Gui-Pi-Tang Defers Skeletal Muscle and Cardiac Muscle Aging by Promoting Mitochondrial Remodeling by Cai C, Wang M, Yang D, Jing C, Li Y, Xu H, Liu F, Zhao D

“…Changjiu Cai,1,* Manying Wang,2,* Dan Yang,2 Chenxu Jing,2 Yingna Li,3 Hanying Xu,4 Fangbing Liu,5 Daqing Zhao5 1Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, Jilin, People’s Republic of China; 2Research Center of Traditional Chinese Medicine, Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, Jilin, People’s Republic of China; 3College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin, People’s Republic of China; 4Department of Encephalopathy, Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, Jilin, People’s Republic of China; 5Northeast Asia Institute of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin, People’s Republic of China*These authors contributed equally to this workCorrespondence: Fangbing Liu, Northeast Asia Institute of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin, People’s Republic of China, Email liufb@ccucm.edu.cn Daqing Zhao, Northeast Asia Institute of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin, People’s Republic of China, Email zhaodaqing1963@163.comPurpose: To determine whether Gui-Pi-Tang (GPT) has protective effects on skeletal muscle and cardiac muscle in aged mice.Methods: This study used C57BL6/J mice to establish an in vivo natural aging model, while D-galactose (D-gal)-injured C2C12 and H9c2 cells were employed to create in vitro aging cell models. …”
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Screening and Verification COPD-OSA Overlap Syndrome Core Genes Using Bioinformatics by Qiang S, Wan R, Wu J, Wang C, Cui X, Zhang Y

“…To address this, we explored potential OS mechanisms using bioinformatics.Methods: OSA and COPD gene expression datasets were obtained from the Gene Expression Omnibus (GEO) database. …”
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CLEC3B as a Prognostic and Immunological Biomarker in Pan-Cancer: Multi-Omics Profiling and Validation in Pancreatic Cancer and Exosomes by Nan K, Zhang L, Peng Y, Huang J, Yin S, Zou Y, He K, Zhang M

“…In this study, we explored the potential roles of CLEC3B as a tumor suppressor and in immune function across multiple cancer types.Methods: We visualized outcomes derived from Gene Expression Omnibus (GEO) and diverse online databases. …”
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One‐stage spatial mark–resight analysis reveals an increasing grizzly bear population with declining density near roads by Jesse Whittington, Mark Hebblewhite, Connor Meyer, Barb Johnston, Anne Forshner, Bryan J. Macbeth, Anthony L. Einfeldt, Seth G. Cherry

“…Both methods had >95% credible interval coverage and minimal bias. …”
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Effect of Lamotrigine on Refractory Epilepsy: Clinical Outcomes and EEG Changes by Li Z, Wu P, Chen Q, Tong X, Yang Q

“…Lamotrigine, with its proven efficacy and tolerability, offers potential benefits when combined with traditional medications like valproate, though its comprehensive impact on clinical outcomes and neurological markers requires further study.Objective: To analyze the improvement effect of combined application of lamotrigine on refractory epilepsy patients and its impact on patients’ EEG and neurological function.Methods: This retrospective cohort study analyzed the clinical data of 93 patients with refractory epilepsy who were admitted to our hospital between January 2023 and June 2024. …”
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T Lymphocyte-Macrophage Hybrid Membrane-Coated Biomimetic Nanoparticles Alleviate Myocarditis via Suppressing Pyroptosis by Targeting Gene Silencing by Xiong Y, Zhang Z, Liu S, Shen L, Zheng L, Ding L, Liu L, Wu L, Hu Z, Li L, Hu Z, Zhang Z, Zhou L, Xu M, Yao Y

“…Herein, we fabricated an innovative immune cell membrane-coated zeolitic imidazolate framework-8 (ZIF-8) nano-delivery platform and explored its effects on myocarditis.Methods: ZIF-8 nanoparticles loaded with siRNA targeting IRF1 (siIRF1) were coated with a T lymphocyte-macrophage hybrid membrane (siIRF1@ZIF@HM NPs) via sonication and extrusion. …”
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Knowledge, Attitudes, and Practices Among Patients Undergoing Gastrointestinal Endoscopy in the Endoscopy Unit of a Tertiary-Care Hospital by Wei L, Niu Q, Ma L, Liu G, Zhang H, Zheng X, Lin Y, Du N, Li L

