Understanding and Overcoming Negative Attitudes That Hinder Adoption of Reablement in Dementia Care: An Explorative Qualitative Study by Tuntland H, Ashfaq K, Zingmark M, Metzelthin SF

“…This study aimed to explore the negative attitudes that hinder the adoption of reablement and to identify strategies to mitigate these factors.Methods: An exploratory qualitative approach involving semi-structured interviews was adopted. …”
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Cutaneous Nontuberculous Mycobacteria Infections Following Cosmetic Procedures: A Retrospective Study by Zeng R, Xiong J, Gao W, Peng J, Shi Y, Zhang W, Jiang H, Cheng C, Ge G, Wang Z, Mei Y, Chen Z, Wang H

“…The diagnosis and treatment of these infections remain a significant challenge for clinicians.Objective: We examined the clinical characteristics, microbiology, histopathology, and treatment strategies of NTM infections following cosmetic procedures, including botulinum toxin injection, lipolysis injection, hyaluronic acid injection, mesotherapy, autologous fat grafting, and other related procedures.Methods: This retrospective study of cosmetology-related cutaneous NTM infections diagnosed based on culture or molecular identification was conducted at a tertiary dermatology hospital in China. …”
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Astragaloside IV Attenuates Chronic Prostatitis by Activating Keap1/Nrf2/HO-1 Pathway: Suppressing Ferroptosis and Enhancing Antioxidant Defense by Shi J, Xuan Y, Zhang Q, Chen J, Zhu W, Zhang H, Duan Y

“…However, regulatory mechanisms linking AS-IV to ferroptosis inhibition in CP/CPPS remain unknown.Patients and Methods: This study aimed to investigate the therapeutic potential of astragaloside IV (the primary bioactive component of Astragalus membranaceus) for the treatment of CP/CPPS by suppressing ferroptosis via the Keap1/Nrf2/HO-1 pathway. …”
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Incidence and Predictors of Acute Kidney Injury Among Critically Ill Adult Patients Admitted at Mbarara Regional Referral Hospital by Muhindo R, Kiptoo J, Tumuhimbise C, Nakyanzi C, Ssentongo FG, Kavubu M, Ssewanyana E, Isiiko J, Kyomya J, Mutekanga A, Aguma AR, Owokuhaisa J, Yadesa TM

“…We evaluated the incidence, predictors, treatment, and outcomes of AKI among very ill adult patients at a public tertiary hospital in southwestern Uganda.Methods: This prospective cohort study categorized patients who had a NEWS-2 above 5 as critically ill. …”
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How Does Disease Severity Affect Clinical Outcomes and Economic Burden of Patients with COPD —— A Retrospective Population-Based Cohort Study in Tianjin, China by Wang L, Huang K, He X, Zhang J, Yang T, Wu J

“…This study aimed to clarify the effect of severity on disease burden by comparing clinical and economic outcomes stratified by disease severity based on the Global Initiative for Chronic Obstructive Lung Disease (GOLD) in a Chinese setting.Methods: A retrospective population-based cohort study was conducted using electronic health records of 80 hospitals (2016– 2019). …”
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Characteristics of the Epidemiological Situation in Patients with Tuberculosis of Various Age Groups Based on the Numerical Criteria of Selective Rating with the Help of the Comput... by Ilnуtskуy G.

“…To study the epidemiological situation on tuberculosis in the patients of different age groups based on the analysis of digital criteria for the random evaluation of official statistics materials for the period 2000-2009 in Ukraine in general and in the Lviv region. Materials and methods. Owing to the computer and informational technologies a selective assessment of the tuberculosis disease in different age groups was carried out. …”
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Enhancing Diabetes Treatment: Comparing Pioglitazone/Metformin with Dapagliflozin Versus Basal Insulin/Metformin in Type 2 Diabetes by Lin Y, Shi J, Yu X, Sun J, Lixia S, Dou J, Zhang M, Li X, Tian Z, Deng H, Feng B, Su Q, Peng Y

