Chinese Massage (Tuina) Attenuates Knee Osteoarthritis by Modulating Autophagy-Related Cytokines: A Multidisciplinary Methodological Investigation by Wang Z, Zhao C, Li M, Zhang L, Diao J, Wu Y, Yang T, Shi M, Lei Y, Wang Y, Li M, Bian Y, Zhou Y, Xu H

“…Zhen Wang,1,* Chi Zhao,1,2,* Mengmeng Li,1,2,* Lili Zhang,1,* Jieyao Diao,1 Yiming Wu,2 Tao Yang,2 Mingwei Shi,2 Yang Lei,2 Yu Wang,3 Miaoxiu Li,4 Yanqin Bian,5 Yunfeng Zhou,1 Hui Xu1,2 1College of Acupuncture and Massage, Henan University of Chinese Medicine, Zhengzhou, People’s Republic of China; 2Acupuncture and Massage Department, The Third Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, People’s Republic of China; 3College of Computer Science, Xidian University, Xian, People’s Republic of China; 4College of Acupuncture and Massage, Shanghai University of Chinese Medicine, Shanghai, People’s Republic of China; 5Orthopaedic Research Laboratory, University of California, Davis, CA, USA*These authors contributed equally to this workCorrespondence: Hui Xu, Email 15036065036@163.comBackground: Tuina therapy has demonstrated its potential in modulating autophagy-related factors in knee osteoarthritis (KOA); however, its core therapeutic targets and specific mechanisms require systematic elucidation through interdisciplinary research.Objective: This study investigated the mechanism by which Tuina alleviates KOA progression using multidimensional approaches, including Mendelian randomization (MR), in vivo experiments, and machine learning.Methods: Genetic data from genome-wide association studies of 60 cytokines and KOA were analyzed using MR analysis to identify autophagy-related factors significantly associated with KOA. …”
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Role of Digoxin in Preventing Cigarette Smoke-Induced COPD via HIF-1α Inhibition in a Mouse Model by Zhang K, Zhou F, Zhu C, Yuan L, Li D, Wang J, Lu W

“…Therefore, in the present study, we chose digoxin as the inhibitor to investigate whether HIF-1α contributes to the progression in a mouse model of COPD and possible mechanism.Methods: The COPD model was established by cigarette smoke (CS) exposed; animals were intragastrically treated with vehicle or different doses of digoxin (0.02 mg/kg and 0.1 mg/kg). …”
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Uso de Moodle para fortalecer competencias ciudadanas en estudiantes de fisioterapia: un diseño pretest-postest (Use of Moodle to strengthen citizenship competencies in physiother... by Milena Boneth-Collante, Jorge Salazar-Rodríguez, Adriana Angarita-Fonseca

“…Objective: To improve citizenship competencies through a pedagogical strategy in the Moodle platform in students registered in the training courses of clinical/administrative physiotherapy practice at the University of Santander, Bucaramanga, Colombia. Methods: A pretest-posttest design was carried out. …”
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Xietu Hemu Prescription Improves Metabolic Dysfunction-Associated Steatotic Liver Disease: A Real-World Cohort Study by Xiang LL, Cao YT, Wang XX, Wang GX, Zhang YJ, Li RH, Qi F, Huai JX, Sun J, He XJ, Zhou XQ

“…Liu-lan Xiang,1,2,* Yu-tian Cao,1,2,* Xiao-xiao Wang,3,* Gao-xiang Wang,1,* Yu-juan Zhang,4 Rui-han Li,1,2 Fang Qi,5 Jia-xuan Huai,1,2 Jing Sun,1,2 Xiao-jin He,3 Xi-qiao Zhou1 1Department of Endocrinology, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, People’s Republic of China; 2The First Clinical Medical College of Nanjing University of Chinese Medicine, Nanjing, People’s Republic of China; 3Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, People’s Republic of China; 4Department of Endocrinology, Seventh People’s Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China; 5Department of Geriatrics, Panjin Liao-Oil Field Gem Flower Hospital, Liaoning, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xi-qiao Zhou, Email zhouxiqiao@njucm.edu.cn Xiao-jin He, Email xomaestro@163.comPurpose: This study aims to evaluate the efficacy of the Xietu Hemu prescription (XHP) in improving metabolic dysfunction-associated steatotic liver disease (MASLD) through a Real World Study approach.Methods: This was a single-center, prospective, real-world cohort study of 262 patients with MASLD who met the inclusion and exclusion criteria from November 2021 to November 2023 at Jiangsu Provincial Hospital of Traditional Chinese Medicine. …”
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Adverse drug reactions and contributing factors in patients with drug-resistant tuberculosis: A 7-year retrospective cohort study in Addis Ababa, Ethiopia by Bisrat Solomon, Yimtubezinash Woldeamanuel, Tigest Ajeme, Mbazi Senkoro, Tsegahun Manyazewal

