Impact of Echinococcus granulosus Cyst Fluid on the Phenotypic Dynamics and Degranulation of RBL-2H3 Mast Cells by Yue Z, Zhou JR, Wang CS, Pu XL, Parehati G, Cao LW, Bayina B, Ye JR

“…Zhen Yue,1,2,* Jing-Ru Zhou,3,* Chun-Sheng Wang,1 Xue-Li Pu,1 Guligeiya Parehati,1 Li-Wei Cao,1 Batesurong Bayina,1 Jian-Rong Ye1 1Department of Anesthesiology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, People’s Republic of China; 2Department of Anesthesiology, Changji People’s Hospital, Changji, 831100, People’s Republic of China; 3Department of Anesthesiology, The Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi, 830063, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jian-Rong Ye, Department of Anesthesiology, The First Affiliated Hospital of Xinjiang Medical University, No. 137, Liyushan South Road, Urumqi, 830054, People’s Republic of China, Tel +86 18999938777, Email ywjianrongym@126.comObjective: This study aimed to evaluate the effects of Echinococcus granulosus cyst fluid (EgCF) on the phenotypic characteristics and degranulation activity of mast cells during echinococcosis-associated hypersensitivity reactions, using the RBL-2H3 rat basophilic leukemia cell line as an in vitro model.Methods: The cytotoxic effects of EgCF on RBL-2H3 cells were assessed using the Cell Counting Kit-8 assay. …”
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Prognostic Value of Apolipoprotein E in Predicting One-year Mortality in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease by Li Y, Wu Q, Li Z, Xiao Y, Wei L

“…This study sought to investigate the correlation between the levels of ApoE and all-cause mortality over one year in individuals who are diagnosed with acute exacerbations of chronic obstructive pulmonary disease (AECOPD).Methods: In this study, we checked serum ApoE concentrations of AECOPD patients on admission and collected the patients’ laboratory and clinical information. …”
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Evaluation of Streptococcus faecalis, Clostridium butyricum, Bacillus mesentericus, Lactobacillus sporogenes, Saccharomyces Boulardi multistrain probiotic formulation in acute gast... by Bhavna Darshan Patel, Girish Kulkarni, Swagata Chowdhuri, Animesh Arya, Kaithayil Mammen John, Ashwini Suyog Patki Doshi, Rathish Nair, Krishnaprasad Korukonda

“…This study evaluates the safety and efficacy of a novel multistrain probiotic formulation in managing AGE and antibiotic-associated diarrhea (AAD). Methods This observational, real-world study included 683 patients from 239 sites across India, assessing the effects of a multistrain probiotic formulation in AGE and AAD. …”
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Exogenous GABA Alleviates Tourette Syndrome-Like Behavior in Sprague-Dawley Rats by Altering Gut Microbiota and Striatum Metabolism by Xu Y, Li LN, He XJ, Wang S, Li X, Feng H, Zhang HF, Song L, Shi HS, Tian XY

“…However, the effect of exogenous GABA administration on tic alleviation remains unreported.Objective: In this study, we aim to investigate the therapeutic effects of exogenous GABA on TS-like behaviors in Sprague-Dawley rats and explore its potential mechanisms, including gut microbiota regulation, oxidative stress mitigation, and restoration of GABA-glutamate balance, to provide insights into TS pathogenesis and alternative treatment strategies.Materials and Methods: A TS model rat was established through intraperitoneal administration of 3,3-Iminodipropionitrile (150 mg/kg/day), followed by GABA (20 mg/kg/day) administration by gavage. 15 minutes of behavioral testing (stereotypical behavior and head twitching behavior) was then conducted. 16S rRNA sequencing identified microbiome changes, and LC-MS assessed striatal metabolite changes.Results: The results showed that a 4-week GABA treatment alleviated TS-like behavior in rats. …”
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Effectiveness and Safety of Acupuncture as an Adjunctive Therapy for Post-Stroke Depression: An Overview of Systematic Reviews by Liu X, Zhu F, Zhang JL, He ZX, Yin S, Wu RH, He YY, Zeng F

“…Acupuncture as an adjuvant therapy shows promise, though current systematic reviews exhibit significant discrepancies in effectiveness/safety evidence with insufficient methodological rigor.Purpose: To evaluate systematic reviews assessing acupuncture as an adjuvant therapy for PSD.Methods: Electronic searches were conducted across eight databases from their inception to March 2024. …”
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Immune Subtypes in Sepsis: A Retrospective Cohort Study Utilizing Clustering Methodology by Zhao J, Dai R, Zhao Y, Tan J, Hao D, Ren J, Wang X, Chen Y, Peng H, Zhuang Y, Zhou S, Chen Y

