Immunological Efficacy and Safety of a New Pneumococcal Polysaccharide Conjugated Thirteen-Valent Vaccine in the Immunization of Adults and Children (Results of Clinical Studies in... by I. V. Feldblium, M. H. Alyeva, A. V. Bikmieva, V. V. Romanenko, O. A. Rychkova, A. N. Galustyan

“…To evaluate the immunological efficacy and safety of the pneumococcal polysaccharide conjugate adsorbed thirteen-valent (PCV13) vaccine in the immunization of adults and children in theRussian Federation.Materials and methods. The immunological efficacy and safety of the pneumococcal polysaccharide conjugated adsorbed thirteen-valent vaccine were studied in a prospective comparative randomized double-blind study in parallel groups in adult volunteers aged 18 to 65 years and a multicenter open comparative study in parallel groups in young children. …”
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Uncovering the Mechanisms of BaBaoWuDanYaoMo Against Influenza A Virus and Virus-Induced Inflammation Based on Network Pharmacology and Pharmacological Evaluation by Lei B, Su Y, Chen R, Chen Z, Liu B, Chen Y, Zhou M, Wang X, Ma Q

“…To predict its therapeutic targets via network pharmacology and verify the therapeutic effect and the mechanism of BB against influenza virus in vitro and in vivo.Material and Methods: The potential active and underlying mechanism of BB in the treatment of influenza virus was predicted through network pharmacological strategies and Molecular Docking. …”
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Utility of 131I-HLX58-Der for the Precision Treatment: Evaluation of a Preclinical Radio-Antibody-Drug-Conjugate Approach in Mouse Models by Liu Y, Wang X, Zhang N, He S, Zhang J, Xu X, Song S

“…Leveraging the radiosensitizing ability of Deruxtecan (DXd) and the internal radiation therapy of 131I for tumors, we aimed to develop the first radio-antibody-drug conjugates (RADCs) for the treatment of gastric cancer.Methods: The CLDN18.2-specific antibody HLX58 was conjugated with the payload DXd through a cleavable maleimide glycynglycyn-phenylalanyn-glycyn (GGFG) peptide linker. …”
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Spleen Volume Dynamics and Survival Outcomes in HCC Patients Undergoing Immune Checkpoint Inhibitors: A Retrospective Analysis by Fu X, Jiang S, Li Y, Guo Y, Gong B, Lou J, Li Y, Wang S, Sun Y, Ren Y, Chen Q, Yang L

“…This study investigated the prognostic impact of spleen volume (SV) on the survival in hepatocellular carcinoma (HCC) patients receiving immune checkpoint inhibitors (ICIs).Patients and Methods: This retrospective study included 224 HCC patients treated with ICIs, categorized into Higher and Lower SV groups by median SV and further into SV increased and Non-SV increased groups based on changes in SV at 3 months after ICIs. …”
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Narrow-Margin Treatment with Modified Mohs Microsurgery for Extramammary Paget’s Disease: A Retrospective Clinical Analysis by Yang J, Yan J, Luo H, Li L, Jiang L, Chen X, Wu L, Chai J, Xue H, Gan L, Liu Y, Chen J, Fei W, Bai Y, Zhu Q, Chen Z, Guo L, Chen Y

“…Jing Yang,1,* Jianna Yan,1,* Hao Luo,1 Liang Li,1 Long Jiang,1 Xuewen Chen,1 Ling Wu,1 Jingxiu Chai,1 Huan Xue,1 Leimeng Gan,1 Yeqiang Liu,2 Jia Chen,3 Wu Fei,2 Yun Bai,4 Quangang Zhu,5 Zhongjian Chen,5 Lehang Guo,6 Yuchong Chen1 1Department of Surgery, Shanghai Skin Disease Hospital Affiliated to Tongji University, Shanghai, People’s Republic of China; 2Department of Pathology, Shanghai Skin Disease Hospital Affiliated to Tongji University, Shanghai, People’s Republic of China; 3Department of Rheumatology and Immunology, Shanghai Skin Disease Hospital Affiliated to Tongji University, Shanghai, People’s Republic of China; 4Department of Central Laboratory, Shanghai Skin Disease Hospital Affiliated to Tongji University, Shanghai, People’s Republic of China; 5Department of Pharmacy, Shanghai Skin Disease Hospital Affiliated to Tongji University, Shanghai, People’s Republic of China; 6Department of Ultrasonography, Shanghai Skin Disease Hospital Affiliated to Tongji University, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yuchong Chen, Department of Dermatologic Surgery Division, Shanghai Skin Disease Hospital Affiliated to Tongji University, Shanghai, People’s Republic of China, Email 973309637@qq.comBackground: To investigate the clinical efficacy of narrow-margin modified Mohs microsurgery (mMMS) in the treatment of extramammary Paget’s disease (EMPD).Methods: A retrospective cohort review was conducted on 52 patients with EMPD who were treated at the Skin Disease Hospital of Tongji University in Shanghai between 2017 and 2023. …”
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Real-World Efficacy and Safety of Anti-PD-1 Antibody Plus Apatinib and Temozolomide for Advanced Acral Melanoma by Zhang J, Tian H, Mao L, Li C, Wei X, Gu J, Wang X, Zhou L, Lian B, Tang B, Yan X, Li S, Cui C, Chi Z, Sheng X, Guo J, Si L

