Macrophage Membrane-Coated Liposomes Delivering Vonoprazan Disrupt Mitochondrial Oxidative Phosphorylation in Diffuse Large B-Cell Lymphoma by Wang W, Wang L, Fan Q, Xu J, Li Y, Xu J, Zhao B, Ge D, Xiong L, Wu Y, Zhu Y, Chen M

“…This study constructed a macrophage membrane-coated liposomal formulation (MM-Lipid@Vpz) for the targeted delivery of vonoprazan to combat DLBCL, which enables the evasion of the reticuloendothelial system, ensuring enhanced specificity in tumor targeting.Methods: The vonoprazan was delivered by encapsulating liposomes with pre-isolated macrophage membranes, targeted to DLBCL cells and evaluated for changes in cell function. …”
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Influence of Polymorphisms in Gene SATB2 on Antipsychotics Response in Chinese Han Population by Du X, Wang Y, Zhang Q, Gao Y, Wang X, Zhao W, Hu X, Zhang Y, Xu Y, Chen B, Zhang J, Liu S, Li X

“…This study explored the correlation between rs1900327, rs7557687, rs733156, and rs6745135 in gene SATB2 and antipsychotics response in the Chinese Han population.Methods: This study included 228 patients with schizophrenia. …”
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Silicone kyphoplasty (elastoplasty) versus traditional cement kyphoplasty for osteoporotic vertebral fractures. Does this new technique reduce the complications? by R. Luque, D. Garríguez, P. Checa Betegon, M. Sanchez, J.L. Perez Gonzalez, I. Dominguez Esteban

“…This study's objective is to compare the results between kyphoplasty with bone cement and with the VK100 silicone. Materials and methods: This is a comparative, prospective study involving 64 patients 64 patients, 23 treated using VK100 and 41 with PMMA. …”
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Psychological Stress and Its Correlations to Patients with Acute Lymphedema After Breast Cancer Surgery by Ge LP, Tang L, Zuo W, Zhou C, Gao T, Li Y, Fu C, Qiu J, Li P, Lu R, Chen L, Xue Y, Shen Z, Shao Z, Di G, Feng W

“…This study aimed to assess the incidence and determinants of anxiety and depression in patients with acute lymphedema (ALE) following breast cancer surgery.Methods: A retrospective study was conducted on 1613 breast cancer patients who underwent surgery at Fudan University Shanghai Cancer Center in 2018. …”
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CD80 Antibody and MTX Co-Engineered Extracellular Vesicles Targets CD80+ Macrophages to Suppress Inflammation and Alleviate Chronic Inflammatory Diseases by Yang J, Zhang H, Wang W, Yin Q, He X, Tao D, Wang H, Liu W, Wang Y, Dong Z, Chen X, Li B

“…However, there are no definitive therapies to reshape the tissue homeostasis between innate immune and adaptive immune cells.Methods: (1) anti-CD80-MTX-EVs was obtained by gradient centrifugation, which were characterized by TEM and DLS, and the associated membrane proteins were identified by Western Blot. (2) The mouse bone marrow-derived macrophages were co-cultured separately with EVs, anti-CD80-EVs, and anti-CD80-MTX-EVs in vitro, and the expression of CD80 on the macrophages surface as well as the proportion of Treg cell generation were detected. (3) EVs, anti-CD80-EVs and anti-CD80-MTX-EVs were injected into mice models of arthritis and periodontitis for treatment, the therapeutic effect was evaluated by the expressions of related cytokines, staining of HE, the proportion of CD80+ macrophages and the phenotypic differentiation of T cells in the tissues.Results: We successfully constructed engineered EVs (anti-CD80-MTX-EVs) targeting inflammatory macrophages for intracellular MTX delivering, which inducing the anti-inflammatory transformation while upregulating the expression of TGF-β of macrophages. …”
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The Jieduan-Niwan Formula Reduces Inflammatory Responses in Acute-on-Chronic Liver Failure Rats by Inhibiting HMGB1-Induced Hepatocyte Pyroptosis by Hou W, Fang P, Liang J, Wei X, Ma C, Gao Y, Zhang Q, Li J

“…The JDNW formula (JDNWF) has a significant clinical effect on ACLF, but its hepatoprotective mechanisms remain elusive.Purpose: To explore the potential molecular mechanisms of the JDNWF in ACLF by HMGB1-induced hepatocyte pyroptosis.Methods: Rats were divided into normal, ACLF, Caspase-1 inhibitor, HMGB1 inhibitor, JDNW, JDNW+Caspase-1 inhibitor and JDNW+HMGB1 inhibitor groups. …”
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Combining Network Pharmacological Analysis and Animal Experiments to Explore the Pharmacological Mechanism of Zhangyanming Tablets in Diabetic Retinopathy by Yang M, Liu H, Zhou J, Wang K, Sun Y, Ning N, Huang Q, Hu J, Liu J, Yan F, Hou X, Chen L, Wang L, Liu F

