Gold and Silver Nanoparticles Efficiently Modulate the Crosstalk Between Macrophages and Cancer Cells by Adamecz DI, Veres É, Papp C, Árva H, Rónavári A, Marton A, Vizler C, Gácser A, Kónya Z, Igaz N, Kiricsi M

“…Since it is fairly unknown how the promising anticancer agents, silver (AgNPs) and gold nanoparticles (AuNPs) affect the bidirectional communication and reprogramming in the tumor stroma, we examined the behavior, the tumor-supporting functions, and the expression of polarization and functional marker genes of TAMs to reveal how these are modulated upon interaction with nanoparticle-exposed cancer cells.Methods: We established co-cultures of murine immortalized J774 or primary bone marrow-derived macrophages with 4T1 breast cancer cells treated with AuNPs or AgNPs or with none of the nanoparticles. …”
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Unveiling PANoptosis in Acute Kidney Injury: An Integrative Multi-Dimensional Approach to Identify Key Biomarkers by Wang N, Zhang L, Xu Z, Xu Q, Lu Y, Niu P, Yan L, Wang L, Cao H, Shao F

“…While this process has been implicated in various inflammatory conditions, its specific role in AKI remains unclear.Methods: The role of PANoptosis in AKI was investigated using single-cell RNA sequencing (scRNA-seq) and bulk transcriptomic data. …”
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Influence of additional risk factors on the antihypertensive efficacy of eprosartan and telmisartan in patients with essential hypertension by V. V. Syvolap, O. V. Vizir-Tronova

“…The aim of this study is to determine the effect of additional risk factors on blood pressure parameters, cardiovascular remodeling and the state of vegetative balance of the heart rhythm in patients with stage II essential hypertension (EH) under treatment with eprosartan and telmisartan. Materials and methods. The study included 100 patients with stage II essential hypertension (EH), 1–2 degrees with a low and moderate risk of developing cardiovascular complications. …”
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Non-Luminal Disease Score for Everolimus in Patients with Hormone Receptor‑positive and Human Epidermal Growth Factor Receptor 2-Negative Advanced Breast Cancer: A Mult... by Tan Y, Jiang H, Tian X, Ma F, Wang J, Zhang P, Xu B, Fan Y, Zhao W

“…Yujing Tan,1,* Hanfang Jiang,2,* Xinzhu Tian,1,* Fei Ma,1 Jiayu Wang,1 Pin Zhang,1 Binghe Xu,1 Ying Fan,1 Weihong Zhao3 1Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100021, People’s Republic of China; 2Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Breast Oncology, Peking University Cancer Hospital & Institute, Beijing, 100142, People’s Republic of China; 3Department of Medical Oncology, Chinese PLA General Hospital, Beijing, 100853, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ying Fan; Weihong Zhao, Email fanying@cicams.ac.cn; zhaowh0818@163.comPurpose: This study aims to explore the role of the non-luminal disease score (NOLUS) for everolimus in patients with hormone receptor-positive and human epidermal growth factor receptor 2-negative (HR+/HER2-) advanced breast cancer (ABC).Methods: NOLUS has previously been established as an algorithm: NOLUS (0– 100) = − 0.45 × ER(%) − 0.28 × PR(%) + 0.27 × Ki67(%) + 73. …”
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Identification and Evaluation of Lipocalin-2 in Sepsis-Associated Encephalopathy via Machine Learning Approaches by Hu J, Chen Z, Wang J, Xu A, Sun J, Xiao W, Yang M

“…Identifying and screening key genes responsible for SAE, as well as exploring potential targeted therapies, are vital for improving the management of sepsis and advancing precision medicine.Patients and Methods: Single-cell RNA sequencing (scRNA-seq) was administrated to identify cell subpopulations related to poor prognosis in septic patients. …”
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Nanoformulations Downregulating METTL16 Combined with mRNA Tumor Vaccines Suppress Triple-Negative Breast Cancer and Prevent Metastasis by Wang R, Zhang Y, Du S, Li Y, Ren Y, Lin J

