The Attractive and Deterring Factors for Medical Students Towards Pathology as a Specialty in Saudi Arabia by Samkari A, Qari TA, Abukhairat Jnr SM, AlQarni G, Assiri R, Boraie SA, Alghamdi KT

“…Box 9515, Jeddah, 21423, Saudi Arabia, Tel +966 55-852-6104, Email sultanahboraie@gmail.comPurpose: This study aims to assess the level of interest in pathology among medical students in Saudi Arabia and identify factors influencing their decision to pursue pathology as a career.Patients and methods: This cross-sectional study was conducted across multiple universities in Saudi Arabia, including Umm Al Qura University, King Faisal University, King Saud bin Abdulaziz University for Health Sciences, Imam Abdulrahman bin Faisal University, Jazan University, and King Khalid University. …”
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Factors Associated with Management of Workplace Violence Competence Among Chinese Nursing Interns by Meng L, He L, Ouyang L, Fu M, Li P, He Y

“…Therefore, this study investigated the current status of management of workplace violence competence (MWVC) and identify associated factors affecting their MWVC among nursing interns.Participants and Methods: A total of 817 nursing interns from six tertiary hospitals in Hunan Province, China, participated in this study in July 2023. …”
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Qingwen Hufei Granules Attenuate Lipopolysaccharide-Induced Acute Lung Injury by Suppressing NLRP3 Inflammasome-Dependent Pyroptosis by Long K, Yang Y, Wang Y, Wang B, Zhou H, Liu Y, Li Y, Yang S, Cao L, Huang T, Liu Y, Zhang H

“…However, the active components and mechanism of action of QHG remain unclear.Methods: Lipopolysaccharide (LPS) induced ALI mouse model. …”
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Viral Mimetic Bacterial Outer Membrane Vesicles for Targeting Angiotensin-Converting Enzyme 2 by Ahn G, Yoon HW, Jeong JH, Kim YH, Shin WR, Song MS, Ahn JY

“…To apply refined OMVs for human theranostic applications, we developed naturally exposed receptor-binding domain (RBD) OMVs grafted with antigen 43 as a minimal modular system targeting angiotensin-converting enzyme 2 (ACE2).Methods: We constructed E. coli-derived OMVs using the antigen 43 autotransporter system to display RBD referred to as viral mimetic Ag43β 700_RBD OMVs. …”
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Budget Impact and Cost–Benefit Analyses of Sodium-Glucose Cotransporter-2 Inhibitors for Patients With Heart Failure in Thailand by Arunmanakul P, Phodha T, Pinta-ay S, Nimworapan M, Phrommintikul A, Thammatacharee N, Dilokthornsakul P

“…Poukwan Arunmanakul,1,2 Tuangrat Phodha,3,* Sakkarin Pinta-ay,1,4 Mantiwee Nimworapan,1,2 Arintaya Phrommintikul,5 Noppakun Thammatacharee,6 Piyameth Dilokthornsakul1,* 1Center for Medical and Health Technology Assessment (CM-HTA), Department of Pharmaceutical Care, Faculty of Pharmacy, Chiang Mai University, Chiang Mai, Thailand; 2Pharmaceutical Care Training Center (PCTC), Department of Pharmaceutical Care, Faculty of Pharmacy, Chiang Mai University, Chiang Mai, Thailand; 3Drug Information and Consumer Protection Center, Center of Excellence in Pharmacy Practice and Management Research, Faculty of Pharmacy, Thammasat University, Rangsit Campus, Pathum Thani, Thailand; 4Department of Pharmacy, Maharaj Nakorn Chiang Mai Hospital, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand; 5Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand; 6Health Systems Research Institute, Nonthaburi, Thailand*These authors contributed equally to this workCorrespondence: Tuangrat Phodha, Drug Information and Consumer Protection Center, Center of Excellence in Pharmacy Practice and Management Research, Faculty of Pharmacy, Thammasat University, Rangsit Campus, Pathum Thani, 99 Paholyothin Road, Khlong Nueng, Khlong Luang District, Pathum Thani, 12120, Thailand, Tel +66 2 986 9214, Email tuangrat25@tu.ac.th Piyameth Dilokthornsakul, Center for Medical and Health Technology Assessment (CM-HTA), Department of Pharmaceutical Care, Faculty of Pharmacy, Chiang Mai University, 239 Suthep, Mueang, Chiang Mai, 50200, Thailand, Tel +66 53 944 342, Email piyameth.dilok@cmu.ac.thPurpose: To assess the budget impact and cost–benefit of incorporating sodium-glucose cotransporter-2 inhibitors (SGLT-2i) into the benefit package for patients with heart failure (HF) under the universal health coverage (UHC) in Thailand.Patients and Methods: A budget impact analysis and cost–benefit model were developed using a five-year time horizon from the payer perspective. …”
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Association Between the Circadian Rhythm of Arterial Blood Pressure and White Matter Lesions in Hospitalized Hypertensive Patients: A Cross-Sectional Study by Shen Y, Xiang W, Chen S, Hou Z, Hong D

