Identification of EARS2 as a Potential Biomarker with Diagnostic, Prognostic, and Therapeutic Implications in Colorectal Cancer by Wang L, Deng X, Tang J, Gong Y, Bu S, Li Z, Liao B, Ding Y, Dai T, Liao Y, Li Y

“…This study identifies key genes associated with lactic acid metabolism and explore their impact on CRC.Patients and Methods: This study utilized data from The Cancer Genome Atlas, Gene Expression Omnibus, other public databases, and our institutional resources. …”
Get full text

A Phase I Study to Evaluate the Safety, Tolerability, Pharmacokinetics of BGT-002, a Novel ATP-Citrate Lyase Inhibitor, in Healthy Chinese Subjects by Liu Y, Yu C, Zhang Y, Xie Z, Wang Y, Qian H, Liang L, Liu Y, Chen Q, Jia J, Yan S, Lai X, Li W, Li J, Zhang Y, Nan F, Yu C

“…., Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Fajun Nan; Chen Yu, Email fjnan@simm.ac.cn; cyu@shxh-centerlab.comObjective: This Phase I study evaluated the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of BGT-002, a novel ATP-citrate lyase (ACLY) inhibitor, in healthy Chinese adults.Methods: This study included three parts: Part I (single-ascending-dose study), Part II (multiple-ascending-dose study), and Part III (food effect study). …”
Get full text

LianChuang ZhiXue Liquid Enema Modulates the Macrophage Polarization of Ulcerative Colitis via Inhibiting the Jagged-1/Notch1 Signaling Pathway by Zhang Y, Liu J, Zhang D, Qian H

“…However, its specific molecular mechanism has not been clarified to explore the underlying macular mechanism of LCZXL enema effect on UC, based on Jagged-1/Notch1 signaling pathway and the macrophage polarization.Methods: After modeling of UC mice, the experiment was conducted in two parts: Experiment I: Control, Model, Mesalazine, Low dose of LCZXL (LCZXL-L), High dose of LCZXL (LCZXL-H); Weight and Disease Activity Index (DAI) scores were recorded on days 1, 3, 5, 7, 9, 11, and 13. …”
Get full text

Prediction of Pathologic Response in Unresectable Hepatocellular Carcinoma After Downstaging with Locoregional and Systemic Combination Therapy by Yang C, Chen Y, Sheng L, Wang Y, Zhang X, Yang Y, Ronot M, Jiang H, Song B

“…Chongtu Yang,1,2,* Yidi Chen,1,2,* Liuji Sheng,1,2 Yanshu Wang,1,2 Xiaoyun Zhang,3 Yang Yang,4 Maxime Ronot,5 Hanyu Jiang,1,2 Bin Song1,2,6 1Department of Radiology, West China Hospital, Sichuan University, Chengdu, People’s Republic of China; 2Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, Sichuan, People’s Republic of China; 3Division of Liver Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, People’s Republic of China; 4Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, People’s Republic of China; 5Department of Radiology, Hôpital Beaujon (Université de Paris), Clichy, France; 6Department of Radiology, Sanya People’s Hospital, Sanya, Hainan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hanyu Jiang; Bin Song, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, People’s Republic of China, Email hanyu_jiang@foxmail.com; songlab_radiology@163.comBackground: The combination of locoregional and systemic therapy may achieve remarkable tumor response for unresectable hepatocellular carcinoma (HCC).Objective: We aimed to investigate the correlation between radiologic and pathologic responses following combination therapy, evaluate their prognostic values, and to establish a non-invasive prediction system for pathologic response.Methods: This single-center retrospective study included 112 consecutive patients with HCC who underwent locoregional and systemic combination therapy followed by liver resection or transplantation. …”
Get full text

Postoperative Adverse Outcomes in Patients With Frailty Undergoing Urologic Surgery Among American Patients: A Propensity-Score Matched Retrospective Cohort Study by Hsu CW, Chang CC, Lam F, Liu MC, Yeh CC, Chen TL, Lin CS, Liao CC

“…Our purpose is to evaluate the association between the mFI-5 and postoperative mortality and complications among patients undergoing urologic surgery.Methods: This retrospective cohort study used the American College of Surgeons National Surgical Quality Improvement Program database from 2015 to 2020. …”
Get full text

Multi-Omics Analysis and Validation of Cell Senescence-Related Genes Associated with Non-Alcoholic Fatty Liver Disease by Gong J, Qin Z, Xiao Y, Li J, Wang Q, Lei L, Li J

