Integrated Profiling Delineated KIF18A as a Significant Biomarker Associated with Both Prognostic Outcomes and Immune Response in Pancreatic Cancer by Nan K, Zhang L, Zou Y, Geng Z, Huang J, Peng Y, Yin S, Zhang M

“…However, its role in pancreatic adenocarcinoma (PAAD) remains unclear.Methods: To evaluate that role, RNA sequencing datasets, complemented by pertinent clinical metadata, were procured from the Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) repositories. …”
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Effects of saline drinking water on growth performance, carcass traits, and blood biochemistry in crossbred Muscovy ducks by Le Thanh Phuong, Nguyen Thi Thuy, Nguyen Thiet

“…This study aimed to investigate the effects of saline drinking water on the growth performance, carcass traits, and blood biochemistry of crossbred Muscovy ducks (Cairina moschata). Materials and Methods: A completely randomized design was used, including five treatments with five replications per treatment. …”
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Association of Vegetable and Fruit Consumption Patterns with Cognitive Function in Older People with Different BMI Ranges: Findings from China by Huang L, Hong Z, Guo Y, Song W, Huang J, Cao W, Cao C, Chen R, Bai Z

“…Therefore, this study aims to explore their relationship, with a special focus on gender differences.Patients and Methods: A cross-sectional survey was conducted in Anhui Province, China, between July and September 2019, and information was collected from 6211 participants regarding socio-demographics, the frequency of vegetable and fruit consumption per week, and cognitive function. …”
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Is diagnostics of Benign Paroxysmal Positional Vertigo with a mechanical rotation chair superior to traditional manual diagnostics? A randomized controlled crossover study by Malene Hentze, Malene Hentze, Dan Dupont Hougaard, Dan Dupont Hougaard, Herman Kingma, Herman Kingma

“…While various techniques and technologies have improved BPPV diagnostics and treatment, optimizing BPPV healthcare pathways requires a comprehensive understanding of the diagnostic modalities across diverse clinical settings.ObjectiveTo compare traditional manual BPPV diagnostics (MD) with diagnostics done with the aid of a mechanical rotation chair (MRC) when using videonystagmography goggles with both modalities.MethodsThis prospective, open-label, randomized diagnostic crossover study involved 215 adults with typical BPPV symptoms at a tertiary University Hospital-based outpatient clinic (Aalborg University Hospital, Denmark). …”
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The Clinical Value of Systemic Immune Inflammatory Index in Predicting the Prognosis of Patients with Bloodstream Infection by Ou S, Lu H, Qu R, Cui X, Xiong Z, Fan F, Yu X, Hasi C

“…Shuheng Ou,1,* Hong Lu,2,* Rui Qu,3 Xiaolong Cui,3 Zhou Xiong,4 Fangfang Fan,5 Xiao Yu,5 Chaolu Hasi2 1Academy of Medical Sciences, Shanxi Medical University School, Taiyuan, People’s Republic of China; 2Department of Laboratory Medicine, First Hospital of Shanxi Medical University, Taiyuan, People’s Republic of China; 3First Clinical Medical College, First Hospital of Shanxi Medical University, Taiyuan, People’s Republic of China; 4School of Public Health, Anhui Medical University, Hefei, People’s Republic of China; 5NHC Key Laboratory of pneumoconiosis, Shanxi Key Laboratory of respiratory diseases, Department of pulmonary and critical care medicine, First Hospital of Shanxi Medical University, Taiyuan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Chaolu Hasi, Email hasichaolu1967@163.comIntroduction: We analyzed the correlation between systemic immune inflammatory index (SII), systemic inflammatory response index (SIRI), systemic inflammatory index (AISI), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR) and mortality in patients with bloodstream infection to determine their application potential in predicting the prognosis of bloodstream infection.Methods: We calculated SII, SIRI, AISI, NLR, PLR, and MLR in 469 patients with bloodstream infections. …”
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Comparison of breastfeeding practice among Iranian and Afghan refugee mothers: a prospective cohort study in Iran by Zohreh Heidary, Mostafa Saeedinia, Haniyeh Fathi, Shima Rafiee, Zohre Khalajinia, Parvaneh Sadeghimoghadam, Mohammadamin Parsaei

“…Abstract Background Breastfeeding is a critical health equalizer and predictor of significant maternal and infant health outcomes, profoundly influenced by the socioeconomic and cultural status of mothers. …”
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The GLP-1 receptor agonist liraglutide inhibits necroptosis and neuroinflammation in a mouse model of Parkinson’s disease with diabetes co-morbidity by Xiaomin Zhang, Pengyang Du, Bo Bai, Peng Feng, Xia Lian, Christian Hölscher, Yongqing Wang, Guofang Xue

