The Role of EZH2 in Initiating Epigenetic Regulation of CRSwNP by Zeng R, Wang Y, Song X, Wang J

“…Particularly on EZH2, a key epigenetic regulator and histone methyltransferase, to explore its potential for CRSwNP immunotherapy.Patients and Methods: A total of 86 individuals were included between July 2021 and July 2023, including 43 patients with CRSwNP who underwent nasal polyp surgery and 43 patients with a deviated septum. …”
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Epidemiology of neonatal disorders attributable to low birthweight-global burden of disease research, 1990–2021 by Qi Zhang, Lan Luo, Lai-lai Yan, Lai-lai Yan, Jing Guo, Hui-jun Wu, Zi-wei Zhang, Yu-hua Zhu, Rui Qiao, Rui Qiao

“…BackgroundTo evaluate global, regional, and national trends in the burden of neonatal diseases attributable to LBW, as well as associated health inequalities, from 1990 to 2021.MethodsUsing data from the Global Burden of Disease Study (GBD2021), we analyzed deaths and DALYs due to LBW-attributable neonatal diseases. …”
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Lifestyle and Job-Related Factors Associated with Sleep Quality: Gender-Specific Insights from Taiwanese Hospital Physicians by Hou WH, Hsu TC, Chen FL, Wu JC

“…In this cross-sectional study, we explored gender-specific differences in factors associated with sleep quality in physicians.Participants and Methods: Self-report questionnaires were distributed to 401 hospital physicians in Taiwan. …”
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Diagnostic Utility of Pentraxin 3 Expression in Septic Cardiomyopathy: Findings from a Prospective Observational Study by Cui N, Lv XW, Shao TH, Yu ZB, Chen Z, Sun T, Li TM, Zhang JW, Hu ZJ

“…Na Cui,1,2,* Xiao-Wei Lv,2,* Teng-Hao Shao,2 Zhan-Biao Yu,2 Zhi Chen,2 Tao Sun,2 Tie-Min Li,2 Jin-Wen Zhang,2 Zhen-Jie Hu1 1Department of Critical Care Medicine, The Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang, 050010, People’s Republic of China; 2Department of Critical Care Medicine, Affiliated Hospital of Hebei University, Baoding, 071000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhen-Jie Hu, Department of Critical Care Medicine, The Fourth Affiliated Hospital of Hebei Medical University, No. 12, Jiankang Road, Shijiazhuang, 050010, People’s Republic of China, Tel +86 13933856908, Email 46400533@hebmu.edu.cnObjective: The aim of this study is to investigate the expression levels of Pentraxin 3, PTX3 in patients with septic cardiomyopathy, SCM and evaluate its diagnostic potential for predicting SCM.Methods: A prospective observational study was conducted involving 122 patients diagnosed with septic shock between February 2023 and August 2024. …”
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Cerebral Amyloid Angiopathy-Related Inflammation: Clinical Characteristics and Treatment Experience by Wang X, Li J, Fu Q, Zheng H, Duan S, Gao Y, Luo H, Xu Y

“…Xue Wang,1,* Jiaqi Li,1,* Qichang Fu,2,* Honglin Zheng,1,3 Suying Duan,1 Yuan Gao,1,4 Haiyang Luo,1,3 Yuming Xu1,3,4 1Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, People’s Republic of China; 2Department of Magnetic Resonance, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, People’s Republic of China; 3NHC Key Laboratory of Prevention and Treatment of Cerebrovascular Disease, Zhengzhou, Henan, People’s Republic of China; 4Henan Key Laboratory of Cerebrovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Haiyang Luo, Department of Neurology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Jian-She East Road, Zhengzhou, Henan, 450000, People’s Republic of China, Email fccluohy@zzu.edu.cn Yuming Xu, Department of Neurology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Jian-She East Road, Zhengzhou, Henan, 450000, People’s Republic of China, Email xuyuming@zzu.edu.cnObjective: The present study aims to analyze the clinical manifestations, laboratory results, neuroimaging features, treatment interventions, and outcomes in a cohort of patients with cerebral amyloid angiopathy-related inflammation (CAA-ri), providing a deeper understanding of this rare subtype of CAA and enhancing diagnostic precision in clinical practice.Methods: We conducted a systematic retrospective review of clinical records from 13 consecutive patients who met the diagnostic criteria for probable CAA-ri and were evaluated at the First Affiliated Hospital of Zhengzhou University between January 2021 and August 2024.Results: The study cohort comprised 13 patients (7 males, 6 females; mean age 65.2 years, range 42– 81), predominantly presenting with subacute onset (53.8%, n=7). …”
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The Role of Robot-Assisted Technique in Treating Adult Degenerative Scoliosis with Circumferential Minimal Invasive Correction Surgery – A Retrospective Analysis of 51 Co... by Zhang Q, Chen Z, Lin Y, Zhang X, Wu W, Liang Y