“…Jianhua Gong,1– 3,* Zhijie Qin,3,* Yihao Xiao,3,* Jixue Li,3 Qing Wang,3 Liping Lei,4 Jiangfa Li3 1Department of Hepatobiliary and Pancreatic Surgery, The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei, 443003, People’s Republic of China; 2Department of Hepatobiliary and Pancreatic Surgery, Yichang Central People’s Hospital, Yichang, Hubei, 443003, People’s Republic of China; 3Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, 541001, People’s Republic of China; 4Department of geriatric medicine, The First Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, 541001, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jianhua Gong, Department of Hepatobiliary and Pancreatic Surgery, The First College of Clinical Medical Science, China Three Gorges University, Yichang Central People’s Hospital, No. 183 Yiling Ave, Yichang, Hubei, 443003, People’s Republic of China, Tel +86-13886703242, Email 38891488@qq.com Jiangfa Li, Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, 541001, People’s Republic of China, Tel +86-18907839510, Email 247546160@qq.comObjective: To assess causal links between senescence-related genes and non-alcoholic fatty liver disease (NAFLD) using summary-data Mendelian randomization (SMR) and colocalization analyses.Methods: Our study examined the relationship between senescence and NAFLD by integrating DNA methylation, gene expression, and protein quantitative trait loci (mQTL, eQTL, and pQTL) data. …”
Get full text

The Higher Incidence of Liver Injury in HCC Patients Compared to Other Malignancies During Immune-Checkpoint Inhibitor Therapy is Primarily Due to Tumor Progression by Wang Y, Liu L, Zhao M, Chen W, Chen Y, Zhao X

“…Yan Wang,1,* Liwei Liu,2,* Mengyu Zhao,1,* Wei Chen,3 Yu Chen,2 Xinyan Zhao1 1Liver Research Center, Beijing Friendship Hospital, Key Laboratory on Translational Medicine on Cirrhosis, National Clinical Research Center for Digestive Disease, Capital Medical University, Beijing, People’s Republic of China; 2Fourth Department of Liver Disease (Difficult & Complicated Liver Diseases and Artificial Liver Center), Beijing You’an Hospital, Capital Medical University, Beijing, People’s Republic of China; 3Department of Gastroenterology, Beijing Friendship Hospital, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, National Clinical Research Center for Digestive Disease, Beijing Digestive Disease Center, Capital Medical University, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xinyan Zhao, Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory on Translational Medicine on Cirrhosis, National Clinical Research Center for Digestive Disease, 95 Yong-an Road, Xi-Cheng District, Beijing, 100050, People’s Republic of China, Email zhao_xinyan@ccmu.edu.cn Yu Chen, Fourth Department of Liver Disease (Difficult & Complicated Liver Diseases and Artificial Liver Center), Beijing You’an Hospital, Capital Medical University, No. 8, Xi Tou Tiao, Youanmen Wai, Fengtai District, Beijing, 100069, People’s Republic of China, Email chybeyond1071@ccmu.edu.cnBackground: The study explores the incidence and clinical features of immune-related liver injury (irLI) in hepatocellular carcinoma (HCC) patients compared to those with other malignancies receiving immune checkpoint inhibitors (ICIs).Methods: A retrospective analysis was conducted on patients treated with ICIs at Beijing Friendship Hospital. …”
Get full text

Impact of Gender, Age, and Obesity on Childhood Obstructive Sleep Apnea: A Cross-Sectional Study of 4,668 Children by Huang G, Wang Q, Chang L, Ye S, Liu J, Lu Y, Li T, Zhan X, Liang J, Cheng Y, Gu Q

“…This study aimed to explore how these factors influence OSA in pediatric patients.Patients and Methods: This cross-sectional study was conducted at the Sleep Center of the Children’s Hospital Affiliated with the Capital Institute of Pediatrics from January 2017 to May 2023. …”
Get full text

Zhongfeng Xingnao Liquid Ameliorated the Early Impairment of Intracerebral Hemorrhage by Inhibiting NF-κB/NLRP3 Axis in Rats by Yang H, Luo B, Du Y, Guo J, Zhang S, Wang P, Dai Y, Lu Y, Xu S

“…This study aims to elucidate the optimal timing for ZFXN administration within hours of symptom onset and its underlying mechanisms, focusing on NF-κB/NLRP3-mediated neuroinflammation.Methods: ICH was induced by injection of autologous arterial blood into the left caudal nucleus. …”
Get full text

Predictive Significance of Admission-Day Blood Routine-Derived Indices for 30-Day Mortality Risk in Elderly Patients with Bacterial Pneumonia by Huang X, Huang L, Zhao S, Yuan L, Wang X, Tang G, Yuan K, Xiao M