“…Our objective was to assess the KAP regarding gastrointestinal endoscopy in the Endoscopy Unit among those referred for diagnostic procedures.Patients and Methods: Patients scheduled for gastrointestinal endoscopy completed self-administered questionnaires to gather demographic information and evaluate their KAP scores. …”
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Contribution of Interleukin-1 Receptor-Associated Kinase 1 Gene Polymorphism to Systemic Lupus Erythematosus in Chinese Patients by Zhao L, Xu W, Du S, Xi F, Shi X, Liu R

“…The aim of the current study was to analyze the association between the IRAK1 polymorphisms (rs3027898 and rs1059702) and SLE in a Chinese cohort.Patients and Methods: A total of 150 SLE patients and 168 healthy controls of Chinese ethnicity were included in this study. …”
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Effects of Preoperative Magnesium Sulphate Infusion on Emergence Agitation and Postoperative Quality of Recovery in Patients Undergoing Thoracoscopic Lobectomy by Pu Y, Geng X, Wang M, Lv G, Hu Z, Fang C, Zhang X, Li W, Fan X, Chen X

“…This study aimed to examine the effects of preoperative magnesium sulphate infusion on emergence agitation and postoperative quality of recovery in patients undergoing thoracoscopic lobectomy.Patients and Methods: 84 patients undergoing thoracoscopic lobectomy were randomly assigned to either the magnesium sulphate group (group M) or the control group (group C). …”
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Shear bond strength to sound and caries-affected dentin of sim-plified “etch-and-rinse” and “self-etch” adhesives and the hybrid layer micromorphology by Drobac Milan, Stojanac Igor, Ramić Bojana, Premović Milica, Petrović Ljubomir

“…All tested compsite systems bond equally well on sound and caries-affected dentin. …”
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IINS Vs CALLY Index: A Battle of Prognostic Value in NSCLC Patients Following Surgery by Cheng H, Ma J, Zhao F, Liu Y, Wu J, Wu T, Li H, Zhang B, Liu H, Fu J, He H, Zhu C, Ren H, Yang C, Qin S

“…Hao Cheng,1,* Jiao Ma,1,* Fengyu Zhao,2 Yiwei Liu,3 Jie Wu,4 Tao Wu,1 Hui Li,1 Boxiang Zhang,3 Hui Liu,5 Junke Fu,3 Haiqi He,3 Cailin Zhu,3 Hong Ren,3 Chengcheng Yang,2 Sida Qin3 1Department of Rehabilitation, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 2Department of Oncology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 3Department of Thoracic Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 4Department of Radiation Oncology, Shaanxi Provincial People’s Hospital, Xi’an, Shaanxi, People’s Republic of China; 5Biobank, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China*These authors contributed equally to this workCorrespondence: Sida Qin, Department of Thoracic Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, 277 West Yanta Road, Xi’an, Shaanxi, 710061, People’s Republic of China, Tel +86 15388666585, Email qinsida@xjtu.edu.cn Chengcheng Yang, Department of Oncology, The First Affiliated Hospital of Xi’an Jiaotong University, 277 West Yanta Road, Xi’an, Shaanxi, 710061, People’s Republic of China, Tel +86 17629260656, Email ccyang@xjtufh.edu.cnObjective: This research sought to assess the predictive potential of the inflammation-immunity-nutrition score (IINS) and the high-sensitivity C-reactive protein-albumin-lymphocyte (CALLY) index in individuals with NSCLC post-surgery.Methods: The study enrolled 506 patients with NSCLC undergoing R0 resection at the First Affiliated Hospital of Xi’an Jiaotong University. …”
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Effects of Short Naps on EEG Microstates: Improving Sleep Deprivation-Induced Cognitive Impairment by Ma C, Peng J, Li Y, Ouyang A, Huang Y, He W, Zhu Y, Fang P

“…This study aims to explore the effects of napping on cognitive impairments cause by SD and the potential mechanisms of cognitive recovery.Patients and Methods: We recruited forty-two healthy volunteers and recorded their EEG signals and psychomotor vigilance task (PVT) data at three time points: rested wakefulness, post-SD, and post-nap. …”
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Genetic Insights Into Lipid Traits and Lipid-Modifying Drug Targets in Pregnancy Complications: A Two-Sample Mendelian Randomization Study by Shao H, Xu C, Zhang C, Li L, Wu P, Chen Z, Guan R

