Sheng-Jiang Powder Alleviates Th17/Treg Immune Imbalance of Experimental Autoimmune Encephalomyelitis by Regulating the Fatty Acids Metabolism by Wu L, Xu H, Xia H, Peng L, Qin L, Gong Q, Zhao M, Wu Z, Zhao Y, Zheng Z

“…Sheng-Jiang powder (SJP), a traditional Chinese medicine formula, has demonstrated anti-inflammatory effects and may offer a novel therapeutic option for MS.Aim: This study aimed to investigate the therapeutic efficacy and underlying mechanism of SJP in myelin oligodendrocyte glycoprotein 35– 55 (MOG35-55)-induced experimental autoimmune encephalomyelitis (EAE) mice.Methods: The efficacy of SJP was assessed using the MOG35-55-induced EAE model. …”
Get full text

Predictive Value of Plasma D-Dimer for Cerebral Herniation Post-Thrombectomy in Acute Ischemic Stroke Patients by Zhang W, Xing W, Feng J, Wen Y, Zhong X, Ling L, He J

“…This study aims to explore the predictive value of emergency preoperative plasma D-dimer levels in cerebral herniation after successful thrombectomy.Methods: Between January 2019 and December 2023, patients with AIS who received a successful thrombectomy in our single comprehensive stroke center were retrospectively enrolled. …”
Get full text

From East to West: Regional Disparities in Depressive and Anxious Symptoms Among Chinese Adolescents by Yang R, Yang XJ, Wan JL, Wang LL, Deng H, Chen JX, Zhou SJ

“…Rui Yang,1,* Xing-Jie Yang,2,* Jin-Ling Wan,3 Lei-Lei Wang,2 Hu Deng,2 Jing-Xu Chen,2 Shuang-Jiang Zhou2 1Beijing Anding Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Beijing HuiLongGuan Hospital, Peking University HuiLongGuan Clinical Medical School, Beijing, People’s Republic of China; 3Zhangjiakou Shalingzi Hospital, Zhangjiakou Mental Health Center, Zhangjiakou, Hebei, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jing-Xu Chen, Beijing HuiLongGuan Hospital, Peking University HuiLongGuan Clinical Medical School, Beijing, 100096, People’s Republic of China, Tel +86-10-83024442, Email chenjx1110@163.com Shuang-Jiang Zhou, Beijing HuiLongGuan Hospital, Peking University HuiLongGuan Clinical Medical School, Beijing, 100096, People’s Republic of China, Tel +86-10-83024135, Email zhoushuangjiang@126.comBackground: To explore the prevalence and determinants of depressive and anxious symptoms among adolescents in China, focusing on regional disparities, cognitive function, psychological resilience, and family functioning.Methods: A total of 39854 adolescents, aged 12– 18 years, participated in this survey. …”
Get full text

Correlation Of Fut2 And Fut3 Gene Polymorphisms With Inflammatory Bowel Disease In Guangxi Zhuang Population by Lv X, Huang Z, Li S, Xu X, Chen D, Han L, He Y, Huang S, Wu H, Qi Y, Wei L, Chen M, Zhan L, Lv X

“…Xiaodan Lv,1,* Zhou Huang,2,* Shiquan Li,3 Xiaofang Xu,3 Deyi Chen,3 Lichun Han,3 Yu He,1 Shan Huang,1 Huiling Wu,1 Yunwei Qi,1 Liqiang Wei,1 Min Chen,1 Lingling Zhan,1 Xiaoping Lv3 1Department of Clinical Laboratory, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, People’s Republic of China; 2Department of Emergency Medicine, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, People’s Republic of China; 3Departments of Gastroenterology, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaoping Lv, Departments of Gastroenterology, the First Affiliated Hospital of Guangxi Medical University, No. 6 of Shuangyong Street, Qingxiu District, Nanning, Guangxi Zhuang Autonomous Region, 530021, People’s Republic of China, Email lxxp58@hotmail.comObjective: This study aimed to investigate the association between the polymorphisms of the FUT2 gene (rs1047781, rs601338) and the FUT3 gene (rs3745635, rs28362459) with susceptibility to inflammatory bowel disease (IBD) in the Zhuang population of Guangxi.Methods: Intestinal mucosal tissues were collected from 113 Zhuang patients (41 with Crohn’s disease [CD] and 72 with ulcerative colitis [UC]) and 120 han patients (42 with CD and 78 with UC), all of whom were unrelated and diagnosed with IBD, as well as from 106 Zhuang and 119 han unrelated healthy controls, from January 2021 to December 2023. …”
Get full text

sJAM-C as a Potential Biomarker for Coronary Artery Stenosis: Insights from a Clinical Study in Coronary Heart Disease Patients by Wang D, Mao L, Li K, Wang L, Wang Y, Yang L