“…This study aims to investigate the ameliorative effects and specific mechanisms of ZYMT on DR.Methods: Key regulatory genes and potential therapeutic targets of ZYMT for DR were evaluated using network pharmacological analysis. …”
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The Efficacy and Safety of Simultaneous Vaccination with Polysaccharide Conjugate Vaccines Against Pneumococcal (13-Valent Vaccine) and <i>Haemophilus influenzae</i> Type b Infecti... by Ekaterina Alexeeva, Tatyana Dvoryakovskaya, Anna Fetisova, Ivan Kriulin, Elizaveta Krekhova, Anna Kabanova, Vladimir Labinov, Elizaveta Labinova, Mikhail Kostik

“…Our study aimed to evaluate the safety and efficacy of simultaneous immunization with 13-valent polysaccharide conjugate vaccines (PCV13) against <i>S. pneumoniae</i> (SP) and <i>Hemophilus influanzae</i> type b infections (HibV) in children with JIA without systemic manifestations. <b>Methods</b>: A total of 371 non-systemic JIA patients who received 13PCV and HibV were included in this prospective cohort study. …”
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SPECIFIC FEATURES OF DEFORMATION OF THE CONTINENTAL AND OCEANIC LITHOSPHERE AS A RESULT OF THE EARTH CORE NORTHERN DRIFT by Mikhail A. Goncharov, Yuri N. Raznitsin, Yuri V. Barkin

“…Formation of such structures is caused by the upper horizontal flow of meridional convection.Meridional convection occurs due to drifting of the Earth core towards the North Pole (which is detected by a number of independent methods) and resistance of the mantle to drifting (Figures 26, and 27).By comparing the equations that describe the model of the northern drift of the lithosphere and the model of the core drift towards the North Pole, it is possible to establish a quantitative ‘bridge’ between the structures of meridional compression of the lithosphere and the core drifting structures.Conclusions based on the model of the northern drift of the lithosphere conform to many independent data and concepts, such as disturbance of the isostatic equilibrium of the Antarctica lithosphere and its high standing; the anomalously wide shelf of the Arctic ocean (Figure 28а) and the increased thickness of the sediment cover, that is rich in hydrocarbons, in combination with the ultralow velocity of spreading in Gakkel Ridge; the approximately equal areas of Antarctica and the Arctic ocean as antipodes (Figure 28б); elongation (according to GPS data) of the parallels in the Southern hemisphere, and their shortening in the Northern hemisphere (Figure 26); radial (relative to the South Pole) rifts and other lineaments in Antarctica (Figures 29, and 30); the sub-concentric (relative to the same pole) system of spreading around Antarctica, which develops northward into the submeridional system including three ‘trunks’ at a distance of about 90° (Figure 31).Due to the higher velocity of the northern drift of the lithosphere within the band with the middle meridian 100° E – 80° W, wherein the main mass of the continental lithosphere is concentrated and whose two ‘poles’ are marked by the axes of the African and Pacific superplumes (Figures 3, 4, 5, and 32), the following specific features have developed: maximum elongation of the Antarctic continent in the Southern (‘stretched’) hemisphere (Figure 28 б); maximum shortening of the Arctic ocean in the Northern (‘compressed’) hemisphere (Figure 28а); maximum spreading velocity in the SouthEastern Indian Ridge (Figure 33); maximum northern component of the horizontal displacements velocity (according to GPS data) (Figure 34); the mantle Sunda diapir of maximum width and depth (to 400 km); the Himalayas as an orogen of maximum height; Tibet as a plateau of maximum width and height; and Baikal as a rift of maximum length and depth. …”
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The Association Between High-Sensitivity C-Reactive Protein and the Progression of Arteriosclerosis: The Kailuan Study by Li W, Liang P, Ma X, Gao Y, Bai X, An S, Wang X, Chen S, Wu S

“…I, Handan Central Hospital, NO. 15, Zhonghuanan Street, Hanshan District, Handan, Hebei, 056001, People’s Republic of China, Tel +86 18103300116, Email wangxin2167@163.comObjective: To explore the association between high-sensitivity C-reactive protein (hs-CRP) and the progression of arteriosclerosis.Methods: Using a prospective cohort study design, 11,577 participants from the Kailuan Study cohort who underwent at least two brachial-ankle pulse wave velocity (baPWV) examinations and met the inclusion criteria were included as the study subjects. …”
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Study of senile astheny markers against the background of acute inflammatory process in elderly and senile patients in emergency abdominal surgery by M. B. Danyliuk, S. M. Zavhorodnii, Ye. R. Fedotov, Ye. K. Mykhalchenko, I. V. Dobrodub

