Grass hay mixed-in creep feed or separately-fed differentially affects digestive development in pre- and post-weaning piglets by Renjie Yao, Tetske G. Hulshof, Hubèrt M. J. van Hees, An Cools, Mattijs Merckx, Dominiek Maes, Geert P. J. Janssens

“…This study investigated the effect of grass hay offered to suckling piglets either separately or included in their creep feed, combined with nursery diets with or without grass pellet inclusion on growth performance and gastrointestinal development. Methods Thirty-six litters (14–15 piglets per litter) were divided into three equal groups of 12 litters per treatment during the suckling phase: control group (CON) received regular creep feed; GH group received chopped grass hay as-is in separate feeders alongside regular creep feed; PGH group received regular creep feed but barley and wheat were replaced by 28% grass pellets. …”
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Adipose-Derived Mesenchymal Stem Cells Accelerate Diabetic Foot Ulcer Healing by Promoting Macrophage M2 Polarization Through Downregulation of EREG and CSTA by Cao J, Zhang X, Li Z, Zhang S, Guo L, Liu Z, An W, Xu L, Li L, Long X, Yang Y

“…This study aims to identify macrophage polarization-associated molecules in DFU and explore whether ADSCs promote DFU healing by regulating these molecules.Patients and Methods: Macrophage polarization-associated differentially expressed genes (MA-DEGs) were screened from GSE134431 and GSE80178 datasets. …”
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Nonshrinkable Thermosensitive Hydrogels Combined with Bispecific Anti-PSMA/CD3 T-Cell Engager for Effective Against Tumors in Mice Model by Wei PS, Chou PY, Hsu HY, Chen M, Chen YJ, Tsai TH, Wen BY, Sheu MT, Chuang KH, Lin HL

“…Innovative delivery systems, like thermosensitive hydrogels, show the potential to enhance stability, sustained release, and therapeutic efficacy.Methods: We developed PEGylated PLGA (PEG–PLGA) thermosensitive hydrogels with a nonshrinkable property (nsTPPgels) for effective controlled release and loaded them with bispecific anti-prostate surface membrane antigen (PSMA) Fab/anti-CD3 scFv T-cell engager (BiPTE) to form in situ drug deposits with a sustained-release profile after subcutaneous injection. …”
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Clinical Characteristics and Mechanism Discussion of Peripheral Nerve Injury in 2 Cases of Severe Viral Meningoencephalitis by Guo X, Zheng M, Wei Z, Song J, Wang X, Shen Z, Guo X, Zhang N, Xing Y, Zhang Y, Zhang W, Du R, Qiu B, Tian S, Wang Z

“…This study analyze the prognosis, clinical characteristics, and outcomes of patients with PN secondary to CNS infections to aid early diagnosis and improve prognosis.Methods: Clinical data from two patients admitted to our Neurology Department with PN secondary to severe viral meningoencephalitis were collected, summarized, and analyzed. …”
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Comparative Effectiveness and Safety of Molecular Targeted Therapy Plus PD-(L)1 with or without TACE in Unresectable Hepatocellular Carcinoma: A Retrospective Study by Liu J, Wang Y, Cui L, Nie Y, Li C, Tan W, Li Y, Bai Y, Wan T, Hu B, Liu Z, Hu M, Wang M, Duan F