“…Xiaoling Huang,1,* Lihua Huang,2,* Shicai Zhao,1 Lingyan Yuan,3 Xing Wang,4 Guanghua Tang,4 Kaifen Yuan,5 Min Xiao4 1Department of Respiratory, Sichuan Provincial People’s Hospital East Sichuan Hospital & Dazhou First People’s Hospital, Dazhou, Sichuan, People’s Republic of China; 2Department of Infection Disease, The First Affiliated Hospital of Dali University, Dali, Yunnan, People’s Republic of China; 3Department of Endocrinology, First People’s Hospital of LuLiang County, Qujing, Yunnan, People’s Republic of China; 4Department of Laboratory Medicine, Sichuan Provincial People’s Hospital East Sichuan Hospital & Dazhou First People’s Hospital, Dazhou, Sichuan, People’s Republic of China; 5Department of General Medicine, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Kaifen Yuan, Department of General Medicine, The Second Affiliated Hospital of Kunming Medical University, No. 374, Dianmian Avenue, Wuhua District, Kunming, Yunnan, 650000, People’s Republic of China, Email 2548733853@qq.com Min Xiao, Department of Laboratory Medicine Sichuan Provincial People’s Hospital East Sichuan Hospital & Dazhou First People’s Hospital, 522 Xiwai Tashi Road, Tongchuan District, Dazhou, Sichuan, 635000, People’s Republic of China, Email xiaominkv@163.comObjective: To investigate the prognostic value of hematological indices derived from routine blood tests in assessing 30-day mortality risk among elderly patients with bacterial pneumonia at the time of admission.Methods: This study was conducted in the Second Affiliated Hospital of Kunming Medical University. …”
Get full text

Anthrahydroquinone-2,6-Disulfonate Restores Lung Function in COPD Through Keap1/Nrf2 Pathway Activation by Li Z, Chen J, Zhang J, Li N, Yi Y, Lu H, Li M, Liu R, Chen Y, Liu X

“…This study aimed to investigate the therapeutic effects of AH2QDS on COPD by exploring its mechanisms involving the Keap1-Nrf2 pathway via in vivo and in vitro models.Methods: This study induced COPD-like pathology by using LPS in combination with CS / CSE, establishing both in vivo and in vitro models to evaluate the effects of AH2QDS on lung function, histopathology, oxidative stress markers, levels of inflammatory cytokines, and apoptosis. …”
Get full text

Effect of COVID-19 restriction measures on multidrug resistant tuberculosis case notifications and treatment outcomes at treatment centres in Uganda by Pamela Okwir Apio, Lydia Nakiyingi, Charles Batte, Pius Mukisa, John Mukisa, Monica Okwir Acen, Andrew Weil Semulimi, Achilles Katamba, Joan Nakayaga Kalyango

“…This study aimed to assess the effect of COVID-19 restriction measures on MDR-TB case notifications and treatment outcomes at treatment centres in Uganda. Methods This was a retrospective cohort study in which a total of 483 participants were enrolled—238 before (March 2018-February 2020) and 245 during (March 2020-February 2022) COVID-19 restrictions. …”
Get full text

A cost-effectiveness analysis of sotorasib as second-line treatment for patients with KRAS-G12C-mutated metastatic non-small cell lung cancer (mNSCLC) in Switzerland by Tämer El Saadany, Judith Lupatsch, Michael Mark, Michaela Barbier, Tarun Mehra, Matthias Schwenkglenks, Roger von Moos

“…Our analysis assessed the cost-effectiveness of sotorasib as a second-line treatment in Swiss patients with non-small cell lung cancer from the perspective of the Swiss statutory health insurance system. METHODS: A partitioned survival model based on the CodeBreak 200 trial was constructed with a time horizon of 10 years and a discount rate of 3% for costs and quality-adjusted life years (QALYs). …”
Get full text

ROS/pH Dual-Responsive Hydrogel Dressings Loaded with Amphiphilic Structured Nano Micelles for the Repair of Infected Wounds by Wang J, Lin Y, Fan H, Cui J, Wang Y, Wang Z

“…The toxins secreted by bacteria cause persistent inflammation and excessive oxidative stress, resulting in serious tissue damage and ultimately delay wound healing.Methods: Herein, a ROS/pH dual-responsive hydrogel dressing loaded with amphiphilic structured nano micelles was developed for efficiently promoting infected wound healing. …”
Get full text

Exploring Biomarkers Related to Cell Adhesion in Polycystic Ovary Syndrome Using Bioinformatics and Conducting Experimental Validation by Zhu J, Qi X, Zhang Z, Zhou Q, Gu R, Wu X, Zhong L