“…This study aimed to analyze the effect of sJAM-C on coronary artery stenosis and to verify whether sJAM-C could be a biomarker for coronary artery stenosis.Patients and Methods: The participants registered at the Beijing Luhe Hospital, Capital Medical University in the cross-sectional study. …”
Get full text

Pharmacokinetic Changes and Influencing Factors of Polymyxin B in Different ECMO Modes by Xu M, Chen N, Yu YW, Pan XY, Li T

“…This study aimed to clarify the changes in PK parameters and identify factors influencing PMB levels in patients receiving venovenous or venoarterial ECMO.Patients and Methods: A prospective PK study was performed in 11 patients receiving ECMO with resistant bacteria. …”
Get full text

Association Between Dietary Patterns and All-Cause Mortality in Individuals with Hypertension and Osteoporosis: A Retrospective Cohort Study by Guan J, Ding L, Wang Y, Zhu Z, Pan M, Du L, Yin N

“…Jianhua Guan,* Liang Ding,* Yifei Wang,* Zhongsheng Zhu,* Mingmang Pan, Li Du, Nuo Yin Department of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital South Campus (Shanghai Fengxian District Central Hospital), Shanghai, 201599, People’s Republic of China*These authors contributed equally to this workCorrespondence: Nuo Yin, Department of Orthopedics, South Hospital of the Sixth People’s Hospital Affiliated to Shanghai University of Medicine & Health Sciences (Shanghai Fengxian District Central Hospital), No. 6600 South Fenggong Road Fengxian District, Shanghai, 201599, People’s Republic of China, Tel +86 18916174997, Email nuoyindoc_SUMHS@outlook.comObjective: To explore the association of dietary patterns with all-cause mortality in individuals with hypertension and osteoporosis.Methods: Data on individuals aged ≥ 20 years who completed bone mineral density tests were retrieved from the National Health and Nutrition Examination Survey database. …”
Get full text

Cancer Recurrence Fear and Return to Work in Breast Cancer Survivors:The Mediating Effects of Health Literacy by Zhu X, Lei J, Chen R, Chen Z, Xiong Z, Yang L, Jiang M, Zhang H

“…By employing structural equation modeling, we examine the mediating effect of health literacy on the interplay between cancer recurrence fear and the ability to return to work.Patients and Methods: We conducted a survey involving 190 breast cancer survivors, utilizing a general information questionnaire, the Concern About Recurrence Scale, and the Health Literacy Management Scale.Results: Our findings indicate that only 54.2% of the participants successfully returned to work. …”
Get full text

Heat-Stable Carbetocin in the Management of Postpartum Haemorrhage in Low- and Middle-Income Countries: A Comprehensive Review of Clinical Evidence, Cost-Effectiveness, Implementat... by Adnani QES, Adepoju VA, Jamil S

“…Low- and middle-income countries disproportionately bear this burden, often due to compromised cold chains for oxytocin and insufficient staff training.Methods: This review synthesized thirty publications on heat stable carbetocin (HSC) published from January 2018–March 2025. …”
Get full text

Association Between Triglyceride to High-Density Lipoprotein Cholesterol Ratio and Insulin Resistance in Mongolian Adults by Narkhajid G, Oyuntugs B, Yagaantsetseg A, Bolormaa E, Anuurad E, Enkhmaa B, Berglund L, Bayasgalan T

“…This study aimed to investigate its association with HOMA-IR adjusting for waist circumference among Mongolian adults.Materials and Methods: This cross-sectional study, conducted at the Mongolian National University of Medical Sciences Hospital, included 365 participants over 35 who participated in health check-up examinations (mean age 46.8 ± 8.8 years, 37.0% male). …”
Get full text

