Development and Validation of a Risk Predictive Model for Adverse Postoperative Health Status of Elderly Patients Undergoing Major Abdominal Surgery Using Lasso-Logistic Regression by Wang Y, Yang Y, Li W, Wang Y, Zhang J, Wan J, Meng X, Ji F

“…The aim of this study was to identify risk factors that can predict the health status of patients aged 80 and over after major abdominal surgery and to establish a nomogram model.Methods: We conducted a retrospective study of elderly patients (aged 80+) who underwent major abdominal surgery at the First Affiliated Hospital of Soochow University from January 2017 to June 2023. …”
Get full text

The Neutrophil Percentage-to-Albumin Ratio as a New Predictor of All-Cause Mortality in Maintenance Hemodialysis Patients by Shi C, Wang J, Liu W, Mo Y, Huang Y, Wei X, Huo D, Huang A

“…This study aimed to investigate the association between NPAR and all-cause mortality in MHD patients.Methods: Patients undergoing maintenance hemodialysis in the blood purification department of The First Affiliated Hospital of Guangxi Medical University from January 2021 to June 2021 were prospectively studied. …”
Get full text

Coix Seed Oil Alleviates DSS-Induced Ulcerative Colitis via Intestinal Barrier Repair and Ferroptosis Regulation by Zeng YX, Li NR, Deng BY, Gu YF, Lu SF, Liu Y

“…Here, the effects and mechanisms of CSO on ulcerative colitis (UC) in vivo are systematically investigated.Methods: Firstly, the UC mice was replicated by 3% DSS, and assessed the efficacy of CSO by observing the fecal occult blood, colon length, DAI score and pathological histomorphological changes of colon tissues. …”
Get full text

Diagnostic Value of Glycosylated Extracellular Vesicle microRNAs in Gastric Cancer by Wang S, Ma C, Ren Z, Zhang Y, Hao K, Liu C, Xu L, He S, Zhang J

“…This study aimed to develop a novel diagnostic model based on miRNAs from glycosylated extracellular vesicles and evaluate its effectiveness in diagnosing gastric cancer.Methods: GlyExo-capture technology was used to isolate glycosylated extracellular vesicles from serum samples. …”
Get full text

PM2.5 Induces Cell-Specific Transcriptomic Alterations in the Lungs of Juvenile Mice by Gui B, Li Y, Li K, Wang J, Fan W, Li L, Wu Q, Chen H

“…However, its cell-type-specific effects on the lungs and the underlying molecular mechanisms remain poorly defined.Methods: This study established a juvenile mouse model of PM2.5 airway exposure to assess transcriptional alterations in lung cells via single-cell RNA sequencing (scRNA-seq). …”
Get full text

Hemiarthroplasties via Posterior Trochanter Osteotomy for Treating Femoral Neck Fractures in Post-Cerebrovascular Disease by Jia YA, Qiao LN, Liu ZB, Xue L, Bi WM, Chen MF, Kang K, Wang F

“…Ying-Ao Jia,1,* Li-Na Qiao,2,* Zhi-Bin Liu,1 Liang Xue,1 Wei-Ming Bi,1 Meng-Fei Chen,1 Kai Kang,1 Fei Wang1 1Department of Orthopaedics, Affiliated Hospital of Yan’an University, Yan’an, 716000, People’s Republic of China; 2Department of Pathology, Affiliated Hospital of Yan’an University, Yan’an, 716000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Fei Wang, Department of Orthopaedics, Affiliated Hospital of Yan’an University, Yan’an, Shaanxi, 716000, People’s Republic of China, Tel +86 18691133000, Email ww_ff@sina.comObjective: The study investigated to examine the clinical outcomes of hemiarthroplasties using posterior femoral trochanter osteotomy for the treatment of femoral neck fractures in patients at the sequelae stage of cerebrovascular disease.Methods: A retrospective analysis was conducted on the data of 53 patients who had been admitted to the Department of Orthopedics at Yan’an University Affiliated Hospital between May 2020 and May 2023. …”
Get full text

A cash transfer plus gender transformative economic empowerment intervention seeking to improve the wellbeing of caregivers of children and adolescents living with HIV in South Afr... by Darshini Govindasamy, Nwabisa Shai, Nelly Mwandacha, Stanley Carries, Nokwanda Sithole, Kalysha Closson, Arvin Bhana, Lovemore Sigwadhi, Laura Washington, Andrew Gibbs, Angela Kaida

