Diffusion mechanisms of coal-measure helium and their implications for helium accumulation: A case study of the Taiyuan Formation, northern Qinshui Basin, China by Yong MA, Zhiyuan XIN, Jianfa CHEN, Yuhong LI, Xiutao ZHANG, Haojie JIANG, Zeya CHEN

“…This severely restricts further research on the accumulation patterns of coal-measure helium.MethodsThis study investigated a coal seam in the Taiyuan Formation in the northern Qinshui Basin and mudstones in the coal seam roof. …”
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Diffuse and Strong TTF-1 Expression Predicts Response to Pemetrexed-Based Immunochemotherapy in Advanced Lung Adenocarcinoma by Yamada J, Jimbo N, Yamasaki N, Hatakeyama Y, Kiriu T, Iwamoto N, Matsumura K, Katsurada M, Okuno K, Nakata K, Tachihara M

“…We evaluated the cut-off of TTF-1 considering the percentage of positive cells and staining intensity as a predictive factor.Patients and Methods: We conducted a retrospective multicenter study of patients with advanced lung adenocarcinoma or NSCLC favor adenocarcinoma treated with immunochemotherapy. …”
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Shu-Feng-Jie-Biao Formula Ameliorates Influenza A Virus-Induced Acute Lung Injury by Inhibiting NF-κB and ERK MAPK Signaling Pathways by Lei B, Huang W, Peng W, Mu J, Liu Y, Zhou C, Cheng T, Wei X, Pan L, Zheng Y, Fang B

“…This study aimed to explore its mechanisms and effects for the treatment of influenza.Methods: Network pharmacology was used to explore the underlying mechanism of SFJBF against influenza. …”
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Boron Phenylalanine-Modified Polydopamine Nanoparticles for Targeted Delivery of Danusertib in Non-Small Cell Lung Cancer by Xu Y, Chen X, Zhang L, Li P, He J, Zhu M, Makvandi P, Jin X

“…This study aimed to evaluate the therapeutic potential of nanomedicine-based delivery of the Aurora-A inhibitor Danusertib (Danu) in NSCLC treatment.Methods: Boron phenylalanine (BPA)-modified polydopamine (PDA) was used as a carrier to load Danu, preparing B-PDA@Danu nanoparticles. …”
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Major Predominant Serotypes and Virulence Genes and Antibiotic Resistance Characteristics of Klebsiella pneumoniae Clinical Isolates in Middle and East China by Pan WK, Chen SN, Yang MJ, Tao LP, Wang MQ, Zhang XW, Xu YH, Yan J, Qin JF, Sun AH

“…Predominant serotypes, virulence genes, and resistance characteristics of K. pneumoniae isolates from patients in different regions of China require further investigation.Methods: K. pneumoniae isolates from patients and healthy individuals in middle and east China were identified using an auto-bacterial detector. …”
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Induced Sputum Transcriptomics Profile and Serum C3 are Associated with Asthma Severity by Du F, Wang H, Chen Z, Xiong W, Wang Q, Li B, Li R, Li L, Shen Y, Zhu T

“…Then, this study aimed to explore asthma severity-associated transcriptomics profile and promising biomarkers for asthma severity prediction.Methods: In discovery cohort, induced sputum cells from 3 non-severe and 3 severe asthma patients were collected and analyzed using RNA-seq. …”
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Quercetin, a Compound of the Total Flavonoids of Periploca forrestii Schltr., Ameliorates Rheumatoid Arthritis by Targeting TNF-α by Chen S, Xue W, Wu Z, Lu D, Zheng L, Zhou M, Li Y, Wang Y, Liu T

“…This study investigates the specific compounds of TFPF responsible for TNF-α inhibition and delineates their mechanism of action.Methods: L929 cells and luciferase-based assays were used to assess anti-TNF-α activity. …”
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Social Support, Quality of Life, and Financial Toxicity Among Patients with Hepatocellular Carcinoma by Liu S, Xie Y, Li T, Huang Y, Xu D, Cai L, Fu Y, Chen J, Zhang Y, Huang J, Hu Z

“…Shuyue Liu,1– 3,* Yawen Xie,1– 3,* Tiantian Li,1– 3,* Yanxia Huang,1– 3 Danting Xu,1– 3 Linli Cai,1– 3 Yizhen Fu,1– 3 Jinbin Chen,1– 3 Yaojun Zhang,1– 3 Jia Huang,4 Zili Hu1– 3 1Department of Liver Surgery, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, People’s Republic of China; 2Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, People’s Republic of China; 3Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, People’s Republic of China; 4Reproductive Medicine Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510060, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jia Huang, Reproductive Medicine Center, The First Affiliated Hospital, Sun Yat-sen University, No. 58 Zhongshan Er Road, Guangzhou, Guangdong, 510060, People’s Republic of China, Tel +86 13828442672, Email hjia@mail.sysu.edu.cn Zili Hu, Department of Liver Surgery, Sun Yat-sen University Cancer Center, No. 651 Dongfeng Road East, Guangzhou, Guangdong, 510060, People’s Republic of China, Tel +86-20-87343115, Email huzl1@sysucc.org.cnBackground & Aims: Despite the significant hepatocellular carcinoma (HCC) patient population, gaps exist in understanding their survivorship journey.Methods: Patients diagnosed with HCC at all stages were recruited at Sun Yat-sen University Cancer Center from August 1, 2023, to December 30, 2023. …”
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Leonurine Attenuates CCl4-Induced Hepatic Fibrosis in Mice via the Hippo-YAP Pathway by Wang P, Bai J, Ye M, Huang Z, Chen J, Sun L, Zhong X, Zheng Y, Ma T, Fu W, Du Y

