Effect and mechanism of Juluo decoction combined with Ruhe powder in treatment of rat model of hyperplasia of mammary glands by NIE Weihong, LIU Hongxi, SUN Guoxin, LIU Chengcong, ZOU Xiao

“…Objective To investigate the effect and mechanism of Juluo Decoction combined with Ruhe Powder in the treatment of rat model of hyperplasia of mammary glands. Methods A total of 40 specific pathogen-free female Sprague-Dawley rats, aged 7-8 weeks, were randomly divided into control group (group A), hyperplasia of mammary glands group (group B), Rupixiao treatment group (group C), and Juluo Decoction+Ruhe Powder treatment group (group D), with 10 rats in each group. …”
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First Results of a Randomized Controlled Trial of Hemoblock in Patients with Large Incisional Hernias by E. N. Degovtsov, P. V. Kolyadko, V. P. Kolyadko, A. V. Satinov

“…Improving the results of surgical treatment of patients with large incisional hernias.MATERIAL AND METHODS. Design of a simple blind randomized controlled trial with a 90 percent study power, α-error equal to 0.05 and β-error equal to 0.10. …”
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Estudio piloto sobre las respuestas motrices y psicológicas de jugadores y entrenadores durante la competición a la propuesta de reglas para mini-balonmano playa (Pilot study on p... by Juan Antonio Sánchez-Sáez, Juan Pablo Morillo-Baro, José Miguel Sánchez Malia, Daniel Lara Cobos, Jose Luis Arias-Estero

“…The study followed a mixed methods approach, quantitative and qualitative. The design was quasi-experimental with post-test measures. …”
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Gingerols and Shogaols of Zingiber officinale var. sunti Valeton as Potential Allosteric Agonists of Human GABAA Receptor by in silico Pharmacology Approach by Kuswandani F, Wilar G, Wahyuni IS, Megantara S, Pitaloka DAE, Levita J, Jiranusornkul S

“…Anti-anxiety drugs, such as benzodiazepines, alleviate anxiety disorders by enhancing the activity of gamma-aminobutyric acid type A (GABAA) receptors through positive allosteric regulation at the α 1/γ 2 interface extracellular domain.Purpose: To elucidate the binding energy and stability of gingerols and shogaols toward human GABAA receptor (hGABAAR), compared to their known allosteric agonist (diazepam), and further phytochemical analysis in the ethanol extract of Z. officinale var. sunti Valeton rhizome (EEZO).Methods: The ligands, namely gingerols (6-, 8-, and 10-gingerol) and shogaols (6-, 8-, and 10-shogaol), were evaluated by pre-ADMET screening tools and molecular docking simulation towards hGABAAR α 1/γ 2 subtype (PDB ID: 6X3X). …”
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Impact of Elevated Oestrogen Levels on hCG Trigger Day on Clinical Pregnancy Outcome and OHSS Incidence in Long-Acting GnRHa Down-Regulated IVF/ICSI-ET Cycles by Yan Y, Jiang J, Mei J, Shen X, Jiang Y, Xing J, Huang C

“…This study aimed to investigate whether E2 levels on the hCG trigger day affect pregnancy outcome in long-acting gonadotropin releasing hormone agonist (GnRHa) down-regulated in-vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET) cycles.Methods: This is a retrospective study including 6967 patients undergoing their first long-acting GnRHa down-regulated IVF/ICSI-ET cycles at the Reproductive Medicine Centre of Nanjing Drum Tower Hospital from January 2016 to December 2021. …”
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Prevalence of use, perceptions of harm and addictiveness, and dependence of electronic cigarettes among adults in Kuwait: A cross-sectional study by Munairah Alshaibani<sup>*<sup/>, Mays Alajmi<sup>*<sup/>, Noura Alabduljalil, Hajar Alajmi, Yousef Alsalem, Danah Aloqab, Hamad Alawadhi, Sara Sayed Ali, Yaqoub Sharhan, Ahmed Alzeeny, Ali H. Ziyab

“…Given the lack of epidemiologic data in Kuwait, this study sought to estimate the prevalence of e-cigarette use, assess perceptions of harm and addictiveness of e-cigarettes, measure the level of dependence on e-cigarettes and assess factors associated with dependence level among adults. Methods A cross-sectional study enrolled adults (n=3032, aged ≥18 years) living in Kuwait using a web-based questionnaire. …”
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Three-dimensional analysis of the proximal radial shaft and its intramedullary canal: a cadaver imaging study by Johannes M. Sieberer, MS, Michael Cobo, BS, Albert L. Rancu, BS, Julia LaMonica, MD, Kelsey Brennan, Lynn E. Copes, PhD, Steven M. Tommasini, PhD, Daniel H. Wiznia, MD, Lisa L. Lattanza, MD