“…This study aimed to assess the incidence of adverse drug reactions and contributing factors in patients on drug-resistant tuberculosis treatment in Addis Ababa, Ethiopia. Methods: A facility-based, retrospective cohort study was conducted on patients with drug-resistant tuberculosis who were followed up in two major drug-resistant tuberculosis treatment sites, St. …”
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The observance of maternal rights charter in labor with postpartum anxiety in mothers delivering at maternity hospitals by Marziye Shahpari, Mahnaz Zarshenas, Marzieh Akbarzadeh

“…The present study aimed to determine the relationship between maternal rights charter observance during labor and postpartum anxiety. Materials and methods: This was a cross-sectional study. We investigated the observance of maternal rights charter using a researcher-made questionnaire. …”
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Predicting Sleeping Disorders After mTBI: A Role for Inflammation and Brain Network Biomarkers by Du R, Yu Y, Zhu X, Wang R, Yang Y, Li Y, Zhang S, Su H

“…Rui Du,1,* Yue Yu,1– 4,* Xiwen Zhu,2 Ranchao Wang,1 Yu Yang,1 Yang Li,1 Subo Zhang,3 Hui Su4 1Department of Radiology, Zhenjiang First People’s Hospital, Zhenjiang, Jiangsu, People’s Republic of China; 2Department of Surgery, Lishui People’s Hospital, Nanjing, Jiangsu, People’s Republic of China; 3Department of Radiology, The Second People’s Hospital of Lianyungang, Lianyungang, Jiangsu, People’s Republic of China; 4Department of Radiology, Gaoyou People’s Hospital, Yangzhou, Jiangsu, People’s Republic of China*These authors contributed equally to this workCorrespondence: Subo Zhang, Department of Radiology, The Second People’s Hospital of Lianyungang, No. 41 Hailian East Road, Haizhou District, Lianyungang, Jiangsu, People’s Republic of China, Tel +0518-85775003, Email zhangsubolyg@126.com Hui Su, Department of Radiology, Gaoyou People’s Hospital, No. 10, Dongyuan Road, Gaoyou, Jiangsu, People’s Republic of China, Tel +86 18852869930, Email 18852869930@163.comPurpose: To predict the occurrence of sleeping disorders (SD) in patients with mild traumatic brain injury (mTBI) 3 months after injury.Methods: This study recruited a total of 232 patients with mTBI and underwent a three-month follow-up period. …”
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PPIH Expression Correlates with Tumor Aggressiveness and Immune Dysregulation in Hepatocellular Carcinoma by Bei J, Sun Z, Fu R, Huang X, Huang J, Luo Y, Li Y, Chen Y, Wei Z

“…This study investigates the role of Peptidyl-prolyl isomerase H (PPIH) in HCC by analyzing its expression, prognosis, methylation levels, and relationship with immune cell infiltration.Methods: We utilized bulk sequencing and clinical data from UCSC Xena and the GTEx database for preprocessing and subsequent differential expression analysis of PPIH in tumor and adjacent normal tissues, evaluating prognostic parameters like overall survival and disease-free interval between low and high PPIH expression groups. …”
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Dietary Habits, Anthropometric Values, and Microvascular Reactivity in Older Persons of Both Sexes Living at Retirement Home in Osijek, Croatia by Drenjančević I, Prošić I, Firi L, Stupin A, Jukić I