“…This study aims to investigate the effect of Leo on liver fibrosis and clarify the mechanisms at play.Methods: We employed a mouse model of liver fibrosis induced by carbon tetrachloride (CCl4) and utilized LX-2 cells to investigate the mechanisms through which Leo exerts its effects.Results: Mice administered CCl4 displayed an elevated hepatic index, considerable necrosis as revealed by H&E staining, and significantly heightened serum markers of liver injury (ALT and AST). …”
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Combined TACE with Targeted and Immunotherapy versus TACE Alone Improves DFS in HCC with MVI: A Multicenter Propensity Score Matching Study by Chen X, Wu X, Peng W, Liu L, Liu X, Wan X, Xu H, Zheng Y, Zhao H, Mao Y, Lu X, Sang X, Chang X, Zhou K, Pan J, Guan M, Hu D, Tan H, Zhang Y, Du S

“…This study evaluates the efficacy of different adjuvant treatments on disease-free survival (DFS) and overall survival (OS) in HCC patients with MVI following curative resection.Methods: A retrospective cohort of 409 HCC patients with MVI who underwent curative resection from three clinical centers between 2017 and 2024 was analyzed. …”
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The Combination of Curcumae Radix and Syzygium Aromaticum Extracts Mitigates Benign Prostatic Hyperplasia through Anti-Proliferative and Anti-Inflammatory Effects by Geum Hwa Lee, Yu Seob Shin, Ji Hyun Kim, Da hee Shim, Hwa Young Lee, Luo Zhao, Mohammad Mamun Ur Rashid, Hwang Eui Cho, Jong Jin Lee, Min Kyoung Kim, Do Sung Kim, Hyun Jun Park, Han Jung Chae

“…The study aimed to investigate the anti-proliferative mechanism of Curcumae Radix (CR) and Syzygium aromaticum (SA) extracts using RWPE-1 cells and testosterone propionate (TP)-induced BPH rats. Materials and Methods: In vitro experiments were performed to assess the synergistic anti-proliferative effects of an equal mixture of CR and SA extracts on TP-treated RWPE-1 cells. …”

Searching for Axion Dark Matter Gegenschein of the Vela Supernova Remnant with FAST by Wenxiu Yang, Yitian Sun, Yougang Wang, Katelin Schutz, Yichao Li, Calvin Leung, Wenkai Hu, Shuanghao Shu, Kiyoshi Masui, Xuelei Chen

“…Based on our observation strategy, data processing methods, and results, the expected sensitivity will reach ∼10 ^−11 GeV ^−1 with ∼2000 hr of observation in the future.…”
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Intervention effect and mechanism of Dracocephalum moldavica L. extract on bleomycin-induced pulmonary fibrosis in rats by Xiaoyu SUN, Li CHEN, Ruifang GAO, Hui YU, Min JIN

“…ObjectiveTo elucidate the targets and potential mechanism underlying the anti-pulmonary fibrosis efficacy of Dracocephalum moldavica L. extract by employing an amalgamation of network pharmacology and empirical verification. MethodsThe chemical composition of the extract of Dracocephalum moldavica L. was retrieved with the help of China National Knowledge Infrastructure (CNKI) and Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP). …”
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Conventional and Conformal Radiotherapy with and without Beam Intensity Modulation in Patients with Stage II Hodgkin’s Lymphoma with Supradiaphragmal Lesions by YuN Vinogradova, EI Ivanova, AI Chumachenko, EV Smirnova, GI Andreev, AM Kalesnik, NA Vorob’ev, NV Il’in

“…Overall 5- and 10-year survival (OS) was equal and accounted for 98.0 ± 1.4 %, the disease-free survival (DFS) was also equal between groups and accounted for 85.9 ± 1.3 %. …”
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A Comparative Analysis of Energy Efficiency of Two Sprinkler Irrigation Systems for Wheat Cultivation (Case Study: Dehgolan Plains, Kurdistan) by P. Tahmasbi, F. Dalvand, S.A. Hosseini, B. Karimi, H. Ghadrshnas

