Mitophagy-Related Gene CHDH Predicts Prognosis and Immune Response and Inhibits Proliferation and Migration in vitro and in vivo of Oral Squamous Cell Carcinoma by Chen L, Zhou Z, Guo L, He Z, Luo W, Fu Y, Xiao Q, Liu B, Huang P

“…Mitophagy is a special type of cellular autophagy that plays an important role in tumors, but its role in OSCC is still unclear.Methods: Mitophagy-related genes (MRGs) were obtained from the GeneCards database. …”
Get full text

Injectable Nanocomposite Hydrogel for Accelerating Diabetic Wound Healing Through Inflammatory Microenvironment Regulation by Chen Y, Li Y, Song H, Liu X, Zhang H, Jiang J, Liu H, Zhuo R, Cheng G, Fang J, Xu L, Qi Y, Sun D

“…Employing zeolitic imidazolate framework-8 (ZIF-8) as a drug delivery platform, integrated within a temperature-sensitive injectable hydrogel, presents an intriguing strategy for the closure of various irregular wounds, modulation of inflammatory responses, and promotion of angiogenesis.Methods: Herein, ZIF-8 loaded with curcumin (Cur) combined with methylcellulose/carboxymethyl chitosan (MCC) thermosensitive hydrogel was described. …”
Get full text

Xingxiao Pill Suppressed the Progression of Non-Small Cell Lung Cancer by Targeting SREBP1/FASN–Induced Fatty Acid Biosynthesis via PI3K/AKT/mTOR Signaling Pathway by Zhou X, Hu X, Zhang Z, Lin S, Lin X, Zhou T, Bai Y, Hu K

“…This study aimed to evaluate the potential efficacy of XXP in treating NSCLC and to investigate how XXP regulates fatty acid biosynthesis in NSCLC.Methods: A lung carcinoma mouse model was created by transplanting Lewis lung carcinoma (LLC) cells into male C57BL/6 mice. …”
Get full text

Effect of telemedicine-supported structured exercise program in patients with chronic low back pain: a randomized controlled trial. by Yuan Feng, Chuanmei Zhu, Huizhen Liu, Tianjie Bao, Chongyang Wang, Zezhang Wang, Xiaoyi Wang, Ruishi Zhang, Yujia Zhang, Shaojun Zhang, Lin Yang, Siyi Zhu, Chengqi He

“…<h4>Objectives</h4>To compare the clinical outcomes of patients with CLBP following a telemedicine intervention versus usual care therapy.<h4>Materials and methods</h4>An open label, randomized controlled trial (RCT) was conducted over eight weekly sessions. …”
Get full text

Impacts of Prior Anti-Osteoporosis Treatments on Sequential Denosumab Responses in BMD Changes Among Postmenopausal Osteoporosis Women in East China: Real-World Data Analysis by Guan G, Du Y, Tang W, Chen M, Yu W, Li H, Cheng Q

“…Guoyu Guan,1 Yanping Du,2,&amp;ast; Wenjing Tang,2 Minmin Chen,2 Weijia Yu,2 Huilin Li,2 Qun Cheng2,&amp;ast; 1Department of Geriatrics, Huadong Hospital, Fudan University, Shanghai, People’s Republic of China; 2Department of Osteoporosis and Bone Disease, Huadong Hospital, Fudan University, Shanghai, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Qun Cheng, Department of Osteoporosis and Bone Disease, Huadong Hospital, Fudan University, No. 221, Yan’an West Road, Shanghai, 200040, People’s Republic of China, Email chengqun@fudan.edu.cn Yanping Du, Department of Osteoporosis and Bone Disease, Huadong Hospital, Fudan University, No. 221, Yan’an West Road, Shanghai, 200040, People’s Republic of China, Email yanpingdu@fudan.edu.cnPurpose: This study aimed to investigate the impacts of prior anti-osteoporosis treatments on bone mineral density (BMD) changes in Chinese postmenopausal women with osteoporosis following 1-year Denosumab (Dmab) therapy.Patients and Methods: This retrospective cohort study enrolled 381 postmenopausal women, all receiving a 1-year Dmab treatment. …”
Get full text