“…Methods Caregivers of CALHIV will be recruited from public sector HIV clinics within the eThekwini Municipality, KwaZulu-Natal, South Africa. …”
Get full text

Exploring The Role of TOP2A in the Intersection of Pathogenic Mechanisms Between Rheumatoid Arthritis and Idiopathic Pulmonary Fibrosis Based on Bioinformatics by Shi S, Hong X, Zhang Y, Chen S, Huang X, Zheng G, Hu B, Lu M, Li W, Zhong Y, Sun G, Ouyang Y

“…Our study aims at exploring the genetic-level pathogenic mechanism of these two diseases.Methods: We carried out bioinformatics analysis on the GSE55235 and GSE213001 datasets. …”
Get full text

Patient and public involvement and engagement with underserved communities in dementia research: Reporting on a partnership to co‐design a website for postdiagnostic dementia suppo... by Claudio Di Lorito, Sarah Griffiths, Marie Poole, Chandrika Kaviraj, Martin Robertson, Neil Cutler, Jane Wilcock

“…This study aimed to report on a PPIE partnership between academics and members of the public from underserved communities to co‐design Forward with Dementia—Social Care, a resource and information website supporting people receiving a dementia diagnosis. Methods The PPIE partnership was set up in four stages: 1–identifying communities that have been under‐represented from PPIE in dementia research; 2—recruiting PPIE partners from these communities; 3—supporting PPIE partners to become confident to undertake their research roles and 4—undertaking research co‐design activities in an equitable fashion. …”
Get full text

Long-term results of lymphedema treatment with Combined lymph node transfer and collagen scaffolds: An Observational Study by Dimitrios Dionyssiou, Antonios Tsimponis, Eleni Georgiadou, Konstantina Mamaligka, Efterpi Demiri

“…Our observational study aimed to examine the hypothesis that nanofibrillar collagen scaffolds (NCS) combined with VLNT can provide guided lymphagiogenesis creating long-lasting lymphatic pathways. Methods: Twenty-four patients (21 female, 3 male) underwent a lymphatic microsurgery for upper (n = 11) or lower (n = 13) limb secondary lymphedema and completed at least 18 months follow-up were selected and equally divided in 2 groups; Group-A underwent VLNT, Group-B underwent combined VLNT and NCS procedure. …”
Get full text

Deciphering Immunometabolic Landscape in Rheumatoid Arthritis: Integrative Multiomics, Explainable Machine Learning and Experimental Validation by Dong Q, Wu J, Zhang H, Chen X, Xu X, Chen J, Shi C, Luo L, Zhang D

“…This study explores the complex immunometabolic landscape of RA to identify potential therapeutic targets.Patients and Methods: We integrated genome-wide association study (GWAS) data involving 1,400 plasma metabolites, 731 immune cell traits, and RA outcomes from over 58,000 participants. …”
Get full text

Effectiveness of Finnish SISU training in enhancing prehospital personnels’ work performance: A randomised controlled pilot study by Hanna Vihonen, Janne Karvonen, Harri Gustafsberg, Juha-Matti Huhta, Heidi Kangasniemi, Timo Jama, Sanna Hoppu

“…‘Sisu’ is a Finnish word meaning the combination of toughness and resilience. Methods This randomised controlled pilot study was conducted in Päijät-Häme, Finland. …”
Get full text

Design, Synthesis, and Biological Evaluation of Novel Hydroxytyrosol Derivatives as Protectors for Vascular Endothelium Against Lipid Overload by Hou XX, Wang S, Ma XX, Wen Y, Li ZJ, Liu XY, Zhang X, Zhang Y, Qin XY

“…The aim of the study was to design and synthesize novel hybrid molecules to improve HT’s biological efficiency.Materials and Methods: A pharmacophore connection strategy was used to design and synthesize novel hybrid molecules by combining HT or its analogues with adamantane (ADM). …”
Get full text

Working time distribution and administrative burden in Austrian community health nursing: A cross-sectional survey by Raimund M. Kovacevic, Doris A. Behrens, Walter Hyll