“…Yi Lin,1,* Jianxia Shi,1,* Xuemei Yu,2 Jiao Sun,3 Suo Lixia,4 Jiaqing Dou,5 Min Zhang,6 Xiaohua Li,7 Zhufang Tian,8 Hongyan Deng,9 Bo Feng,10 Qing Su,11 Yongde Peng1 1Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, People’s Republic of China; 2Central Hospital of Fengxian District, Shanghai, People’s Republic of China; 3Huadong Hospital Affiliated to Fudan University, Shanghai, People’s Republic of China; 4Shanghai Jiading Central Hospital, Shanghai Jiading Central Hospital, Shanghai, People’s Republic of China; 5Chaohu Hospital of Anhui Medical University, Chaohu, People’s Republic of China; 6Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Shanghai, People’s Republic of China; 7Seventh People’s Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China; 8Xi‘an Central Hospital, Xi’an, Shanxi, People’s Republic of China; 9Wuhan Fourth Hospital, Wuhan, People’s Republic of China; 10Dongfang Hospital Affiliated to Tongji University, Shanghai, People’s Republic of China; 11Xinhua Hospital Affiliated to Shanghai Jiaotong University, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yongde Peng, Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University, 100 haining Road, Shanghai, 200080, People’s Republic of China, Tel +86-13386259649, Email pengyongde0908@126.comAim: The aim of this study was to compare the efficacy and safety of fixed-dose combination (FDC) of pioglitazone and metformin supplemented with dapagliflozin (test group) with those of basal insulin supplemented with metformin (control group) in patients with inadequately controlled type 2 diabetes mellitus (T2DM).Methods: This 16-week, prospective, randomized, open-label study enrolled patients aged 18– 75 years with glycated hemoglobin (HbA1c) levels between ≥ 8% and ≤ 11%. …”
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Related Risk Factors That Predict Moderate to Severe Asthma Attack in Children: Analysis Based on Logistic Regression and Decision Tree by Li Q, Fan Y, Luo R, Hu J, Wang L, Ai T

“…Qianqian Li, Yinghong Fan, Ronghua Luo, Jie Hu, Li Wang,* Tao Ai* Pediatric Respiratory Medicine Department, Chengdu Women’s and Children’s Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Li Wang, Department of Pediatric Respiratory Medicine, Chengdu Women’s and Children’s Central Hospital, School of Medicine, University of Electronic Science and Technology of China, 1617 Riyue Avenue Section 1 Qingyang District, Chengdu, Sichuan, 610000, People’s Republic of China, Tel +8618908015531, Email 625664758@qq.com Tao Ai, Department of Pediatric Respiratory Medicine, Chengdu Women’s and Children’s Central Hospital, School of Medicine, University of Electronic Science and Technology of China, 1617 Riyue Avenue Section 1 Qingyang District, Chengdu, Sichuan, 610000, People’s Republic of China, Tel +8613981931891, Email ait1108@163.comPurpose: To analyse the related risk factors of moderate to severe asthma attack in children by logistic regression and decision tree.Patients and Methods: A retrospective analysis of clinical data of children diagnosed with asthma attacks in our hospital from January 2020 to August 2023 was conducted. …”
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The Follicular Output Rate was Improved with 3-Day Letrozole Administration Compared with 5-Day Letrozole Administration Under Progestin-Primed Ovarian Stimulation by Wang X, Tian J, Tian L, Chen X, Zhang Z, Diao H, Zhang Y

“…This study compared the effects of a 5-day regimen with those of a 3-day regimen of letrozole within PPOS, focused on the follicular output rate (FORT) and blastocyst formation rates.Patients and Methods: From January 2017 to January 2020, 1,754 infertility patients who received PPOS protocol were divided into two groups: 577 patients received 2.5 mg/day LE for 5 days (LE 5-day), and 1177 patients received the same dose of LE for 3 days (LE 3-day). …”
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Risk score for predicting mortality including urine lipoarabinomannan detection in hospital inpatients with HIV-associated tuberculosis in sub-Saharan Africa: Derivation and extern... by Ankur Gupta-Wright, Elizabeth L Corbett, Douglas Wilson, Joep J van Oosterhout, Keertan Dheda, Helena Huerga, Jonny Peter, Maryline Bonnet, Melanie Alufandika-Moyo, Daniel Grint, Stephen D Lawn, Katherine Fielding