“…Robot-assisted technique demonstrates lots of advantages but the data about its application in treating ADS is limited in literatures.Methods: A total of 51 cases diagnosed with ADS were retrospectively analyzed. …”
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Effectiveness of Group and Individual Counselling Interventions on COVID-19 Vaccination Intention Among Industrial Employees in Romania by Dumitra GG, Camen AR, Nechita F, Pîrlog MC, Kamal C, Dogaru CA, Radu M, Gheorghe EC, Dumitrescu EM, Dinescu VC, Surugiu R, Oancea CN, Turcu-Stiolica A

“…This study aims to measure the level of vaccine hesitancy, identifying the factors contributing to it, and to evaluate the effectiveness of two targeted interventions—group and individual counseling—designed to address vaccine hesitancy among employees in seven industrial companies in Romania during the Coronavirus disease 2019 (COVID-19) pandemics.Methods: A total of 256 participants were included in the study, and interventions were delivered by family physicians and occupational medicine specialists trained in motivational interviewing (MI) techniques. …”
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Ketamine Infusion as an Adjunct to Opioid Analgesia in Pediatric Patients with High-Risk Neuroblastoma Undergoing Treatment with Dinutuximab: Adverse Effects and Safety in a Non-IC... by Streby KA, Tobias JD, McPhaden E, Downie S, Stanek J, Roth C, Patel PO

“…In addition, the secondary objective is to describe the toxicities of pain management with opioids versus opioid plus ketamine.Methods: A retrospective chart review of 40 hRNBL patients receiving dinutuximab at Nationwide Children’s Hospital, from 2010 to 2022, was conducted. …”
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Examination on the Acceptability, Feasibility and Effectiveness of a Digital Cognitive Training Software in Patients With Stable Schizophrenia in China by Yang L, Tang Y, Zhu J, Xu L, Wang M, Sun W, Shi C

“…Liu Yang,1,* Yajing Tang,1,* Jiahui Zhu,2 Lingzi Xu,3 Mingqia Wang,1 Wei Sun,3 Chuan Shi1 1Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, People’s Republic of China; 2The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, People’s Republic of China; 3Beijing Infinite Brain Technologies, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Chuan Shi, Peking University Sixth Hospital, 51 huayuan North Road, Beijing, 100089, People’s Republic of China, Email shichuan@bjmu.edu.cn Wei Sun, Beijing Infinite Brain Technologies, 40 Xiaoyun Road, Beijing, 100004, People’s Republic of China, Email sunwei@wjbrain.comObjective: This single-arm study aimed to explore the acceptability and effectiveness of a digital cognitive training software (IBT-004) in patients with stable schizophrenia.Methods: This study conducted an 8-week home-based cognitive training program, IBT-004, for patients with stable schizophrenia. …”
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Improving Large Language Models’ Summarization Accuracy by Adding Highlights to Discharge Notes: Comparative Evaluation by Mahshad Koohi Habibi Dehkordi, Yehoshua Perl, Fadi P Deek, Zhe He, Vipina K Keloth, Hao Liu, Gai Elhanan, Andrew J Einstein

“…For this purpose, we aim to prove a hypothesis that summaries generated by LLMs of discharge notes in which detailed information is highlighted are likely to be more accurate than summaries of the original notes. MethodsTo test our hypothesis, we randomly sampled 15 discharge notes from the MIMIC III database and highlighted their detailed information using an interface terminology we previously developed with machine learning. …”
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Prediction of Clinical Bronchiectasis from Asymptomatic Radiological Bronchiectasis by Fan Y, Li Z, Jiang N, Zhou Y, Song J, Yu F, Zhang J, Wang X

“…Whether the ARB could progress to CB and the risk factors to speed up the process are poorly understood.Methods: This was an observational cohort study. 370 patients with radiological bronchiectasis were included in Wuhan Union Hospital in 2018. 296 ARB patients were followed up in 2022 to verify if they progressed to CB and divided the development and validation of clinical prediction models into a training set (n=207) and a validation set (n=89) by the ratio of 7:3. …”
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Telemedical treatment of diabetic foot ulcer in rural and remote areas: a prospective single centre randomised controlled clinical trial by Usman H Malabu, Venkat N Vangaveti, Julie Goodall, Jacqueline Bulbrook, Erik Biros, Harshal Deshmukh, Kunwarjit S Sangla