“…Jiangtao Liu,1,* Yan Wang,2,* Li Cui,2 Yan Nie,1 Chao Li,1 Wenle Tan,2 Ye Li,1 Yanhua Bai,1 Tao Wan,3 Bingyang Hu,3 Zhe Liu,3 Minggen Hu,3 Maoqiang Wang,2 Feng Duan2 1Department of Gastroenterology, Hainan Hospital of Chinese People’s Liberation Army (PLA) General Hospital, Sanya, Hainan, 572000, People’s Republic of China; 2Department of Interventional Radiology, Chinese People’s Liberation Army (PLA) General Hospital, Beijing, 100853, People’s Republic of China; 3Faculty of Hepato-Biliary-Pancreatic Surgery, Chinese People’s Liberation Army (PLA) General Hospital, Beijing, 100853, People’s Republic of China*These authors contributed equally to this workCorrespondence: Feng Duan, Email duanfeng@vip.sina.comObjective: This study aims to compare the effectiveness and safety of TACE combined with molecular targeted therapy (MTT) plus Programmed death-ligand 1 (PD-(L)1) antibodies versus MTT plus PD-(L)1 antibodies for HCC patients.Methods: Data from HCC patients who received either MTT plus PD-(L)1 (systemic therapy group) or TACE combined with MTT plus PD-(L)1 (combination therapy group) were retrospectively analyzed. …”
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Unravelling the Information Contained in the Single Items of the COPD Assessment Test for Different Outcomes and Smoking Status in Patients with COPD: Results from COSYCONET by Alter P, Kahnert K, Trudzinski FC, Bals R, Watz H, Speicher T, Söhler S, Rabe KF, Wouters EFM, Vogelmeier CF, Jörres RA

“…We evaluated the information that each of the questions and the total score contributed to outcomes and characteristics of chronic obstructive lung disease (COPD), including their dependence on smoking status.Methods: Patients with COPD of the COSYCONET cohort with Global Initiative for Chronic Obstructive Lung Disease (GOLD) grades 1– 4 and the former grade 0 were included. …”
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Risk and Prognostic Factors for Bloodstream Infections Due to Clonally Transmitted Acinetobacter baumannii ST2 with armA, blaOXA-23, and blaOXA-66: A Retrospective Study by Ji J, Chen W, Jiang P, Zheng J, Shen H, Liu C, Zhang Y, Liao X, Yang Z, Cao X, Wu C

“…The risk and prognostic factors for BSIs caused by clonally transmitted A. baumannii ST2, carrying armA, blaOXA-23 and blaOXA-66, remain unclear.Methods: We retrospectively analyzed 97 hospitalized patients with A. baumannii BSI (January 2019–May 2022). …”
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ASSESSMENT OF THE OCCLUSAL RELATIONS NATURE AT THE STAGES OF ORTHOPEDIC REHABILITATION OF PERSONS WITH PERIODONTAL TISSUE DISEASES COMPLICATED BY DENTITION DEFECTS by О.V. Bida, О.V. Bida

“…The aim of the study is to improve the effectiveness of orthopedic treatment of periodontal diseases complicated by defects of the dentition with the control of occlusal relationships with a computerized T-Scan III system. Materials and methods. We have examined 87 persons aged between 30 and 69 years with generalized periodontitis of I – III severity, complicated by partial loss of teeth of different sizes and topography, and a control group of the same age in 10 patients with intact dentition and physiological forms of occlusion without clinically diagnosed periodontal diseases. …”
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Socioeconomic inequalities in patient-reported outcome measures among total hip and knee arthroplasty patients: a comprehensive analysis of instruments and domains by Joshua M. Bonsel, Max Reijman, Erin M. Macri, Jan A. N. Verhaar, Liza N. van Steenbergen, Gouke J. Bonsel

“…This study explores which self-reported PROMs and their specific domains are most involved. Methods We obtained data from the Dutch Arthroplasty Registry (2014–2022), including over 100,000 THA/TKA patients with complete preoperative and 12-month follow-up PROMs. …”
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Efficacy and Safety of Biologics Targeting Type 2 Inflammation in COPD: A Systematic Review and Network Meta-Analysis by Li S, Yi B, Wang H, Xu X, Yu L