“…The integration of this formulation with emerging mRNA tumor vaccines aimed to effectively inhibit the growth and metastasis of TNBC.Research Methods: Using microfluidic technology, efficient siRNA encapsulation in lipid nanoparticle (LNP) yielded LNP/siMETTL16 and selective organ-targeting LNP/siMETTL16 (SORT-LNP/siMETTL16). …”
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Telehealth Modality Preferences for Video and Voice-Only Visits Among US Clinicians and the Public: Cross-Sectional, Web-Based Survey Study by Rachel C Forcino, Julie K Johnson, Glyn Elwyn

“…ObjectiveWe aimed to identify telehealth modality preferences (voice vs video) among clinicians and the populations they serve and explore the barriers to telehealth use from clinician and public perspectives. MethodsWe conducted 2 independent, cross-sectional, web-based surveys. …”
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Hypoxic Burden and T90% as Predictive Indicators of Cardiovascular Risk and Myocardial Ischemia in Patients with Obstructive Sleep Apnea by Zeng W, Wu S, Liu Z, Yuan L, Chen B, Rong Y

“…Wenmei Zeng,1,* Sulong Wu,2,* Zhuofan Liu,1 Long Yuan,1 Bilin Chen,1 Yan Rong1 1Department of Pulmonary and Critical Care Medicine, Shenzhen Qian Hai She Kou Free Trade Zone Hospital, Shenzhen, 518067, People’s Republic of China; 2Department of Emergency Intensive Care Medicine, Shenzhen Qian Hai She Kou Free Trade Zone Hospital, Shenzhen, 518067, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yan Rong, Department of Pulmonary and Critical Care Medicine, Shenzhen Qian Hai She Kou Free Trade Zone Hospital, No. 36, Gongye 7th Road, Nanshan District, Shenzhen, 518067, People’s Republic of China, Tel +86-13622230015, Email shanshuisahala@163.comPurpose: This study analyzed the role of hypoxic burden and the percentage of time with blood oxygen saturation below 90% (T90%) in assessing the myocardial ischemia and cardiovascular risk in obstructive sleep apnea (OSA) patients using portable sleep monitors.Patients and Methods: We conducted a prospective observational study of hospitalized OSA patients diagnosed by portable sleep monitors at a single tertiary center in Southern China from January 2022 to March 2024. …”
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Effect of Esketamine on Cognitive Recovery After Propofol Sedation for Outpatient Colonoscopy: A Randomized Clinical Trial by Liu D, Gao X, Zhuo Y, Cheng W, Yang Y, Wu X, Yang H, Yao Y

“…This study investigated the effects of esketamine on multiple dimensions of recovery, particularly cognition, in patients undergoing colonoscopy with propofol-based sedation.Patients and Methods: We conducted this randomized, double-blinded, placebo-controlled trial from January 6, 2023, to May 20, 2024, at two hospitals in China. …”
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Inhibition of the MRSA Biofilm Formation and Skin Antineoplastic Activity of Ethyl Acetate Roots and Aerial Parts Extracts from <i>Geum urbanum</i> L. by Lyudmila Dimitrova, Maya M. Zaharieva, Lilia Tserovska, Milena Popova, Vassya Bankova, Hristo Najdenski

“…<b>Objectives:</b> The aim of our study was to evaluate the antibiofilm potential of ethyl acetate roots (EtOAcR) and aerial parts (EtOAcAP) extracts from the perennial Bulgarian plant <i>Geum urbanum</i> L. against methicillin-resistant <i>S. aureus</i> (MRSA) NBIMCC 8327. <b>Methods</b>: The effects of both extracts on the expression of biofilm-related genes, <i>ica</i>A and <i>ica</i>D, were investigated. …”
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Association and Comparison of Systemic Inflammation Indicators and Myocardial Injury After Noncardiac Surgery in Older Patients by Meng B, Zhang K, Liu C, Yao S, Li Z, Lou J, Fu Q, Liu Y, Cao J, Mi W, Li H

