Association Between Neutrophil Percentage to-Albumin Ratio, Neutrophil to-Lymphocyte Ratio, Platelet-to Lymphocyte Ratio and in-Hospital Mortality in Elder Patients with Bloodstrea... by Yu Z, Liu C, Gong M, Zhang P, Pei C, Liu X, Han X, Zhu P, Xu G, Du Y

“…This study aimed to investigate the association and the predictive value of NPAR, NLR and PLR with in-hospital mortality.Methods: This study included older patients with BSI who were hospitalized in a large healthcare center in Beijing from December 2011 to January 2024. …”
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Reduced Thioredoxin Regulates IL-1β Secretion via NLRP3 of IL-1β+ Alveolar Macrophages in COPD by Wang L, Shi R, Li Z, Ma R, Wang C, Xu C, Guo R, Xiao C, Du X, Yang W

“…The aim of this paper is to investigate the changes in the redox protein thioredoxin (TRX) in COPD and the role TRX plays in IL-1β release.Methods: We analyzed data from single-cell RNA sequencing (scRNA-seq) of COPD lung tissue in the GEO database. …”
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Triphasic CT Radiomics Model for Preoperative Prediction of Hepatocellular Carcinoma Pathological Grading by Huang H, Pan X, Zhang Y, Yang J, Chen L, Zhao Q, Huang L, Lu W, Deng Y, Huang Y, Ding K

“…., Shanghai, 200232, People’s Republic of China; 3Department of Pathology, The Third Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530031, People’s Republic of China; 4Department of Radiology, The First People’s Hospital of Qinzhou, Qinzhou, Guangxi, 530550, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ke Ding, Department of Radiology, The Third Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, 530031, People’s Republic of China, Email 272480365@qq.com Yingying Huang, Department of Radiology, The First People’s Hospital of Qinzhou, Qinzhou, Guangxi, 530031, People’s Republic of China, Email 273749105@qq.comObjective: This study aimed to develop and validate a triphasic CT-based radiomics model for the synchronous prediction of multiple critical pathological markers in hepatocellular carcinoma (HCC).Materials and Methods: This retrospective study analyzed 174 patients with 187 hepatocellular carcinoma (HCC) lesions. …”
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Preoperative radiological parameters correlated to hallux valgus recurrence after distal chevron metatarsal osteotomy by Y. Hernanz-González, J.C. Martínez-Ávila, E. Sánchez-Morata, A. Gómez-Sánchez, J.D. Serrano-Alonso, J. Vilá-Rico

“…The goal of this study was to analyze radiologic outcomes after distal chevron metatarsal osteotomy and to identify specific preoperative radiological parameters correlating with radiological recurrence. Materials and methods: One hundred twenty patients (134 feet) in patients with symptomatic moderate or severe HV deformity who underwent distal chevron metatarsal osteotomy at our hospital between 2014 and 2019 were included in the present study. …”
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Mechanistic Insights into Shenzhuo Formula for Diabetic Retinopathy: Integrating UPLC-Q-TOF-MS/MS, Network Pharmacology, Single-Cell RNA Sequencing Data, and Experimental Validatio... by Zang X, Zhang L, Ma J, Wang A, Ding L, Wang Y, Sun J, Li J, Hang X, Li X, Zhao L

“…This study aims to investigate the underlying mechanisms of SZF to expand treatment strategies for DR.Methods: SZF components were analyzed using Ultra Performance Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometry/Mass Spectrometry (UPLC-Q-TOF-MS/MS). …”
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A Multi-Algorithm Machine Learning Model for Predicting the Risk of Preterm Birth in Patients with Early-Onset Preeclampsia by Xu Y, Zu Y, Zhang Y, Liang Z, Xu X, Yan J