“…We therefore aimed to develop and validate a simple clinical risk score to predict mortality in high-burden, low-resource settings.<h4>Methods and findings</h4>A cohort of HIV-positive adults with laboratory-confirmed TB from the STAMP TB screening trial (Malawi and South Africa) was used to derive a clinical risk score using multivariable predictive modelling, considering factors at hospital admission (including urine lipoarabinomannan [LAM] detection) thought to be associated with 2-month mortality. …”
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Optimized layout and excavation sequence of deep chambers by Shenghua YIN, Yongyuan KOU, Yun ZHOU, Zepeng YAN, Dexin ZENG

“…The study also examined the influence of different chamber layout methods on stability and provided layout guidelines for primary chamber prioritization, parallel arrangements, and intersecting layouts. …”
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Interleukin-1β in circulating mononuclear cells predicts steatotic liver disease improvement after weight loss in subjects with obesity and prediabetes or type 2 diabetes by Paola Giustina Simeone, Sarah Costantino, Rossella Liani, Romina Tripaldi, Augusto Di Castelnuovo, Armando Tartaro, Alessandro Mengozzi, Francesco Cosentino, Francesco Cipollone, Agostino Consoli, Francesco Paneni, Francesca Santilli

“…Methods Thirty-two obese subjects with prediabetes (n = 16) or newly diagnosed T2D (n = 16), were randomized to the glucagon-like peptide receptor agonist (GLP1-RA) liraglutide or lifestyle counselling until achieving a comparable weight loss. …”
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Chronic Inflammation Index-Based Tumor Subsite Classification Correlated with Chemotherapy Benefit and Survival Outcomes in Stage II-III Colorectal Cancer by Lu Y, Ye QY, Mei O, Li YN, Peng Y, Ying HQ, Cheng XX

“…Ying Lu,1,&amp;ast; Qiu-Ying Ye,1– 3,&amp;ast; Ou Mei,4,&amp;ast; Ya-Nan Li,1 Yue Peng,1 Hou-Qun Ying,1,3,5 Xue-Xin Cheng1 1Department of Clinical Laboratory, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, People’s Republic of China; 2Department of Medical Technology, Jiangxi Medical College, Shangrao, 334000, People’s Republic of China; 3Department of Laboratory Medicine, Central Hospital of Shangrao City, Shangrao, 334000, People’s Republic of China; 4Department of Orthopedics, Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, 330006, People’s Republic of China; 5Shangrao Medical Center, The Second Affiliated Hospital of Nanchang University, Shangrao, 334000, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Xue-Xin Cheng, Department of Clinical Laboratory, Immunity and Inflammation Key Laboratory of Jiangxi Province, The Second Affiliated Hospital of Nanchang University, No. 1 of Minde Road, Nanchang, 330006, People’s Republic of China, Tel/Fax +86 0791-86297662, Email cxxncu@163.com Hou-Qun Ying, Department of Clinical Laboratory, Immunity and Inflammation Key Laboratory of Jiangxi Province, The Second Affiliated Hospital of Nanchang University, No. 1 of Minde Road, Nanchang, 330006, People’s Republic of China, Tel/Fax +86 0791-86297662, Email yinghouqun2013@163.comPurpose: This study aimed to develop and validate an integrated inflammatory prognostic index and to investigate associations between primary tumor location, chronic inflammatory status, adjuvant chemotherapy response, and survival outcomes in stage II–III colorectal cancer (CRC).Patients and Methods: A total of 1413 stage II–III CRC patients who underwent radical resection were enrolled and divided into discovery and validation cohorts. …”
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The Persistent Threat of Chronic Inflammation on the Mortality Among Cervical Cancer Survivors: A Mendelian Randomization and Machine Learning Analysis Using UK Biobank and Chinese... by Wang J, Chen Z, Guan M, Ma Z, Peng L, Chen J, Fiori PL, Carru C, Capobianco G, Coradduzza D, Zhou L

