Evaluating the Performance and Potential Bias of Predictive Models for Detection of Transthyretin Cardiac Amyloidosis by Jonathan Hourmozdi, MD, MSAI, MA, Nicholas Easton, MSAI, Simon Benigeri, MSAI, James D. Thomas, MD, Akhil Narang, MD, David Ouyang, MD, Grant Duffy, BS, Ross Upton, PhD, Will Hawkes, PhD, Ashley Akerman, PhD, Ike Okwuosa, MD, Adrienne Kline, MD, PhD, Abel N. Kho, MD, Yuan Luo, PhD, Sanjiv J. Shah, MD, Faraz S. Ahmad, MD, MS

“…Bias auditing met fairness criteria for equal opportunity among patients who identified as Black. …”
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Characterizing anticoagulation reversal practices in Colombia: Initial insights from a national registry by Sebastián Seni-Molina, Santiago Posso Marín, Juan Esteban Masmela, María Camila Naranjo-Ramírez, Arturo D. Mora, Juliana María Gutiérrez-Posso, Julio Diez-Sepúlveda, Juan David Victoria-Salcedo, Ana Cristina Montenegro Arenas, Camilo Andrés Rueda Ortiz, Edgar David Gómez Lahitton, Hoover O. León-Giraldo, Juan Esteban Gómez-Mesa

“…Despite its importance, evidence in Colombia is limited. Methods: RECCANT-AR (Registro Colombiano de Clínicas de Anticoagulación y el Uso de Agentes Reversores) is a multicenter, observational, ambispective study analyzing anticoagulated patients requiring reversal therapy due to bleeding or procedural needs. …”
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Efficacy and safety of intensive triglyceride-lowering therapy on reducing recurrence of hypertriglyceridemia-associated pancreatitis (REDUCE): protocol for a multicentre, randomis... by Tao Chen, Weiqin Li, Chunping Zhu, Na Liu, Xin Xu, Lihui Deng, Dong Wu, Yao Wu, Jianhua Wan, Xin Huang, Lu Ke, Wenhua He, Hongwei Zhang, Duan Wang, Nong-Hua Lu, Yin Zhu, Ling Ding, Jianing Li, Jianwen Sheng, Nonghua Lu, Huifang Xiong, Liang Xia, Gaifang Liu, Jinyi Sheng, Lingyu Luo, Yupeng Lei, Huajing Ke, Lanting Wang, Shihang Zhang, Zhihua Tang, Youshun Liu, Guan Gui, Yingjie Chen, Yinyu Pan

“…The efficacy and safety of intensive TG-lowering therapy on reducing recurrence of HTG-AP trial aims to determine whether intensive TG-lowering therapy (with a TG goal of <150 mg/dL (equal to 1.7 mmol/L)), compared with usual care (with a TG goal of <500 mg/dL (equal to 5.65 mmol/L)), can reduce recurrence in patients after a first episode of HTG-AP.Methods and analysis This is an investigator-initiated, multicentre, open-label, parallel, superiority, randomised, controlled trial. …”
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The Effect of Postoperative Tranexamic Acid and Dexamethasone on Quality of Recovery After Arthroscopic Rotator Cuff Repair: a Double-Blinded, Randomized Controlled Trial by Jiang X, Xu C, Yuan C, Gao W, Liu W, Wang Y, Wang H, Yu W, He Y

“…Our goal is to relieve the acute postoperative pain and promote fast recovery and rapid discharge for ARCR patients.Patients and Methods: Ninety-six patients who underwent ARCR from December 2023 to March 2024 were enrolled in this double-blinded, randomized control trial (Registration number, ChiCTR2300078507). …”
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Comparative Analysis of ICS Combined with LABA versus Addition of Omalizumab on Transcriptomic Expression Profiles in Patients with Allergic Asthma by Liang YR, Chang CH, Huang SY, Wu YK, Yang MC, Huang KL, Tzeng IS, Hsieh PC, Lan CC

“…Therefore, this study aims to investigate the transcriptomic expression profiles and clinical outcomes between patients receiving ICS with LABA therapy and those adding omalizumab.Materials and Methods: This is a prospective, real-world study that enrolled 26 participants, divided into three groups: Group 1, ICS with LABA (n=10); Group 2, ICS with LABA plus omalizumab (n=12); and Group 3, healthy controls (n=4). …”
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PENURUNAN KADAR GULA DARAH AKIBAT PEMBERIAN EXTRA VIRGIN OLIVE OIL (Studi pada Tikus Galur Sprague Dawley yang Diinduksi Pakan Tinggi Lemak) by SH Bintari, K Nugraheni