“…We hypothesize that IC morphology differs significantly between age, sex, and height groups. Methods: One hundred fifty-one three-dimensional models of the PR and the corresponding ICs were created from CT scans of adult females and males with average height, divided into 3 equally sized age groups (25-30, 40-45, and 60-65 years), and adult females and males of short and tall built. …”
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Quantifying the impacts of diverse vegetation-covered patterns on hillslope soil erosion: a case experiment of alfalfa-covered hillslopes by Chong Yao, Qingwei Zhang, Kebing Chen, Shige Zhang, Ming Zhu, Zhijia Gu, Wei Yan, Faqi Wu

“…However, knowledge about the influence of herbage spatial distribution pattern on hillslope erosion is still limited.MethodsIn the current study, runoff plots (length × width × depth, 2 × 1 × 0.5 m) with slope gradient of 8.75%–36.40% and a side-spray rainfall simulator with rainfall intensity of 90 mm h-1 were adopted to rainfall simulation. …”
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The effect of follow-up reexamination on the long-term prognosis of patients with acute coronary syndrome undergoing coronary angiography by Chao Wang, Lina Cui, Xianqin Ma, Meng Sun, Yulin Wang, Fuhong Dong, Chen Zhao, Xueqin Tian, Yini Wang, Haihong Zhang, Tianhui Cao, Xinyu Hou, Jian Wu, Sining Hu, Jiannan Dai, Duolao Wang, Haibo Jia, Bo Yu

“…This study proposes a follow-up center-based secondary prevention program to assess whether a structured cardiologist-led follow-up and reexamination protocol influences ACS patient prognosis. Methods A total of 9,534 ACS patients undergoing coronary angiography were retrospectively included and divided into a reexamination group (n = 6,804) and a non-reexamination group (n = 2,730) according to whether they were reexamined within one year or not. …”
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Evaluating the association of transient receptor potential cation channel subfamily A member 1 gene polymorphisms with pain sensitivity: results from an adaptive recall by genotype... by Aidan P. Nickerson, Laura J. Corbin, Nicholas J. Timpson, Megan Nott, Oliver Blanshard, Katie Foy, Fang Fang Quek, Christopher Geddie, Keith Phillips, Frances M.K. Williams, Anthony E. Pickering, James P. Dunham

“…This prospective, double-blind, adaptive recall-by-genotype study assessed the effects of nonsynonymous variation in transient receptor potential ankyrin 1 (TRPA1) on thermal and mechanical detection and pain thresholds before and after topical application of the TRPA1 agonist cinnamaldehyde. Methods:. Five putative gain-of-function TRPA1 variants were assessed within the ALSPAC cohort (aged 27–30). …”
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Development of a high-sensitivity vertical flow immunoassay for the detection of Rift Valley fever virus by Alexander J. Summers, Haydon J. Hill, Jasmine P. Devadhasan, Jian Gu, Vanessa Berner, Sujata G. Pandit, Marcellene A. Gates-Hollingsworth, Kathryn J. Pflughoeft, Douglas C. Montgomery, Supriya Atta, Tuan Vo-Dinh, David P. AuCoin, Frederic Zenhausern

“…The prototype diagnostic described in this research was shown to be more sensitive than traditional methods, such as lateral flow dipstick tests. Moreover, the VFI is readily deployable at the point of care in resource-limited settings. …”
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Comparative Study on Associations Between Lung Cancer Prognosis and Diagnostic Criteria Set by the European Palliative Care Research Collaboration and the Asian Working Group for C... by Utae Katsushima, Takuya Fukushima, Jiro Nakano, Naoya Ogushi, Kazuki Fujii, Yutaro Nagata, Keisuke Kamisako, Yukiko Okuno, Yuta Okazaki, Kentaro Nakanishi, Kiyori Yoshida, Tatsuki Ikoma, Yuki Takeyasu, Yuta Yamanaka, Hiroshige Yoshioka, Kimitaka Hase, Takayasu Kurata

“…We compared both criteria to determine differences in diagnostic rates and their association with lung cancer prognosis. Patients and Methods This single‐center, retrospective cohort study considered lung cancer outpatients receiving chemotherapy. …”
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GRAPHIC NOVEL TRANSLATION: SEMIOTIC AND MULTIMODAL PERSPECTIVE by Anna V. Khodorenko.