“…Huttlera 4, Osijek, 31000, Croatia, Tel +385912241406, Email ines.drenjancevic@mefos.hrPurpose: To examine the correlation between dietary habits, anthropometric measurements, and microvascular reactivity with respect to sex in older adults (aged > 65 years) residing in organized accommodation within retirement homes.Patients and Methods: Sixty-nine older persons who live in a retirement home in Osijek, Croatia volunteered to participate (34 men and 35 women) in this observational cross-sectional study. …”
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Prevalence of iron deficiency in acute and chronic heart failure according to different clinical definitions by Lukas Lanser, Gerhard Pölzl, Moritz Messner, Maria Ungericht, Marc‐Michael Zaruba, Jakob Hirsch, Stefan Hechenberger, Stefan Obersteiner, Bernhard Koller, David Haschka, Hanno Ulmer, Guenter Weiss

“…The aim of this analysis was to assess the true ID prevalence in HF patients on the basis of different ID definitions. Methods We performed a retrospective analysis of 329 AHF and 613 CHF patients, recruited between 02/2021 and 05/2022 at the Innsbruck Medical University (47%/32% female, median age 81/64 years). …”
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Effect of Neutrophil Elastase Inhibitor (Sivelestat Sodium) on Oxygenation in Patients with Sepsis-Induced Acute Respiratory Distress Syndrome by Wu T, Wang T, Jiang J, Tang Y, Zhang L, Jiang Z, Liu F, Kong G, Zhou T, Liu R, Guo H, Xiao J, Sun W, Li Y, Zhu Y, Liu Q, Xie W, Qu Y, Wang X

“…This trial aimed to evaluate the effect of sivelestat sodium on oxygenation in patients with sepsis-induced ARDS.Methods: We conducted a multicenter, double-blind, randomized, placebo-controlled trial enrolling patients diagnosed with sepsis-induced ARDS admitted within 48 hours of the advent of symptoms. …”
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Fear of Cataract Surgery and Vision Loss: The Effects of Health Literacy and Patient Comprehension at an Academic Hospital-Based Eye Clinic by Hu S, Wey S, Yano RA, Kelly LD

“…Samantha Hu,1 Stephanie Wey,1,2 Rainier Arthur Yano,1 Lisa Diane Kelly1,2 1University of Cincinnati College of Medicine, Cincinnati, OH, USA; 2University of Cincinnati Department of Ophthalmology, University of Cincinnati Medical Center, Cincinnati, OH, USACorrespondence: Samantha Hu, University of Cincinnati Department of Ophthalmology, 3130 highland Avenue, Cincinnati, OH, 45219, USA, Tel +1 720 879 3076, Fax +1 513 558 3108, Email hust@mail.uc.eduPurpose: This qualitative study assessed the relationship between health literacy and perceptions surrounding fear of cataract surgery and fear of vision loss in patients presenting to a Midwestern, urban, safety-net hospital-based clinic setting.Patients and Methods: Forty-two patients were recruited from the Hoxworth Eye Clinic at the University of Cincinnati Medical Center. …”
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Selective Deletion of HLA-B, and -C Class I Genes Promotes Immunocompatibility of Humanized Skin Graft Model by Cobos-Figueroa L, Notario L, Mir C, Molpeceres C, Lauzurica S, López D, Lorente E, Lauzurica P

“…Laura Cobos-Figueroa,1,2,* Laura Notario,1,* Carmen Mir,1 Carlos Molpeceres,2 Sara Lauzurica,2 Daniel López,1 Elena Lorente,1,* Pilar Lauzurica1,* 1Centro Nacional de Microbiología, Insituto de Salud Carlos III, Majadahonda, Madrid, Spain; 2Centro Láser, Universidad Politécnica de Madrid, Madrid, Madrid, Spain*These authors contributed equally to this workCorrespondence: Laura Notario, Centro Nacional de Microbiología, Insituto de Salud Carlos III, Ctra. de Pozuelo, 28, Majadahonda, Madrid, 28222, Spain, Tel +34 918223718, Email lnotario@isciii.esBackground: The treatment of extensive burns requires rapid allogeneic skin transplantation, but HLA diversity poses a significant challenge in finding histocompatible donor-recipient matches.Methods: In this study, we developed a humanized skin graft model using HLA class I transgenic mice to closely examine the HLA-mediated immune response in skin transplantation. …”
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The proportion of endometrial tumours associated with Lynch syndrome (PETALS): A prospective cross-sectional study. by Neil A J Ryan, Raymond McMahon, Simon Tobi, Tristan Snowsill, Shona Esquibel, Andrew J Wallace, Sancha Bunstone, Naomi Bowers, Ioana E Mosneag, Sarah J Kitson, Helena O'Flynn, Neal C Ramchander, Vanitha N Sivalingam, Ian M Frayling, James Bolton, Rhona J McVey, D Gareth Evans, Emma J Crosbie

