Clinical Characteristics and Seizure Outcomes in Antibody-Positive Autoimmune Limbic Encephalitis by Song H, Xu S, Du BQ, Lai QL, Cai MT, Li H, Hu Y, Ding Y, Ding MP, Zhang YX, Shen CH

“…We aimed to investigate the clinical characteristics and seizure outcomes in a cohort with antibody-positive ALE.Methods: We consecutively recruited patients with antibody-positive ALE and new-onset seizures between July 2014 and February 2024. …”
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Cornus officinalis Protects Against Steroid-Induced Osteonecrosis of the Femoral Head Through Inhibiting Inflammatory Responses and Apoptosis via Network Pharmacology and Experimen... by Wang Y, Fan Y, Li M, Song Z, Wang P, Xie F, Miao Y, Wang Y, Zhang P, Zhan Q

“…This study is to investigate the mechanisms of SZY against SONFH via network pharmacology and experimental validation analysis.Methods: The active components and related targets of SZY and related-SONFH targets were collected from public databases. …”
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cAMP/PKA/CREB/GLT1 signaling involved in the antidepressant-like effects of phosphodiesterase 4D inhibitor (GEBR-7b) in rats by Liu X, Guo H, Sayed MDSM, Lu Y, Yang T, Zhou D, Chen Z, Wang H, Wang C, Xu J

“…Next, we also investigated the alterations of cyclic adenosine monophosphate (cAMP), protein kinase A (PKA) catalytic subunit (PKAca), cAMP response element-binding (CREB), and glutamate transporter 1 (GLT1) levels produced by GEBR-7b in the rats model of depression.Methods: Effects of GEBR-7b on CUS (35 days)-induced depression-like behaviors were examined by measuring immobility time in the forced swimming test (FST). …”
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Psychometric validation of the Chronic Ocular Pain Questionnaire (COP-Q) by Amy Findley, Brigitte J. Sloesen, Nicola Hodson, Agkreta Leventi, Ben Pascoe, Rob Arbuckle, Paul O’Brien, Christel Naujoks, Michela Montecchi-Palmer, Diana Plaza, Paul M. Karpecki, Pedram Hamrah

“…This study assessed the psychometric properties of the COP-Q to determine the adequacy of the COP-Q as a ‘fit-for-purpose’ instrument to derive trial endpoints for future clinical studies in COSP. Methods Patients with COSP completed the COP-Q daily for four weeks on an electronic, touch-screen, tablet device as part of a longitudinal, observational study in the United States (N = 124). …”
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Recurrence Prediction by Multi-Omics in the Patient with Colorectal Peritoneal Metastases After Cytoreductive Surgery: A Prospective Biomarker Study by Chen C, Gong Z, Zhang Z, Gu H, Zhu A, Peng D, Li B, Wang J, Hu Y, Wang D, Sun L

“…This study evaluated tumor tissue biomarkers and combined circulating tumor DNA (ctDNA) and methylation analysis via ultra-deep next-generation sequencing (NGS) for recurrence prediction.Methods: CRCPM patients undergoing surgery were enrolled (n=21). …”
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The Practices of Public Hospital Registered Nurses Regarding Post-Stroke Dysphagia, in China by Lu QY, Bu MR, Zhu Y, Huang ZY, Gao SH, Yuan C

“…A multi-center descriptive cross-sectional design was utilized.Participants and Methods: From March 2 to April 18, 2024, 1010 nurses from 14 provinces in China completed an online questionnaire through convenient sampling. …”
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ADL and Cognitive Function in Chinese Elderly: Mediating Role of Social Participation and Moderating Role of Intergenerational Support by Li W, Xin D, Feng X, Li Y, Zhu W, Xu J, Yin S

“…Wanling Li,1,2,* Dinuo Xin,2,* Xiaofang Feng,2 Yueqin Li,2 Wenjuan Zhu,2 Jiajia Xu,2 Shiyu Yin1 1Department of Nursing, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of China; 2Department of Nursing, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, 030032, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shiyu Yin, Department of Nursing, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, Hubei, 430030, People’s Republic of China, Tel/Fax +86-18834896110, Email 1538746173@qq.com Jiajia Xu, Department of Nursing, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, 030032, People’s Republic of China, Tel/Fax +86-351-8379512, Email xujiajia392@163.comPurpose: This study aimed to explore the relationship between activities of daily living (ADL) and cognitive function in Chinese elderly, and to analyze in depth the mediating and moderating roles of social participation and children’s intergenerational support in this relationship, in order to provide a reference basis for delaying cognitive decline in the elderly.Patients and Methods: Based on data from the 2020 wave of China Health and Retirement Longitudinal Survey (CHARLS 2020), this study included 5612 subjects aged 60 years and older, and extracted main variables such as demographic information, ADL, social participation, cognitive function, and children’s intergenerational support. …”
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The CT-Imaging Location of Lumbar 3 Sympathetic Radiofrequency Thermocoagulation for Sympathetic-Related Diseases Therapy by Wang R, Gao Z, Ma L