Risk of All-Cause Mortality in US Adults With Preserved Ratio Impaired Spirometry: An Observational Study by Xiao S, Ou J, Qiu W, Ye C, Li N, Chen S, Lai Y, Deng Z, Wu F, Shen Y

“…We explored the all-cause mortality risk of individuals with PRISm in a large sample of the general population.Methods: We used data from the National Health and Nutrition Examination Survey III and 2007– 2012. …”
Get full text

Measuring the effects of community polygyny on intimate partner violence: a multilevel modeling using nationally representative cross-sectional data by Zacharie Tsala Dimbuene, Bright Opoku Ahinkorah, Dickson Abanimi Amugsi

“…Furthermore, the paper tested interactions between the community polygyny and (i) polygyny at women’s level; (ii) women’s education; and (iii) urban residence. Methods The paper used recent Demographic and Health Surveys of four countries in Central Africa (Democratic Republic of the Congo, Cameroon, Gabon, and Chad). …”
Get full text

Diagnostic Value of ADC in Distinguishing Endometrial Cancer from Atypical Endometrial Hyperplasia and Within Molecular Subtypes by Xu S, Abdifatah Mohamed R, Xu J, Yao Y, Gu Y, Tang W, Jia X

“…Shengjie Xu,1,* Ridwan Abdifatah Mohamed,1,* Juan Xu,1,2 Yao Yao,3 Yun Gu,4 Wenwei Tang,3 Xuemei Jia1,2 1Department of Gynecology, Women’s Hospital of Nanjing Medical University, Nanjing Women and Children’s Healthcare Hospital, Nanjing, 210004, People’s Republic of China; 2Nanjing Medical Key Laboratory of Female Fertility Preservation and Restoration, Nanjing, 210004, People’s Republic of China; 3Department of Radiology, Women’s Hospital of Nanjing Medical University, Nanjing Women and Children’s Healthcare Hospital, Nanjing, 210004, People’s Republic of China; 4Department of Pathology, Women’s Hospital of Nanjing Medical University, Nanjing Women and Children’s Healthcare Hospital, Nanjing, 210004, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wenwei Tang, Department of Radiology, Women’s Hospital of Nanjing Medical University, Nanjing Women and Children’s Healthcare Hospital, Nanjing, 210004, People’s Republic of China, Email tww3077@163.com Xuemei Jia, Department of Gynecology, Women’s Hospital of Nanjing Medical University, Nanjing Women and Children’s Healthcare Hospital, No. 123 Mochou Road, Nanjing, 210004, People’s Republic of China, Email xmjia@njmu.edu.cnPurpose: The study aimed to evaluate the effectiveness of using specific indicators, particularly the apparent diffusion coefficient (ADC), alone or in combination to differentiate endometrial cancer (EC) from atypical endometrial hyperplasia (AEH) and to explore non-invasive biomarkers for the molecular classification of EC.Methods: A retrospective analysis was conducted on 300 EC and 126 AEH cases who had undergone preoperative magnetic resonance imaging, complete blood count, coagulation profile testing, and tumor biomarkers assessment. …”
Get full text

Stented Biological Prosthesis Versus Mitral Allograft in Surgical Treatment of Tricuspid Valve Infective Endocarditis by Mikhail Nuzhdin, Yury Malinovsky, Maksim Galchenko, Roman Komarov, Aleksey Fokin, Nikita Nadtochiy

“…This study aimed to compare outcomes between stented biological valves and mitral allografts (MAs) for tricuspid valve replacement (TVR). Methods: A total of 54 patients with IE underwent TVR using either a stented bioprosthesis (B) or MA between January 2016 and July 2024. …”
Get full text

The short-term effects of different cold spell definitions on asthma outpatient visits in Lanzhou, China by Jianjun Wu, Xizhuoma Zha, Xuelin Ren, Boxi Feng, Ying Zhang, Linghong Wang, Xingmin Wei, Yahui Xie, Jia Zhang, Jie Lu

“…This study aimed to identify the optimal definition of cold spells in Lanzhou, China, and examine their association with outpatient asthma visits, identifying potentially vulnerable populations. Methods This study collected daily asthma outpatient records, along with meteorological and air pollutant data, from January 1, 2017, to December 31, 2020, in Lanzhou, Gansu Province. …”
Get full text