“…The main objective of this study is to evaluate the energy consumption indexes of wheat in farms under fixed-mobile sprinkler classic and Willet rain irrigation systems. Materials and MethodsThis study was conducted in the farms of Dehgolan plains where the energy consumption trend of input factors in two irrigation systems was investigated. …”
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Effectiveness of mucoactives (carbocisteine and hypertonic saline) in addition to usual airway clearance management with usual airway clearance management alone in acute respirator... by Mike Clarke, Marc Chikhani, Cliona McDowell, Ranjit Lall, Michael McKelvey, Margaret McFarland, Brenda O'Neill, Cecilia O'Kane, Murali Shyamsundar, Gavin Perkins, Clifford C Taggart, Gordon Sturmey, Barry Williams, John Warburton, Paul Dark, Bronwen Connolly, Ashley Agus, Naomi Dickson, Mark Borthwick, Bronagh Blackwood, Daniel F McAuley, Christina Campbell, Judy Bradley

“…Participants will be equally allocated across four trial arms. All participants will receive usual airway clearance management. …”
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HPV genotyping agreement between paired cervical cytological sample and biopsy across lesion severity and vaccination by Shimin Chen, Qiaoyun Du, Jian Yin, Xiaoqian Xu, Wen Chen, Qinjing Pan, Xun Zhang, Ying Hong, Wenhua Zhang, Bin Liu, Jianfeng Cui, Shangying Hu, Fanghui Zhao

“…Thus, investigating genotyping agreement between these two sample types and potential influence of lesion severity and vaccination status on their degree of concordance is essential for understanding their diagnostic reliability. Methods Paired cervical cytological samples and formalin-fixed paraffin-embedded (FFPE) biopsies from 392 cervical intraepithelial neoplasia or cancer (CIN+) cases (187 CIN1, 111 CIN2, 94 CIN3+; 262 unvaccinated, 130 vaccinated) were genotyped using SPF10-DEIA-LiPA25 detection system. …”
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From rural practice to scientific evidence: synergistic antiplasmodial and antioxidant properties of combined Ageratum conyzoides and Bidens pilosa extracts by Patrick Valere Tsouh Fokou, Courthney Akwi Mboh, Kenneth Lifoter Navti, Marius Jaurès Tsakem Nangap, Raoul Kemzeu, Canis Parfait Donbou Djiotie, Aubin Youbi Kamche, Hubert Nana Djigang, Arnold Tegen Tah, Mariscal Brice Tchatat Tali, Lauve Rachel Tchokouaha Yamthe, Vincent Ngouana, Fabrice Fekam Boyom

“…Aim: This study evaluates the in vitro and in vivo antiplasmodial, hemolytic, and antioxidant activities of a combined extract of Ageratum conyzoides (A. conyzoides) and Bidens pilosa (B. pilosa), a traditionally used but scientifically unvalidated combination. Methods: Plant leaves were extracted via aqueous decoction and cold maceration, combining equal parts to mimic traditional preparation. …”
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Sex differences in resting skeletal muscle and the acute and long-term response to endurance exercise in individuals with overweight and obesity by Simon I. Dreher, Thomas Goj, Christine von Toerne, Miriam Hoene, Martin Irmler, Meriem Ouni, Markus Jähnert, Johannes Beckers, Martin Hrabě de Angelis, Andreas Peter, Anja Moller, Andreas L. Birkenfeld, Annette Schürmann, Stefanie M. Hauck, Cora Weigert

“…As biological sex impacts glucose and fatty acid handling in skeletal muscle, we hypothesized sex differences at the transcriptomic and proteomic level in the acute response to exercise and after an 8-week exercise intervention. Methods: We analyzed skeletal muscle biopsies from 25 sedentary subjects (16f/9 m) with overweight and obesity using transcriptomics and proteomics at baseline, after acute exercise, and following an 8-week endurance training program. …”
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The impact of physical activity on progression-free and overall survival in metastatic breast cancer based on molecular subtype by Philipp Ziegler, Andreas D. Hartkopf, Markus Wallwiener, Lothar Häberle, Hans-Christian Kolberg, Peyman Hadji, Hans Tesch, Johannes Ettl, Diana Lüftner, Volkmar Müller, Laura L. Michel, Erik Belleville, Pauline Wimberger, Carsten Hielscher, Hanna Huebner, Sabrina Uhrig, Lena A. Wurmthaler, Carolin C. Hack, Christoph Mundhenke, Christian Kurbacher, Peter A. Fasching, Rachel Wuerstlein, Michael Untch, Wolfgang Janni, Florin-Andrei Taran, Michael P. Lux, Diethelm Wallwiener, Sara Y. Brucker, Tanja N. Fehm, Andreas Schneeweiss, Chloë Goossens

“…Therefore, we here evaluated the effect of physical activity on progression-free and overall survival (PFS, OS) in metastatic breast cancer, specifically looking at molecular subtypes. Methods International Physical Activity Questionnaire (IPAQ) questionnaires, filled out by patients enrolled in the prospective PRAEGNANT registry (NCT02338167; n = 1,270) were used to calculate metabolic equivalent task (MET) minutes, which were subsequently categorized into low (n = 138), moderate (n = 995) or high IPAQ categories (n = 137). …”
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