Gender-based differences in career paths, parenthood and perspectives on professional barriers among Asian ophthalmologists by Claire L Peterson, Brian S.Y. Yeo, Shelley Yin-Hsi Chang, Rachel S Chong, Marcus Ang, Anna CS Tan, Tina Wong, Andrew S.H. Tsai

“…Background: Gender equality in Asia remains under-researched, especially within medical fields. …”
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Monitoring of liver and kidney profiles in anesthesiologists working in a regional reference teaching hospital in Northern Italy: analysis of health surveillance data using a linea... by Alborz Rahmani, Guglielmo Dini, Alfredo Montecucco, Luca Priano, Marco Leonetti, Alessia Manca, Bruno Kusznir Vitturi, Paolo Durando

“…Moreover, we assessed the appropriateness of applying linear mixed models to occupational health data. Material and Methods A retrospective cohort study was conducted using health surveillance data from a cohort of anesthesiologists and a cohort of unexposed physicians working at the Polyclinic Hospital San Martino of Genoa, Italy, during 2016–2022. …”
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An Integrated Nomogram Combining Deep Learning and Radiomics for Predicting Malignancy of Pulmonary Nodules Using CT‐Derived Nodules and Adipose Tissue: A Multicenter Study by Shidi Miao, Qifan Xuan, Hanbing Xie, Yuyang Jiang, Mengzhuo Sun, Wenjuan Huang, Jing Li, Hongzhuo Qi, Ao Li, Qiujun Wang, Zengyao Liu, Ruitao Wang

“…This study aimed to construct a deep learning radiomics clinical nomogram (DLRCN) for predicting malignancy of pulmonary nodules. Methods One thousand and ninety‐eight patients with 6–30 mm pulmonary nodules who received histopathologic diagnosis at 3 centers were included and divided into a primary cohort (PC), an internal test cohort (I‐T), and two external test cohorts (E‐T1, E‐T2). …”
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Mortality risk associated with clinical signs of possible serious bacterial infection (PSBI) in young infants in Africa and Asia: protocol for a secondary pooled analysis by Adejumoke Idowu Ayede, Samir K Saha, Saifuddin Ahmed, Mohammad Shahidul Islam, Gary L Darmstadt, Fabian Esamai, Antoinette Tshefu Kitoto, Ebunoluwa A Adejuyigbe, Yasir Bin Nisar, Shamim Ahmad Qazi, Vaishnavi Bhamidi, Khusbu Adhikari, Ivana Marić, Robinson D Wammanda

“…There is a need to further examine the association of signs of PSBI individually and in combination with risk of mortality and to analyse global data to inform global recommendations.Methods and analysis We will create a dataset that integrates data from population-based studies globally with similar designs that have examined the presence of signs of PSBI identified by frontline health workers throughout the young infant period (days 0 to <60) and that have also recorded infant vital status. …”
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A Phase 1/1B Trial of Pembrolizumab and Trametinib in Advanced NSCLC Enriched for KRAS Mutations by Jonathan W. Riess, MD, MS, Matthew S. Lara, BS, Guillaume Luxardi, PhD, Miguel Lopez de Rodas, MD, Michiko Shimoda, PhD, Karen Kelly, MD, Primo N. Lara, MD, Laurel Beckett, PhD, Arta Monjazeb, MD, PhD, Kurt A. Schalper, MD, PhD, Emanual Maverakis, MD, David R. Gandara, MD

“…This phase 1 study evaluated sequencing schemes of MEKi and ICI with trametinib and pembrolizumab in NSCLC. Methods: In this 3+3 dose escalation study, patients with advanced NSCLC were treated with lead-in trametinib (arm A) or lead-in pembrolizumab (arm B) for cycle 1, followed by a 1.5 to 2 mg oral daily dose of trametinib (d 1–10) with pembrolizumab 200 mg intravenously every 21 days. …”
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Determining the optimum high-flow nasal cannula flow rate to achieve the desired fraction of inspired oxygen: A bench study by Chao-Lan Huang, Chun-Ching Lu, Cheng Chiang, Heng-Sheng Chao, Ting-Yun Chiang, Wei-Nung Teng, Wen-Kuei Chang, Chien-Kun Ting