“…The aim of this retrospective study was to evaluate the efficacy and safety of the triplet regimen for advanced AM in the real-world setting.Methods: The data of patients with advanced AM who received anti-PD-1 antibody plus apatinib and temozolomide at Peking University Cancer Hospital and Institute between September 2019 and December 2023 were analyzed. …”
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Predictive Potential of CRTP5 and SII for Coronary Artery Severity and Myocardial Fibrosis in Patients with NSTE-ACS: An Exploratory Biomarker Study by Ji J, Qiao M, Ding Y, Wei X, Wan D, Wu L, Liu H

“…Jinrui Ji,1,2,* Mu Qiao,3,4,* Ya’nan Ding,1,2,* Xiaoyun Wei,1,2,* Dongyu Wan,1,2,* Lei Wu,1,2,* Hengliang Liu1,2,* 1Clinical Medical Department, Faculty of Medicine, Henan University of Traditional Chinese Medicine, Zhengzhou, 450000, People’s Republic of China; 2Department of Cardiology, People’s Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, 450000, People’s Republic of China; 3Department of Cardiology, Seventh People’s Hospital of Zhengzhou, Zhengzhou, 450000, People’s Republic of China; 4Department of Cardiology, Zhengzhou Cardiovascular Institute, Zhengzhou, 450000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hengliang Liu, Department of Cardiology, People’s Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, 450000, People’s Republic of China, Email hnzzjjr@163.comPurpose: Findings from this research aim to enhance clinical assessments of coronary artery disease severity and myocardial fibrosis (MF).Methods: A total of 523 eligible non-ST-segment elevation acute coronary syndromes (NSTE-ACS) patients were included. …”
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Effectiveness of isoniazid preventive treatment among patients on antiretroviral treatment in Southeast Nigeria: A retrospective cohort study by Chukwuma David Umeokonkwo, Bello Segun, Patrick Nguku, Muhammad Shakir Balogun, Peter Nsubuga, Lilian Bulage, Adanna Anthonia Umeokonkwo, Olufunmilayo Ibitola Fawole

“…We compared the incidence of TB among adult HIV patients on ART who had received IPT for 6 months with those who had not received IPT and identified factors associated with the development of TB to in our operational context. Methods: We conducted a retrospective cohort study on adult HIV patients who commenced ART from January 2010 to December 2016. …”
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IN VITRO STUDY OF SUPERFICIAL ENAMEL LAYER OF PERMANENT TEETH DURING STAGE OF SECONDARY MINERALIZATION by G.M. Grigorenko, L.A. Khomenko, G.V. Sorochenko, L.M. Kapitanchuk

“…The aim of the research - in vitro study of the chemical composition and morphological structure of the superficial enamel layer of permanent teeth immediately after their eruption and 12 months later. Object and methods of the research. We used for the study 15 samples of enamel of permanent teeth (erupted not later than 6 months ago premolars of 11-13 years old children). …”
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Glioma-Associated Mesenchymal Stromal/Stem Cells Derived Exosomal miR-191 Promotes the Proneural-to-Mesenchymal Transition in Glioblastoma Cells via PTEN/PI3K/AKT Signaling by Lv P, Zhang Y, Zhao Z, Wu W, Zhou Y, Liu Z, Wang H, Jiang X, Li S, Yan P, Huang X, Xiang W, Fu P

“…This study aimed to explore the effects and mechanisms of GaMSCs-derived exosomal miRNA-191-5p on the PMT of glioblastoma.Methods and Results: Conditioned medium from three independently established GaMSCs lines (GaMSCs-CM) significantly enhanced the tumorigenicity of glioma cells. …”
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Protective Effect of Resveratrol on Exercise-induced Kidney Injury in Rats by Regulating Keap1-Nrf2 Signaling Pathway by Haitao ZHOU, Ge HU, Jing ZHANG, Qiyun ZHOU, Fei QIN

“…Objective: To investigate the protective mechanism of resveratrol on exercise-induced kidney injury in rats. Methods: Thirty-two 7-week-old SPF-grade male SD rats were randomly assigned to four groups: control group (CONT, n=8), resveratrol group (RESV, n=8), exercise-induced kidney injury model group (EIKIM, n=8), and resveratrol-treated exercise-induced kidney injury group (REIKIM, n=8). …”
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Cifoplastia con silicona (elastoplastia) versus cifoplastia tradicional con cemento para fracturas vertebrales osteoporóticas. ¿Esta nueva técnica reduce las complicaciones? by R. Luque, D. Garríguez, P. Checa Betegon, M. Sanchez, M. Olvera, J.L. Perez Gonzalez, I. Dominguez Esteban