“…Ruxiang Wang,1,* Zhuoyue Gao,2,* Ling Ma1 1Department of Anesthesiology and Pain Medicine, Affiliated Hospital of Jiaxing University, Jiaxing, People’s Republic of China; 2Department of Anesthesiology, Daqing Oilfield General Hospital, Daqing, 163001, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ling Ma, Email 1319108@qq.comPurpose: The location characteristic of the lumbar 3 sympathetic trunk under Computed Tomography (CT) was discovered through 106 cases, imaging analysis after successful lumbar 3 sympathetic radiofrequency thermocoagulation operations serving the clinic and reducing the operation time.Methods: There are 113 patients underwent bilateral L3 lumbar sympathetic thermal radiofrequency procedures in our hospital from January 2017 to January 2021, with 106 cases of successful procedure. …”
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IL-8 Downregulation Mediates the Beneficial Effects of Infection-Induced Fever on Breast Cancer Prognosis by Li H, Liang X, Ma J, Liu Q, Lin Y, Tang J, Ren Z, Liang Z

“…However, the key cytokines and the underlying mechanisms through which fever exerts its anti-tumor effects remain unclear.Patients and Methods: A total of 794 breast cancer patients were recruited between 2008 and 2017, with follow-up extending until October 31st, 2023. …”
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MiRNAs and Neutrophil-Related Membrane Proteins from Plasma-Derived Extracellular Vesicles for Early Prediction of Organ Dysfunction and Prognosis in Septic Patients by Ye R, Wei Y, Li J, Xu M, Xie H, Huang J, Deng L, Li C

“…We sought to investigate the profile of extracellular vesicles (EVs)-mediated communication between plasma and polymorphonuclear neutrophils (PMNs) in sepsis, and to elucidate whether miRNAs and PMN-related membrane proteins from plasma-derived EVs (plasma-EVs) are associated with sepsis-induced organ dysfunction and prognosis.Methods: PMN-derived EVs (PMN-EVs) were isolated from the blood samples of healthy controls (N=3) and patients with septic shock (N=3) after ICU admission. …”
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Hypoxia-induced genome-wide DNA demethylation by DNMT3A and EMT of cancer cells by Biswanath Chatterjee, Pritha Majumder, Chun-Chang Chen, Jing-Ping Wang, Po-Hsuan Su, Hung-Cheng Lai, Ching-Chen Liu, Hsin-Nan Lin, Chen-Hsin A. Yu, Hanna S. Yuan, Che-Kun James Shen

“…Previously, the mammalian DNA methyltransferases (DNMTs) have been shown to possess redox- and Ca++- dependent active DNA 5mC demethylation activities in addition to the cytosine methylation activity. Methods In this study, we have carried out experiments using a range of molecular, cellular, and genome editing approaches including cell culturing, CRISPR/Cas9-editing, si- or sh-RNA-mediated knockdown, quantitative RT-PCR, western blotting, ChIP-qPCR, Na-bisulfite sequencing, EMT and lung colonization assays in conjunction with DNA methylome and DNMT3A ChIP-Seq analyses, Results We found that active DNA demethylation activity of DNMT3A is essential for hypoxia-induced EMT of the SW480 colon cancer cells, its global genomic DNA demethylation, and promoter DNA demethylation/transcriptional activation of EMT-associated genes including TWIST1 and SNAIL1. …”
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Autonomic Nervous Regulation was Associated with Sleep Quality Among Peritoneal Dialysis Patients by Huang B, Qian Y, Gao Y, Chen Z, Zhang L, Mao H, Xing C, Ren H, Wang J

“…However, the relationship between autonomic nervous system activity and sleep remains inadequately elucidated.Methods: This cross-sectional study enrolled adult maintenance PD patients in our center. …”
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Integration of single-cell sequencing and drug sensitivity profiling reveals an 11-gene prognostic model for liver cancer by Qunfang Zhou, Jingqiang Wu, Jiaxin Bei, Zixuan Zhai, Xiuzhen Chen, Wei Liang, Jing Meng, Mingyu Liu

“…Methods We downloaded single-cell sequencing data from GSE189903, grouped cells by cluster markers, and classified epithelial cells into adjacent non-tumor, normal, and tumor cells. …”
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Identification of Epigenetic Alteration of the IFI44L Gene in B Cells of Sjogren’s Syndrome as a Clinical Biomarker and Molecular Significance by Zhang K, Luo Z, Yao X, Lu D, Hong T, Zhu X, Chen M, Wang X