“…ObjectiveTo investigate the effects of the glucagon-like peptide-1 (GLP-1) receptor agonist liraglutide on motor function, necroptosis, and neuroinflammation in the brain in mice with diabetic Parkinson’s disease (PD) and its possible mechanism.MethodsWe prepared a diabetic model with streptozotocin, followed by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced diabetic PD model, along with liraglutide or saline intervention, and the control group with equal volume saline. …”
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Refining Intra-Arterial Therapy Selection for Large Hepatocellular Carcinoma: A Deep Learning Approach Based on Covariate Interaction Analysis by An C, Li L, Luo Y, Zuo M, Liu W, Li C, Wu P

“…However, optimizing IAT selection for large HCC remains challenging due to tumor heterogeneity and varying patient responses.Aim: To develop and validate a deep learning (DL) model for guidance of decision-making between TACE and HAIC for unresectable HCC.Methods: We conducted a retrospective, multi-center study involving 900 patients with large HCC treated with IATs. …”
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Engineered Biomimetic Nanoparticles-Mediated Targeting Delivery of Allicin Against Myocardial Ischemia-Reperfusion Injury by Inhibiting Ferroptosis by Li M, Wu J, Yang T, Zhao Y, Ren P, Chang L, Shi P, Yang J, Liu Y, Li X, Wang P, Cao Y

“…Here, inspired by the natural interaction between neutrophils and inflamed cardiac microvascular endothelial cells (CMECs), a neutrophil membrane-camouflaged nanoparticle for non-invasive active-targeting therapy for IR injury by improving drug delivery to the injured heart is constructed.Methods: In this study, we engineered mesoporous silica nanoparticles (MSNs) coated with a neutrophil membrane to act as a drug delivery system, encapsulating AL. …”
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Association of the Monocyte-to-High Density Lipoprotein Ratio with the FRS and as a Predictor of Cardiovascular Risk in Individuals with Psoriasis Vulgaris by Gu X, Shen H, Jiang J, Gu P, Liu P, Zhao Z, Ge J

“…This retrospective study aimed to investigate the relationship between MHR and the Framingham risk score (FRS) and assess the prognostic significance of this relationship for mid- to high-risk CVD in individuals with psoriasis vulgaris (PsV).Methods: A total of 128 PsV patients and 120 healthy controls were included. …”
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Predictive Value of Bone Metabolism Marker PINP in the Risk of Diabetic Retinopathy: A Cross-Sectional Study by Chen G, Zhang Y, Wang W, Jing Y

“…Guanhua Chen,1,2,* Yuan Zhang,1,2,* Weimin Wang,2,3,* Yali Jing1,2,* 1Department of Endocrinology, Endocrine and Metabolic Disease Medical Center, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, People’s Republic of China; 2Branch of National Clinical Research Centre for Metabolic Diseases, Nanjing, People’s Republic of China; 3Department of Endocrinology, Endocrine and Metabolic Disease Medical Center, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yali Jing, Department of Endocrinology, Endocrine and Metabolic Disease Medical Center, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, 210008, People’s Republic of China, Email jingyalidr@163.comBackground: Given the association between diabetic microvascular disease and bone metabolism, we aimed to investigate the correlation between the concentration of the serum bone turnover marker procollagen type I N-terminal propeptide (PINP) and diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM) in this study.Methods: This was a cross-sectional study. …”
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SGLT-2 inhibitors in the management of acute decompensated heart failure by Anastasia E. Poskakalova, Svetlana N. Nasonova, Igor V. Zhirov, Sergey N. Tereshchenko

“…Evaluation of the six-month efficacy of early dapagliflozin administration in patients with ADHF with a reduced left ventricular ejection fraction (LVEF) in comparison with standard therapy. Materials and methods. The results of the six-month follow-up of 122 patients with ADHF with a reduced LVEF (28±6%), who were divided equally into 2 groups: the standard therapy (group 1) and the sodium-glucose cotransporter-2 inhibitor – dapagliflozin (group 2). …”
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Comparative Morphometric and Histometric Evaluation of Power-Dependent Tissue Ablation Using Fractional Carbon Dioxide Laser by Ryu HG, Park J, Kim H, Kim W, Lee HR, Ko J, Cho SB

“…Although clinical outcomes vary with the energy and pulse settings, comparative morphometric and histometric data on power-dependent tissue interactions are limited.Objective: To evaluate and compare fractional CO2 laser-induced microscopic thermal zones (MTZs) ablation characteristics at peak powers of 30 W and 40 W using an ex vivo porcine skin model.Methods: Ex vivo porcine skin was treated with a fractional CO2 laser at energy levels ranging from 40 to 240 mJ under 30 W and 40 W settings. …”
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Direct and Indirect Effects of Risk Perception and Risk Information on PTSD in Frontline Healthcare Workers by Wu L, Geng S, Zhou Y, Jiao R, Ouyang H, Cheng S, Shang Z, Yan W, Wang J, Jia Y, Li X, Liu W

