Pragmatic, multicentre, factorial, randomised controlled trial of sepsis electronic prompting for timely intervention and care (SEPTIC trial): a protocol by Daniel Brodie, Manish Sharma, Matthew J Cummings, Hassan Mohamed, William N Southern, Edward J Schenck, Benjamin L Ranard, David Y Zhang, Jeremy R Beitler, Min Qian, Jo R Applebaum, Jason S Adelman, Shing M Lee, Richard Trepp, Hanson Hsu, Jean Scofi, Sarah C Rossetti, Natalie H Yip, Baruch S Fertel

“…Despite widespread use, it is unknown whether these sepsis screening and alert tools improve the delivery of high-quality sepsis care.Methods and analysis The Sepsis Electronic Prompting for Timely Intervention and Care (SEPTIC) master protocol will study two distinct populations in separate trials: emergency department (ED) patients (SEPTIC-ED) and inpatients (SEPTIC-IP). …”
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Exploring the Impact of the Multimodal CAPABLE eHealth Intervention on Health-Related Quality of Life in Patients With Melanoma Undergoing Immune-Checkpoint Inhibition: Prospective... by Itske Fraterman, Lucia Sacchi, Henk Mallo, Valentina Tibollo, Savannah Lucia Catherina Glaser, Stephanie Medlock, Ronald Cornet, Matteo Gabetta, Vitali Hisko, Vadzim Khadakou, Ella Barkan, Laura Del Campo, David Glasspool, Alexandra Kogan, Giordano Lanzola, Roy Leizer, Manuel Ottaviano, Mor Peleg, Konrad Śniatała, Aneta Lisowska, Szymon Wilk, Enea Parimbelli, Silvana Quaglini, Mimma Rizzo, Laura Deborah Locati, Annelies Boekhout, Lonneke V van de Poll-Franse, Sofie Wilgenhof

“…CAPABLE is an extensively tested eHealth app, including educational material, remote symptom monitoring, and well-being interventions. MethodsThis prospective pilot study compared an exploratory cohort that received the CAPABLE smartphone app and a multisensory smartwatch for 6 months (intervention) to a 2:1 individually matched historical prospective control group. …”
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Imaging and Clinical Outcomes Six Months After Middle Meningeal Artery Embolization with Squid for Chronic Subdural Hematoma: A Prospective Study by Ángela H. Schmolling, Carlos Pérez-García, Isabel Bérmudez, Alfonso López-Frías, Eduardo Fandiño, Carmen Trejo, Santiago Rosati, Daniel Padrón, Lara Guardado, José Carlos Méndez, Juan Arrazola, Manuel Moreu

“…This study assesses MMA embolization with Squid, both as a standalone procedure and as an adjunct to surgery. <b>Methods:</b> Our prospective registry included 101 patients with 134 CSDH cases treated at two tertiary care centers from December 2020 to January 2024. …”
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Efficacy of Rikkunshito on Chemotherapy-Induced Nausea and Vomiting in Patients With Uterine Corpus or Cervical Cancer Treated With Cisplatin-Based Regimen-Placebo-controlled, Doub... by Yosuke Konno MD, Shunsuke Ohnishi MD, Shinichiro Minobe PhD, Eiji Nomura PhD, Takayuki Nagasawa PhD, Etsuko Fujimoto MD, Tatsuru Ohara PhD, Shin Nishio MD, Hisamori Kato PhD, Yoshihito Yokoyama PhD, Etsuko Miyagi PhD, Hideki Tokunaga PhD, Koji Nishino MD, Akira Kikuchi PhD, Yoshio Yoshida PhD, Takashi Iwata PhD, Daito Noguchi MD, Wataru Kudaka PhD, Shunsuke Oyamada PhD, Keisuke Ariyoshi PhD, Kota Kihara PhD, Hidemichi Watari MD

“…Rikkunshito, a Japanese traditional herbal medicine, has been shown to improve cisplatin-induced anorexia and functional dyspepsia, and our exploratory study found that rikkunshito has an additive beneficial effect on CINV in patients with uterine corpus and cervical cancer receiving cisplatin containing chemotherapy (JORTC KMP-02). Methods: One hundred eighty patients with uterine corpus or cervical cancer who were scheduled to receive treatment with a cisplatin based regimen as initial chemotherapy were enrolled across 17 Japanese institutions. …”
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The Prognostic Value of Platelet Kinetics Assessment in Pediatric Chronic Idiopathic Thrombocytopenic Purpura by Nebojsa Igrutinovic, Jelena Pantovic, Bojana Markovic, Marija Medovic, Milica Cekerevac, Vladimir Markovic, Strahinja Odalovic, Sanja Knezevic, Ana Vujic, Isidora Mihajlovic, Nevena Stojadinovic, Dragan Knezevic, Nina Urakovic, Ivana Andrejevic, Gordana J. Ristic, Vladimir Slavkovic, Kristina Andric, Rasa Medovic