“…It is caused by hyperglycemia induced by high-fat diet. Several alternative methods of treatment and prevention widely used is consuming olive oil. …”
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Comparison of the effects of remimazolam and dexmedetomidine on the quality of recovery in functional endoscopic sinus surgery: a randomized clinical trial by Yaqiong Li, Hui Zhou, Fanfan Gao, Qianqian Guan, Shengbin Wang, Yvqing Tan, Shenghong Hu

“…The aim of this study was to compare the effects of remimazolam and dexmedetomidine with respect to the QoR-40 score of patients who have undergone FESS. Methods A total of 120 patients (18–65 years) scheduled for FESS were randomly allocated to Group R, Group D or Group C. …”
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The Prognostic Value of Neutrophil-to-Lymphocyte Ratio and Lymphocyte-to-Monocyte Ratio in Patients with Hepatocellular Carcinoma Receiving HAIC-Based Conversion Hepatectomy: A Dua... by Li D, Fan Y, He B, Tang Y, Deng G, Guo R, Deng M, Tang D

“…This study evaluated the prognostic significance of neutrophil-to-lymphocyte ratio (NLR) and lymphocyte-to-monocyte ratio (LMR) in patients with HCC who received HAIC-based hepatectomy.Methods: This dual-center retrospective study included 390 patients who received HAIC-based conversion resection to investigate the relationship of NLR and LMR with survival outcomes, adverse events, and risk factors.Results: A total of 390 patients with HCC who received HAIC-based conversion liver resection were included. …”
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Restless Legs Syndrome Patients with Early Onset Disease or a Relevant Family History Associated with Pramipexole Ineffectiveness but Not Pregabalin by Ying M, Wang T, Zhang T, Zhai Z, Zhang L

“…Factors that affect medication efficacy remain unclear; different RLS subtypes may respond differently to various drugs.Objective: To identify factors associated with the ineffectiveness of pramipexole and pregabalin in patients with various subtypes of RLS.Methods: This retrospective nested case–control study enrolled 257 RLS patients prescribed pramipexole or pregabalin between March 2019 and April 2024 at the sleep center of Sir Run Run Shaw Hospital. …”
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Serum Osteopontin Enhances Hepatocellular Carcinoma Diagnosis and Predicts Anti-PD-L1 Immunotherapy Benefit by Wu M, Zou F, He S, Pi Y, Song Y, Chen S, Li L

“…Miantao Wu,1,2,* Fei Zou,3,* Suyin He,4,* Yingqi Pi,5 Yiling Song,1,2 Shulin Chen,1,2 Linfang Li1,2 1State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, People’s Republic of China; 2Department of Laboratory Medicine, Sun Yat-sen University Cancer Center, Guangzhou, People’s Republic of China; 3Department of Oncology, The First Affiliated Hospital of Chongqing Medical and Pharmaceutical College, Chongqing Key Laboratory of Prevention and Treatment for Occupational Diseases and Poisoning, Chongqing, People’s Republic of China; 4State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, People’s Republic of China; 5Department of Clinical Laboratory, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, People’s Republic of China*These authors contributed equally to this workCorrespondence: Linfang Li, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, 510060, People’s Republic of China, Email lilf@sysucc.org.cn Shulin Chen, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, 510060, People’s Republic of China, Email chenshl@sysucc.org.cnBackground: Osteopontin (OPN), a phosphorylated glycoprotein encoded by SPP1, critical in hepatic inflammation and fibrosis, requires further investigation for its role on hepatocellular carcinoma (HCC) and predictive value for anti-programmed cell death ligand 1 (anti-PD-L1) immunotherapy responses.Methods: Publicly available datasets were utilized to explore OPN expression in HCC. …”
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Adipose Tissue-Derived Extracellular Vesicles Loaded with miR-141-3p Regulate Obesity-Induced Insulin Resistance by Targeting Glycogen Synthesis and Gluconeogenesis by Wang Z, Ma T, Bai G, Fang Q, Ou B, Chen M, Xu P, Tian M, Xu A, Ma Y