“…The aim of our work was to determine the influence of the acute inflammatory process on the diagnostic value of markers of senile asthenia in emergency abdominal surgery. Material and methods. The basis of the work included 92 (100.0 %) patients, the average age in the entire group was 72.0 ± 2.3 years. …”
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Profilaxia tromboembólica farmacológica e por compressão pneumática intermitente em 563 casos consecutivos de abdominoplastia Pharmacologic and intermittent pneumatic compression t... by Endrigo Piva Pontelli, Jean Marc Scialom, Taiza Elaine Grespan dos Santos-Pontelli

“…The pharmacological and mechanical protocols for thromboembolic prophylaxis in abdominoplasty were equally effective.…”
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Real-World Effectiveness of Single-Inhaler Triple Treatment Through Assorted Respiratory Outcomes When Switched From Multiple-Inhaler Triple Therapies (RESTART): A Prospective Coho... by Lim H, Kim DH, Hong SH, Shin J, Lee H, Shin K, Ra SW, Lee SJ

“…The Real-World Effectiveness of Single Inhaler Triple Treatment through Assorted Respiratory Outcomes when Switched from Multiple Inhaler Triple Therapies (RESTART) study aimed to evaluate the clinical benefits of switching from MITT to SITT using fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) in a real-world Korean setting.Patients and Methods: This prospective, multicenter, observational study enrolled 107 patients, aged 40 and older, with diagnosed COPD, all previously on MITT. …”
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Effectiveness and Safety of Systemic Therapy and Stereotactic Body Radiotherapy in Oligoprogressive and Oligometastatic Hepatocellular Carcinoma by Song Z, Zheng X, Wang H, Dong D, Zhu X, Geng J, Li S, Song M, Du R, Zhang Y, Liu Z, Cai Y, Li Y, Wang W

“…Zhuo Song,1,&amp;ast; Xuan Zheng,1,&amp;ast; Hongzhi Wang,1,&amp;ast; Dezuo Dong,1 Xianggao Zhu,1 Jianhao Geng,1 Shuai Li,1 Maxiaowei Song,1 Rongxu Du,1 Yangzi Zhang,1 Zhiyan Liu,1 Yong Cai,1 Yongheng Li,2 Weihu Wang1 1Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital &amp; Institute, Beijing, 100142, People’s Republic of China; 2State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing Key Laboratory of Carcinogenesis and Translational Research, Department of Radiation Oncology, Peking University Cancer Hospital &amp; Institute, Beijing, 100142, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Weihu Wang, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital &amp; Institute, No. 52 Fu-Cheng Road, Haidian District, Beijing, 100142, People’s Republic of China, Email wangweihu88@163.comPurpose: This study explored the efficacy and safety of combining systemic therapy with stereotactic body radiotherapy (SBRT) for oligoprogressive (OP) and oligometastatic (OM) hepatocellular carcinoma (HCC).Patients and Methods: From January 2017 to June 2023, 37 HCC patients (28 OP, 9 OM) receiving systemic therapy and SBRT were identified. …”
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Interleukin Family-Based Signature Relates to Cancer-Associated Fibroblasts Spatial Distribution and Immune Therapy Response in Pancreatic Carcinoma by Cheng Y, Xiao S, Li X, Wang B, Lei Y, Sun P, Ma L, Zhu Y

“…However, the correlation between the IL family, CAFs infiltration, and PC prognosis remains uninvestigated.Methods: An IL family expression pattern for prognosis was constructed using a stepwise Cox proportional hazards regression model using TCGA data. …”
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Peripheral TNF-&amp;alpha; and CD8+/CD28+ T Lymphocytes as Alternatives for PD-L1 Prediction in Breast Cancer Tumor Microenvironment: Stratified by Neoadjuvant Therapy by Wu J, Ou X, Yuan K, Shi F, Zhou Q, Lyu S, Li Y, Zhao Y, Cao Y, Sun J, Song Q

“…This study aimed to explore peripheral blood-based alternatives to PD-L1 tissue detection in breast cancer (BC), particularly stratification by neoadjuvant therapy (NAT).Methods: A total of 134 cases were recruited, the peripheral lymphocyte subtypes and cytokines were detected by flow cytometry and PD-L1 expression in tumor microenvironment (TME) was detected by immunohistochemistry and assessed by two qualified pathologists.Results: The patients with positive PD-L1 expression had peripheral CD8+/CD28+ T lymphocytes 20% higher than those with negative expression (p = 0.008) with the area under the receiver operating characteristic curve (AUC) being 0.64 (p = 0.002). …”
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The efficacy of training based on the family-centered empowerment model on the mental health of aged women: a stratified randomized controlled trial by Nasrin Mohammadi Someia, Shirin Barzanjeh Atri, Hossein Namdar Areshtanab, Azizeh Farshbaf‑Khalili, Soraya Babaie