Altered Structure-Function Coupling Associated with Attention Decline in Shift Work Disorder by Wu Z, Feng S, Li K, Dong L, Zhang L, Ning Y, Yin D

“…This study aimed to examine the role of changed SFC in abnormal attentional network function in SWD.Methods: Thirty-four patients with SWD and thirty-two healthy controls were recruited. …”
Get full text

Association Between Daytime Sleepiness and Quality of Life in Chinese Adolescents: A Moderated Mediation of Cognitive Dysfunction and Depressive Symptoms by Li W, Hu N, Yang X, Zheng W, Tong J, Song J, Song Y, Gao X, Wang Z, Liu W, Wang L, Tan Y, Wang C, Deng H

“…However, the interrelationships among these variables remain unclear, particularly regarding whether cognitive function moderates the association between daytime sleepiness and quality of life.Methods: A large-scale cross-sectional survey was conducted among 52,964 students (grades 7– 12) across five geographically diverse regions of China. …”
Get full text

Myocardium-to-cavity ratio derived from simultaneous 99mTc-PYP/201Tl dual-isotope SPECT imaging to differentially diagnose transthyretin cardiac amyloidosis by Shozo Yamashita, Kenichi Nakajima, Teppei Kitano, Hiromu Kato, Tatsuya Yoneyama, Haruki Yamamoto, Kunihiko Yokoyama

“…This study evaluates the clinical utility of the M/C ratio by comparing it to the H/CL ratio. Methods/results We retrospectively analyzed 121 consecutive patients with suspected cardiac amyloidosis who underwent dual-isotope 99mTc-PYP/201Tl imaging. …”
Get full text

Exploring the Therapeutic and Gut Microbiota-Modulating Effects of Qingreliangxuefang on IMQ-Induced Psoriasis by Yu Z, Wang Y, Guo Y, Zhu R, Fang Y, Yao Q, Fu H, Zhou A, Ma L, Shou Q

“…Zhengyao Yu,1– 5,&ast; Yingying Wang,2,3,6,&ast; Yingxue Guo,2,3,6 Ruotong Zhu,1,4 Yimiao Fang,1 Qinghua Yao,7 Huiying Fu,2,3,5,6 Ang Zhou,8 Lili Ma,1 Qiyang Shou2,3,5,6 1The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, Zhejiang, 310006, People’s Republic of China; 2The Second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310053, People’s Republic of China; 3Jinhua Academy, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310053, People’s Republic of China; 4The First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310053, People’s Republic of China; 5Yongkang Hospital of Traditional Chinese Medicine, Jinhua, Zhejiang, 321300, People’s Republic of China; 6School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310053, People’s Republic of China; 7The Second Affiliated Hospital of Zhejiang Chinese Medical University, Xinhua Hospital of Zhejiang Province, Hangzhou, Zhejiang, 310005, People’s Republic of China; 8Department of Dermatology, Yiwu Central Hospital Medical Community Choujiang Hospital District, Yiwu, Zhejiang, 322000, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Lili Ma, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, Zhejiang, 310006, People’s Republic of China, Email lilyma163@163.com Qiyang Shou, The Second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310053, People’s Republic of China, Email sqy133@126.comPurpose: To investigate the therapeutic and gut microbiota-modulating effects of Qingreliangxuefang (QRLXF) on psoriasis.Materials and Methods: We used network pharmacology, a computational approach, to identify key bioactive compounds and biological targets, and explored the molecular mechanisms of QRLXF. …”
Get full text

RESULTS OF TREATMENT OF EDENTULOUS PATIENTS WITH DENTURES MADE OF «FTORAX» by V.M. Dvornyk, H.M. Kuz, O.B. Tumakova, O.S. Shemetov, V.S. Kuz

“…The work is focused on the study of the functional state of the masticatory muscles and the restoration of masticatory effectiveness in edentulous patients, for whom dentures were made in the prosthodontics clinic from the acrylic base material «Ftorax». Material and methods. Hot curing plastic based on fluorine-containing acrylic copolymers «Ftorax» was used in the work. …”
Get full text

The results of investigating the efficacy and safety of non-medical switching from the original rituximab to its biosimilar in rheumatoid arthritis patients (AMBIRA study) by M. A. Korolev, Yu. B. Ubshaeva, N. Y. Banshchikova, E. A. Letyagina, A. A. Mullagaliev