“…Shujie Li,1,* Baiyi Yi,1,* Huan Wang,2 Xianghuai Xu,1 Li Yu1 1Department of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, People’s Republic of China; 2Clinical Research Center, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xianghuai Xu, Department of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, No. 389 Xincun Road, Shanghai, 200065, People’s Republic of China, Email 05849@tongji.edu.cn Li Yu, Department of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, No. 389 Xincun Road, Shanghai, 200065, People’s Republic of China, Email 96778@tongji.edu.cnPurpose: This study aims to comparatively evaluate the efficacy and safety profiles of biologic agents targeting type 2 inflammation in COPD.Methods: As of September 1, 2024, we identified and screened eight clinical studies evaluating biologic agents targeting type 2 inflammation for COPD treatment from multiple databases. …”
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Transcutaneous Electrical Acupoint Stimulation (TEAS) Facilitates Postoperative Recovery in Day Lung Cancer Surgery: A Randomized Controlled Trial by Wu S, Lou J, Zou H, Wang W, Zhang Y, Xu Y, Hou X, Wu J

“…This study evaluated whether Transcutaneous Electrical Acupoint Stimulation (TEAS) reduces postoperative pain and analgesic use in lung cancer surgery.Methods: In this randomized, sham-controlled trial at a tertiary hospital in Shanghai, 100 patients (18– 70 years old, ASA I–II) who underwent day lung cancer surgery (video-assisted thoracoscopic pulmonary wedge resection) were enrolled. …”
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Aneurysm Wall Enhancement and Systemic Inflammation Jointly Contribute to Cognitive Dysfunction in Untreated Unruptured Intracranial Aneurysm Patients by Wu XB, Luo B, Guo X, Liu CC, Liu YA, Ye JS, Fan SY, Li QJ, Wang SW

“…We assessed cognitive function and its association with inflammatory markers in UIA patients.Methods: The study included 120 consecutive patients with UIAs diagnosed between September 2018 and December 2023 and a control group of 27 healthy adults at our institution. …”
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Simulating the risk of heat stress on grain maize production under arid and semi-arid conditions by Khosro Azizi, Sajjad Rahimi-Moghaddam

“…Furthermore, the risk window for maize flowering in each region was equal to the first day of the year with a temperature of over 36 °C until the last day of the year with a temperature above 36 °C. …”
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Photothermal Antibacterial Effect of Gold Nanostars Coating on Titanium Implant and Its Osteogenic Performance by Li L, Wu J, Liu L, Zhang P, Zhang Y, Zhou Z, Gao X, Sun S

“…The research aimed to enhance osseointegration through surface modification while leveraging GNS’s photothermal effect for on-demand antibacterial activity, offering a dual-functional strategy to improve implant performance.Methods: GNSs were synthesized and anchored onto titanium surfaces through surface modification via silanization. …”
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Evaluation of Luteolin Nanosuspensions on Pharmacokinetics of Atorvastatin: Drug-Drug Interactions Using Rat Models by Liang Y, Sun B, Yang M, Meng X, Wang M, Yang L, AI-Hamyari B, Zhang Y, Shen Y, Meng S

“…This study aims to explore the pharmacokinetic (PK) drug-drug interactions (DDIs) of LUT toward ATV and the influencing mechanisms involving CYP450s and OATPs, and using the physiologically based pharmacokinetic (PBPK) models extrapolated to humans to optimize the DDIs dosage regimens for subsequent research.Methods: Luteolin nanosuspensions lyophilized powder (LUT-NS-LP) were prepared for improving LUT’s solubility and bioavailability, the effects of both LUT on the ATV CYP450s enzyme kinetics and LUT-NS-LP/LUT on the PK behavior of ATV in rats were further studied by UPLC. …”
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Association Between Sleep and Vertigo Severity in Benign Paroxysmal Positional Vertigo: Mediating Role of Psychological Factors by Xing J, Xu X, Shan H, Wu J, Liu P, Shi W, Ren P, Liu J, Huang Y, Mi B