“…The PTSD checklist for DSM-5 (PCL-5), risk information questionnaire, and risk perception questionnaire are utilized to collect data.Methods: Bivariate correlation analysis and structural equation modelling are performed to analyze the mediating role of risk perception in the relationship between risk information and PTSD.Results: The estimated prevalence of PTSD among frontline healthcare workers is 28.2%. …”
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Auto-Immune Glial Fibrillary Acidic Protein Astrocytopathy with Active Intrathecal Epstein-Barr Virus: A Single-Center Case Series Report by Yu X, Zou Y, Li M, Wang L, Feng W, Wei L, Yang L, He J, Bu H, Li Y

“…This study reports a case series of auto-immune GFAP astrocytosis with positive cerebrospinal fluid (CSF) EBV DNA, describing its clinical manifestations and treatment experience.Patients and Methods: In the serial case study, we reported six patients diagnosed with GFAP astrocytopathy having intrathecal EBV.Results: The significant signs included headache, fever and urination disorder, ataxia, limb weakness, numbness, consciousness disorder, psychological disorder, and blindness, among others. …”
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Dynamic Nomogram for Predicting the Fall Risk of Stroke Patients: An Observational Study by Wu Y, Jiang X, Wang D, Xu L, Sun H, Xie B, Tan S, Chai Y, Wang T

“…The study aimed to develop and verify a dynamic nomogram model for predicting the falls risk in stroke patients during rehabilitation.Methods: An observational study design was adopted, 488 stroke patients were treated in a tertiary hospital from March to September 2022 were investigated for fall risk factors and related functional tests. …”
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Case Reports: Chemokine and Cytokine Profiling in Patients with Herpetic Uveitis by Nguyen NV, Linderman SL, Fashina T, Devine M, Conrady CD, Shantha JG, Ahmed R, Yeh S

“…Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, Nebraska, USA, Tel +1 402 559-2020, Email syeh@unmc.eduPurpose: To report cytokine/chemokine profiles of ocular fluid in two patients with herpetic uveitis.Methods: Cytokine and chemokine profiling of ocular fluid was performed in two patients with herpetic uveitis. …”
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Does Seasonality Affect Peptic Ulcer Perforation? A Single-Center Retrospective Study by Iva Krajnović, Zenon Pogorelić, Iva Perić, Marija Ćavar, Matija Borić

“…With the advancement of modern medicine, including the widespread use of proton pump inhibitors, and the effects of climate change, this study aimed to assess potential seasonal variations in the incidence of peptic ulcer perforation in our region. <i>Methods:</i> This retrospective analysis included 104 adult patients (mean age: 61.5 ± 14.7 years) who underwent surgical treatment for peptic ulcer perforation between January 2021 and April 2024. …”
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A Multifunctional Low-Temperature Photothermal Nanomedicine for Melanoma Treatment via the Oxidative Stress Pathway Therapy by Zhang D, Liu X, Li X, Cai X, Diao Z, Qiu L, Chen X, Liu Y, Sun J, Cui D, Ye Q, Yin T

“…The main objective of this study was to construct a multifunctional nanomedicine (GNR@PEG-Qu) to investigate its therapeutic effect on melanoma from the oxidative stress pathway.Methods: First, the nanomedicine GNR@PEG-Qu was synthesized and characterized, and its photothermal and antioxidant properties were confirmed. …”
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Comparison of Efficacy and Safety Outcomes of Different Doses Schedules of Thalidomide for Treating Moderate-to-Severe &beta;-Thalassemia Patients by Yang WJ, Shi LD, Liang Y, Liang LM, Zhang H, Wang L, Zhou Q

“…Wei-Jia Yang,1,&ast; Lian-dong Shi,2,&ast; Ye Liang,3,&ast; Li-ming Liang,4,&ast; Hao Zhang,5 Li Wang,2 Qian Zhou1 1Department of Eugenics and Genetics, Guilin People’s Hospital, Guilin, Guangxi Zhuang Autonomous Region, 541002, People’s Republic of China; 2Department of Ultrasound, Guilin People’s Hospital, Guilin, Guangxi Zhuang Autonomous Region, 541002, People’s Republic of China; 3Department of Cardiology, The People’s Hospital of Guangxi Zhuang Autonomous Region, and Institute of Cardiovascular Diseases, Guangxi Academy of Medical Sciences, Nanning, 530000, People’s Republic of China; 4Department of Genetic Metabolism Center Laboratory, Guilin Women and Children’s Hospital, Guilin, Guangxi Zhuang Autonomous Region, 541001, People’s Republic of China; 5Department of Pharmacy, Guilin People’s Hospital, Guilin, Guangxi Zhuang Autonomous Region, 541002, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Wei-Jia Yang, Department of Eugenics and Genetics, Guilin People’s Hospital, No. 12 of Wenming Road, Xiangshan District, Guilin, Guangxi Zhuang Autonomous Region, 541002, People’s Republic of China, Tel +86 18977300052, Fax +86 07732881579, Email weijiayangywj@126.comObjective: In this study, we evaluated the effectiveness and safety of thalidomide by clinically observing 48 individuals with β-thalassemia who have been administered thalidomide in small and medium doses over a period of two years.Methods: Thalidomide’s efficacy was gauged by tracking hemoglobin (Hb) level alterations post its administration. …”
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