Regulatory Effects of Zhenxin Formula in Treating Doxorubicin-Induced Heart Failure: Network Pharmacology and Animal Experimental Verification by Wu Q, Wang H, Wang YH, Du J, Li B, Gan XN, Liu CY, Liang J, Liu C, Cao M

“…Qiong Wu,1,* Hao Wang,2,* You Hua Wang,1 Jun Du,3 Bo Li,3 Xiao-Na Gan,3 Chen-Yang Liu,2 Jing Liang,2 Chang Liu,2 Min Cao2 1Department of Cardiology, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China; 2Department of Emergency, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China; 3Nutrilite Health Institute, Amway (China) R&D Center, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Chang Liu, Department of Emergency, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Xunhui, 725 South Wan-Ping Road, Shanghai, 200032, People’s Republic of China, Tel +862164385700, Email doctorlchang@163.com Min Cao, Department of Emergency, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Xunhui, 725 South Wan-Ping Road, Shanghai, 200032, People’s Republic of China, Tel +862164385700, Email caomin_cm@163.comObjective: This study aimed to elucidate the mechanisms underlying the protective effects of Zhenxin Formula (ZXF) against doxorubicin (Dox)-induced HF through the integration of network pharmacology, phospho-antibody array analysis, and experimental validation.Methods: The active components and potential targets of ZXF were identified via the Traditional Chinese Medicine Systems Pharmacology (TCMSP) platform, while HF-associated target genes were retrieved from the OMIM, Genecards, and TTD databases. …”
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Prevalence of CYP2C19 Variants in Patients with Cardiovascular Disease from the Yunnan-Guizhou Plateau in Southwestern China by Li XP, Wang JL, Lei SX, Chen BY, Ma X, He F, Yue CF, Liu HX, Hu JP, Xiong Q, Ji T, Zhang ZF, Sun Y, Li HW

“…Here, differences in CYP2C19 alleles, genotypes, and phenotypes in patients with cardiovascular disease from the Yunnan-Guizhou Plateau were systematically surveyed to provide a reference for appropriate treatment approaches.Methods: The CYP2C19*2, *3, and *17 variants were determined by RT-qPCR in 1934 patients with cardiovascular disease from 10 different areas of the Yunnan-Guizhou Plateau. …”
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Continuous Flow Ventilatory Support (Clinical Experience) by Pavol Török, Peter Сandík, Ján Šalantay, Milan Májek, Ján Kolník

“…Despite the use of different forms of ventilatory support, disconnection of patients from artificial ventilation is unsuccessful in 10—30% of cases despite the fact that the clinical and biochemical criteria are met.Objective: to discuss the efficiency of the new ventilation regime — continuous flow ventilatory support in the clinical setting.Methods: continuous flow ventilatory support with an original licensed multi-jet insufflation catheter or a terminal one-orifice catheter nasally inserted into the trachea was applied to 70 patients. …”
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Optimal Utilization of Donors Aged ≥65 Y in Lung Transplantation to Increase Donor Availability While Maintaining Comparable Posttransplant Outcomes by Marniker A. Wijesinha, PhD, Maksim Korotun, DO, Michael L. Terrin, MD, Craig J. Fryman, MD, Manish R. Mohanka, MD, Si M. Pham, MD, Aldo T. Iacono, MD

“…Utilizing older donors (≥65 y) in lung transplantation can greatly expand donor availability while potentially maintaining typical survival outcomes in certain subpopulations, such as older recipients, especially compared to survival with single lung transplants (which comprise ~20%–25% of US lung transplants according to recent data). Methods. This study included US adult lung transplants from 2010 to 2021 in the Scientific Registry for Transplant Recipients. …”
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Predictive Significance of the Monocyte-to-High-Density Lipoprotein Cholesterol Ratio in Post-Percutaneous Coronary Intervention Contrast-Induced Nephropathy Among Patients with Co... by Lin A, Peng Y, Shao J, Chen L, Lin Y