“…Bingbing Meng,1,2,&ast; Kai Zhang,1,2,&ast; Chang Liu,2,3 Siyi Yao,1,2 Zhao Li,1,2 Jingsheng Lou,1,2 Qiang Fu,1,2 Yanhong Liu,1,2 Jiangbei Cao,1,2 Weidong Mi,1,2,4 Hao Li1,2,4 1Medical School of Chinese People’s Liberation Army (PLA), Beijing, People’s Republic of China; 2Department of Anesthesiology, The First Medical Center, Chinese People’s Liberation Army General Hospital (PLAGH), Beijing, People’s Republic of China; 3Nankai University, Tianjing, People’s Republic of China; 4National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Weidong Mi; Hao Li, Department of Anesthesiology, The First Medical Center, Chinese People’s Liberation Army General Hospital (PLAGH), 28th Fuxing Road, Haidian District, Beijing, 100853, People’s Republic of China, Email wwdd1962@aliyun.com; lihao301@126.comObjective: To identify the association between preoperative inflammatory state and myocardial injury after noncardiac surgery (MINS) in older patients using systemic inflammation indicators neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII) and to compare their clinical predictive values.Methods: This study included patients aged ≥ 65 years who underwent noncardiac surgery between January 2017 and August 2019. …”
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Engaging Community-Dwelling Older Adults in Research: Qualitative Substudy of Factors Impacting Participation by Bryah Boutilier, Grace Warner, Brianna Wolfe, Sorayya Askari, Elaine Moody, Parisa Ghanouni, Tanya Packer

“…The substudy aimed to identify motivations that influence older adults’ engagement in research and barriers to their participation. MethodsData collection involved qualitative semistructured interviews with 27 older adults, with a mean age of 77 (SD 5.4), who had completed a comprehensive assessment. …”
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Diagnostic and prognostic significance of detecting mutations in the <i>BRAF, TERT, RAS, RET/PTC, PAX8/PPARG</i> in the material of fine needle aspiration biopsy thyroid nodules in... by A. A. Musaelyan, S. V. Lapin, V. D. Nazarov, E. S. Kozorezova, S. L. Vorobyev, S. V. Orlov

“…In group 2, using the genetic panel sensitivity and specificity were equal: 36.4 and 93.9 %, respectively. positive and negative predictive values were 66.7 and 81.6 %, respectively. …”
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Associations Between Health Literacy and Chronic Disease Prevalence Among Employees in Chinese Petroleum Companies: A Cross-Sectional Study by Ma H, Su Y, Zhao S, Wang Y, Wei X, Qu H

“…However, its specific role in this workforce is not well understood.Objective: This study investigates the associations between health literacy and the prevalence and number of chronic diseases among employees in a Chinese petrochemical company.Methods: In March 2022, a cross-sectional survey collected 39,491 valid responses from employees of a large petrochemical company in Shandong Province, China. …”
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Sericin-Assisted Green Synthesis of Gold Nanoparticles as Broad-Spectrum Antimicrobial and Biofilm-Disrupting Agents for Therapy of Bacterial Infection by Cai R, Cheng Q, Zhao J, Zhou P, Wu Z, Ma X, Hu Y, Wang H, Lan X, Zhou J, Tao G

“…Therefore, it is critical to develop simple and effective strategies to kill bacteria and remove biofilms.Methods: The present study used sericin as a reducing and stabilizing agent to synthesize sericin-gold nanoparticles (Ser-Au NPs) and tested its colloidal stability under different pH and salt concentration conditions. …”
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DIAGNOSIS OF CAROTID PARAGANGLIOMA: MULTIDISCIPLINARY ASPECTS by I. V. Stepanov, M. S. Ol’shanskiy, D. Yu. Kharitonov, V. V. Dmitriev, A. V. Podoprigora, A. S. Shcherbinin

“…Objective: to enhance the efficiency of diagnosis and treatment of  carotid paragangliomas, by introducing of a multidisciplinary approach into clinical practice.Material and methods. A total of 15 cases of paragangliomas have been followed up for 10 years. …”
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SIRT2 Promotes NLRP3-Mediated Microglia Pyroptosis and Neuroinflammation via FOXO3a Pathway After Subarachnoid Hemorrhage by Sun JQ, Sheng B, Gao S, Liu XZ, Cui Y, Peng Z, Chen XX, Ding PF, Zhuang Z, Wu LY, Hang CH, Li W