“…Applying methods of ADM in the process of analysing graphic novel results from the necessity to respond to the main challenges of ADM theory for the studies in theory and practice of translation, as well as semiotics and general linguistics. …”
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Artificial Intelligence-Based Large Language Models Can Facilitate Patient Education by Xochitl Bryson, BA, Marleni Albarran, BS, Nicole Pham, MPH, Arianne Salunga, DO, Taylor Johnson, MD, MPH, Grant D. Hogue, MD, Jaysson T. Brooks, MD, Kali R. Tileston, MD, Craig R. Louer, MD, Ron El-Hawary, MD, Meghan N. Imrie, MD, James F. Policy, MD, Daniel Bouton, MD, Arun R. Hariharan, MD, Sara Van Nortwick, MD, Vidyadhar V. Upasani, MD, Jennifer M. Bauer, MD, Andrew Tice, MD, John S. Vorhies, MD

“…We used an expert panel to compare LLM-generated and professional society-authored answers to frequently asked questions about pediatric scoliosis. Methods: We used three publicly available LLMs to generate answers to 15 frequently asked questions (FAQs) regarding pediatric scoliosis. …”
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Efficacy and safety of 650 nm invasive laser acupuncture on non-specific chronic low back pain: a randomized clinical trial by Yejin Hong, Dongwoo Nam, Dongwoo Nam, Changsop Yang, Byoung-Kab Kang, Ae-Ran Kim, Kyung Min Shin, Jihye Kim, Saerom Jeon, Gwang-Cheon Park, Jae-Hong Kim, Jae-Hong Kim

“…BackgroundThe study aims to determine whether 650 nm invasive laser acupuncture (ILA) is safe and effective for pain relief in patients with non-specific chronic low back pain (NSCLBP).MethodsThis randomized clinical trial was conducted in two hospitals in Korea. …”
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Markers of Epstein–Barr virus in clinical assessment of Russian patients with nasopharyngeal cancer by K. V. Smirnova, N. B. Senuta, I. V. Botezatu, A. V. Ignatova, T. E. Dushenkina, A. A. Zolotarev, A. V. Lichtenstein, V. E. Gurtsevich

“…Epstein–Barr virus (EBV) is equally widespread in the endemic and non-endemic world regions for nasopharyngeal cancer (NPC). …”
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Detection of EGFR Mutations (Ex19Del, T790M, S768I, C797S, Ex20ins, G719X, L858R, L861Q) in Non-small Cell Lung Carcinoma and its Association with Various Clinicopathological Param... by Aditya A Mundra, Abha Mathur, Ram Mohan Jaiswal, Maneesh Vijayvargiya, Neha Sethi, Manoj Sharma, Shweta Bansal, Shikha Goyal

“…Aim: The aim of this study was to detect EGFR mutations in NSCLC and associate the mutation status with clinicopathological parameters. Materials and Methods: The present cross-sectional study was conducted in the Department of Oncopathology and Transplant Immunology Molecular lab at Mahatma Gandhi Hospital, Jaipur, Rajasthan, India, from June 2023 to May 2024. …”
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Pyrethroid-resistant malaria vector Anopheles gambiae restored susceptibility after pre-exposure to piperonyl-butoxide: results from country-wide insecticide resistance monitoring... by Bilali Kabula, Yeromin P. Mlacha, Naomi Serbantez, Samwel L. Nhiga, Sigsbert Mkude, Samson Kiware, James S. Michael, Victor Mero, Sarah-Blythe Ballard, Adeline Chan, Said Abbasi, Charles D. Mwalimu, Nicodem J. Govella

“…Monitoring of insecticide resistance is, therefore, critical for the selection and assessment of the programmatic impact of insecticide-based interventions. Methods The study was conducted country-wide across 22 sentinel districts of Tanzania between May and July 2023 using standard World Health Organization susceptibility test with 1×, 5×, and 10× of deltamethrin, permethrin, and alpha-cypermethrin and discriminating concentrations of 0.25% pirimiphos-methyl. …”
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Effect of staining and whitening systems on color stability of computer aided design/computer aided manufacturing lithium disilicate glass ceramic by Nadia S. Al-Angari, Shahad Quwayhis, Nouf Almayouf, Shahad Meaigel, Abdulelah Aldahash, Sarah S. Al-Angari

“…Purpose: To investigate the effect of coffee stain and whitening systems on the color stability of CAD/CAM glazed lithium disilicate glass-ceramics (LDGCs). Methods:  68 glazed LDGC discs (12 × 10 × 2 mm) were fabricated using blocks of CAD/CAM systems (IPS e.max CAD ceramic). …”
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Bridging the Gap: A Qualitative Study Exploring the Impact of the Involvement of Researchers With Lived Experience on a Multisite Randomised Control Trial in the National Probation... by Elizabeth Simes, Stephen Butler, Elizabeth Allison, Barbara Barrett, Anthony Bateman, Angus Cameron, Mike Crawford, Alison Frater, Zoe Hoare, Mary McMurran, Paul Moran, Stephen Pilling, James Wason, Jessica Yakeley, Peter Fonagy

“…This qualitative study aimed to explore the value of involving researchers with lived experience of the criminal justice system as data collectors in the Mentalization for Offending Adult Males (MOAM), a multisite RCT conducted in the National Probation Service in England and Wales. Methods Semi‐structured interviews were conducted with 30 trial participants and 17 key stakeholders, either in person or via telephone. …”
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