Human Neural Stem Cells Reduce Hypoxia-Ischemic Neurological Impairment Through the Regulation of Inflammatory M1/M2 Microglias in Rats by Ding YB, Zhao Y, Chen BY, Wang Q, Wang ZY, Luan Z, Yi B

“…Ya-Bing Ding,1,2,* Yuan Zhao,1– 3,* Bing-Yu Chen,1 Qian Wang,1 Zhao-Yan Wang,1 Zuo Luan,1,2 Bin Yi4 1Department of Pediatrics, The Sixth Medical Center of PLA General Hospital, Beijing, People’s Republic of China; 2Department of Pediatrics, The Second School of Clinical Medicine, Southern Medical University, Guangzhou, People’s Republic of China; 3Department of Neonatology, Children’s Hospital of Shanxi, Women Health Centre of Shanxi, Taiyuan, People’s Republic of China; 4Department of Pediatrics, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zuo Luan, Department of Peadiatric, The Sixth Medical Center of PLA General Hospital, Beijing, 100048, People’s Republic of China, Tel +86-18600310270, Fax +86-1066958303, Email luanzuodoctor@126.com Bin Yi, Gansu Provincial Maternity and Child-care Hospital, Lanzhou, Gansu, 730000, People’s Republic of China, Email www.0931@163.comObjective: This study aims to investigate the therapeutic efficacy and migration of human neural stem cell (hNSC) therapy in a rat model of moderate to severe Hypoxic-ischemic encephalopathy (HIE).Methods: hNSCs were transplanted into the brain ventricle of HIE-induced rats. …”
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Effect of cervical traction on cervicogenic headache in patients with cervical radiculopathy: a preliminary randomized controlled trial by Anis Jellad, Amine Kalai, Amr Chaabeni, Cyrine Ben Nasrallah, Atef Ben Nsir, Mahbouba Jguirim, Asma Belguith Sriha, Zohra Ben Salah Frih, Mohamed Hedi Bedoui

“…The purpose of the study was to make a preliminary estimate of efficacy of adding MICT to conventional rehabilitation on CGH in patients with cervical radiculopathy. Methods A total of 36 CR patients with CGH were randomly allocated to 3 equally sized groups (A, B and C). …”
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The Mechanism of Sijunzi Decoction Suppresses Gastric Cancer Metastasis via the m6A Methyltransferase METTL14 Based on Untargeted Metabolomics Studies and Network Pharmacology Anal... by Li X, Zhao L, Wang J, Ma T, Zhou J, Bian Y, Guo J

“…However, additional research is necessary to comprehend the mechanisms beneath the therapeutic potential of SJZ in gastric cancer.Objective: This research endeavored to analyze how SJZ treats gastric cancer using network pharmacology and experimental validation.Methods: Liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) and network pharmacology were applied to systemically clarify the mechanism of SJZ against gastric cancer. …”
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Aggregation of Stress Granules Induced by Hypoxia and Lipopolysaccharide via PKR-p-eIF2α Pathway and 4EBP1 Pathway Inhibits the Inflammatory Response in Peri-Implantitis by Li S, Ma C, Fan C, Liu Y, Li J, Yin B, Zhong L, Bai N, Li Z

“…Shuang Li,1,2,* Chunling Ma,3,* Chun Fan,4 Yanshan Liu,5 Jian Li,2,6 Baoheng Yin,1,2 Lingmei Zhong,7 Na Bai,1,2 Zhiyuan Li3 1Department of Prosthodontics, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, People’s Republic of China; 2School of Stomatology, Qingdao University, Qingdao, Shandong, People’s Republic of China; 3Medical Research Center, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, People’s Republic of China; 4Department of Periodontology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, People’s Republic of China; 5Department of Maxillofacial Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, People’s Republic of China; 6Department of Oral Implantology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, People’s Republic of China; 7Department of Pulmonary and Critical Care Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhiyuan Li, Email zyli0120@163.com Na Bai, Email na.bai@qdu.edu.cnObjective: To investigate whether stress granules (SGs) exist in peri-implantitis (PI) and to explore the formation mechanism and role of SGs in the response of human gingival fibroblasts (hGFs) to hypoxia or LPS.Methods: Gingival tissues were collected from patients with PI and from healthy individuals. …”
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Growth Differentiation Factor-15 as a Potential Biomarker for Renal Involvement in POEMS Syndrome by Huang Y, Chen J, Yao Y, Zhang L, Li Y, Li J