“…We aimed to determine the actual FiO2 under different respiratory conditions and develop a regression model using a spontaneous breathing lung model. Methods: A spontaneous breathing simulation model was built using an airway manikin and a model lung. …”
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Efficacy and safety of electroacupuncture and electroacupuncture combined with warm needling for subjective tinnitus: A multicenter, three-arm randomized controlled trial by Lai Fun Ho, Yuanqi Guo, Liyi Chen, Herbert Fung, Wai Yan Mak, Siu Chuen Cheung, Ping Him Tsang, Min Chen, Kam Leung Chan, Hongwei Zhang, Wai Tsz Chang, Bacon Fung-Leung Ng, Zhi Xiu Lin

“…Objective: To evaluate the clinical efficacy and safety of electroacupuncture (EA) and electroacupuncture combined with warm needling (EAWN) on reducing tinnitus loudness and tinnitus-related distress among older adults. Methods: This multicenter, assessor-blinded, parallel-group, randomized clinical trial was conducted from December 2022 to April 2024 at three out-patient clinics in Hong Kong. …”
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Large-scale analysis highlights obesity as a risk factor for chronic, non-communicable inflammatory diseases by Sadegh Mousavi, Katja Bieber, Henner Zirpel, Artem Vorobyev, Henning Olbrich, Cristian Papara, Cristian Papara, David A. De Luca, David A. De Luca, Diamant Thaci, Enno Schmidt, Gabriele Riemekasten, Peter Lamprecht, Matthias Laudes, Khalaf Kridin, Khalaf Kridin, Khalaf Kridin, Ralf J. Ludwig, Ralf J. Ludwig

“…Yet, several knowledge gaps remain: For several CIDs, inconsistent results have been reported, relating to their obesity-imposed risk, data on most rare CIDs remain unavailable, sex differences and racial disparities remain mostly unaddressed.MethodsA large-scale cohort study compared the risk of developing 46 CIDs in individuals with overweight/obesity (n=3,101,824) to an equal number of non-overweight/obese individuals. …”
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A matched pilot cohort study of intravenous omadacycline in the treatment of severe pneumonia associated with carbapenem-resistant Acinetobacter baumannii by Dayu Chen, Yechao Chen, Yechao Chen, Na Hu, Qiaoling Gu, Qiaoling Gu, Jingjing Kan, Jingjing Kan, Jinchun Liu, Haixia Zhang

“…We conducted this study to explore the efficacy of omadacycline in CRAB-caused severe pneumonia.MethodsThis retrospective cohort study was performed by collecting data on severe CRAB-caused pneumonia cases treated with omadacycline or tigecycline at Nanjing Drum Tower Hospital from January 2022 to June 2024. …”
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Cognitive Impairment in CMV Seropositive and CMV Seronegative Deceased Donor Kidney Transplant Recipients by Maheen Z. Abidi, MD, Xiaomeng Chen, MSPH, Yi Liu, ScM, Nadia M. Chu, PhD, Aarti Mathur, MD, PhD, Adriana Weinberg, MD, Bruce Kaplan, MD, Silas Norman, MD, Jingyao Hong, MHS, Dorry L. Segev, MD, PhD, Kristine M. Erlandson, MD, Mara A. McAdams-DeMarco, PhD

“…We tested whether CMV was associated with post-KT cognitive impairment. Methods. In a 2-center prospective cohort study of 574 KTRs (mean age: 54.7 y), we obtained CMV donor/recipient (D/R) serostatus and measured pre- and post-KT cognitive function using the Modified Mini-Mental State Examination. …”
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Screening and mechanistic study of natural compounds that enhance T cell anti-tumor effects post-heat treatment by Zhaoyi Wang, Zhongqi Diao, Yiyan Zhang, Jiangying Liu, Yeshan Li, Zijin Sun, Huimin Zhen, Haojia Wang, Siyun Yang, Tieshan Wang, Lei Ni