Tumor Necrotic Factor-Alpha (−308A/G, rs1800629) and Interleukin-13 (R130Q, rs20541) Gene Polymorphisms as Predictors of Severe Asthma in Pilot Cohort of Kuwaiti Populati... by Al-Ahmad M, Ali A, Maher A, Haider MZ

“…Box 24923, Safat, 13110, Kuwait, Tel +965-24636515, Fax +965-25332719, Email mona.alahmad@ku.edu.kwBackground: Genetic factors, along with sociodemographic characteristics, are believed to play a significant role in asthma pathogenesis.Objective: This study investigated the role of Interleukin-13 (IL-13) and Tumor Necrosis Factor-alpha (TNF-α) gene polymorphisms, in conjunction with clinical characteristics, in predicting asthma severity.Methods: A total of 214 asthma patients (98 mild, 116 severe) and 121 healthy individuals were genotyped using PCR-RFLP for IL-13 (R130Q, rs20541) and TNF-α (− 308A/G, rs1800629) polymorphisms. …”
Get full text

Semaglutide Alleviates Ovarian Oxidative Stress and Autophagy via the PI3K/AKT/mTOR Pathway in Mice with Polycystic Ovary Syndrome by Guo S, Li X, Liu M, Feng M, Wang X, Xue H, Zhang L

“…Here, we aim to assess the effects of semaglutide (a weekly preparation of GLP-1RAs) on PCOS in vivo.Methods: C57BL/6J female mice aged 3 weeks were subcutaneously injected with dehydroepiandrosterone and fed high-fat diet for 3 weeks to establish PCOS model. …”
Get full text

Comprehensive Pan-Cancer Analysis Identifies IGFL1 as an Oncogenic Biomarker and Immunotherapeutic Target with Experimental Validation in Bladder Cancer by Liang Z, An Y, He J, Zhu Z, Jiang K, Chen K, Sun F

“…This study aimed to investigate IGFL1 expression and its prognostic and immunological significance across cancers, with experimental validation in bladder cancer (BLCA).Methods: Data from TCGA, GTEx, and TIMER2.0 were analyzed to assess IGFL1 expression across cancers and its associations with prognosis, immune subtypes, immune infiltration, and tumor-related genomic features. …”
Get full text

Construction and Validation of a Hospital Mortality Risk Model for Advanced Elderly Patients with Heart Failure Based on Machine Learning by Shang S, Wei M, Lv H, Liang X, Lu Y, Tang B

“…Shuai Shang,1,2,* Meng Wei,1,2,* Huasheng Lv,1,2,* Xiaoyan Liang,1,2 Yanmei Lu,1,2 Baopeng Tang1,2 1Department of Cardiac Pacing and Electrophysiology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, People’s Republic of China; 2Xinjiang Key Laboratory of Cardiac Electrophysiology and Remodeling, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, People’s Republic of China*These authors contributed equally to this workCorrespondence: Baopeng Tang, Department of Cardiac Pacing and Electrophysiology, Xinjiang Key Laboratory of Cardiac Electrophysiology and Remodeling, The First Affiliated Hospital of Xinjiang Medical University, No. 137, South Liyushan Road, Xinshi Zone, Urumqi, People’s Republic of China, Email tangbaopeng1111@163.com Yanmei Lu, Department of Cardiac Pacing and Electrophysiology, Xinjiang Key Laboratory of Cardiac Electrophysiology and Remodeling, The First Affiliated Hospital of Xinjiang Medical University, No. 137, South Liyushan Road, Xinshi Zone, Urumqi, People’s Republic of China, Email gracy@189.cnPurpose: This study aimed to develop and validate a model based on machine learning algorithms to predict the risk of in-hospital death among advanced elderly patients with Heart Failure (HF).Methods: A total of 4580 advanced elderly patients who were admitted to the hospital and diagnosed with HF from May 2012 to September 2023 were included in this study, among whom 552 cases (12.5%) died. …”
Get full text

Mapping Connection and Direction Among Symptoms of Sleep Disturbance and Perceived Stress in Firefighters: Embracing the Network Analysis Perspective by Liu B, Zou M, Liu L, Wu Z, Jin Y, Feng Y, Jia Q, Li M, Ren L, Yang Q

“…Hence, this study aimed to elucidate the relationship between sleep disturbances and perceived stress in firefighters through network analysis approaches.Methods: A total of 786 Chinese firefighters were included in this study. …”
Get full text