“…We aimed to comprehensively evaluate the genetic association between inflammation and cervical cancer, and construct an accurate prognosis model based on circulating inflammatory parameters and indexes with machine learning (ML) algorithms.Patients and Methods: We tested the genome-wide association of circulating inflammatory molecules (CIMs) (91 circulating inflammatory cytokines and 10 inflammatory cells) and summary data retrieved from the UK biobank (cases = 1659 and controls =381,902) with two-sample Mendelian randomization (MR) and colocalization analyses. …”
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Adipocyte-derived small extracellular vesicles exacerbate diabetic ischemic heart injury by promoting oxidative stress and mitochondrial-mediated cardiomyocyte apoptosis by Lu Gan, Jianli Zhao, Peng Yao, Theodore A. Christopher, Bernard Lopez, Wayne B. Lau, Walter Koch, Erhe Gao, Xinliang Ma, Yajing Wang

“…Combining in vitro mechanistic investigation and in vivo proof-concept demonstration, we determined the underlying molecular mechanism responsible for diabetic sEV-induced cardiomyocyte apoptosis after MI/R. Methods and results: Adult mice were fed a high-fat diet (HFD) for 12 weeks. sEV were isolated from plasma or epididymal adipose tissue. …”
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IL-22 Alleviates Sepsis-Induced Acute Lung Injury by Inhibiting Epithelial Cell Apoptosis Associated with STAT3 Signalling by Zhu C, Chen J, Yan Z, Wang F, Sun Z, Liu Z, Li Y, Chen X, Bao Z, Li Q, Chen Z

“…This study aimed to investigate the therapeutic efficacy of IL-22 in sepsis and explore the regulatory mechanisms involved.Methods: A mouse caecal ligation and puncture (CLP) model of sepsis was established, and the effect of IL-22 was investigated as indicated. …”
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RAR-Based Prognostic Model for Predicting Overall Survival in Hepatitis B Virus-Related Hepatocellular Carcinoma: A Multicenter Study by Tan M, Liu Y, Dai W, Chen Y, Cai D, Chen B, Wang J, You R, Li D, Huang H

“…This study aimed to develop and validate a novel prognostic nomogram integrating the red blood cell distribution width-to-albumin ratio for predicting patients’ overall survival.Patients and Methods: A retrospective cohort of 1403 patients was divided into training, internal validation, and external validation cohorts. …”
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Hypoglycemic and antihyperglycemic effects of Abelmoschus esculentus and Alchornea cordifolia in normal and alloxan-induced diabetic rats by Barnabé Lucien Nkono Ya Nkono, Adjia Hamadjida, Damolai Gounkagou, Fidèle Ntchapda, Sélestin Sokeng Dongmo, Pierre Kamtchouing

“…Therefore, this study aimed to investigate the hypoglycemic and antihyperglycemic effects of aqueous extract of A. esculentus fruits and A. cordifolia leaves. Material and Methods: Fresh Abelmoschus esculentus fruits and the powder from the dried leaves of Alchornea cordifolia leaves were prepared by maceration in the aqueous phase (200 mg/100 mL and 50 mg/100 mL respectively) for 24 h, then filtered and concentrated in an oven at 45 °C. …”
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The Perceptions of Husbands Regarding Early Marriage in Community Settings in Bengkulu, Indonesia: A Case-Control Study by Jipri Suyanto, Steyo Adiningsih, Rina Isnawati, Anna Lystia Poetranto, Nona Rahmaida Puetri, Muhammad Ibrahim Desem, Lisa Andriani Lienggonegoro, Suriyani Tan, Diki Bima Prasetio, Sri Susanty

“…Objective:This study aims to examine the correlation between husbands’ perspectives and early marriage in the community setting of Bengkulu, Indonesia. Methods:This research employs a quantitative methodology with a case-control study design. …”
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A New Risk Prediction Tool for Bleeding and Adverse Cardiovascular Events in Patients with Pre-Existing Coronary Stents Undergoing Gastrointestinal Cancer Surgery by Xu ZY, Hao XY, Zhang Z, Zhang J, Gao L, Li T, Wang XX

“…Therefore, this study will establish a prediction tool that can predict both bleeding events and major adverse cardiovascular events (MACEs).Methods: Multicenter clinical data from 3127 gastrointestinal cancer surgery patients with a history of coronary stent implantation were utilized to establish and validate our prediction tool. …”
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