“…Therefore, our objective was to conduct a randomized controlled trial comparing the effectiveness of telemedical treatment in rural settings with the standard tertiary healthcare approach for managing diabetic foot ulcers. Methods The study was conducted between 2016 and 2022. …”
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GA-LDV: A Promising Derivative of 18β-Glycyrrhetinic Acid with Enhanced in vitro and in vivo Anti-Cancer Properties by Zheng J, Feng Q, Gao Q, Wang Y, Zhao S, Zhang X, Zhao M

“…Jiaying Zheng,1,* Qiqi Feng,1,* Qi Gao,1 Yaonan Wang,1 Shurui Zhao,1 Xiaoyi Zhang,1 Ming Zhao1,2 1Beijing Area Major Laboratory of Peptide and Small Molecular Drugs, Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Capital Medical University, Beijing, 100069, People’s Republic of China; 2Beijing Laboratory of Biomedical Materials and Key Laboratory of Biomedical Materials of Natural Macromolecules, Department of Biomaterials, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing, 100026, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ming Zhao, Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Capital Medical University, Beijing, 100069, People’s Republic of China, Tel +861083911535, Fax +861083911533, Email maozhao@126.com Xiaoyi Zhang, Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Capital Medical University, No. 10, Youanmenwaixitoutiao, Fengtai District, Beijing, 100069, People’s Republic of China, Tel +861083911530, Fax +861083911533, Email zhangdd@ccmu.edu.cnPurpose: The clinical translation of 18β-Glycyrrhetinic acid (GA) is impeded by its relatively low antitumor potency and poor aqueous solubility, we developed a novel derivative of GA by incorporating the Leu-Asp-Val (LDV) tripeptide to enhance its anti-tumor and anti-metastatic activities both in vitro and in vivo, thereby increasing its potential as a therapeutic agent for cancer treatment.Methods: The water solubility of GA-LDV was evaluated. …”
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The Duration of Prophylactic Antibiotic Use for Esophageal Cancer Patients with Postoperative Infection and Nutritional Status by Ning D, Zhou L, Shi G, Fu M

“…Dong Ning,1,* Lin Zhou,2,* Guidong Shi,1 Maoyong Fu1 1Department of Thoracic Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, People’s Republic of China; 2Department of Ultrasound, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Dong Ning, Department of Thoracic Surgery, Affiliated Hospital of North Sichuan Medical College, No. 1, Maoyuan South Road, Shunqing District, Nanchong, Sichuan, 63000, People’s Republic of China, Email dongningcb@21cn.comObjective: To verify the hypothesis that “the prophylaxis use time of antibiotics after esophageal cancer (EC) surgery ≤ 24 hours is associated with a lower postoperative infection rate and improvement of nutritional indicators”, a retrospective cohort analysis was conducted to compare the infection incidence and differences in serum nutritional indicators among patients with different medication durations (< 24 hours, 24– 48 hours, > 48 hours), and to identify independent risk factors for postoperative infection.Methods: A retrospective analysis was conducted on the data of 566 patients who underwent EC surgery in Affiliated Hospital of North Sichuan Medical College from January 2020 to October 2022. …”
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3D-Printed PCL-Based Scaffolds with High Nanosized Synthetic Smectic Clay Content: Fabrication, Mechanical Properties, and Biological Evaluation for Bone Tissue Engineering by Furtado ASA, Cunha MHS, Sousa LMR, Brito GC, Verde TFCL, Filgueiras LA, Sobral-Silva LA, Santana MV, Sousa GF, Santos FEP, Mendes AN, Figueredo-Silva J, Maia Filho ALM, Marciano FR, Vasconcellos LMR, Lobo AO

“…The main challenge lies in achieving a uniform distribution of nanoceramics across low to high concentrations within the polymer matrix while preserving mechanical properties and biological performance essential for successful osseointegration.Methods: This study utilized 3D printing to fabricate PCL scaffolds enriched with nanosized synthetic smectic clay (LAP) to evaluate its effects on structural, chemical, thermal, mechanical, and degradative properties, with a focus on in vitro biological performance and non-toxicity. …”
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EPIDEMIOLOGY AND SURVIVAL OF PATIENTS WITH MALIGNANT TUMORS OF CONNECTIVE AND SOFT TISSUE by V. M. Merabishvili, O. F. Chepik, E. N. Merabishvili