“…Yanhong Xu,1,* Yizheng Zu,2,* Ying Zhang,1,* Zewei Liang,1 Xia Xu,1,3– 5 Jianying Yan1,3– 5 1College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University Fujian Maternity and Child Health Hospital, Fuzhou, Fujian, People’s Republic of China; 2The Affiliated Changzhou Second People’s Hospital of Nanjing Medical University, Changzhou, Jiangsu, People’s Republic of China; 3Fujian Clinical Research Center for Maternal-Fetal Medicine, Fuzhou, Fujian, People’s Republic of China; 4Laboratory of Maternal-Fetal Medicine, Fujian Maternity and Child Health Hospital, Fuzhou, Fujian, People’s Republic of China; 5National Key Obstetric Clinical Specialty Construction Institution of China, Fuzhou, Fujian, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xia Xu, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University Fujian Maternity and Child Health Hospital, No. 18 Daoshan Road, Gulou District, Fuzhou, Fujian, People’s Republic of China, Email xuxia0623@fjmu.edu.cn Jianying Yan, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University Fujian Maternity and Child Health Hospital, No. 18 Daoshan Road, Gulou District, Fuzhou, Fujian, People’s Republic of China, Email yanjy2019@fjmu.edu.cnPurpose: To analyze the risk factors for preterm birth in patients with early-onset preeclampsia (EOPE) based on multi-algorithm machine learning and to construct a predictive model to explore the predictive value of the model.Methods: A retrospective analysis was conducted on 442 EOPE patients from a single tertiary center, divided into preterm birth (< 37 weeks, n=358) and term-born (≥ 37 weeks, n=84) groups. …”
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Insufficient Evidence to Recommend Shu Mian Capsule in Managing Depression With or Without Comorbid Insomnia: A Systematic Review With Meta-Analysis and Trial Sequential Analysis by Zhao FY, Xu P, Kennedy GA, Jin X, Wang YM, Zhang WJ, Yue LP, Ho YS, Fu QQ, Conduit R

“…Fei-Yi Zhao,1– 3,* Peijie Xu,4,* Gerard A Kennedy,2,* Xiaochao Jin,5,6 Yan-Mei Wang,3 Wen-Jing Zhang,3 Li-Ping Yue,1 Yuen-Shan Ho,7 Qiang-Qiang Fu,8 Russell Conduit2 1Department of Nursing, School of International Medical Technology, Shanghai Sanda University, Shanghai, 201209, People’s Republic of China; 2School of Health and Biomedical Sciences, RMIT University, Bundoora, Melbourne, VIC, 3083, Australia; 3Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200071, People’s Republic of China; 4School of Computing Technologies, RMIT University, Melbourne, VIC, 3000, Australia; 5Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, People’s Republic of China; 6Shanghai Jiaotong University School of Nursing, Shanghai, People’s Republic of China; 7School of Nursing, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Hong Kong SAR, People’s Republic of China; 8Yangpu Hospital, School of Medicine, Tongji University, Shanghai, 200090, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yuen-Shan Ho, School of Nursing, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Hong Kong SAR, People’s Republic of China, Tel +852 2766-6410, Fax +852 2364-9663, Email janice.ys.ho@polyu.edu.hk Qiang-Qiang Fu, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, 200090, People’s Republic of China, Tel + 86 021-6569 0520, Fax + 86 021-6569 6249, Email qiangqiang.fu@tongji.edu.cnAim: This systematic review with trial sequential analysis (TSA) aims to evaluate the efficacy and safety of Shu Mian Capsule (SMC), a commercial Chinese polyherbal preparation, for managing depression with or without comorbid insomnia.Methods: Controlled clinical trials assessing SMC against waitlist control, placebo or active controls, or as an adjunct treatment were searched across seven databases. …”
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The Intelligence Structures of School-Age Children with Attention Deficit Hyperactivity Disorder: A Multicenter Cross-Sectional Study in China by Zhu L, Jia F, Cao A, Hao Y, Li F, Liu R, Li H, Yu X, Zhao J, Li F, Zhang Y, Yu Y, Wei H, Dai Y, Zhang X, Liu X, Peng B, Li T, Chen L

“…The present study was aimed at investigating the intelligence structures of school-age children with ADHD who speak Chinese, using a multicenter and large sample size approach, offering some references for clinicians.Patients and Methods: 772 children aged 6 to 12 years with ADHD took part in the cross-sectional study. …”
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Febuxostat Improves Postprandial Glucose Regulation and Insulin Sensitivity in Hyperuricemic Individuals with Prediabetes or Newly Diagnosed Type 2 Diabetes: A Prospective Cohort S... by Liu S, Liu Q, Gu R, Wu M, Meng S, Yan L, Chen Q, Zhu C, Chen S, Xu B, Liu F, Chen H

“…This study aimed to investigated the impact of the urate-lowering drug febuxostat on blood glucose levels, insulin sensitivity, and β-cell function in subjects with HUA who present with normoglycemia, prediabetes, or newly diagnosed type 2 diabetes (T2DM).Methods: We assessed the glucose metabolism of participants with HUA using a 3-h oral glucose tolerance test (OGTT). …”
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Diaphragm Fatigue Does Not Impact Breathing Mechanics or Function in People with Chronic Low Back Pain by Mitchell UH, Robinson LT, Brinkman J, Bruening DA, Bowden AE, Allen SP

