods: This randomized, cross-over, multi-national, questionnaire-based study investigates the equivalence and psychometric properties of the QLQ-F17 compared to the functional scales of the QLQ-C30. …”
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Dynamics of Clinical Manifestations and Social Functioning in Schizophrenia: A Non-interventional Observational Study of Paliperidone Palmitat Dosage Forms by Aleksandr M. Reznik, Olga A. Karpenko, Elena A. Shumakova, Aleksandr V. Mudrak, Andrey V. Sokolov, Svetlana V. Nazimova, Alina M. Saifulina, Anton M. Eliseenko, Tatjana K. Matvievskaya, Angelina N. Khannanova, Vladimir I. Revenko, Dmitriy V. Scherbakov, Yuriy L. Martynyuk, Aleksandr L. Arbuzov, Oleg A. Yacenko, Polina N. Alekseeva, Aleksandr B. Berdalin, Larisa A. Burygina

“…CONCLUSION: Treatment with different forms of paliperidone provides a roughly equal pace reduction in the severity of schizophrenia, including positive and negative symptoms. …”
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Wound Healing Properties of Plant-Based Hydrogel and Oleogel Formulations in a Rat Scald Burn Model by Oana Janina Roșca, Alexandru Nistor, Georgeta Hermina Coneac, Ioana Viorica Olariu, Ana-Maria Cotan, Roxana Racoviceanu, Elena Rodica Heredea, Adelin Ciudoiu, Gabriela Didea, Camelia Mihaela Lupou, Florin Borcan, Teodora Hoinoiu, Cristina Adriana Dehelean, Lavinia Lia Vlaia, Codruța Marinela Șoica

“…Post-burn, rats were divided into three equal subgroups, and topical formulations were applied daily. …”
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Impact of maternal antenatal nutrition and infection treatment interventions on Longitudinal Infant Development and Growth in rural Ethiopia: protocol of the LIDG child follow-up s... by Alemayehu Worku, Yemane Berhane, Luke C Mullany, Charles A Nelson, Lian V Folger, Anne CC Lee, Maria Andersson, Parul Christian, Krysten North, Yoseph Yemane Berhane, Nebiyou Fasil, Sitota Tsegaye, Kalkidan Yibeltal, Fred Van Dyk, Sara Cherkerzian, Firehiwot Workneh, Workagegnhu Tarekegn Kidane, Theresa I Chin, Sarah K G Jensen, Mulatu Melese, Unmesha Roy Paladhi, Betelhem Haimanot Abate, Atsede Teklehaimanot, Tizita Lemma Melka, Stephen Pihl, Winko W An, Sonya V Troller-Renfree, Moriah E Thomason, Terrie Inder, P Ellen Grant

“…This study will examine the effects of prenatal nutrition and infection management interventions on long-term growth and neurodevelopmental outcomes of offspring.Methods The Enhancing Nutrition and Antenatal Infection Treatment (‘ENAT’) study (ISRCTN15116516) was a pragmatic, open-label, 2×2 factorial, randomised clinical effectiveness study implemented in 12 rural health centres in Amhara, Ethiopia. …”
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Application value of nucleic acid MALDI-TOF MS in mycobacterial species identification and drug resistance detection in Mycobacterium tuberculosis by Xiaofang Liu, Honghong Niu, Donglin Guo, Huixia Gao, Lihong Wu, Jingyang Liu, Chunfeng Bai, Yuxi Li, Peilong Wang, Zhengfeng Zhou, Yuling Wang, Jianqin Liang, Wenping Gong

“…For NTM, nucleic acid MALDI-TOF MS had 89.29% sensitivity and 97.14% specificity, with an area under the curve (AUC) of 0.932, which was superior to other methods. The nucleic acid MALDI-TOF MS identified 28 NTM species, while real-time PCR identified only 12. …”
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Erector spinae plane block versus caudal epidural block in pediatric surgery: a systematic review and meta-analysis of randomized clinical trials by Barbara Bombassaro Masiero, Deivyd Cavalcante, Fatemeh Akbarpoor, Capela António Dicazeco Pascoal, Lubna Al-Sharif, Fellipe Feijó Halfeld, Lucas Cael Azevedo Ramos Bendaham, Patricia Viana, Jesslyn N. Haryianto, Maria Luiza de Souza Rasia, Mariana Copetti de Almeida Cunha, Ana Djulia Tesche, Júlia Caletti Roth de Oliveira, Rafael Arsky Lombardi