“…To estimate dynamics of incidence of malignant tumors of connective and soft tissue on the basis of public reporting, to calculate the index accuracy and observed and relative survival rates by histological forms, including sarcomas. Material and methods. To perform a detailed study there were selected, for two periods of observation, respectively 1054 patients (1995–2001) and 919 patients (2002–2008). …”
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Cecal coccidiosis in Japanese quails (Coturnix Japonica): Eimeria tsunodai identification and comparative prophylactic phytochemotherapy with immune stimulant impact by Reham M. ElBakrey, Amal A.M. Eid, Ahmed A. ElKholy, Mohamed R. Mousa, Mohamed A. El-Morsy, Walaa S. Abdelaziz

“…A selected E. tsunodai was used to evaluate the comparative anticoccidial efficacy of a commercial herbal product containing oregano and garlic essential oils (EOs) as a prophylactic supplement via drinking water taking into consideration that it had never been applied in quails' coccidiosis before. Methods: A total of 300 Japanese quails were equally assigned to four groups. …”
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Eepidemiological Interregional Multicenter Study of Healthcare-Associated Infections in the Intensive Care Units. First Results by R. V. Polibin, E. B. Brusina, O. V. Kovalishena, E. V. Glushkova, A. A. Gridina, B. I. Aslanov, N. I. Briko

“…The intensive development of medical technologies is accompanied by equally rapid changes in the epidemic process of healthcare-associated infections (HAIs). …”
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Integration of Diaphragmatic Ultrasonography and Intra-Abdominal Pressure Measurement for Optimizing Weaning from Mechanical Ventilation by Su D, Li R, Chen Z, Cui N, Yu Z, Ding X, Wu J

“…Dan Su,1,* Ruixin Li,1,* Zhi Chen,2 Na Cui,1 Zhanbiao Yu,1 Xiaoxu Ding,1 Jiaqian Wu1 1Intensive Care Unit, The Affiliated Hospital of Hebei University, Baoding, Hebei Province, 071000, People’s Republic of China; 2Department of Hepatobiliary Surgery, The Affiliated Hospital of Hebei University, Baoding, Hebei Province, 071000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhi Chen, Department Hepatobiliary Surgery, The Affiliated Hospital of Hebei University, No. 212 of Yuhua Road, Lianchi District, Baoding, Hebei Province, 071000, People’s Republic of China, Tel +86 13832296881, Fax +86 0312-5983782, Email chenzhi6295@126.com Na Cui, Intensive Care Unit, The Affiliated Hospital of Hebei University, No. 212 of Yuhua Road, Lianchi District, Baoding, Hebei Province, 071000, People’s Republic of China, Tel +86 13503382865, Fax +86 0312 5983752, Email nacuilika@126.comObjective: The objective of this study was to evaluate the effectiveness of diaphragmatic ultrasonography in conjunction with intra-abdominal pressure (IAP) measurement for assessing diaphragm function and determining the optimal timing for weaning from mechanical ventilation (MV).Methods: A cohort of 100 patients undergoing MV at the intensive care department of the Affiliated Hospital of Hebei University between January 2023 and July 2023 was enrolled. …”
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Application Effectiveness of a Pre-Analytical Quality Management Pathway Based on the Structure–Process–Outcome Model by Cui L, Li W, Li Y, Feng X, Wang Y, Gao P

“…Liping Cui,1,* Wanling Li,1,2,* Yueqin Li,3 Xiaofang Feng,3 Yue Wang,4 Pei Gao4 1Department of Nursing, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, 030032, People’s Republic of China; 2Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of China; 3Department of General Medical, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, 030032, People’s Republic of China; 4Nursing College, Shanxi Medical University, Taiyuan, 030032, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yueqin Li, Department of General Medical, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, No. 99 Longcheng Street, Xiaodian District, Taiyuan, Shanxi, 030032, People’s Republic of China, Tel +86 0351-8368114, Email li_yueqin@163.comObjective: This single-center, before-and-after study applied the structure–process–outcome (SPO) model to pre-analytical quality control to investigate its effect on laboratory testing quality, nursing practices, patient satisfaction, and clinician trust in test results.Methods: A before-and-after design was conducted in a provincial Class A tertiary hospital. …”
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