“…Jia-Qing Sun,1,5,&ast; Bin Sheng,2,5,&ast; Sen Gao,2,5,&ast; Xun-Zhi Liu,2,5 Yue Cui,4,5 Zheng Peng,2,5 Xiang-Xin Chen,2,5 Peng-Fei Ding,3,5 Zong Zhuang,2,5 Ling-Yun Wu,2,5 Chun-Hua Hang,1– 5 Wei Li2– 5 1Department of Neurosurgery, Nanjing Drum Tower Hospital, Drum Tower Hospital Clinical College, Xuzhou Medical University, Nanjing, People’s Republic of China; 2Department of Neurosurgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, People’s Republic of China; 3Department of Neurosurgery, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, People’s Republic of China; 4Department of Neurosurgery, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, People’s Republic of China; 5Neurosurgery Institute of Nanjing University, Nanjing, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Chun-Hua Hang; Zong Zhuang, Department of Neurosurgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, 210006, People’s Republic of China, Tel +86 25 83106666-11902 ; +86 25 83106666-11901, Email hang_neurosurgery@163.com; zhuangzong@njglyy.comPurpose: This study primarily elucidating the specific mechanism of SIRT2 on neuroinflammation and microglial pyroptosis in a mouse model of SAH.Patients and Methods: CSF were collected from 57 SAH patients and 11 healthy individuals. …”
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Routine Laboratory Markers-Based Machine Learning Model for Predicting Severe Kawasaki Disease in Pediatric Patients by Wu M, Chen J, Gao Y, Chen H, Li W

“…This study introduces a novel machine learning approach for the early prediction of SKD in pediatric populations, utilizing routinely collected laboratory parameters.Methods: We extracted patients’ age, sex, and 67 standard laboratory markers from the clinical records of 1,466 patients diagnosed with KD at the Children’s Hospital of Nanjing Medical University. …”
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Peran Gembala Sidang Dalam Mengajar Dan Memotivasi Untuk Melayani Terhadap Pertumbuhan Rohani Pemuda by Talizaro Tafonao

“…In finding the answers of this study, researchers used quantitative research methods with descriptive research type. After conducted field research and data processing using SPSS 19 program with the result are: First, Based on correlation analysis (r) Spearmen model, then obtained correlation analysis results that there is correlation between the influence of the role of pastor in teaching with spiritual growth of youth GKII Shalom Kalasan of 0.461. …”
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The Chain Mediating Role of Hope and Posttraumatic Growth Between Social Support and Psychological Distress Among Lung Cancer Patients by Huang JG, Xu CH, Shi YM, Jiang J, Huang FM, Xu LL

“…Jin-Gui Huang,1,&amp;ast; Chen-Han Xu,2,&amp;ast; Yu-Mei Shi,1 Juan Jiang,3 Feng-Mei Huang,1 Ling-Li Xu4 1Department of Medical Oncology, Chongqing University Cancer Hospital, Chongqing, 400030, People’s Republic of China; 2College of Computer Science, Chongqing University, Chongqing, 400000, People’s Republic of China; 3Department of Gastroenterology, Chongqing University Cancer Hospital, Chongqing, 400030, People’s Republic of China; 4Department of Human Resources, Chongqing University Cancer Hospital, Chongqing, 400030, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Ling-Li Xu, Department of Human Resources, Chongqing University Cancer Hospital, No. 181, Hanyu Street, Shapingba District, Chongqing, 400030, People’s Republic of China, Tel +86 15823276672, Email 15823276672@163.comPurpose: This research was designed to explore whether hope and posttraumatic growth (PTG) played a mediating role between social support and psychological distress in patients diagnosed with lung cancer.Patients and Methods: A hospital-based cross-sectional study was carried out on 502 lung cancer patients. …”
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