“…Identifying distinct clinical phenotypes may enable more targeted therapeutic interventions and improve patient care.Objective: This study aims to use clustering analysis techniques to identify different immune subtypes in sepsis patients and explore their clinical relevance and prognosis.Methods: The study included 236 patients from the EICU at Shanghai Tenth People’s Hospital, who met the Sepsis 3.0 diagnostic criteria. …”
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How to Choose Treatment Regimens for Idiopathic Membranous Nephropathy Patients with PLA2R-Negative: A Single-Center Retrospective Cohort Study by Zhou Z, Zou Y, Ke B, Shen W

“…This study aimed to evaluate the efficacy and adverse events of these three treatment regimens in IMN patients with PLA2R-negative.Methods: This study included 46 PLA2R-negative IMN patients confirmed by renal biopsy and immunofluorescence from the Department of Nephrology, the Second Affiliated Hospital of Nanchang University between September 2021 and October 2023. …”
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Dynamical lymphadenectomy as a component of multidisciplinary approach while doing operative interventions for pancreatic cancer by O. Yu. Usenko, M. Yu. Nychytailo, M. S. Zagriichuk, V. V. Kropelnytskyi, N. E. Klochkova, Yu. V. Nezhentseva, Ya V. Romaniv, O. O. Pidopryhora, D. M. Skrypka

“…To improve the results of treatment of pancreatic cancer, using modification of volumes of lymphadenectomy and application of multidisciplinary approach. Materials and methods. Into the investigation 16 patients, suffering a moderately differentiated (G2) adenocarcinoma of the pancreatic gland head (II stage of the disease) were included. …”
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The Influence of Emphysema on Treatment Response to Biologic Therapy in Severe Asthma by Biener L, Morobeid H, Pizarro C, Kuetting D, Nickenig G, Skowasch D

“…Our aim was to examine the effects of emphysema on biologic treatment response in SA in this retrospective cohort study.Methods: Pulmonary emphysema was examined using computed tomography. …”
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Activation of the Reelin/GSK-3β/p-Tau Signaling Pathway in the Hippocampus of Patients with Temporal Lobe Epilepsy by Lin J, Lin X, Fu YJ, Li X, Li X, Wang Y, Zhao L, Yu S, Piao YS

“…Juan Lin,1,2,* Xinyu Lin,1,* Yong-Juan Fu,1 Xuran Li,3 Xin Li,3 Yujiao Wang,1,4 Lihong Zhao,1 Shun Yu,3 Yue-Shan Piao1,5,6 1Department of Pathology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, People’s Republic of China; 2Department of Pathology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510120, People’s Republic of China; 3Department of Neurobiology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, People’s Republic of China; 4Department of Pathology, Shanxi Provincial People’s Hospital, Affiliated People’s Hospital of Shanxi Medical University, Taiyuan, 030012, People’s Republic of China; 5Clinical Research Center for Epilepsy, Capital Medical University, Beijing, 100053, People’s Republic of China; 6National Center for Neurological Disorders, Beijing, 100053, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yue-Shan Piao, Email yueshanpiao@126.com; Shun Yu, Email yushun103@163.comPurpose: In this study, we evaluated the presence of tau deposition and protein expression of Reelin/GSK-3β/p-Tau signaling pathway in the hippocampus of patients with temporal lobe epilepsy (TLE).Methods: A total of 37 cases of TLE with and without hippocampal sclerosis (HS) were selected histopathologically for our study with 5 autopsy cases as the control group. …”
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Lysyl Oxidase-Like 1 (LOXL1) Up-Regulation in Chondrocytes Promotes M1 Macrophage Activation in Osteoarthritis via NF-κB and STAT3 Signaling by Jiang Y, Wang S, Zhu W, Liu X, Yang Y, Huo L, Ye J, Ma Y, Zhou Y, Yang Z, Mao J, Wang X

“…There is still a lack of biomarkers for OA, so it cannot be intervened in time.Methods: OA biomarkers were identified from human cartilage datasets using LASSO and SVM-RFE, followed by ROC analysis. …”
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Effect of Imeglimin, a Novel Anti-Diabetic Agent, on Insulin Secretion and Glycemic Variability in Type 2 Diabetes Treated with DPP-4 Inhibitor: A 16-Week, Open Label, Pilot Study by Itsukaichi A, Yoshikawa F, Fuchigami A, Iwata Y, Sato G, Miyagi M, Hirose T, Uchino H