“…Therefore, we performed this systematic review with meta-analysis to compare both techniques. Methods: We searched PubMed, Embase and Cochrane Central for Randomized Controlled Trials (RCTs) comparing ESPB versus CEB in pediatric patients undergoing abdominal and sub-abdominal surgeries. …”
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Approaches used to prevent and reduce the use of restrictive practices on adults with learning disabilities: a realist review by Joy Duxbury, Alina Haines-Delmont, John Baker, Peter Baker, Gary Bourlet, Elaine Craig, James Ridley, Rachel Whyte, Beth Morrison, Michaela Thomson, Anthony Tsang, Tella Lantta

“…In line with realist methods, eight context–mechanism–outcome configurations and an overarching programme theory were used to explain the why and how of preventing and reducing the use of restrictive practices for people with a learning disability. …”
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Qingda granules mitigate cardiac inflammation in spontaneously hypertensive rats via the MCP-1/CCR2 signaling pathway by Jianfeng CHU, Huai WANG, Tianyi WANG, Meizhong PENG, Xueling ZHOU, Yan LU, Shan LIN, Aling SHEN, Changgeng FU, Jun PENG

“…Objective: This study investigated effects and underlying mechanisms of Qingda granules (QDG) on cardiac inflammation in spontaneously hypertensive rats (SHRs). Methods: Twelve SHRs (17 weeks old) were randomly divided into SHR and SHR + QDG groups, with six rats in each group. …”
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Colorectal cancer risk factors: A multi-center, case-control study in Egypt by Essam A. El-Moselhy, Mohamed M. Abdel-Halim, Alshaimaa M.M. Eid Eid, Ahmed M. Ghazy, Neamat A. Abdelmageed, Amir A. Eldamaty, Sherif A. Sherif, Asmaa A. Attia, Fatma M. Kotb, Abdelhamid A. Abdelhafez, Mohamad M. Abdelnaser, Mohamed H. El Sisi, Ahmed M. Abdelnaby, Moshira A. Ibrahim, Osama O. Khalil, Mohmed Tag El-Din, Esam M. Osman, Abd-Elnaser S. Mohammed, Alyaa H. Abo-Rahma, Ahmed E. Abdrabo, Ayman M. El Guindy, Karima M-S Kholief

“…This study aimed to define characteristics and risk factors (RFs) of CRC in Egypt. Methods: A multi-center, hospital-based, case-control study was conducted. …”
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Non-Invasive Ventilation Failure in Pediatric ICU: A Machine Learning Driven Prediction by Maria Vittoria Chiaruttini, Giulia Lorenzoni, Marco Daverio, Luca Marchetto, Francesca Izzo, Giovanna Chidini, Enzo Picconi, Claudio Nettuno, Elisa Zanonato, Raffaella Sagredini, Emanuele Rossetti, Maria Cristina Mondardini, Corrado Cecchetti, Pasquale Vitale, Nicola Alaimo, Denise Colosimo, Francesco Sacco, Giulia Genoni, Daniela Perrotta, Camilla Micalizzi, Silvia Moggia, Giosuè Chisari, Immacolata Rulli, Andrea Wolfler, Angela Amigoni, Dario Gregori

“…This study aims to identify predictors of first-attempt NIV failure in PICU patients by testing various machine learning techniques and comparing their predictive abilities. <b>Methods</b>: Data were sourced from the TIPNet registry, which comprised patients admitted to 23 Italian Paediatric Intensive Care Units (PICUs). …”
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Impact of Low Hand Grip Strength on Quality of Life, Utilization of Healthcare, and Mental Health in Individuals with Airflow Limitation by Kim SH, Zo S, Kong SA, Cho JH, Do JG, Shin SH, Park HY

“…However, data on the impact of sarcopenia on quality of life, utilization of healthcare, and mental health in individuals with AFL are limited.Patients and methods: We used data from the 2014– 2019 Korea National Health and Nutrition Examination Survey (KNHANES), and participants with AFL were included. …”
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An Evaluation of the Safety, Immunogenicity, and Protective Efficacy of a Combined Diphtheria–Tetanus–Acellular Pertussis, <i>Haemophilus influenzae</i> Type b, and ACYW135 Meningo... by Xiuwen Sui, Zhujun Shao, Yuanyuan Ji, Hairui Wang, Qingfu Xu, Bochao Wei, Zhuojun Duan, Chang Wang, Ying Yang, Jiayu Zhao, Tao Zhu

“…<b>Background</b>: The combined diphtheria–tetanus–acellular pertussis (three-component), <i>Haemophilus influenzae</i> type b (Hib, conjugate), and ACYW135 meningococcal (conjugate) vaccine (DTaP-Hib-MCV4) offers a promising alternative to single-component vaccines, potentially simplifying immunization schedules and improving vaccination coverage. <b>Methods</b>: We evaluated the safety, immunogenicity, and protective efficacy of DTaP-Hib-MCV4 in animal models. …”
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