“…This two-sample Mendelian Randomization (MR) study investigated the causal relationship between lipid traits and pregnancy complications and evaluated the impact of lipid-modifying drug targets.Methods: Genetic instruments for lipid traits and targets for lipid-modifying drugs were obtained from the Global Lipids Genetics Consortium. …”
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Dynamic Changes in ALFF and DC in Subthreshold Depression Before and After ICBT Intervention by Wang Y, Ying Y, Zhu Z, Wang L, Yang Y, Zhang L, Yu W, Liang Y, Zhang H, Ji Y, Pan Y

“…This study aimed to examine changes in intrinsic brain activity in SD and their further alterations after ICBT intervention.Patients and Methods: Twenty-five individuals with SD and 25 matched healthy controls (HC) were enrolled. …”
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Automatic Real-Time Detection and Diagnosis of Liver Tumor with Ultrasound by Wu CH, Sheu JC, Chou PL, Lee J, Nien HC

“…We aimed to develop deep learning (DL) models to automatically diagnose and detect hepatic lesions in a larger dataset, with HCC as the dominant malignancy.Methods: We enrolled patients diagnosed with hepatic tumors using abdominal ultrasound between January 2002 and December 2020 in a retrospective cohort with a diagnosis of malignant and benign lesions. …”
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IL-6/IL-6R Signaling Blockade Alleviates Chronic Allograft Rejection by Modulating Germinal Center B Cells and Allograft Inflammation in Murine Cardiac Transplantation by Xia R, Shi X, Zhang H, Zeng W, Yang Z, Xu J, Wang J, Miao Y, Liao T

“…In this study, we investigate the preventive efficacy and underlying mechanism of IL-6/IL-6R signaling blockade.Methods: The CR model in mice was constructed using allogeneic cardiac transplantation with CTLA4-Ig injection. …”
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Comparative efficacy and safety of nitinol vs. novel fully biodegradable occluders for transcatheter patent foramen ovale closure in migraine treatment: a retrospective cohort stud... by Rui-lin Li, Jing-juan Huang, Jie Ming, Ying Hao, Wei Wen, Yun-li Shen, Li Lin, Lin-xiang Lu

“…Nevertheless, the comparative effectiveness and safety of traditional nitinol vs. fully biodegradable occluders remain to be fully elucidated and warrant further investigation.Materials and methodsThis retrospective cohort study included 158 migraine patients with a confirmed patent foramen ovale (PFO) and a grade II–III right-to-left shunt (RLS) as determined by contrast-enhanced transthoracic echocardiography (cTTE), who underwent transcatheter PFO closure at Shanghai East Hospital, Tongji University, between October 2023 and January 2024. …”
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Distribution characteristics, source apportionment, and health risk assessment of metals and metalloids in PM2.5 in a southern city in 2019 by Yaxin QU, Suli HUANG, Chao WANG, Jie JIANG, Jiajia JI, Daokui FANG, Shaohua XIE, Xiaoheng LI, Ning LIU

“…ObjectiveTo assess the distribution characteristics of metals and metalloids in outdoor PM2.5 in a southern city of China, conduct source apportionment, and evaluate the associated health risks, thereby providing theoretical support for further pollution control measures. MethodsPM2.5 samples were collected in districts A, B, and C of a southern China city, and the concentrations of 17 metals and metalloids were detected by inductively coupled plasma-mass spectrometry (ICP-MS). …”
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Association between serum albumin and severe impairment of activities of daily living in patients with stroke: a cross-sectional study by Ranran Bi, Yupeng Shi, Manrong Li, Xiaochen Liu, Zhenchao Ma, Yiqing Huang, Bingyin Liang, Fang Cui

“…This study aims to provide further results.Materials and methodsThis study examined cross-sectional data from patients aged 18 years or older with a diagnosis of stroke confirmed by cranial CT or MRI within 24 h of admission, gathered from January 2020 to August 2022. …”
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Effect of Telemedicine-Supported Structured Exercise Program in Patients with Chronic Low Back Pain: Study Protocol for a Randomized Controlled Trial by Feng Y, Jia C, Liu H, Bao T, Wang C, Wang Z, Huang J, Jiang Y, Wang X, Zhang R, Zhang Y, Zhang S, Zhu S, He C

“…Consequently, further research is warranted to clarify the impact of telemedicine-supported structured exercise programs on patients with CLBP.Patients and Methods: This randomized controlled trial will include patients with CLBP who have not received exercise therapy in the past three months. …”
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