“….”, Switzerland) to its biosimilar (Acellbia®, “BIOCAD”, Russia) by non-medical reasons in rheumatoid arthritis patients.Subjects and methods. 40 rheumatoid arthritis patients on basic therapy who had taken at least one course of original rituximab (MabThera®) 1000 mg twice in 2 weeks more than 6 months ago were included. …”
Get full text

Biomimetic Aggregation-Induced Emission Luminogens Mediated Effective Phototherapy and Immune Checkpoint Blockade for the Synergistic Treatment of Lung Cancer by Yang L, Wei M, Deng X, He L, Lin Y, Lin X, Zhou D, Li M, Qin A, Zhang L, Ouyang Z

“…However, the disadvantages including hydrophobicity, low specificity, and short circulation lifetime limited their efficacy on cancer therapy.Methods: We developed a biomimetic AIEgens constructed using CD8+ T cells membrane to camouflage the AIEgen C41H37N2O3S2 (named BITT) nanoparticles (termed TB). …”
Get full text

The Negative Regulatory Role of Transcriptional Regulator H-NS on the Type VI Secretion System in Acinetobacter baumannii by Zhang Y, Zhou H, Kong J, Hu P, Zhang Y, Cao J, Zhou B

“…We explored potential targets of H-NS mediated silencing or activation within the regulation of A. baumannii T6SS, along with the specific regulatory mechanisms involved, thereby providing a theoretical foundation for further research on A. baumannii invasive infections stemming from mixed infections and the development of therapeutic target.Methods: Using the plasmids pAT04 and pYMAb2-hyg, we constructed A. baumannii ATCC19606 strains with the hns gene knocked out (ABΔhns) and overexpressed (ABhns+). …”
Get full text

Using Human‐Centred Design to Codesign Patient Engagement Tools With a Patient Advisory Council: Successes and Challenges by Madelyn Knaub, Santiago Leon, Surakshya Pokharel, Veronika Kiryanova, Kim Giroux, Prachi Khanna, Anna Rychtera, D'Arcy Duquette, Pamela Mathura, Nancy Verdin, Anshula Ambasta

“…Objective To describe the process of using a HCD approach to co‐build patient engagement tools with PRPs and to identify successes and challenges encountered. Methods A HCD working group was formed from a Patient Advisory Council (PAC) that supports a research program to optimize laboratory test ordering in hospitalized patients. …”
Get full text

Application of Intravoxel Incoherent Motion in the Prediction of Intra-Tumoral Tertiary Lymphoid Structures in Hepatocellular Carcinoma by Ma L, Liao S, Zhang X, Zhou F, Geng Z, Hu J, Zhang Y, Zhang C, Meng T, Wang S, Xie C

“…., Ltd, Beijing, People’s Republic of China; 4Central Research Institute, United Imaging Healthcare, Shanghai, People’s Republic of China; 5Center of Hepato-Pancreato-Biliary Surgery, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, 510080, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Chuanmiao Xie, Department of Radiology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, People’s Republic of China, Email xchuanm@sysucc.org.cn Shutong Wang, Center of Hepato-Pancreato-Biliary Surgery, Center of Hepato-Pancreato-Biliary Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510080, People’s Republic of China, Email wangsht23@mail.sysu.edu.cnObjective: To explore the value of intravoxel incoherent motion (IVIM) sequences in predicting intra-tumoral tertiary lymphoid structures (TLSs).Materials and Methods: This prospective study pre-operatively enrolled hepatocellular carcinoma (HCC) patients who underwent magnetic resonance imaging including IVIM sequences, between January 2019 and April 2021. …”
Get full text

Identification and Validation of Epithelial Cell Centre Regulatory Transcription Factors in the Gastric Cancer Microenvironment by Su G, Wang J, Liu S, Fu X, Li Y, Pan G