“…Optimizing the cytotoxic effects of immune cells under in vitro culture conditions represents a current hot research topic in this domain.MethodsIn the current experiment, we conducted in vitro heat treatment on Jurkat-derived T cells at 39°C. …”
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Immunomodulatory Effects of <i>Cucurbita pepo</i> L. Extract in Chronic Stress-Induced Dysregulation of Lymphoid Organs in Rats by Safa H. Qahl, Hailah M. Almohaimeed, Sami A. Algaidi, Ashwaq H. Batawi, Zuhair M. Mohammedsaleh, Tarek Hamdy Abd-Elhamid, Nawal H. Almohammadi, Nasra N. Ayuob, Amany Refaat Mahmoud

“…(<i>CP</i>) on chronic unpredictable mild stress (CUMS)-induced changes in lymphoid organs through evaluating its effect on the histological structure of spleen, thymus gland, and lymph nodes compared to the antidepressant fluoxetine (FLU). <b>Materials and Methods</b>: Fifty male albino rats equally distributed into five groups that included control, control + <i>CP</i>, CUMS-exposed, FLU-treated, and <i>CP</i>-treated groups were used in this study. …”
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Comparative Efficacy and Safety of Cryoballoon vs Laser Balloon Ablation for Pulmonary Vein Isolation in Patients With Paroxysmal Atrial Fibrillation by Mahmoud Ali, Dorota Magdon, Abdulghani Mounir, Lynn Erickson, James Adefisoye, Jim Kanani, Andy Kieu, Abdullah Malik, Ali Ali, Nour Ghosoun, Jodi Zilinski, Arshad Jahangir, M. Eyman Mortada, Imran Niazi, Atul Bhatia

“…We used real-world patient data to investigate differences in arrhythmia-free survival, procedure and fluoroscopy times, and complications between these techniques. Methods: In this single-center, retrospective study of 178 patients with symptomatic paroxysmal AF referred for first-time pulmonary vein isolation (PVI), 103 underwent CBA, and 75 underwent LBA. …”
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Surgical long-term outcomes of Hirschsprung Disease in the Democratic Republic of Congo: a case series of 31 patients in a resource-limited setting by Fabrice Gulimwentuga Cikomola, Arsene Daniel Nyalundja, Alliance Wani Bisimwa, Bijoux Safi Matabaro, Franck Masumbuko Mukamba, Costa Musilimu Sudi, Paul Budema Munguakonkwa, Leon-Emmanuel Mukengeshayi Mubenga, Kinja Nyamugabo, Désiré Munyali Alumeti, Théophile Kabesha, Marc Miserez, Dieudonné Mushengezi Sengeyi

“…We aimed at assessing the long-term follow-up outcomes following an innovate resection approach in South Kivu, eastern DRC. Methods In this case series, the authors elucidate the admissions for HD spanning from 2016 to 2021 at a Pediatric Surgical Center in the DRC. …”
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Examining patient safety protocols amidst the rise of digital health and telemedicine: nurses’ perspectives by Ateya Megahed Ibrahim, Ibrahim Naif Alenezi, Asmaa Kamal Hassan Mahfouz, Ishraga A. Mohamed, Marwa A. Shahin, Elsayeda Hamdy Nasr Abdelhalim, Laila Zeidan Ghazy Mohammed, Takwa Rashwan Mohamed Abd-Elhady, Rehab Saad Salama, Aziza Mohamed Kamel, Rania Abdel Khalik Gouda, Noura Elgharib Mohamed Moustafa Eldiasty