“…This study investigated gene expression and epigenetic changes in IFI44L, analyzing its correlation with disease activity and clinical indicators.Methods: Differentially expressed genes (DEGs) were identified from the GSE199868 dataset, while IFN-I-related genes were collected from GeneCards. …”
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High BMP7 Expression May Worsen Airway Disease in COPD by Altering Epithelial Cell Behavior by Dong W, Xie M, Ming C, Li H, Xu X, Cui L, Wang W, Li Y

“…Previous research has shown that BMP7 is highly expressed in the airway epithelia of patients with COPD, but its role in airway disease has not been fully elucidated.Methods: A lung tissue cohort and a sputum cohort were included in the study. …”
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Cinobufagin Suppresses Lipid Peroxidation and Inflammation in Osteoporotic Mice by Promoting the Delivery of miR-3102-5p by Macrophage-Derived Exosomes by Geng Z, Sun T, Yu J, Wang N, Jiang Q, Wang P, Yang G, Li Y, Ding Y, Zhang J, Lin G, Zhao Y

“…This research aims to ascertain the bone-protective properties of cinobufagin and investigate underlying mechanisms.Methods: Mice were ovariectomized to establish an osteoporosis model, followed by intraperitoneal injections of cinobufagin and cinobufagin-treated RAW.264.7-derived exosomes for therapy. …”
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Gubi Decoction Ameliorates Porous Cartilage Endplate in an Intervertebral Disc Degeneration Model Mouse Through Inhibition of NF-κB Activity and Pyroptosis by Yao S, Li Y, Ruan H, Wu L, Zeng H

“…Our prior studies have highlighted the therapeutic potential of Gubi decoction (GBD) in alleviating knee osteoarthritis, however, but the specific mechanism of GBD in treating IVDD is not clear.Objective: To ascertain the clear mechanism of GBD for enhancing its therapeutic efficacy in treating lVDD, through comparison of its effects across different doses of GBD and clinical positive control drugs using a mouse IVDD model.Methods: In this study, 8-week-old male mice were treated with lumbar spine instability (LSI) surgery to construct IVDD model mice. …”
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Downregulation of EB1 impedes Cx43 localization and cardiac conduction after hypothermic ischemia-reperfusion in rats by Chunlei Wen, Rongfeng Yang, Jing Yi, Ying Cao, Yuting Song, Li An, Zijun Wang, Hong Gao

“…This study aims to investigate the role and mechanisms of EB1 in hypothermic ischemia-reperfusion arrhythmia. Methods 4–6 week old male Sprague-Dawley (SD) rats were randomly assigned to four groups with a control group receiving no treatment. …”
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Association Between High Jugular Bulb and Sudden Sensorineural Hearing Loss: A Computed Tomography Based Study by Wanting Y, Rafiq M, Wu J, Jin L, Liu G, Cheng C

“…Yang Wanting,1,* Muhammad Rafiq,2,3,* Juan Wu,4 Long Jin,4 Gang Liu,5 Chunsong Cheng2,3 1Department of Otolaryngology, First Clinical Medical College of Anhui University of Traditional Chinese Medicine, Hefei, Anhui, 23003, People’s Republic of China; 2Jiangxi Key Laboratory for Sustainable Utilization of Chinese Materia Medica Resources, Lushan Botanical Garden, Chinese Academy of Sciences, Jiujiang, Jiangxi Province, 332900, People’s Republic of China; 3Lushan Xinglin Institute for Medicinal Plants, Jiujiang Xinglin Key Laboratory for Traditional Chinese Medicines, Jiujiang, Jiangxi Province, 332900, People’s Republic of China; 4Department of Otolaryngology, First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei, Anhui, 230031, People’s Republic of China; 5School of Clinical Medicine, Anqing Medical College, Anqing, Anhui, 246000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Gang Liu, Email 1015799606@qq.com Chunsong Cheng, Email chengcs@lsbg.cnObjective: To explore the correlation between high jugular bulb (HJB) and sudden sensorineural hearing loss (SSNHL) by collecting and analyzing data from patients diagnosed with sudden sensorineural hearing loss (SSNHL) accompanied by HJB.Methods: A total of 62 patients with acute deafness admitted to the Otolaryngology ward of the First Affiliated Hospital of Anhui University of Chinese Medicine from October 2023 to June 2024 were included. …”
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An innovative Hearing AED alarm system shortens delivery time of automated external defibrillator – A randomized controlled simulation study by Chih-Yu Chen, Jeffrey Che-Hung Tsai, Shao-Jen Weng, Yen-Ju Chen

“…The aim of this study is to determine if this novel Hearing AED alarm system shortens the AED delivery time. Methods: This was a randomized controlled simulation study. …”
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