“…Growth differentiation factor-15 (GDF-15) is related with renal function, but few studies have focused on it in renal impairment of POEMS syndrome.Objective: To evaluate the potential of circulating GDF-15 concentration as a biomarker for renal function in POEMS syndrome.Methods: 150 Chinese patients, diagnosed with POMES syndrome, were enrolled and divided into three subgroups according to their chemotherapy stage. …”
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Development and Validation of Predictive Models for Inflammatory Bowel Disease Diagnosis: A Machine Learning and Nomogram-Based Approach by Dong R, Wang Y, Yao H, Chen T, Zhou Q, Zhao B, Xu J

“…This study aimed to develop predictive models for diagnosing IBD, Crohn’s disease (CD), and Ulcerative colitis (UC) by combining two approaches: machine learning (ML) and traditional nomogram models.Methods:  Cohorts 1 and 2 comprised data from the UK Biobank (UKB), and the First Hospital of Jilin University, respectively, which represented the initial laboratory tests upon admission for 1135 and 237 CD patients, 2192 and 326 UC patients, and 1798 and 298 non-IBD patients. …”
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Multinational cross-sectional study and meta-analysis on radicular grooves, C-shaped canals, and taurodontism in mandibular first premolars across 20 countries by Fatma Pertek Hatipoğlu, Güldane Magat, Mohmed Isaqali Karobari, Glynn Dale Buchanan, Maira Kopbayeva, Nessrin Taha, Rafael Fernández-Grisales, Olga Bekjanova, Peter Luu, Sebastian Bürklein, Abdulbaset Mufadhal, Xenos Petridis, María Fernanda Mora, Surendar Sugumaran, Safaa Allawi, Anja Ivica, Wen Yi Lim, Abdulrahman Fadag, Rohan Jagtap, Tomasz Kulczyk, Suha Alfirjani, Paulo J. Palma, Ömer Hatipoğlu

“…This study aimed to investigate the prevalence and regional variations of C-shaped canals, RGs, and taurodontism across 20 countries using CBCT imaging and meta-analytic methods. A multicenter, cross-sectional study analyzed CBCT datasets from 6,000 participants (12,000 teeth) distributed equally across 20 countries. …”
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DONOR-TRANSMITTED CORONARY ATHEROSCLEROSIS by B. L. Mironkov, V. V. Chestukhin, R. Sh. Saitgareev, V. M. Zakharevich, V. N. Poptsov, A. Ya. Kormer, G. A. Akopov, T. A. Khalilulin, A. M. Golts, A. R. Zakiryanov, V. V. Golubitsky, N. Yu. Zakharevich, S. V. Gautier

“…To estimate opportunities, prospects and safety of using heart transplants from aged donors who are at high risk of coronary atherosclerosis.Materials and methods. Over the period from March 1987 to May 2014450 heart transplantations (HTx) were performed in V.I.Shumakov Federal Research Center of Transplantology and Artifi cial Organs. …”
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A modified Delphi consensus statement on the role of biopsy in small renal masses by Darryl E. Bernstein, Hannah Warren, Joseph Santiapillai, Geraldine Fox, William H. Wildgoose, Grant D. Stewart, Jim Armitage, Pieter Le Roux, Frank X. Keeley Jr, Nicholas Campain, Ben Challacombe, Hazel Warburton, Carlotta Palumbo, Riccardo Campi, Stjin H. J. Muselaers, Miles Walkden, Steve Bandula, Dominic Yu, Michael Gonsalves, My‐Anh Tran‐Dang, Nazanin Etessami, Pedro Oliveira, Anna Calio, Soha El‐Sheikh, Tze Wah, Axel Bex, Ravi Barod, Kurinchi Gurusamy, Maxine G. B. Tran