“…This study aimed to identify and analyze the biomarkers associated with cell adhesion-related genes (CRGs) for treating PCOS and their biological mechanisms.Patients and Methods: In this study, GSE80432 was used to identify differentially expressed genes (DEGs) (PCOS vs control group) through differential expression analysis. …”
Get full text

Non-Cognitive Behavioral Therapy Psychological Interventions May Not Make the Difference in Children and Adolescents With Chronic Pain by Perlman L, Malka N, Terry O, Nguyen A, Guimarães Ferreira Fonseca L, Ingelmo JI, Ingelmo P

“…The aim of this retrospective cohort study with secondary retrospective matched case–control analysis was to evaluate the impact of interruption of non-CBT psychological interventions, namely psychoanalysis and psychodynamic psychotherapy, on children and adolescents with chronic pain conditions during the SARS-CoV-2 pandemic.Materials and Methods: We included pediatric patients with primary and secondary chronic pain conditions evaluated by our team during the SARS-CoV-2 pandemic. …”
Get full text

Lobetyolin Suppressed Osteoclastogenesis and Alleviated Bone Loss in Ovariectomy-Induced Osteoporosis via Hindering p50/p65 Nuclear Translocation and Downstream NFATc1/c-Fos Expres... by Xiu C, Luo H, Huang W, Fan S, Yuan C, Chen J, Xu C, Yao C, Hong D, Zhang L

“…Chunmei Xiu,1,2,* Hua Luo,3,* Weixing Huang,4,5,* Shaohua Fan,3 Chiting Yuan,3 Jiangjie Chen,3 Chenghao Xu,3 Can Yao,3 Dun Hong,1,3 Liwei Zhang1,3 1Institute of Bone Metabolism, Taizhou Hospital of Zhejiang Province, School of Medicine, Zhejiang University, Taizhou, 317000, People’s Republic of China; 2Department of Clinical Medicine, Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, 310015, People’s Republic of China; 3Orthopedic Department, Taizhou Hospital of Zhejiang Province, School of Medicine, Zhejiang University, Taizhou, 317000, People’s Republic of China; 4General Surgical Department, Taizhou Hospital of Zhejiang Province, School of Medicine, Zhejiang University, Taizhou, 317000, People’s Republic of China; 5Department of Nursing, Zhejiang University School of Medicine First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Liwei Zhang, Email medzlw@sina.com Dun Hong, Email hongd@enzemed.comPurpose: To investigate the therapeutic potential of lobetyolin (LBT), a bioactive compound derived from Codonopsis pilosula, against bone loss in postmenopausal osteoporosis (PMOP).Methods: To investigate the therapeutic potential of LBT in osteoporosis, a multifaceted approach involving network pharmacology and molecular docking was employed to identify relevant targets and elucidate mechanisms of action. …”
Get full text

Non-Invasive Prenatal Diagnosis of Chromosomal and Monogenic Disease by a Novel Bioinspired Micro–Nanochip for Isolating Fetal Nucleated Red Blood Cells by Li N, Sun Y, Cheng L, Feng C, Sun Y, Yang S, Shao Y, Zhao XZ, Zhang Y

“…However, challenges in identifying, enriching, and detecting fNRBCs limit their diagnostic potential.Methods: To overcome these obstacles, we developed a novel biomimetic chip, replicating the micro-nano structure of red rose petals on polydimethylsiloxane (PDMS). …”
Get full text

IGF1R Promotes Th17/Treg Cell Development in Experimental Autoimmune Prostatitis by Guan Y, Yue S, Chen Y, Cheng A, Li H, Yang F, Liu Y, Liang C, Meng J

“…We investigated the potential function of insulin-like growth factor 1 (IGF1) -related ligands in chronic prostatitis in the current study.Methods: In this study, we established the chronic experimental autoimmune prostatitis mouse model H&E staining was used to assess immune cell infiltration in prostate tissue, while RT-qPCR and Western blot analyses were performed to validate gene and protein expression differences across groups, respectively. …”
Get full text

Association Between Uric Acid to HDL-C Ratio and Metabolic Dysfunction-Associated Steatotic Liver Disease in Type 2 Diabetes Mellitus: A Cross-Sectional Study by Zhu X, Yin H, Han J, Zhang X, Han Q, Sun W, Liu Y, Tao W, Liu X, Wang G, Li L

“…This study aimed to evaluate the association between UHR and MASLD in a T2DM population.Methods: In this cross-sectional study, we analyzed clinical data from 1081 T2DM patients (464 without MASLD, 617 with MASLD). …”
Get full text