“…The study aimed to explore how education based on family‑centered empowerment model affects mental health in aged women. Methods This randomized controlled trial involved a group of 60 elderly women aged 60 years and older, specifically selected from elderly-friendly health centers in Tabriz-East Azerbaijan, who were randomly assigned to either an intervention or control group with an equal ratio. …”
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A Dual-Sequence MRI-Based Radiomics Model for Predicting High-Intensity Focused Ultrasound Ablation Efficacy in Adenomyosis Treatment by Sun M, Deng X, Xing H, Zhang R, Fu B, Ai T, Wang F, Wang X, Chen L, Mao X, Wu F

“…Mengmeng Sun,1,2,&amp;ast; Xinyi Deng,3,&amp;ast; Hui Xing,1,4 Rui Zhang,3 Bingbing Fu,1 Tao Ai,5 Fang Wang,6 Xuechun Wang,6 Lei Chen,6 Xiaogang Mao,1,4 Feng Wu3 1Department of Obstetrics and Gynecology, Xiangyang Central Hospital, Affiliated Hospital of Hubei, University of Arts and Science, Xiangyang, People’s Republic of China; 2School of Medicine, Wuhan University of Science and Technology, Wuhan, People’s Republic of China; 3Department of Radiology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, People’s Republic of China; 4Hubei Provincial Clinical Research Center for Cervical Lesions, Xiangyang, People’s Republic of China; 5Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China; 6Department of Research and Development, United Imaging Intelligence, Shanghai, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Feng Wu, Department of Radiology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, No. 136 Jinzhou Road, Xiangyang, Hubei, 441021, People’s Republic of China, Email wufeng@hbuas.edu.cn Xiaogang Mao, Department of Radiology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, No. 136 Jinzhou Road, Xiangyang, Hubei, 441021, People’s Republic of China, Email tjmumxg@163.comPurpose: The aim of this study is to develop a predictive model for the therapeutic efficacy of high-intensity focused ultrasound (HIFU) ablation in the treatment of adenomyosis, utilizing dual-sequence MRI radiomics.Methods: A retrospective analysis was conducted on 114 patients diagnosed with adenomyosis who underwent ultrasound-guided HIFU ablation under conscious sedation between July 2021 and July 2023. …”
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Depressive disorders and quality of live in patients with acute coronary syndrome in real clinical practice by E. V. Konstantinova, E. A. Koroleva, A. G.   Popova, E. E.  Popov, D. A. Anichkov, A. V. Svet, A. P. Nesterov, M. Yu. Gilyarov

“…In Group I the score on SDS was higher or equal to 50 (depression) in 18 % of cases: 15 % female and 3 % male patients (p &lt;0.05). …”
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Development and Validation of a New Immune-Inflammatory-Nutritional Score to Predict Pathological Complete Response in Triple-Negative Breast Cancer Undergoing Neoadjuvant Chemothe... by Wang S, Song Y, Ding J, Li M, Wang Y, Bai Y, Zi H, Sun J, Fan C, Chen H, Luo T, Wang T

“…Shuai Wang,1,&amp;ast; Yuting Song,2,&amp;ast; Jiajun Ding,1 Mengxuan Li,1 Yidi Wang,1 Yujie Bai,1 Haoyi Zi,1 Jianing Sun,1 Cong Fan,1 He Chen,1 Ting Luo,2 Ting Wang1 1Department of Thyroid, Breast and Vascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi, People’s Republic of China; 2Institute of Breast Health Medicine, Department of Medical Oncology, Cancer Center, Breast Center, West China Hospital, Sichuan University, Chengdu, Sichuan, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Ting Wang, Department of Thyroid, Breast and Vascular Surgery, Xijing Hospital, Fourth Military Medical University, No. 127, Changle West Road, Xi’an, Shaanxi, 710032, People’s Republic of China, Email ting_w100@126.com Ting Luo, Institute of Breast Health Medicine, Department of Medical Oncology, Cancer Center, Breast Center, West China Hospital, Sichuan University, 37 Guoxue Alley, Wuhou District, Chengdu, Sichuan, 610000, People’s Republic of China, Email luoting@wchscu.cnPurpose: To construct a novel immune-inflammatory-nutritional (IIN) score based on peripheral blood biomarkers related to inflammation, immunity, and nutrition, and to predict the efficacy of neoadjuvant chemotherapy (NAC) in patients with triple-negative breast cancer (TNBC).Patients and Methods: We retrospectively selected 431 patients with TNBC from Xijing Hospital, and then randomly divided the patients into a training set and an internal validation set in a ratio of 7:3. …”
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