“…Aijie Lin,1,* Yanchun Peng,2,* Jiayi Shao,1 Liangwan Chen,3 Yanjuan Lin2,4 1School of Nursing, Fujian Medical University, Fuzhou, Fujian, People’s Republic of China; 2Department of Nursing, Fujian Medical University Union Hospital, Fuzhou, Fujian, People’s Republic of China; 3Department of Cardiac Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian, People’s Republic of China; 4Department of Cardiac Surgery Nursing, Fujian Medical University Union Hospital, Fuzhou, Fujian, People’s Republic of China*These authors contributed equally to this workCorrespondence: Liangwan Chen, Department of Cardiac Surgery, Fujian Medical University Union Hospital, No. 29 Xinquan Road, Fuzhou, Fujian, 350001, People’s Republic of China, Email fjxhlwc@163.com Yanjuan Lin, Department of Nursing, Fujian Medical University Union Hospital, No. 29 Xinquan Road, Fuzhou, Fujian, 350001, People’s Republic of China, Email fjxhyjl@163.comPurpose: This study aimed to examine the connection between monocyte-to-high-density lipoprotein cholesterol ratio (MHR) and contrast-induced nephropathy (CIN) and to introduce a novel perspective to early clinical diagnosis of CIN.Patients and Methods: This single-center bidirectional cohort study included 1771 patients with coronary artery disease (CAD) who underwent elective percutaneous coronary intervention (PCI) from January 2017 to July 2022 at the Fujian Medical University Union Hospital. …”
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Clinical Characteristics and Independent Risk Factors for Multidrug-Resistant Klebsiella pneumoniae Bloodstream Infections: A Retrospective Analysis from China by Xu P, Mao Y, Chen Q, Luo X, Lin R, Zheng C

“…Panpan Xu,1,* Yifeng Mao,1,* Qingqing Chen,2,3,* Xinhua Luo,4 Ronghai Lin,1 Cheng Zheng1 1Department of Critical Care Medicine, Taizhou Municipal Hospital (Taizhou University Affiliated Municipal Hospital), School of Medicine, Taizhou University, Taizhou, Zhejiang, 318000, People’s Republic of China; 2Rehabilitation Center, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, Zhejiang, 318000, People’s Republic of China; 3Neurorehabilitation Center, Taizhou Rehabilitation Hospital, Taizhou Enze Medical Center (Group), Taizhou, Zhejiang, 318000, People’s Republic of China; 4Department of Clinical Microbiology Laboratory, Taizhou Municipal Hospital (Taizhou University Affiliated Municipal Hospital), School of Medicine, Taizhou University, Taizhou, Zhejiang, 318000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Cheng Zheng, Department of Critical Care Medicine, Taizhou Municipal Hospital (Taizhou University Affiliated Municipal Hospital), School of Medicine, Taizhou University, Taizhou, Zhejiang, 318000, People’s Republic of China, Email dr.zhengcheng@foxmail.com Ronghai Lin, Department of Critical Care Medicine, Taizhou Municipal Hospital (Taizhou University Affiliated Municipal Hospital), School of Medicine, Taizhou University, Taizhou, Zhejiang, 318000, People’s Republic of China, Email tylinrh@163.comPurpose: This study aimed to analyze the clinical characteristics and risk factors of multidrug-resistant Klebsiella pneumoniae bloodstream infections (MDR KP-BSI) compared to non-MDR KP-BSI among adult patients in China, providing guidance for clinicians to prevent MDR KP-BSI.Patients and Methods: A retrospective analysis of 240 adult patients with KP-BSI (2019– 2023) was conducted. …”
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COTE and Pulmonary Comorbidities Predict Moderate-to-Severe Acute Exacerbation and Hospitalization in COPD by Chen Q, Wang X, Yao X, Zhang L, Liu X