“…The aim of this study was to examine the importance of APK as a prognostic instrument in the selection of therapy in children with chITP. <b>Methods:</b> Retrospective, observational research, which included chITP children who were treated and subjected to APK in Serbia for 25 years (total number was 152). …”
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Abnormal Brain Functional Connectivity in Patients with Chronic Obstructive Pulmonary Disease and Correlations with Clinical and Cognitive Parameters by Han KI, Yeo Y, Jo HJ, Jo MJ, Park Y, Park TS, Jung SJ, Bae JH, Jang SH, Choi J, Park DW, Kim TH

“…In this study, we used resting-state functional magnetic resonance imaging to investigate brain functional connectivity (FC) abnormalities in patients with COPD and explored the correlation between abnormal FC and COPD-related clinical parameters.Methods: Forty-one patients with COPD, without a definite diagnosis of cognitive impairment or depression, and 30 age- and sex-matched controls were recruited. …”
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Human Mesenchymal Stem Cell-Derived Exosomes as Engineering Vehicles of Daunorubicin for Targeted c-Mpl+ AML Therapy by Li C, Wen Y, Wang J, Li L, He Y, Cheng Y, Chen J, Huang J, Ouyang C, Liu Y, Zhou R, Chen H, Li F, Guo Q, Chen Y, Chen C, Zhang Q

“…This study aimed to develop a type of targeted exosomes (Exos) capable of delivering anticancer drugs directly to c-Mpl+ AML cells.Methods: Human umbilical cord mesenchymal stem cells (hUCMSCs) were isolated as the source of Exos. …”
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MRI Features and Neutrophil-to-Lymphocyte Ratio (NLR)-Based Nomogram to Predict Prognosis of Microvascular Invasion-Negative Hepatocellular Carcinoma by Wei Y, Huang X, Pei W, Zhao Y, Liao H

“…Yunyun Wei,1,2,&ast; Xuegang Huang,3,&ast; Wei Pei,1,2,&ast; Yang Zhao,1,2 Hai Liao1,2 1Department of Medical Imaging Center, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, 530021, People’s Republic of China; 2Guangxi Key Clinical Specialty (Medical Imaging Department), Nanning, Guangxi, 530021, People’s Republic of China; 3Department of Infectious Diseases, The First People’s Hospital of Fangchenggang City, Fangchenggang, Guangxi, 538021, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Hai Liao, Department of Medical Imaging Center, Guangxi Medical University Cancer Hospital, No. 71 hedi Road, Nanning, Guangxi, 530021, People’s Republic of China, Tel +86-771-5334951, Email 42442427@qq.comPurpose: This study aimed to develop a novel nomogram to predict recurrence-free survival (RFS) for microvascular invasion (MVI)-negative hepatocellular carcinoma (HCC) patients after curative resection.Patients and Methods: A total of 143 pathologically confirmed MVI-negative HCC patients were analyzed retrospectively. …”
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Proposal and Verification of New Revised Criteria for ABPA/ABPM Diagnosis by Cai R, Ge H, Liu B, Tang Y, Wang J, Chen X, Liu B, Hu X, Deng S, Li H, Dai L, Tang J, Wu C, Gong X, Wang G, Li X, Feng J

“…In 2021, Asano et al introduced new diagnostic criteria for allergic bronchopulmonary mycosis (ABPM), which were found to improve diagnostic sensitivity compared to existing criteria, but the specificity was lower.Methods: To develop revised scoring criteria for ABPA/ABPM diagnosis, delphi surveys were conducted with two rounds in 14 experts. …”
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Outcome Following Chest Tube Removal with Respect to Phase of Respiration in Chest Trauma Patients: A Randomised Controlled Trial by Ritesh Kumar, Sandeep Chauhan, Mahavir Singh, Mohammed Faiz, Deepak, Gaurav Sharma, Manish Kumar Yadav, Sanjay Marwah

“…Aim: To compare the outcome in terms of complications like RP following chest tube removal with respect to phase of respiration in chest trauma patients and risk factors responsible for development of these complications. Materials and Methods: The present study was a randomised controlled trial conducted at the Department of Surgery, Pt. …”
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Berberine Intervention Mitigates Myocardial Ischemia-Reperfusion Injury in a Rat Model: Mechanistic Insights via miR-184 Signaling by Yang H, Cao G, Li X, Zhao Z, Wang Y, Xu F