“…This study's objective is to compare the results between kyphoplasty with bone cement and with the VK100 silicone. Materials and methods: This is a comparative, prospective study involving 64 patients, 23 treated using VK100 and 41 with PMMA. …”
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Acupuncture Modulates Spatiotemporal Neuronal Dynamics in Mild Cognitive Impairment: A Protocol for Simultaneous EEG-fMRI Study by Li YQ, Chen ZW, He H, Liu YW, Ye F, Yang ZQ, Li DH, Bao QN, Zhang XY, Zhong WQ, Wu KX, Yao J, Xu P, Yang SQ, Wang ZW, Yin ZH, Liang FR

“…However, no studies have investigated the detailed mechanisms underlying this effect.Methods: This randomized controlled neuroimaging trial will enroll 60 patients with MCI, who will be randomly assigned to one of two groups: a real acupuncture (RA) group or a sham acupuncture (SA) group. …”
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Targeted Next-Generation Sequencing in Pneumonia: Applications in the Detection of Responsible Pathogens, Antimicrobial Resistance, and Virulence by Liu B, Bao Z, Chen W, Xi X, Ge X, Zhou J, Zheng X, Zhang P, Deng W, Ding R, Zhou M, Fang J

“…We aimed to explore the applicability of tNGS in the co-detection of the responsible pathogens, antimicrobial resistance (AMR) genes, and virulence genes in patients with pneumonia.Methods: A prospective study was conducted among patients with suspected pneumonia at Ruijin Hospital from March 1 to May 31, 2023. …”
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The efficacy of moxibustion on the pressure pain threshold and substance P / leukotriene B4 contents in serum to patients with rheumatoid arthritis by Siyu Tao, Yi Yang, Jie Tang, Xue Wang, Nannan Jiang, Yuan Li, Ping Wu

“…Objective: To observe the effects of moxibustion on pressure-pain thresholds (PPTs) in affected joints and non-joint areas, as well as the contents of substance P (SP) and leukotriene B4 (LTB4) in serum of patients with rheumatoid arthritis (RA), and to explore the analgesic mechanism of moxibustion in RA patients. Methods: A total of 72 patients with RA were randomly and equally classified into the control and treatment groups. …”
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Effect of Different Doses of Intrathecal Nalbuphine as Adjuvant to Hyperbaric Bupivacaine on Characteristics of Subarachnoid Block in Pelvic and Lower Limb Orthopaedic Surgeries: A... by Anupama Kumari, Shraddha Jogani, Nilesh Shah, Sara Mary Thomas

“…Aim: To compare the sensory and motor blockade, time of two-segment regression, time for rescue analgesia, haemodynamic effects and sedative effects between hyperbaric 0.5% levobupivacaine and hyperbaric 0.75% ropivacaine. Materials and Methods: This prospective, double-blinded and randomised clinical study was conducted in the Department of Anaesthesiology, Shrimati Bhikhiben Kanjibhai Shah Medical Institute and Research Centre (a tertiary care institute), Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara, Gujarat, India, from September 2023 to July 2024, with a sample size of 40 patients. …”
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Second Victim Syndrome Among Healthcare Professionals: A Systematic Review of Interventions and Outcomes by Ong TSK, Goh CN, Tan EKYE, Sivanathan KA, Tang ASP, Tan HK, Ng QX

“…This systematic review aimed to synthesize the evidence on the outcomes of available interventions targeting SVS.Methods: We systematically searched MEDLINE, Embase, and the Cochrane Library databases, covering all records up to July 7, 2024. …”
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Effects of exercise intensity on soleus muscle myostatin and follistatin levels of hyperglycaemic rats (Efectos de la intensidad del ejercicio sobre la miostatina y folistatina de... by Sepideh Azhir, Eidy Alijani, Sergio Francisco Martínez Huenchullán, Hamid Amni, Julien Baker, Farid Farhani

“…The purpose of this study was to compare two training programs, moderate-intensity constant (MICT) and high-intensity interval training (HIIT), on soleus mRNA levels of Mstn and Fs in an animal model of hyperglycaemia. Material and Methods: 36 male Wistar rats, were divided into control (n=18) and hyperglycaemic (HG, n=18; induced by a single intraperitoneal dose of Streptozotocin) groups. …”
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TRAP1 Improves Diabetic Retinopathy by Preserving Mitochondrial Function by Li Y, Xu W, Zhao G, Guo Y, Wang L, Du Q, Fei Y, Hu X, Hu H, Chen L, Xu Y

“…Tumor necrosis factor-associated protein 1 (TRAP1), a mitochondrial chaperone regulating stress responses, remains unexplored in DR pathogenesis.Methods: We established in vivo and in vitro models of DR. …”
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Investigation into the Efficacy of Formic Acid Fumigation for Inactivating Clinically Isolated Filamentous Fungi by Yuan K, Tian B, Zhan A, Chen Z, Ye L, Ling Y, Liu S, Bai X, Zhao Y

“…We aim to develop an efficient inactivation protocol for molds and provide valuable insights into laboratory techniques for fungal inactivation.Methods: Initially, 238 clinical isolates from 23 species of molds were evaluated for the inactivation efficacy of formic acid, formaldehyde, and peracetic acid. …”
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