“…Qinglin Chen,1,* Xinmao Wang,1,* Xiujuan Yao,1 Luo Zhang,2– 4 Xiaofang Liu1 1Department of Respiratory and Critical Care Medicine, Beijing Tongren Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Beijing Laboratory of Allergic Diseases, Beijing Municipal Education Commission, Beijing, People’s Republic of China; 3Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, People’s Republic of China; 4Key Laboratory of Otolaryngology Head and Neck Surgery of Ministry of Education of China, Beijing Institute of Otolaryngology, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaofang Liu, Department of Respiratory and Critical Care Medicine, Beijing Tongren Hospital, Capital Medical University, No.2, Xinanhuan Road, Yizhuang District, Beijing, 100176, China, Email xfliutrhos@163.com Luo Zhang, Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University; Key Laboratory of Otolaryngology Head and Neck Surgery of Ministry of Education of China, Beijing Institute of Otolaryngology, No. 17, Hougou Hutong, Chongnei, Dongcheng District, Beijing, 100730, China, Email dr.luozhang@139.comPurpose: The aim of this study was to explore the predictive value of the chronic obstructive pulmonary disease (COPD) specific comorbidity test index (COTE) and pulmonary comorbidities for moderate-to-severe acute exacerbation and hospitalization in COPD patients.Patients and Methods: This was a retrospective cohort study. …”
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Impact of COVID-19 lockdown-associated visitor restrictions on mother-child interaction and emotional state of women in the puerperium – a retrospective cohort study by Irina Höhn, Anett Hernadi, Reto Zihlmann, Christina Coelius, Katharina Walter, Amr Hamza, Nicole Ochsenbein-Kölble, Leonhard Schäffer

“…As secondary endpoints, we defined the influence of the restrictions on breastfeeding, the length of hospital stay, patient satisfaction during the inpatient stay due to the reduced number of visitors, and postpartum complications after discharge. MATERIALS AND METHODS:The study was conducted at a university-affiliated teaching hospital in Switzerland. …”
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Survival Benefit of Adjuvant Treatment with Huaier Granules Plus Lenvatinib in Hepatocellular Carcinoma Patients with Tumors Greater Than 5 cm After Radical Hepatectomy by Liu C, Bai Y, Bai Q, Parra MA, Zhao L, Zou J, Cao Q, Liu H, Yang H

“…This study investigated potential adjuvant treatment strategies for HCC patients who exhibit multiple recurrence factors after radical resection.Methods: A retrospective analysis was conducted on data from 243 patients who underwent radical resection for HCC and exhibited high recurrence factors at the First Affiliated Hospital of Harbin Medical University. …”
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Spatial Epidemiologic Analysis of Fetal Birth Defects in Guangxi, China by Peng Z, Huang X, Wei J, Chen B, Liang L, Feng B, Wei Q, He S

“…Zhenren Peng,1– 5,* Xiuning Huang,4,5,* Jie Wei,4,5,* Biyan Chen,4,5 Lifang Liang,4,5 Baoying Feng,4,5 Qiufen Wei,1– 5 Sheng He1– 5 1Birth Defects Research Laboratory, Guangxi Clinical Research Center for Birth Defects, Nanning, 530002, People’s Republic of China; 2Birth Defects Research Laboratory, Guangxi Key Laboratory of Reproductive Health and Birth Defect Prevention, Nanning, 530002, People’s Republic of China; 3Birth Defects Research Laboratory, Guangxi Clinical Research Center for Pediatric Diseases, Nanning, 530002, People’s Republic of China; 4Birth Defects Research Laboratory, Birth Defects Prevention and Control Institute of Guangxi Zhuang Autonomous Region, Nanning, 530002, People’s Republic of China; 5Birth Defects Research Laboratory, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530002, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qiufen Wei, Birth Defects Research Laboratory, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, No. 59 Xiangzhu Avenue, Nanning, Guangxi Zhuang Autonomous Region, 530002, People’s Republic of China, Email Wqf2024@163.com Sheng He, Birth Defects Research Laboratory, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, No. 59 Xiangzhu Avenue, Nanning, Guangxi Zhuang Autonomous Region, 530002, People’s Republic of China, Email heshengbiol@163.comPurpose: To apply various spatial epidemiological approaches to detect spatial trends and geographical clusters of birth defects (BDs) prevalence in Guangxi, China, and to explore the risk factors for BDs.Methods: Between 2016 and 2022, the Guangxi Birth Defects Monitoring Network (GXBDMN) monitored a total of 4.57 million fetuses in this study. …”
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RGD-Functionalized Ginsenoside Rg3 Liposomes for Alleviating Oxidative Stress and Choroidal Neovascularization in Age-Related Macular Degeneration by Zhou J, Zhao D, Niu S, Meng W, Chen Z, Li H, Liu Y, Zou L, Li W