“…Aim This study examines the factors influencing the successful adoption of digital health and telemedicine technologies from the nurses’ perspective, focusing on ensuring patient safety and enhancing organizational readiness for digital health integration. Methods A cross-sectional study included 246 nurses from outpatient healthcare centers in Egypt. …”
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S index: a predictor comparable to ultrasound shear wave elastography in assessing liver fibrosis in patients with chronic hepatitis B by Sujuan Guo, Lu Gan, Feng Du, Qiang Feng, Jiahua Li, Qinyun Wan, Qiannan Meng, Yaoren Zhang, Yonghao Ji, Jianxue Liu

“…Objective To evaluate diagnostic performance of ultrasound shear wave elastography (USWE), S index, Z index, Fibrometer in continuous differentiation of liver fibrosis in a retrospective chronic hepatitis B patients’ cohort. Materials and methods We collected liver stiffness values measured by USWE and laboratory indicators from 146 patients with chronic hepatitis B at Baoji Central Hospital. …”
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Effect of Hypertensive Disorders of Pregnancy (HDP) on maternal and perinatal birth outcomes in Eastern Ethiopia: a prospective cohort study by Ebisa Zerihun, Firaol Girma, Nimona Amena, Wubet Tazeb Wondie, Belete Feyera Olkaba, Lemma Mideksa Egu, Solomon Seyife Alemu, Gemechu Gelan Bekele, Belay Tafa Regassa, Meseret Robi Tura, Fekadu Abera Kebede

“…Objectives The aim of this study was to examine the effect of hypertensive disorders of pregnancy on maternal and perinatal birth outcomes in Eastern Ethiopia. Methods We employed a prospective cohort study design involving 374 pregnant women, equally divided into hypertensive ((n = 187) and normotensive (n = 187). …”
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Longer Drug Retention of Interleukin-12/23 or Interleukin-17 Inhibitors Compared With TNF Inhibitors in Female Patients With TNF Inhibitor-Experienced Psoriatic Arthritis by Godehard A. Scholz, MD, PhD, Eleftherios Papagiannoulis, MSc, Christoph Blapp, MSc, Raphael Micheroli, MD, Adrian Ciurea, MD, Michael J. Nissen, MD, Nikhil Yawalkar, MD, Diana Dan, MD, Jennifer Amsler, MD, Almut Scherer, PhD, Burkhard Möller, MD

“…Objective: To compare the effectiveness of Interleukin (IL)-12/23 or IL-17A inhibitors (summarized to inhibitors of the Th17 cell generation or function, Th17i) with tumor necrosis factor inhibitors (TNFi) in patients with TNFi-experienced psoriatic arthritis (PsA). Patients and Methods: We conducted a comparative effectiveness study by taking advantage of prospectively collected patients with PsA data from the Swiss Clinical Quality Management in Rheumatic Diseases register, encompassing the interval from January 1, 2015 to August 1, 2021. …”
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Distinct sex differences in ethanol consumption and operant self-administration in C57BL/6J mice with uniform regulation by glutamate AMPAR activity by Sara Faccidomo, Sara Faccidomo, Vallari R. Eastman, Taruni S. Santanam, Katarina S. Swaim, Seth M. Taylor, Clyde W. Hodge, Clyde W. Hodge

“…This study aims to elucidate SABV in ethanol (EtOH) consumption by evaluating its reinforcing effects and regulation by glutamate AMPA receptor activity in male and female mice.MethodsC57BL/6J mice (male and female) were assessed for EtOH intake under continuous and limited access conditions in the home cage. …”
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Predicting infection with COVID-19 disease using logistic regression model in Karak City, Jordan [version 3; peer review: 2 approved] by Lina AlTamimi, Liana Dalaeen, Anas Khaleel, Wael Abu Dayyih, Abdallah Ahmed Elbakkoush, Mohammad Niazi, Baker Albadareen, Zainab Zakaraya, Alhareth Ahmad

“…This study aimed to test the predictors that probably contributed to the infection with COVID-19 using a binary logistic regression model. Methods Based on data collected by Google sheet of COVID-19 infected and non-infected persons in Karak city, analysis was applied to predict COVID-19 infection probability using a binary logistic regression model. …”
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