“…This study aimed to investigate the regulatory effects of adipose tissue-derived EVs on obesity-induced hepatic insulin resistance and to elucidate the underlying molecular mechanisms by which EV-mediated signaling contributes to metabolic dysfunction.Methods: EVs with miR-141-3p knockout or overexpression were constructed and administered to both in vitro cell models and in vivo mouse models to investigate the regulatory role and underlying mechanisms of miR-141-3p-mediated adipose tissue-derived EVs in obesity-induced hepatic insulin resistance.Results: miR-141-3p is significantly upregulated in adipose tissue-derived EVs from high-fat diet (HFD)-fed mice, as well as in other obesity-related conditions. …”
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Network Pharmacology Approach to Unveiling the Mechanism of Wolfberry Mulberry Raspberry Decoction in the Treatment of Sepsis-Induced Myocardial Dysfunction by Zhang Q, Wen L, Li J, Liu P, Sun X, Liu Q, Chen X, Zhang Y

“…Qingqiong Zhang,1,* Lianbin Wen,1,* Junxian Li,2 Peng Liu,1 Xuechun Sun,1 Qingsong Liu,2,3 Xiaomei Chen,4 Yanfang Zhang5 1Department of Geriatric Cardiology, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610072, People’s Republic of China; 2Department of Traditional Chinese Medicine, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610072, People’s Republic of China; 3School of Acu-Mox and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, People’s Republic of China; 4Department of Geriatrics, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 610075, People’s Republic of China; 5Department of Public Health Center, People’s Hospital of Ningxia Hui Autonomous Region, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, 750002, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yanfang Zhang, Department of Public Health Center, People’s Hospital of Ningxia Hui Autonomous Region, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, 750002, People’s Republic of China, Email zhangyanfang@nxrmyy.com Xiaomei Chen, Department of Geriatrics, Hospital of Chengdu University of Traditional Chinese Medicine, 39 Shi-Er-Qiao Road, Jinniu District, Chengdu, Sichuan, 610072, People’s Republic of China, Tel +86-18080407013, Email 3612556@qq.comObjective: To investigate the mechanisms by which the Wolfberry Mulberry Raspberry Decoction (WMRD) affects Sepsis-Induced Myocardial Dysfunction (SIMD) using network pharmacology and experimental validation.Methods: We explored the TCM Systems Pharmacology Database to gather biological data for WMRD compounds. …”
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Mapping the Brain’s Role in Osteoarthritis: New Evidence for Prevention by Di J, Xi Y, Liu Y, Qi L, Chen S, Qin Y, Xiang C

“…Jingkai Di,1,2,* Yujia Xi,3,* Yaru Liu,4 Likun Qi,3 Shuai Chen,1,2 Yingda Qin,3 Chuan Xiang1,2 1Department of Orthopedics, Second Hospital of Shanxi Medical University, Taiyuan, People’s Republic of China; 2Shanxi Provincial Key Laboratory of Bone and Soft Tissue Injury Repair, Taiyuan, People’s Republic of China; 3The Second Hospital of Shanxi Medical University, Taiyuan, People’s Republic of China; 4The Third Hospital of Shanxi Medical University, Taiyuan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Chuan Xiang, Department of Orthopedics, Second Hospital of Shanxi Medical University, Taiyuan, People’s Republic of China, Tel +86 15903410351, Email chuanxiang@sxmu.edu.cnPurpose: This study explores the causal link between brain structural parameters and Osteoarthritis (OA), aiming to prevent OA progression.Patients and Methods: We used two-sample Mendelian randomization. …”
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A Randomized Controlled Trial for the Optimal Implementation of Psoriasis Treatment by Integrating Chinese and Western Medicine by Yu Y, Sun X, Hu R, Xia P, Wei Y, Yang W, Huang N, Ding Y, Guo S, Yang C, Weng H, Zhang Y, Ding X, Huang Q, Zhou X, Li X, Li B

“…Currently, the prevalent guideline-recommended regimen is based on psoriasis severity; however, no corresponding studies have been conducted on the hierarchical selection of integrated Chinese and Western medicine treatments.Objective: To explore the optimal implementation of psoriasis treatment by integrating Chinese and Western medicine.Methods: We conducted a 16-week multicenter single-blind randomized controlled trial in China between December 2019 and July 2022. …”
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Long COVID in Elderly COPD Patients: Clinical Features, Pulmonary Function Decline, and Proteomic Insights by Li S, Zhao H, Zhang M, Yuan T, Chai D, Shen Z, Qin C, Li Y, Pan M