“…This study aimed to develop a multitargeted therapeutic strategy for AMD by leveraging the antioxidant and anti-angiogenic properties of ginsenoside Rg3 (Rg3).Methods: RGD-Rg3@Lips was formulated to encapsulate Rg3 and modified with (Arginine-Glycine-Aspartic Acid, RGD) peptides for targeted delivery. …”
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Insulin-Like Growth Factor Binding Protein, Acid-Labile Subunit Serum Level During the Acute and Convalescent Stage of SARS-CoV-2 Infection Depicted in a Longitudinal Study of 72 P... by Gad H, Mahmoud MA, Antar M, Sayed Ahmed A, Laudanski K

“…Here, we investigate if serum IGFALS during the acute response to SARS-CoV-2 will not be likely to accompany immune response during acute phase and convalescence.Patients and Methods: We recruited patients hospitalized with PCR-confirmed SARS-CoV-2 infection in 2020 and have blood collected after securing consent (tadm), at 48 hours (t48hrs), 7 days (t7d), and after discharge from hospital (tlong). …”
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The contribution of personalized video feedback to robotic partial nephrectomy training in realistic 3D tumor kidney models: design, production and implementation by Ahmet Furkan Sarıkaya, Kayhan Tarım, Ersin Köseoğlu, Arif Özkan, İbrahim Can Aykanat, Baris Esen, Umut Can Karaarslan, Mustafa Müdüroğlu, Şevval Kanlı, Murat Can Kiremit, Yakup Kordan, Mevlana Derya Balbay, Tarık Esen, Serdar Aydın, Serdar Aydın, Abdullah Erdem Canda, Abdullah Erdem Canda

“…This study investigates the impact of 3D-printed renal models and video-based feedback on skill acquisition in robotic partial nephrectomy training.MethodsForty urology residents without prior robotic surgery experience participated in this study. …”
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Analysis of Cardiotoxicity and Risk Factors of Breast Cancer Chemotherapy Drugs: A Five-Year Single-Centre Retrospective Study in Early Breast Cancer by Ju F, Gu H, Yu L, Zhao G, Liu Y, Yin D, Niu J, Xue T, Yin C, Jiao L, Li C, Wu J, Ji Y

“…Feng Ju,1,* Hong Gu,1,* Lijiang Yu,2 Guangyu Zhao,1 Yin Liu,1 Dengyang Yin,1 Jiali Niu,1 Ting Xue,1 Chunxia Yin,1 Lingyun Jiao,1 Chaoqun Li,1 Jian Wu,3 Yong Ji4 1Department of Pharmaceutical Administration, Jingjiang People’s Hospital Affiliated to Yangzhou University, Jingjiang, Jiangsu, 214500, People’s Republic of China; 2Department of Oncology, Jingjiang People’s Hospital Affiliated to Yangzhou University, Jingjiang, Jiangsu, 214500, People’s Republic of China; 3Department of Rehabilitation, Jingjiang People’s Hospital Affiliated to Yangzhou University, Jingjiang, Jiangsu, 214500, People’s Republic of China; 4Department of General Surgery, Jingjiang People’s Hospital Affiliated to Yangzhou University, Jingjiang, Jiangsu, 214500, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jian Wu, Department of Rehabilitation, Jingjiang People’s Hospital Affiliated to Yangzhou University, No. 28, Zhongzhou Road, Jingjiang, Jiangsu, 214500, People’s Republic of China, Tel +86 0523-84995225, Email wu_wuwujianhh1201@21cn.com Yong Ji, Department of General Surgery, Jingjiang People’s Hospital Affiliated to Yangzhou University, No. 28, Zhongzhou Road, Jingjiang, Jiangsu, 214500, People’s Republic of China, Tel +86 0523-84995225, Email jiyong_jy615@163.comObjective: To investigate the cardiotoxicity of breast cancer (BC) chemotherapy drugs and analyse their risk factors.Methods: Through the electronic medical record system, the data of 415 patients with early BC (EBC) who had undergone a complete chemotherapy cycle were retrospectively collected within 5 years from the beginning of chemotherapy. …”
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Impact of Subsequent Treatment on Clinical Outcomes in Patients with EGFR-Mutant Non-Small Cell Lung Cancer Transformed to Small-Cell Lung Cancer by Chen CY, Ko HW, Hu PW, Chang CY, Chen CY, Chang SC, Chiu YC, Wei YF