“…However, little is known about the relationship between WMLs and altered circadian rhythms of blood pressure (BP) in patients with essential hypertension.Methods: This cross-sectional observational study enrolled patients diagnosed with essential hypertension. …”
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Population Pharmacokinetic/Pharmacodynamic Study of Linezolid in Hospital-Acquired Pneumonia Patients with Renal Insufficiency by Xu J, Chen X, Zhang Q, Zhuang Z, Yuan Y, Duan L, Shi L, Zhu C, Li J, Lu J, Yu Y, Tang L

“…The objective of this study was to compare the outcomes of linezolid versus teicoplanin in HAP patients with renal insufficiency and to explore optimal dosage strategy for linezolid.Methods: The retrospective study enrolled adult patients treated with intravenous linezolid or teicoplanin at Suzhou Municipal Hospital between July 2018 and August 2023. …”
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The Association Between Medication Adherence, Internalized Stigma and Social Support Among Outpatients with Major Depressive Disorder in a Malaysian Hospital: A Cross-Sectional Stu... by Halim R, Kaur M, Syed Mokhtar SS, Chemi N, Sajatovic M, Tan YK, Siau CS, Ng CG

“…This study aimed to investigate poor adherence prevalence and the demographic and clinical factors associated with poor medication adherence among patients with MDD.Methods: This cross-sectional survey recruited participants using universal sampling from a major hospital in Selangor, Malaysia. …”
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Factors Influencing Mechanical Ventilation and Inpatient Palliative Care Utilization in Patients With Chronic Obstructive Pulmonary Disease by Kao LT, Yang CC, Wu YC, Ko SC, Liang YS, Liao KM, Ho CH

“…In this study, we aimed to investigate inpatient palliative care utilization among hospitalized patients with COPD requiring mechanical ventilation and examine the associated risk factors and clinical outcomes.Patients and Methods: A retrospective nested case-control study was conducted using population-based claims datasets from 2017 to 2021. …”
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Mechanism of Qingdai in Alleviating Acute Lung Injury by Inhibiting the JAK2/STAT3 Signaling Pathway by Qi L, Wang S, Guo T, Qi Z, Wu S, Gao D, Yan Z, Tan B, Yang A

“…This investigation demonstrated QD alleviated LPS-induced ALI in mice and exerted anti-inflammatory effects by inhibiting the JAK2/STAT3 signaling pathway.Methods: The active compounds of QD were identified through UPLC-LTQ-Orbitrap-MS/MS. …”
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Distinct Roles of HHLA2 and PD-L1 in the Immune Cell and Prognosis of Hepatocellular Carcinoma by Wang CH, Chen SL, Yang X, Wu T, Liu LL, Yun JP

“…This study aims to elucidate the expression patterns of HHLA2 and PD-L1 in HCC, their associations with tumor-infiltrating lymphocytes (TILs), and their impact on clinical outcomes.Methods: Immunohistochemistry (IHC) was employed to evaluate HHLA2 and PD-L1 expression in 547 HCC tissue samples. …”
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Assessment of Diagnostic Knowledge and the Management of Bell’s Palsy Among Primary HealthCare Physicians in Saudi Arabia by Al Jaber MY, Al Shammari A, Al Subaie FT, Alhowaish Z, Al Harbi MM, AlNaaim SA

“…Particular emphasis was placed on identifying critical knowledge gaps that may affect clinical decision-making, especially in corticosteroid dosing and standardized diagnostic approaches.Patients and Methods: A cross-sectional observational study was conducted in Al-Ahsa, Saudi Arabia. …”
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Sex-Biased CD3ζ 3ʹ-UTR SNP Increased Incidence Risk in Aplastic Anemia by Guo L, Zhang Y, Liu X, Xiao Y, Luo W, Fang S, Li Y, Lai J, Li Y, Li B

“…In this study, our aim was to analyze whether CD3ζ 3ʹ-UTR SNPs were associated with AA susceptibility and had influence on CD3ζ protein level and provide new research data for exploring the pathogenesis of aplastic anemia.Patients and Methods: We screened the genotypes of SNPs in 101 healthy individuals and 91 AA patients by PCR-RFLP and sequencing. …”
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Associations of Protein Classes With Cross-Reactivity and Cross-Sensitization in Furry Animal Allergens: A Component-Resolved Diagnostics Study by Lu J, Zhu H, Yang Q, Xu Y, Huang Z, Sun B