“…Guomiao Su,1,&ast; Juan Wang,2,&ast; Shiyue Liu,1,&ast; Xiaonan Fu,1 Yanxi Li,1 Guoqing Pan1 1Department of Pathology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yun Nan, People’s Republic of China; 2Clinical Laboratory, Yunnan Province Third People’s Hospital, Kunming, Yun Nan, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Yanxi Li; Guoqing Pan, Department of Pathology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yun Nan, People’s Republic of China, Email liyanxicuhk@163.com; guoqing_pan@163.comPurpose: To identify the epithelial cell centre regulatory transcription factors in the gastric cancer (GC) microenvironment and provide a new strategy for the diagnosis and treatment of GC.Methods: The GC single-cell dataset was downloaded from the Gene Expression Omnibus (GEO) database. …”
Get full text

Mindfulness-based programmes for mental health promotion in adults in nonclinical settings: A systematic review and meta-analysis of randomised controlled trials. by Julieta Galante, Claire Friedrich, Anna F Dawson, Marta Modrego-Alarcón, Pia Gebbing, Irene Delgado-Suárez, Radhika Gupta, Lydia Dean, Tim Dalgleish, Ian R White, Peter B Jones

“…We reviewed trials to assess whether MBPs promote mental health relative to no intervention or comparator interventions.<h4>Methods and findings</h4>Following a detailed preregistered protocol (PROSPERO CRD42018105213) developed with public and professional stakeholders, 13 databases were searched to August 2020 for randomised controlled trials (RCTs) examining in-person, expert-defined MBPs in nonclinical settings. …”
Get full text

Comparison of the Impact of tNGS with mNGS on Antimicrobial Management in Patients with LRTIs: A Multicenter Retrospective Cohort Study by Li D, Li Q, Huang Z, Wu W, Fan X, Liu J, Li R, Zhang Q, Su X

“…However, the impact of tNGS and mNGS on antimicrobial stewardship in patients with LRTIs remains unclear.Methods: Patients diagnosed with LRTIs who underwent tNGS or mNGS between June 2021 and January 2024 were included. …”
Get full text

Platelet Membrane-Coated Poly (Lactic-Co-Glycolic Acid) Nanoparticles as a Targeting Drug Delivery System for Multidrug-Resistant Breast Cancer by Song B, Na YG, Kim BJ, Jin M, Song YH, Kim DE, Hwang S, Baek JS, Lee HK, Cho CW

“…To overcome these challenges, we developed a triple-functionalized nanocarrier system incorporating poly(lactide-co-glycolide) (PLGA)-based nanoparticles (PNs), D-α-tocopheryl polyethylene glycol succinate (TPGS) for P-gp inhibition, and platelet membrane (PM) coating for targeted tumor delivery.Methods: The PM-coated TPGS-modified PNs with PTX (PTPNs) was characterized by particle size analysis, transmission electron microscopy (TEM), and protein assay to confirm PM coating. …”
Get full text

Integrating CEUS Imaging Features and LI-RADS Classification for Postoperative Early Recurrence Prediction in Solitary Hepatocellular Carcinoma: A Machine Learning-Based Prognostic... by Liang L, Pang J, Zhang B, Que Q, Gao R, Wu Y, Peng J, Zhang W, Bai X, Wen R, He Y, Yang H

“…Li Liang,1,2,&amp;ast; Jinshu Pang,1,&amp;ast; Bulin Zhang,2 Qiao Que,1 Ruizhi Gao,1 Yuquan Wu,1 Jinbo Peng,1 Wei Zhang,2 Xiumei Bai,1 Rong Wen,1 Yun He,1 Hong Yang1 1Department of Medical Ultrasound, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, People’s Republic of China; 2Department of Medical Ultrasound, Liuzhou People’s Hospital, Liuzhou, Guangxi Zhuang Autonomous Region, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Hong Yang, Department of Medical Ultrasound, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning, Guangxi Zhuang Autonomous Region, People’s Republic of China, Tel +8607715356706, Email yanghong@gxmu.edu.cn Yun He, Department of Medical Ultrasound, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning, Guangxi Zhuang Autonomous Region, People’s Republic of China, Tel +8607715356706, Email heyun@gxmu.edu.cnPurpose: To develop and validate a machine learning (ML) model for predicting early postoperative recurrence in hepatocellular carcinoma (HCC) patients by integrating contrast-enhanced ultrasound (CEUS) features with Liver Imaging Reporting and Data System (LI-RADS) classification.Materials and Methods: A retrospective analysis was conducted on data from 279 patients who underwent surgical resection for HCC. …”
Get full text