“…Abstract Objective To understand the variable utilisation of diagnostic biopsy for small renal masses (SRM) across the urology community, we worked with expert clinicians and patients to produce a consensus statement on the role of biopsy and to identify research gaps. Methods In phase I, qualitative interviews were performed to identify potential statements on the role of biopsy and research gaps. …”
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Molecular Monitoring of RUNX1-RUNX1T1 Transcript Level in Acute Myeloblastic Leukemias on Treatment by LL Girshova, EG Ovsyannikova, SO Kuzin, EN Goryunova, RI Vabishchevich, AV Petrov, DV Motorin, DV Babenetskaya, VV Ivanov, KV Bogdanov, IV Kholopova, TS Nikulina, YuV Mirolyubova, YuA Alekseeva, AYu Zaritskii

“…To estimate the dynamics of the RUNX1-RUNX1T1 level and relevant clinical manifestations during the monitoring of various stages of the program therapy and after its completion. Methods. The article presents a description of 10 cases of AML with isolated RUNX1-RUNX1T1 expression (n = 4) and the expression in combination with different molecular and cytogenetic abnormalities (n = 6). …”
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Closing the Sex-Based Differences in Stroke Care: Insights from a Large Telestroke Network on Treatment and Postacute Management by Soledad Pérez-Sánchez, Ana Barragán-Prieto, Juan Bautista Loscertales, Juan Antonio Cabezas Rodríguez, Elena Zapata-Arriaza, Laura Amaya Pascasio, Andrés Hermosín Gómez, Miguel Ángel Gamero García, Benito Galeano, Javier Fernández, Blanca Pardo Galiana, Ana Domínguez Mayoral, Leire Ainz Gómez, Jose Fernández Navarro, Cristina del Toro, Manuel Medina, Reyes de Torres, Pablo Baena, Francisco Moniche, Roberto Valverde Moyano, Patricia Martínez, Alejandro González, Joan Montaner

“…We investigated whether women are attended in a similar way to men in the telestroke network with specialized stroke physicians. Methods: A prospective registry of ischemic strokes recorded in the centralized Andalusian telestroke network was analyzed, focusing on sex differences. …”
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SIGNIFICANCE OF ETV6-RUNX1 FUSION GENE TRANSCRIPT DETECTION IN PEDIATRIC B-CELL PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA WITH TRANSLOCATION t(12;21)(p13;q22) by G. A. Tsaur, Т. О. Riger, A. M. Popov, T. Yu. Verzhbitskaya, L. V. Vakhonina, A. A. Vlasova, Yu. V. Olshanskaya, А. N. Kazakova, O. V. Streneva, O. V. Makarova, S. V. Tsvirenko, L. I. Saveliev, О. R. Arakaev, L. G. Fechina

“…Of note, defined TL for ETV6-RUNX1/ABL1 at days 15, 36, 85 were equal to prognostically important levels for flow cytometry MRD.Conclusion. …”
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Spectrum of gynecologic malignancies in Northeastern Nigeria by Dauda A. Katagum, Uchenna S. Ezenkwa, Sunday E. Achanya, Aliyu I. Lawan, Dauda E. Suleiman, Mairo U. Kadaura, Abba Kabir, Adamu I. Adamu, Abubakar Kolomi Modu, Hadiza Usman, Sophia H. L. George, Matthew Schlumbrecht, Bala M. Audu

“…Here, four-year multi-institutional data on gynecologic cancers in northeastern Nigeria were examined to determine their distribution by age and subtype.Patient and MethodsThis is a cross-sectional descriptive study using available data on histologically diagnosed gynecologic cancers archived in the pathology departments and/or cancer registries of six tertiary hospitals in northeastern Nigeria over four years. …”
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Efficiency of cell-based assays in detecting AChR antibodies in myasthenia gravis sera with low antibody concentrations as determined by radioimmunoprecipitation assay by John S. Tzartos, Aigli G. Vakrakou, Katerina Karagiorgou, Vasiliki Zouvelou, Elisabeth Chroni, Valentina Damato, Francesca Beretta, Stavroula Salakou, Eirini Sfyroera, Dimitra Veltsista, Konstantinos Voumvourakis, Sotirios Giannopoulos, Georgios Tsivgoulis, Socrates Tzartos, Socrates Tzartos, Socrates Tzartos