“…Additionally, the study explored the role of the miR-184/NOTCH1 signaling pathway in mediating these effects.Methods: Male Wistar rats were randomly assigned to five groups: sham-operated control, I/R injury, I/R treated with berberine, I/R treated with inhibitor NC and I/R treated with a miR-184 inhibitor. …”
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The role of the control of “life’s essential 8” for prevention on heart failure and all-cause mortality in patients with hypertension: the Kailuan cohort study by Jing Wang, Shuilin Wu, Liuxin Li, Jing Wu, Shiqiu Meng, Xueying Qin, Xin Chen, Shoulin Wu, Jie Shi, Yanping Bao, Feng Wang

“…However, evidence on the beneficial effects and necessity of LE8 control is still lacking, especially for hypertension. Methods The study population was drawn from the Kailuan cohort, hypertensive population at baseline with the non-hypertensive population matched 1:1 according to age and sex were involved in this analysis. …”
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Epidemiology of Overweight and Obesity in Early Childhood in China and Associated Factors by Li H, Xiang W, Yi Y, Huang X, Luo H, Cai Y, Liu L, Li H, Huang Y, Luo Q, Fan L, Lin Q

“…Hongai Li,1,&amp;ast; Wei Xiang,1,2,&amp;ast; Yajun Yi,3 Xiaoyan Huang,1 Hailing Luo,1 Yuhua Cai,1 Li Liu,1 Haidan Li,1 Yan Huang,1 Qing Luo,1 Lichun Fan,1 Qiuyu Lin1 1Department of Pediatrics, Hainan Women and Children’s Medical Center (Children’s Hospital Affiliated to Hainan Medical University), Haikou, 570206, People’s Republic of China; 2National Health Commission (NHC) Key Laboratory of Control of Tropical Diseases, Hainan Medical University, Haikou, 571199, People’s Republic of China; 3Department of Medicine, Vanderbilt University Medical School, Nashville, TN, 37212, USA&amp;ast;These authors contributed equally to this workCorrespondence: Qiuyu Lin, Department of Pediatrics, Hainan Women and Children’s Medical Center (Children’s Hospital Affiliated to Hainan Medical University), Haikou, People’s Republic of China, Tel +8615595779936, Fax +86089836689190, Email 45024711@qq.com Lichun Fan, Department of Pediatrics, Hainan Women and Children’s Medical Center (Children’s Hospital Affiliated to Hainan Medical University), Haikou, People’s Republic of China, Tel +8618689852199, Email 285562830@qq.comObjective: To evaluate the epidemiological landscape and identify the risk factors associated with overweight and obesity in early childhood in China.Methods: We collected measurements of weight and height and calculated the body mass index (BMI) for preschool children. …”
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Modified Zuo Gui Wan Ameliorates Ovariectomy-Induced Osteoporosis in Rats by Regulating the SCFA-GPR41-p38MAPK Signaling Pathway by Song C, Yan Q, Ma Y, Li P, Yang Y, Wang Y, Li W, Wan X, Li Y, Zhu R, Liu H, Zhang Z

“…We aimed to validate the anti-OP effect of MZGW and explore its underlying mechanism.Methods: An ovariectomy (OVX) rat model in vivo and a RANKL-induced osteoclasts (OCs) model in vitro were established. …”
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The Predictive Effects of Atherogenic Indices and Remnant Cholesterol on Gestational Diabetes Mellitus Risk by Cheng Y, Song J, Zhao L, Yin J, Lu X, Zhao Y, Sun G

“…Yao Cheng,1,&amp;ast; Jieping Song,2,&amp;ast; Lei Zhao,1,&amp;ast; Jieyun Yin,3 Xinfeng Lu,4 Yun Zhao,1 Guoqiang Sun1 1Obstetrics Department, Maternal and Child Health Hospital of Hubei Province, Wuhan, Hubei, People’s Republic of China; 2Medical Genetics Center, Maternal and Child Health Hospital of Hubei Province, Wuhan, Hubei, People’s Republic of China; 3Department of Epidemiology and Health Statistics, School of Public Health, Medical College of Soochow University, Suzhou, Jiangsu, People’s Republic of China; 4Medical Record Department, Maternal and Child Health Hospital of Hubei Province, Wuhan, Hubei, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Guoqiang Sun, Obstetrics Department, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuluo Road No. 745, Hongshan District, Wuhan, 430070, People’s Republic of China, Email sunguoqiang@hbfy.com Yun Zhao, Obstetrics Department, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuluo Road No. 745, Hongshan District, Wuhan, 430070, People’s Republic of China, Email zhao020060@163.comPurpose: This study aimed to investigate the predictive effects of atherogenic indices and remnant cholesterol on the risk of GDM.Patients and Methods: This observational study was conducted based on the Hospital’s clinical information system. …”
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Analysis of the results of treatment of patients with malignant tumors of the salivary glands by V. T. Vayradyan, A. M. Mudunov, V. D. Ermilova, R. I. Azizyan, I. A. Zaderenko, S. B. Aliyeva, E. L. Dronova