“…The aim of this study was to establish the prevalence of LS and the diagnostic accuracy of LS testing strategies in an unselected EC population.<h4>Methods and findings</h4>This was a prospective cross-sectional study carried out at a large United Kingdom gynaecological cancer centre between October 2015 and January 2017. …”
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Comparison Between Low-Dose Esketamine and Dexmedetomidine on Postoperative Recovery Quality Among Patients Undergoing Humeral Trauma Surgery in Interscalene Brachial Plexus Block:... by Chen J, Qi Y, Zhang J, Sun B, Zhang M, Meng X, Zhou M, Wang L

“…In this report, we examined the effect of low-dose esketamine versus dexmedetomidine on postsurgical recovery among patients who underwent humerus surgery with interscalene brachial plexus block.Patients and Methods: In this prospective, randomized, controlled study, 141 patients aged 18 to 65 years who underwent humerus reduction and internal fixation were recruited. …”
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Development and Validation of a Predictive Nomogram for Myelosuppression Risk in Chronic Hepatitis B Patients Treated with Peginterferon by Fu J, Deng T, Zheng T, Shi P, Zhu W, Tao M, Wen Z, Wu X

“…In this study, we identified risk factors associated with increased myelosuppression, and incorporated them into a predictive nomogram.Patients and Methods: This study is designed as a case-control study. …”
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[Artículo traducido] Parámetros radiológicos preoperatorios correlacionados con la recidiva del hallux valgus después de una osteotomía en chevron distal by Y. Hernanz-González, J.C. Martínez-Ávila, E. Sánchez-Morata, A. Gómez-Sánchez, J.D. Serrano-Alonso, J. Vilá-Rico

“…The goal of this study was to analyze radiologic outcomes after distal chevron metatarsal osteotomy and to identify specific preoperative radiological parameters correlating with radiological recurrence. Materials and methods: One hundred twenty patients (134 feet) in patients with symptomatic moderate or severe HV deformity who underwent distal chevron metatarsal osteotomy at our hospital between 2014 and 2019 were included in the present study. …”
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Development and Validation of a Cost-Effective Machine Learning Model for Screening Potential Rheumatoid Arthritis in Primary Healthcare Clinics by Wu W, Hu X, Yan L, Li Z, Li B, Chen X, Lin Z, Zeng H, Li C, Mo Y, Wu Y, Wang Q

“…This study focuses on a screening model for primary healthcare, aiming to improve early RA screening accuracy and efficiency at a relatively lower cost, reducing delays in GPs’ recognition of RA.Methods: We randomly selected 2106 participants from the RA group or combined control group (comprising healthy individuals and patients with non-RA rheumatic diseases) at Peking University Shenzhen Hospital as the developing cohort. …”
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Effectiveness of Minimally Invasive Hepatectomy in Patients with Early or Intermediate-Stage Hepatocellular Carcinoma: A Multi-Institutional Cohort Study in an Asian Population by Chen HK, Chang KC, Shao SC, Soong RS, Chen YC, Wu CF, Wu TH, Chou TS, Chan SC, Lai ECC

“…However, the effectiveness of MIH has yet to be well established.Patients and Methods: This retrospective cohort study included patients aged 20 years and older, newly receiving MIH for HCC with Barcelona Clinic Liver Cancer (BCLC) classification stage 0, A or B from 2010 to 2019. …”
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Prognostic Factors and Nomogram for Klebsiella pneumoniae Infections in Intensive Care Unit by Du C, Zhang H, Zhang Y, Zhang H, Zheng J, Liu C, Lu F, Shen N

“…Therefore, we aimed to identify the risk factors for mortality in patients with K. pneumoniae infections and develop a nomogram model for prognosis.Methods: Patients diagnosed with K. pneumoniae infection were recruited from the intensive care unit of Peking University Third Hospital. …”
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