“…Participants: Out of the N = 220 eligible community health nurses, 121 (55%) nurses answered the questions relevant to working time analysis and 115 (52%) for studying regional disparity of service delivery. Methods: The analysis used descriptive statistics, statistical tests, and regression analysis, employing Excel®, Stata® and R. …”
Get full text

Bidirectional Relationship Between Hypoalbuminemia and Postoperative Pneumonia in Elderly Hip Fracture Patients: A Retrospective Cohort Study by Wang J, Yu H, Xu X, Guo J

“…However, their bidirectional relationship in elderly HF patients remains underexplored.Methods: This retrospective cohort study was conducted in China enrolling elderly patients (≥ 65 years) with HFs between Mar 2020 and Feb 2023. …”
Get full text

Opaganib Promotes Weight Loss and Suppresses High-Fat Diet-Induced Obesity and Glucose Intolerance by Maines LW, Keller SN, Smith RA, Smith CD

“…In the present studies, the effects of opaganib in the well-established model of High-Fat Diet (HFD)-induced obesity have been studied.Methods: Male or female C57BL/6 mice were fed Control Diet (CD) or HFD and treated with vehicle or opaganib by oral gavage once daily, 5 days per week. …”
Get full text

A CDKN2B-Associated Immune Prognostic Model for Predicting Immune Cell Infiltration and Prognosis in Esophageal Carcinoma by Peng X, Han J, Huang J, Zhou L, Chen X, Zhou W

“…This study explored the association between CDKN2B deletion, immunophenotype, and the prognosis of EC.Methods: We investigated CDKN2B status and RNA expression, identified differentially expressed immune-associated genes between wild-type CDKN2B (CDKN2BWT) and deleted CDKN2B (CDKN2Bdeletion) in Cancer Genome Atlas (TCGA) EC samples. …”
Get full text

Rethinking Language by Gastor Mapunda, Tracey Costley, Hannah Gibson, Nancy Kula, Colin Reilly

“…Data from these interviews also highlights the challenges which teachers face relating to language, and the creative methods they use to resolve these challenges. We argue that monolingual approaches to language-in-education are not effective, and that formal training in multilingual, language supportive pedagogies is required to provide teachers with the skills they need to effectively engage with multilingual classrooms. …”
Get full text

Cerebrospinal Fluid Leakage Combined with Blood Biomarkers Predicts Poor Wound Healing After Posterior Lumbar Spinal Fusion: A Machine Learning Analysis by Pang Z, Ou Y, Liang J, Huang S, Chen J, Huang S, Wei Q, Liu Y, Qin H, Chen Y

“…Thus, our primary aim is to using machine learning identify these risk factors and construct a clinical risk prediction model.Methods: We retrospectively reviewed 2516 patients who underwent posterior lumbar spinal fusion at Guangxi Medical University’s Second Affiliated Hospital between August 2021 and August 2023. …”
Get full text

Impact of Antimicrobial Stewardship and Infection Prevention and Control Programmes on Antibiotic Usage and A. baumannii resistance: A 2016–2023 Multicentre Prospective Study by Liu L, Liu B, Li L, Li Y, Zhou X, Li Q

“…Lei Liu,1,2,* Bin Liu,1,2,* Liang Li,1,2 Yu Li,3 Xiangdong Zhou,1,2 Qi Li1,2 1Department of Respiratory Medicine, The First Affiliated Hospital, Hainan Medical University, Haikou, Hainan, People’s Republic of China; 2Hainan Province Clinical Medical Center of Respiratory Disease, Haikou, Hainan, People’s Republic of China; 3Department of Respiratory Medicine, The Fourth Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qi Li, Email lqlq198210@sina.comObjective: This study assesses the efficacy of antimicrobial stewardship (AMS) and infection prevention and control programmes (IPCP) in guiding the use of antibiotics and the control of A. baumannii (AB) resistance at multiple medical centres.Methods: We evaluated the effectiveness of the policy on antibiotic consumption and AB resistance by determining the relationship between the defined daily doses (DDD) for antibiotics – or alcohol-based hand gel (ABHG) consumption – and the incidence of carbapenem-resistant AB (CR-AB), multidrug-resistant AB (MDR-AB) and extensively drug-resistant AB (XDR-AB) at two medical centers from 2016– 2023.Results: In total, 4057 AB isolates were collected; 64.95% of the AB isolates were CR, 59.48% were MDR and 1.41% were XDR. …”
Get full text