“…The purpose of this comparative cross-sectional study is to investigate whether diaphragm fatigue affects breathing mechanics and function in individuals with CLBP.&#x00A0Methods: Volunteers were recruited between the ages of 35– 65 years old with and without CLBP. …”
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Comparison of eight weeks of resistance training and high-intensity intermittent aerobic training on the expression of microRNAs associated with adipose tissue angiogenesis and ant... by Hamid Sadeghian, Marefat Siahkohian, Mohsen Akbarpour Beni, Lotfali Bolboli

“…The aim of this study was to compare the effect of eight weeks of resistance training and high-intensity intermittent aerobic training (HIIAT) on the expression of microRNAs associated with adipose tissue angiogenesis and antiangiogenesis in rats fed a high-fat diet.Materials and Methods: In the experimental study, 60 six-week-old male wistar rats (mean body weight = 192.40 ± 11.35) were obtained from Pasteur Institute of Iran. …”
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The Impact of Triglyceride-Glucose Index on Carotid Atherosclerosis: A Prospective Cohort Study in Middle Aged and Elderly Low-Income in Rural Chinese by Meng J, Lu Y, Gao X, Hao J, Li X, Ning X, Zhang W, Wang J

“…This study aimed to assess the relationship between the TyG index and carotid plaque incidence and IMT changes over a six-year period in a cohort of middle-aged and elderly individuals with low income and low education in rural China.Methods: The study was conducted from 2014 to 2020 in 18 rural villages in Tianjin, China. …”
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Transarterial Chemoembolization, Molecular Targeted Treatments, and Programmed Death-(Ligand)1 Inhibitors, for Hepatocellular Carcinoma with Lung Metastasis: A Retrospective Cohort... by Lu J, Chen X, Liu Y, Ding Y, Li B, Yang J, Peng W, Yang X

“…However, the efficacy of combining TACE with these treatments remains uncertain.Purpose: To compare the efficacy and adverse reactions of TACE combined with MTT and PD-(L)1 versus MTT and (PD-[L]1) in patients with HCC and lung metastasis.Materials and Methods: We retrospectively analyzed data from patients treated between January 2019 and May 2024 at the Affiliated Hospital of Southwest Medical University and West China Hospital of Sichuan University. …”
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Influence of Retinal Venous Pressure on Visual and Structural Outcomes in Eyes with Central Retinal Vein Occlusion Undergoing Anti-VEGF Treatment by Hidasa I, Yang KB, Zhang ML, Wang BY, Zhang GQ, Gao ZY, Liu ZY, Qi P, Xie J, Wang H, Liu L, Zhang H

“…Iko Hidasa,1,* Kai-Bo Yang,1,* Mo-Luan Zhang,2 Bing-Yu Wang,1 Gui-Qi Zhang,1 Zhi-Yu Gao,3 Zhi-Yu Liu,1 Peng Qi,1 Jing Xie,1 Heng Wang,1 Lei Liu,4 Han Zhang1 1Department of Ophthalmology, the First Hospital of China Medical University, Shenyang, People’s Republic of China; 2School of Medicine, Gifu University, Gifu City, Japan; 3Department of Ophthalmology, the Fourth Affiliated Hospital of China Medical University; Eye Hospital of China Medical University; Key Lens Research Laboratory of Liaoning Province, Shenyang, People’s Republic of China; 4Department of Ophthalmology, Guangdong Eye Institute; Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Han Zhang, Department of Ophthalmology, the First Hospital of China Medical University, Shenyang, People’s Republic of China, Email hanzh@cmu.edu.cn Lei Liu, Department of Ophthalmology, Guangdong Eye Institute; Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, People’s Republic of China, Email liulei@gdph.org.cnPurpose: This study investigates the role of retinal venous pressure (RVP) in determining visual and anatomical outcomes in eyes affected by macular edema (ME) secondary to central retinal vein occlusion (CRVO) and treated with anti-vascular endothelial growth factor (VEGF) therapy.Methods: A retrospective observational study analyzed data from 31 eyes of 31 patients with CRVO-induced ME. …”
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Exploring Salvia miltiorrhiza’s Therapeutic Effects on Adenomyosis by Inhibiting TNF-α/HIF-1α/IL-17-Driven Inflammatory Cascade: Mechanistic Insights... by Yang Q, Hong J, Zheng X, Liu X, Lin H, Chen L, Zhong F, Zhang Q, Jiang J, Sun P