“…This study aimed to investigate the clinical factors and treatments associated with outcomes in this group.Patients and Methods: This retrospective multicenter study enrolled patients with SCLC transformed from advanced NSCLC after progression on EGFR-TKI treatment. …”
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A Statistical Approach to Assess Biological Equivalent Mean Organ Dose (MOD) for Different Fractionations in Thoracic Radiotherapy by Siyao Zhong, Guangshan Wang, Xiaohang Qin, Yinghui Li, Bin Sun, Feng-Ming (Spring) Kong, Yuyan Gao, Jian-Yue Jin

“…<b>Purpose:</b> This study aims to provide an approach that can reasonably estimate the possibility of toxicity using a biological equivalent mean organ dose (MOD)-based model from the 2 Gy per fraction era for various fractionations. <b>Methods and Materials:</b> The dose volume histograms (DVHs) of 272 patients treated with radiotherapy for lung cancer at a prescribed dose of 2 Gy × 30 f were used for analysis. …”
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Adherence to Medical Treatment in Elderly Patients with Coronary Artery Disease in the Settings of Primary Outpatient Care by S. K. Zyryanov, S. B. Fitilev, A. V. Vozzhaev, I. I. Shkrebneva, N. N. Shindryaeva, D. A. Klyuev, L. N. Stepanyan, A. M. Lutsenko, A. T. Tsai, A. A. Danilova

“…To study medication adherence in elderly patients with coronary artery disease (CAD) in primary care practice.Material and methods. The study conducted in out-patient clinic of Moscow city. 293 elderly (≥65 years) patients with established CAD included. …”
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Distinct Airway Microbiome and Metabolite Profiles in Eosinophilic and Neutrophilic Asthma by Liu S, Lin Z, Zhou J, Yang X, You L, Yang Q, Li T, Hu Z, Zhan X, Jiang Y, Sun B

“…While allergen triggers are well-known, the role of the airway microbiome and metabolites in asthma exacerbations remains poorly understood.Methods: We recruited 64 participants (24 EA, 20 NEA, 20 healthy controls [HC]) for the discovery cohort, with validation in an external cohort (10 EA, 8 NEA, 8 HC). …”
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Comparing cervical cerclage, pessary and vaginal progesterone for prevention of preterm birth in women with a short cervix (SuPPoRT): A multicentre randomised controlled trial. by Natasha L Hezelgrave, Natalie Suff, Paul Seed, Vicky Robinson, Jenny Carter, Helena Watson, Alexandra Ridout, Anna L David, Susana Pereira, Fatemeh Hoveyda, Joanna Girling, Latha Vinayakarao, Rachel M Tribe, Andrew H Shennan, SuPPoRT Collaborating Team

“…The SuPPoRT "Stitch, Pessary, or Progesterone Randomised Trial" was designed to compare the rate of PTB <37 weeks between each intervention in women who develop a short cervix in pregnancy.<h4>Methods and findings</h4>SuPPoRT was a multicentre, open label 3-arm randomised controlled trial designed to demonstrate equivalence (equivalence margin 20%) conducted from 1 July 2015 to 1 July 2021 in 19 obstetric units in the United Kingdom. …”
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Rapid Initiation of Antiretroviral Therapy Suppresses T Cell Pathological Proliferation and Improves Immune Recovery in People Living with HIV by Ji J, Guo C, Li Z, Cai M, Wang R, Chen X, Zhang Y, Wu H, Zhang T, Zhang Y

“…The objective of this research is to examine how rapid ART affects T-cell pathological proliferation, immune recovery, and systemic inflammation in PWH.Patients and Methods: In this cross-sectional study (conducted at Beijing Youan Hospital, Capital Medical University, China, from April 1 to September 18, 2022), we recruited 39 PWH, including 23 in the rapid ART group (within 30 days) and 16 in the non-rapid ART group (after 180 days). …”
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