“…Objective: improve results of the treatment of patients with malignant salivary gland neoplasm (MSGN).Materials and methods. Analysis of 417 patients suffering from MSGN treated in the Federal State Budgetary Institution “N.N. …”
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Diagnostic Accuracy of the Alice NightOne Single-Belt Monitor for Obstructive Sleep Apnea and Reliability of Wireless Data Transfer by Peng M, Zhang Y, Zhao R, Li J, Zhang X, Deng L, Zhao L, Zhou B, Wang X, Dong X, Han F

“…MaoHuan Peng,1,&amp;ast; YuanYuan Zhang,2,&amp;ast; Rui Zhao,3 Jing Li,1 XueLi Zhang,1 LiHua Deng,4 Long Zhao,1 Bing Zhou,1 XinRu Wang,1 XiaoSong Dong,1 Fang Han1 1Department of Sleep Medicine, Peking University People’s Hospital, Beijing, People’s Republic of China; 2Department of General Practice, Peking University People’s Hospital, Beijing, People’s Republic of China; 3Department of Pulmonary and Critical Care Medicine, Peking University People’s Hospital, Beijing, People’s Republic of China; 4Department of Geriatrics, Peking University People’s Hospital, Beijing, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: XiaoSong Dong, Department of Sleep Medicine, Peking University People’s Hospital, Beijing, 100044, People’s Republic of China, 100044, Email dongxiaosong@pkuph.edu.cnObjective: To validate the performance of a single-belt type 3 portable monitor Alice NightOne for diagnosis of obstructive sleep apnea and its reliability in remote data transmission.Methods: Our study included two parts: in-laboratory Alice NightOne (ANO) monitoring (ANOlab) and home sleep apnea testing (HSAT) using ANO (ANOhome). …”
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Biodegradable Electrospun PLGA Nanofibers-Encapsulated Trichinella Spiralis Antigens Protect from Relapsing Experimental Autoimmune Encephalomyelitis and Related Gut Microbiota Dys... by Sabljić L, Radulović N, Đokić J, Stojanovic DB, Radojević D, Glamočlija S, Dinić M, Golić N, Vasilev S, Uskoković P, Sofronić-Milosavljević L, Gruden-Movsesijan A, Tomić S

“…However, whether timely controlled delivery of ESL1 antigens in vivo, as in natural infections, could enhance its therapeutic potential for MS is still unknown.Methods: To test this, we encapsulated ESL1 antigens into biodegradable poly (lactide-co-glycolic) acid (PLGA) nanofibers by emulsion electrospinning as a delivery system and assessed their release dynamics in vitro, and in an animal MS model, experimental autoimmune encephalomyelitis (EAE), induced 7 days after PLGA/ESL1 subcutaneous implantation. …”
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Knowledge, attitudes, and factors associated with the utilization of youth-friendly sexual and reproductive health services among teenagers and young adults in Kigali City, Rwanda by Julienne Nyirarukundo, Venuste Musugire, Boniface Nsengiyumva, Joella Mukashyaka, Zephanie Nzeyimana

“…This study determined knowledge, attitudes, and factors associated with the utilization of youth-friendly sexual and reproductive health services among teenagers and young adults. Methods This was a quantitative cross-sectional survey in which data were collected from July 8 to 22, 2024. …”
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Clinical Outcomes of Hospitalized Immunocompromised Patients With COVID-19 and the Impact of Hyperinflammation: A Retrospective Cohort Study by Zhang X, Han X, Li C, Cui J, Yuan X, Meng J, Han Z, Han X, Chen W, Xiong J, Xie W, Xie L

“…We aimed to illustrate the inflammation profile and clinical outcomes of hospitalized immunocompromised patients with COVID-19.Methods: We conducted a retrospective study using a multicenter database and included adult hospitalized patients with Corona virus disease 2019 (COVID-19) in China’s late 2022 COVID-19 wave. …”
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