“…Juanli Xing,1,* Xinyu Xu,2– 4,* Hongying Shan,2 Jiaqian Wu,4 Peiyu Liu,5 Wenyan Shi,4 Peihua Ren,2 JinLing Liu,4 Yuge Huang,2 Baibing Mi2 1Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 2Department of Epidemiology and Biostatistics, School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an, Shaanxi, People’s Republic of China; 3Department of Occupational and Environmental Health, School of Public Health, Health Science Center, Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 4Department of Health Science Center, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 5Department of Health Science Center, Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China*These authors contributed equally to this workCorrespondence: Baibing Mi, Department of Epidemiology and Biostatistics Xi’an Jiaotong University Health Science Center, Xi’an, Shaanxi, People’s Republic of China, Email xjtu.mi@xjtu.edu.cnObjective: To investigate the relationship between sleep quality and vertigo severity among patients with benign paroxysmal positional vertigo (BPPV) and to elucidate the mediating effects of anxiety and depression on this association.Methods: We analyzed baseline data from an ongoing cohort study of 1056 BPPV patients in Northwest China. …”
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Efficacy of a 6-month supported online programme (Feeling Safer) for the treatment of persecutory delusions: protocol for a randomised controlled trial by Richard Emsley, Verity Westgate, Daniel Freeman, Thomas Kabir, José Leal, Anthony Morrison, Kate Chapman, Robert Dudley, Laina Rosebrock, Felicity Waite, Louise Isham, Jason Freeman, Stephanie Common, Alex Kenny, Ariane Beckley, Natalie Rouse, Megan McGovern

“…We will also test whether Feeling Safer works equally across gender, age, ethnicity and cognitive functioning (moderation) and whether Feeling Safer works via the targeted psychological processes (mediation).Methods and analysis The study design is a multicentre, single-blind (outcome assessor), parallel, four-arm randomised controlled trial; 484 patients with persistent persecutory delusions will be randomised to one of the four conditions (1:1:1:1): Feeling Safer (added to treatment as usual (TAU)) supported by peer-support workers, or Feeling Safer (added to TAU) supported by graduate mental health workers including assistant psychologists, or Feeling Safer (added to TAU) supported by CBT therapists or TAU. …”
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FDG PET/CT AND PSMA PET/CT IN MUSCULOSKELETAL SOFT TISSUE SARCOMAS by Ellen Nogueira Lima, Thaisa Ramos Freire, Mayara Branco E. Silva, Natalia Tobar Toledo Prudente Silva, Thiago Alves, Allan Santos, Mariana Lima, José Carvalheira, Mauricio Etchebehere, Elba Etchebehere

“…Objectives: Evaluate the potential of PSMA PET/CT in diagnosing different types of STSs compared to FDG PET/CT, with the aim of expanding the clinical management of these patients and the potential of a Theranostics strategy with radiolabeled PSMA. Materials and Methods: Forty-four participants (20 females) with STS were prospectively enrolled and submitted to FDG PET/CT and PSMA PET/CT for primary staging, with a 48-hour interval between studies. …”
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Plasma Exosomal miR-17-5p Regulates Macrophage Polarization by Targeting Bcl11b in Sepsis-Induced Lung Injury by Xian Y, Sun Y, Wang L, Lin L, Wu Z, Zhang K, Chen R

“…The transcription factor Bcl11b, previously linked to immune cell regulation, has not yet been studied in the context of sepsis-associated macrophage reprogramming.Methods: Extracellular vehicles (EVs) were isolated from the plasma of sepsis patients and healthy controls. …”
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Magnesium Isoglycyrrhizinate Alleviates Alectinib-Induced Hepatotoxicity by Inhibiting Mitochondrial Damage-Mediated Pyroptosis by Chen Y, Wang C, Wu Y, Zeng Y, Xie S, Weng J, Guo L, Fu J, Zhou T, Zhang X, Zhou Z

“…This study aims to elucidate how alectinib induces liver injury and to explore a potential protective strategy.Methods: In vitro, AML-12 hepatocytes were incubated with alectinib to determine cell viability and morphology by using CCK-8 assay and optical microscopy, respectively. …”
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