“…Jiancai Lu,1,* Huiqing Zhu,2,* Qingqing Yang,1 Yunjian Xu,1 Zhifeng Huang,1 Baoqing Sun1 1Department of Clinical Laboratory, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, 510120, People’s Republic of China; 2Department of Clinical Laboratory, Huizhou Central People`s Hospital, Huizhou, Guangdong, 516001, People’s Republic of China*These authors contributed equally to this workCorrespondence: Baoqing Sun; Zhifeng Huang, Department of Clinical Laboratory, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, 151 Yanjiang Road, Guangzhou, Guangdong, 510120, People’s Republic of China, Tel +86 020 81568020, Email sunbaoqing@vip.163.com; zfhuang_gzhmu@163.comObjective: This study aimed to investigate the molecular sensitization patterns of cats, dogs, and horses in patients with cat and/or dog sensitization and the IgE cross-reactivity with other furry animals.Methods: In 95 patients diagnosed with allergic diseases and sensitized to cats and/or dogs (confirmed by specific Immunoglobulin E (sIgE) ≥ 0.35 kUA/L to crude cat and/or dog dander extracts), sIgE levels of cat components (Fel d 1/2/4), dog components (Can f 1/2/3/5), horse dander (Equ c 1), as well as allergens from cow, guinea pig, mouse, rat, rabbit, and chicken, were measured. …”
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A Monocyte-Driven Prognostic Model for Multiple Myeloma: Multi-Omics and Machine Learning Insights by Xie L, Gao M, Tan S, Zhou Y, Liu J, Wang L, Li X

“…Nevertheless, the overall pattern of immune cells and MM pathogenesis within the bone marrow tumor microenvironment (BM-TME) remains underexplored.Methods and Results: Firstly, we performed Mendelian Randomization analysis for 731 immunocyte phenotypes and MM, identifying 21 immune traits significantly associated with increased MM risk (OR> 1, PFDR< 0.05). …”
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High Prevalence of Diabetic Retinopathy in an Outpatient Podiatry Clinic and Associated Barriers to Ophthalmic Care by Larimer-Picciani AM, Brown RB, Ruan H, Jones CE, DeBlasio RN, Burns PR, Williams AM, Waxman EL

“…This study assesses the prevalence of DR in a podiatric clinic while also investigating participant-reported barriers to routine ophthalmic follow-up.Methods: We conducted a cross-sectional study that included patients age ≥ 18 (n=62) receiving diabetic foot care at an outpatient podiatric clinic in 2021 and 2022. …”
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The Frequency of CYP2C19*2 Gene Polymorphisms in Burkina Faso Patients Treated with Clopidogrel by Kagambèga YD, Ouattara AK, Ouédraogo TWC, Traoré L, Yaméogo NV, Simpore J

“…This study aimed to assess the frequency of the CYP2C19*2 (rs4244285, 681 G>A1) polymorphism among patients with cardiovascular diseases undergoing clopidogrel therapy.Patients and Methods: This cross-sectional study recruited a total of seventy-three (73) patients from the Cardiology Department of the Centre Hospitalier Universitaire Yalgado Ouédraogo (CHU-YO) between January and June 2023. …”
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Association between infant feeding practices, COVID-19 related cognitive factors, and postpartum depression during the COVID-19 pandemic: a cross-sectional online study in Thailand by Wichukorn Suriyawongpaisal, Punpawee Kittikul, Eun Young Lee, Li-Yin Chien, Yan-Shing Chang, Kelly Pereira Coca, Doungjai Buntup, Seo Ah Hong

“…., COVID-19-vaccination-related belief and COVID-19-related knowledge and attitude) with infant feeding practices and their associations with PPD during the COVID-19 pandemic in Thai postpartum mothers. Methods A cross-sectional online survey was conducted among 840 postpartum mothers whose infants were less than or equal to 6 months old. …”
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Evaluation of a content-based image retrieval system for radiologists in high-resolution CT of interstitial lung diseases by Benjamin Böttcher, Marly van Assen, Roberto Fari, Philipp L. von Knebel Doeberitz, Eun Young Kim, Eugene A. Berkowitz, Felix G. Meinel, Carlo N. De Cecco

“…Abstract Background This retrospective study aims to evaluate the impact of a content-based image retrieval (CBIR) application on diagnostic accuracy and confidence in interstitial lung disease (ILD) assessment using high-resolution computed tomography CT (HRCT). Methods Twenty-eight patients with verified pattern-based ILD diagnoses were split into two equal datasets (1 and 2). …”
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Association of Serum Ferritin Levels With Obstructive Sleep Apnea in Overweight/Obese US Populations: A Population-Based Study From the NHANES by Zhang Y, Zhou P, Xu C, Su H, Li R, Sun L, Yang Y

“…Yang Zhang,1,* Pinglang Zhou,2,* Chuan Xu,3,* Hua Su,1 Rendong Li,1 Longhua Sun,2 Yihan Yang1 1Jiangxi Provincial Key Laboratory of Respiratory Diseases, Jiangxi Institute of Respiratory Diseases, The Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, People’s Republic of China; 2The Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, People’s Republic of China; 3Department of Thoracic Surgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yihan Yang, Jiangxi Provincial Key Laboratory of Respiratory Diseases, Jiangxi Institute of Respiratory Diseases, The Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, People’s Republic of China, Email yangyihan@email.ncu.edu.cn Longhua Sun, The Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, People’s Republic of China, Email ndyfy05715@ncu.edu.cnObjective: To investigate the relationship between serum ferritin levels and OSA in overweight/obese individuals and assess the association between ferritin levels and all-cause mortality in overweight/obese female OSA patients.Methods: Cross-sectional (n = 4,809) and prospective (n = 832) data from overweight/obese adults from the 2005– 2008, and 2015-March 2020 NHANES cycles were analyzed. …”
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