“…However, its mechanisms in addressing adenomyosis remain unclear.Methods: Ultra-performance liquid chromatography coupled with Q Exactive™ HF-X mass spectrometry (UPLC-QE-MS) was employed to identify the constituents of DS. …”
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True- and pseudo-mitral annular disjunction in patients undergoing cardiovascular magnetic resonance by Kamil Stankowski, Federica Catapano, Dario Donia, Renato Maria Bragato, Pedro Lopes, João Abecasis, António Ferreira, Leandro Slipczuk, Pier-Giorgio Masci, Gianluigi Condorelli, Marco Francone, Stefano Figliozzi

“…We investigated the prevalence of pseudo-MAD and true-MAD. Methods: This was a retrospective study, including consecutive patients referred to cardiovascular magnetic resonance (CMR). …”
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IVIG Resistance in Kawasaki Disease: Clinical and Laboratory Risk Factors and the Potential Role of Administration Timing by Peng Y, Jing F, Liu D, Li B, Xu Y, Tan Z, Chen O, Yang Y, Si F, Jiang W, Li C, Cheng Z, Zhou X, Feng S, Su Y, Yi Q

“…The purpose of this study was to determine independent risk factors for IVIG resistance, investigate the response to IVIG treatment at different time points and determine whether the time option of IVIG treatment altered IVIG resistance.Methods: The clinical data of 6264 KD patients in southwest China were analyzed retrospectively. …”
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Development of an Early-Warning Model for Predicting the Capecitabine-Induced Diarrhea by Liu Z, Qiu S, Xu Y, Wang X, Sun J, Cui L, Ye L, Liang Z, Gao S, Chen W, Wang Z

“…The aim of this study was to construct an early-warning model for predicting the Cap-induced diarrhea.Methods: A Cap-induced diarrhea model in mice was constructed in 36 mice, and the exposure levels of Cap and its five metabolites were quantified in plasma and colon and correlated their exposure levels to the diarrhea. …”
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Analyzing Shigella in Wuhan: Serotypes, Antimicrobial Resistance, and Public Health Implications by Deng S, Li C, Zhang H, Xie Y, Wang X, Luo W, Chen Z, Tang F

“…Shiyong Deng,1,* Changzhen Li,1,* Hui Zhang,2,* Yuduan Xie,3,* Xiaomei Wang,1,* Wanjun Luo,4 Zhi Chen,5 Feng Tang1 1Department of Laboratory Medicine, Wuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430016, People’s Republic of China; 2Laboratory Department, Qiaokou Center for Disease Control and Prevention, Wuhan, 430030, People’s Republic of China; 3Department of Clinical Laboratory, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, 100102, People’s Republic of China; 4Hospital-Acquired Infection Control Department, Wuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430016, People’s Republic of China; 5Microbiological Laboratory, Wuhan Center for Disease Control and Prevention, Wuhan, 430024, People’s Republic of China*These authors contributed equally to this workCorrespondence: Feng Tang, Email tang33feng66@163.com Zhi Chen, Email 694867557@qq.comObjective: This study aims to delineate the epidemiological characteristics and antibiotic resistance of Shigella flexneri isolates from Wuhan, focusing on serotype distribution, resistance patterns, and genetic diversity.Methods: Our study analyzed 40Shigella flexneri isolates collected from 2011 to 2022 in Wuhan, assessing their serotype distribution and resistance to multiple antibiotics. …”
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Barriers and Facilitators to Adherence to Exercise-Based Cardiac Rehabilitation Among Coronary Artery Disease Patients: A Scoping Review by Zhao X, Zhang S, Zhang F, Wu X, Zhang Z, Liu Y, Jiang J, Li Z, Li S, Zheng S, Yang X, Ju X, Li H, Gong L, Kong D

“…This limitation hinders the full potential of rehabilitation, necessitating a deeper exploration of the factors influencing exercise adherence and the development of targeted intervention strategies.Objective: This study aims to identify the barriers and facilitators affecting ERCR adherence among CAD patients and provide intervention recommendations for clinical practice.Methods: A systematic search was conducted across nine databases, including PubMed, Cochrane Library, Embase, Web of Science, EBSCO, CNKI, Wanfang, VIP, and CBM. …”
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