“…Shuangyan Li,1,* Hui Zhao,2,* Min Zhang,3 Tingting Yuan,4 Di Chai,5 Zhengyin Shen,3 Chengfeng Qin,2,6 Yanming Li,5 Mingming Pan5 1Beijing Hospital, National Centre of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People’s Republic of China; 2State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing, People’s Republic of China; 3Department of Radiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China; 4Department of Clinical Laboratory, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China; 5Department of Respiratory and Critical Care Medicine, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China; 6Research Unit of Discovery and Tracing of Natural Focus Diseases, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Mingming Pan, Department of Respiratory and Critical Care Medicine, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, No. 1 Dongdan Dahua Road, Beijing, People’s Republic of China, Tel +86-13661129402, Email panmm6@163.comBackground: Elderly patients with chronic obstructive pulmonary disease (COPD) face a heightened risk of developing long coronavirus disease (COVID); however the exact clinical characteristics and underlying mechanisms remain unclear.Methods: We enrolled 85 elderly COPD patients, of whom 43 reported newly onset persistent fatigue (the most dominant complaint of long COVID) within 1 year after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, and they were allocated to the Long-COVID group. …”
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Biomechanical Corneal Parameters in Eyes With Chronic Ocular Hypotony and in Non-Hypotonic Eyes. Self-Controlled Case Series Study by Bouchikh-El Jarroudi R, Roche Fernández K, Romera Romero P, Croitoru-Croitoru T, Goñi-Guarro A, Botella-Garcia J, Sabala Llopart A, Loscos-Arenas J, Videla S

“…Our purpose is to provide evidence and clinical correlation on the biomechanical corneal changes in chronic hypotonic eyes.Patients and Methods: A single-center, transversal, self-controlled case series study was conducted involving patients with at least one chronic hypotonic eye (defined as an intraocular pressure ≤ 6.5 mmHg measured on three separate occasions for at least three months). …”
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Usp18 Mediates D-Dopachrome Tautomerase-Induced Astrocytic Inflammation After Spinal Cord Injury by Zhang X, Hou Y, Cai R, Zhou Y, He B, Cao Z, Li A, Song H, Wang Y, Jiang H, Qi L, Wang Y

“…Whether D-DT activates astrocytic inflammation via regulation of Usp18 deserves further study.Methods: SCI model was prepared by cord contusion at T8-T10 of rats. …”
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Changes of natriuresis and prediction of cardiovascular events in patients with type 2 diabetes and decompensated heart failure over therapy with sodium-glucose cotransporter 2 inh... by O. A. Abdullaev, A. G. Arutyunov, D. P. Vereshchak, E. V. Tavlueva, V. A. Konik, N. A. Bylova, D. V. Puzenko, N. P. Kulagina, I. R. Nurieva, T. V. Zanina, G. P. Arutyunov

“…To evaluate the influence and changes of clinical and water-electrolyte parameters on the risk of cardiovascular events in the early period after decompensated heart failure (HF) in patients with type 2 diabetes (T2D), taking into account the influence of standard diuretic therapy and diuretic therapy in combination with sodium-glucose cotransporter 2 (SGLT-2) inhibitors.Material and methods. The study included 119 patients with type 2 diabetes and class III-IV HF. …”
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Impact of Pan-Immune Inflammation Value on Short-Term Outcomes and Long-Term Prognosis in Patients with Type A Aortic Dissection by Cai H, Shourav, Shao Y, Shuangling S, Duan C, Zhang C, Wu QC

“…This study aims to investigate the relationship between preoperative PIV and both short-term and long-term outcomes in patients with acute TAAD.Methods: This retrospective study included acute TAAD patients who underwent surgical repair between September 2017 and December 2020. …”
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The Role of Applying Metagenomic Next-Generation Sequencing (mNGS) in Periprosthetic Joint Infection with Sinus Tract: A Retrospective Study by Yuan X, Wang Q, Ding H, Li H, Fang X, Zhang W, Huang Z

“…We evaluated mNGS’s role in diagnosing and guiding treatment for PJI with sinus tracts.Methods: This retrospective analysis included 52 PJI patients (2019– 2024). …”
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