“…This study aimed to investigate the efficacy of combining imeglimin with dipeptidyl peptidase-4 inhibitor (DPP-4i), the most frequently prescribed first-line treatment for patients with type 2 diabetes (T2D) in Japan, to improve glycemic control.Patients and Methods: Eleven patients with T2D treated with DPP-4i alone (6.5% ≤ hemoglobin A1C [HbA1c] < 10%) received 1000 mg imeglimin twice daily for 16 weeks. …”
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FoxO1 as a Hub in Immunosenescence Induced by Hepatocellular Carcinoma and the Effect of Yangyin Fuzheng Jiedu Prescription by Xie Y, Yan F, Liu X, Yu L, Yan H, Shang Z, Kong Y, Yang Z

“…The objective of this study is to clarify the mechanism of action of YFJP in treating HCC.Methods: By constructing networks, the active components and molecular targets of YFJP in the treatment of HCC were explored. …”
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Comparative Evaluation of Enamel Surface Abrasion Produced by Three Different Types of Toothbrush Bristle Designs: An In-vitro Study by Akanksha Mohan Karale, Pramod Waghmare, Vidya Dodwad, Pooja pharne, Akshay Karale

“…In this test, a p-value less than or equal to 0.05 was considered statistically significant. …”
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Global Burden of Kidney Cancer Attributable to High Body Mass Index in Adults Aged 60 and Older from 1990 to 2021 and Projections to 2040: A Systematic Analysis for the Global Burd... by Lin J, Zhang Z, Meng X, Yin X, Pu L, Xiang C, Yang J

“…This study analyzes the burden of kidney cancer attributable to high BMI in those aged ≥ 60, clarifying causes and future trends.Methods: Using Global Burden of Disease (GBD) 2021 study, we assessed kidney cancer burden due to high BMI in population aged ≥ 60 from 1990 to 2021, comparing deaths, disability-adjusted life years (DALYs), age-standardized rate (ASR) of DALYs (ASDR), and mortality (ASMR). …”
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Pulmonary and Physical Virtual Reality Exercises for Patients With Blunt Chest Trauma: Randomized Clinical Trial by Tjitske D Groenveld, Indy GM Smits, Naomi Scholten, Marjan de Vries, Harry van Goor, Vincent MA Stirler

“…ObjectiveThis study aimed to assess the effectivity of breathing and physical exercises using VR on the pulmonary recovery of patients with blunt chest trauma at the ward. MethodsA pilot randomized controlled trial was performed. …”
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The Role of Dectin-1-Akt-RNF146 Pathway in &beta;-Glucan Induced Immune Trained State of Monocyte in Sepsis by Guo C, Xu P, Luo W, Zhang J, Sun X, Hoang H, Ma D, Wu D, Zhong J, Miao C

“…However, the role of trained immunity in sepsis has not been fully understood.Methods: We profiled the characteristics of peripheral blood mononuclear cells from septic patients using single-cell RNA sequencing (scRNA-seq) analyses. …”
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Water-Sediment Characteristics and Flow-Sediment Diversion Patterns in Typical Bifurcated Channels in the Middle Reaches of Huaihe River by ZHANG Hui, NI Jin, BEN Peng, WANG Jiu-sheng

“…This study selects the typical bifurcated section from Wangjiaba to Nanzhaoji (hereinafter referred to as “Mengwa section”) in the middle reaches of the Huaihe River, aiming to clarify the variations in water-sediment characteristics and diversion patterns of typical bifurcated channels. [Methods] A combination of cumulative anomaly analysis, Mann-Kendall (M-K) trend test, R/S analysis, and Morlet wavelet analysis was used to study the water-sediment inflow characteristics of the bifurcated channels in the Mengwa section from 1985 to 2020. …”
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HSPA4 Expression is Correlated with Melanoma Cell Proliferation, Prognosis, and Immune Regulation by Wang X, Li Z, Xu J, Wang J, Li Y, Li Q, Niu J, Yang R

“…However, its function in cutaneous malignant melanoma (CMM) remains uncertain.Patients and Methods: The gene and protein expression level of HSPA4 in CMM was investigated with public databases. …”
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Mechanism of a Novel Complex: Zinc Oxide Nanoparticles-Luteolin to Promote Ferroptosis in Human Acute Myeloid Leukemia Cells in Vitro by Wang W, Li Z, Lyu C, Wang T, Han C, Cui S, Wang J, Xu R

“…In this study, we synthesized a new complex: zinc oxide nanoparticles-luteolin (ZnONPs-Lut) and aimed to investigate its effects on cell death in the AML cell line (MOLM-13) in vitro and to elucidate the underlying mechanisms.Methods: We assessed cell viability, quantified changes in gene expression using real-time quantitative PCR (qRT-PCR), and measured changes in ferrous (Fe2+) content, glutathione (GSH) content, malondialdehyde (MDA) content, reactive oxygen species (ROS), and mitochondrial membrane potential (MMP) levels following treatment with different concentrations of MOLM-13 cells with different concentrations of ZnONPs-Lut. …”
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