“…ObjectivesWe investigated whether the acetylcholine receptor (AChR) cluster cell-based assay (CBA) is effective in detecting AChR antibodies in sera from myasthenia gravis (MG) patients with low antibody concentrations, as determined by radioimmunoprecipitation assay (RIPA).MethodsIn this retrospective diagnostic cohort study, 193 RIPA-positive sera from MG patients were analyzed. …”
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Outcomes in Catheter Ablation of Sustained Ventricular Tachycardia in Myocarditis Compared with Ischemic Heart Disease by Sheng Su, Le Li, Xi Peng, Likun Zhou, Zhuxin Zhang, Yulong Xiong, Zhenhao Zhang, Mengtong Xu, Yan Yao

“…For myocarditis patients with VT, CA might be equally effective.…”
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A harmonized dataset relating alternative farmer management practices to crop yield, soil organic carbon stock, nitrous oxide emissions, and nitrate leaching generated using IPCC m... by Roberta Calone, Angela Fiore, Guido Pellis, Maria Luz Cayuela, Gabriele Mongiano, Alessandra Lagomarsino, Simone Bregaglio

“…Current methodologies from the Intergovernmental Panel on Climate Change (IPCC) forassessing the impacts of alternative farming practices on GHG emissions rely on global or country-specific coefficients. However, these methods often do not explicitly account for the combined effects of management practices on carbon and nitrogen cycles or productivity, as this is not required for national GHG inventories. …”
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Study protocol of a randomised controlled trial of prostate radiotherapy in high-risk and node-positive disease comparing moderate and extreme hypofractionation (PRIME TRIAL) by Vedang Murthy, Indranil Mallick, Abhilash Gavarraju, Shwetabh Sinha, Rahul Krishnatry, Tejshri Telkhade, Arunsingh Moses, Sadhna Kannan, Gagan Prakash, Mahendra Pal, Santosh Menon, Palak Popat, Venkatesh Rangarajan, Archi Agarwal, Sheetal Kulkarni, Ganesh Bakshi

“…We hypothesise that a five-fraction schedule of extreme hypofractionation will be non-inferior to a moderately hypofractionated regimen over 5 weeks in efficacy and will have acceptable toxicity and quality of life while reducing the cost implications during treatment.Methods and analysis This is an ongoing, non-inferiority, multicentre, randomised trial (NCT03561961) of two schedules for National Cancer Control Network high-risk and/or node-positive non-metastatic carcinoma of the prostate. …”
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Food intake and influencing factors among primary and secondary school students in rural areas covered by the nutrition improvement program by Wenshuo YOU, Peipei XU, Wei CAO, Mulei CHEN, Qian GAN, Hongliang WANG, Ruihe LUO, Titi YANG, Hui PAN, Jianfen ZHANG, Xiaoning WANG, Qian ZHANG, Juan XU

“…ObjectiveTo analyze the food intake of primary and middle school students in areas implementing the Rural Compulsory Education Student Nutrition Improvement Program in 2021 and its influencing factors. MethodsFollowing the principle of random sampling, in 2021, in 727 national pilot counties in 31 provinces (autonomous regions, municipalities) and the Xinjiang Production & Construction Corps, approximately 10% of primary and middle schools were selected in urban and rural areas, respectively. …”
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Direct high-precision radon quantification for interpreting high-frequency greenhouse gas measurements by D. Kikaj, E. Chung, A. D. Griffiths, S. D. Chambers, G. Forster, G. Forster, A. Wenger, P. Pickers, P. Pickers, C. Rennick, S. O'Doherty, J. Pitt, K. Stanley, D. Young, L. S. Fleming, L. S. Fleming, K. Adcock, E. Safi, T. Arnold, T. Arnold

“…Here we describe standardized approaches regarding (1) instrument maintenance, (2) quality control of the raw data stream, (3) determination and removal of the instrumental background, (4) calibration methods, and (5) response time correction (by deconvolution). …”
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The effectiveness and risks of Treating people with Idiopathic Pulmonary fibrosis with the Addition of Lansoprazole (TIPAL): study protocol for a randomised placebo-controlled mult... by Toby M Maher, A John Simpson, Anthony Cahn, David Thickett, Luke Vale, Allan B Clark, Nazia Chaudhuri, Ian Forrest, Lisa G Spencer, Christopher Ward, Stephen Jones, Ganesh Raghu, Andrew M Wilson, Helen Parfrey, Megan Jones, Matthew Hammond, Jaclyn Ann Smith, Shajahan Wahed

“…Patients are randomised equally to receive two capsules of lansoprazole or two placebo capsules, two times per day for 12 months. …”
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