Seroprevalence of SARS-CoV-2 antibodies in people with an acute loss in their sense of smell and/or taste in a community-based population in London, UK: An observational cohort stu... by Janine Makaronidis, Jessica Mok, Nyaladzi Balogun, Cormac G Magee, Rumana Z Omar, Alisia Carnemolla, Rachel L Batterham

“…It also evaluated whether smell or taste loss are indicative of COVID-19 infection.<h4>Methods and findings</h4>Text messages, sent via primary care centers in London, United Kingdom, invited people with loss of smell and/or taste in the preceding month, to participate. …”
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Restricted kinematic total knee arthroplasty provided better functional outcomes and higher satisfaction rates for Asians of genu varum with apex distal joint line over unrestricte... by Jia Yi Loh, Ming Han Lincoln Liow, Glen Purnomo, Merrill Lee, Jerry Yongqiang Chen, Hee-Nee Pang, Keng Jin Darren Tay, Seng-Jin Yeo

“…Unrestricted calipered KA-TKA targeted equal bone cuts while restricted KA-TKA utilized intraoperative navigation to restrict tibia varus to 4°. …”
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Risk Factors Affecting Quality of Life in Chronic Limb Threatening Ischemia Patients by Wu R, Yu Y, Guo J, Gao X, Tong Z, Guo J, Cui S, Zhang C, Guo L

“…Understanding these relationships could provide insights into optimizing patient management and improving their overall QoL.Patients and Methods: This study was conducted at our center from January 2021 to January 2024. …”
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The Role of PLIN3 in Prognosis and Tumor-Associated Macrophage Infiltration: A Pan-Cancer Analysis by Yang S, Liu H, Zheng Y, Chu H, Lu Z, Yuan J, Xu S

“…This study leverages data retrieved from multiple databases to address these questions.Methods: PLIN3 mRNA and protein expressions were analyzed across a diverse range of normal and cancerous tissues, utilizing data retrieved from multiple databases. …”
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Buyang Huanwu Decoction Alleviates Ischemic Stroke Injury by Inhibiting Ferroptosis via the Nrf2/GPX4 Pathway by Huang H, Liu S, Wu J, Zhu J, Xu J, Yu S, Bei L, Zhang B, Luo Y

“…Despite its long history in stroke treatment, the mechanism of Buyang Huanwu Decoction (BHD) in ferroptosis remains unclear.Methods: Network pharmacology predicted BHD’s active components and pathways, while Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry (UPLC-MS/MS) confirmed its main ingredients. …”
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Exploring the Anti-Inflammatory and Anti-NET Properties of Zidian Zhenxiao Granule in IgA Vasculitis: A Network Pharmacology and Proteomic Study by Zhang X, Yang M, Duan X, Feng X, Fang Y

“…This study aimed to investigate the main component of ZDZX and its underlying mechanism in IgAV treatment.Methods: Combining UHPLC-QE-MS/MS, network pharmacology, 4D-FastDIA proteomics, and a gliadin-induced IgAV murine model, we systematically deciphered ZDZX’s renoprotective and anti-inflammatory mechanisms.Results: 19 key components were identified in ZDZX, targeting 46 IgAV-associated proteins, predominantly enriched in TNF and IL-17 signaling pathways. …”
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The Upregulation of IL-1&beta; Induced by Cisplatin Triggers PI3K/AKT/MMP9 Pathway in Pericytes Mediating the Leakage of the Blood Labyrinth Barrier by Yu M, Jiang WJ, Yu M, Zhou Z, Wang M, Li L

“…However, the relationship between CDDP-induced inflammation and BLB dysfunction remains elusive.Materials and Methods: In vivo and in vitro BLB models were used to explore the inflammatory mechanisms underlying CDDP ototoxicity. …”
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Efficacy of Magnetic Seizure Therapy in Patients with Schizophrenia and Combined fMRI-EEG to Explore the Regulatory Mechanisms of Brain Networks by Wei S, Chen B, Guo Z, Zhang H, Li J, Hu X, Yang C, Li J, Li X, Liu Z, Xu Y, Liu S

“…However, as far as magnetic shock therapy itself is concerned, there are few studies specifically focusing on its efficacy in depth, and the mechanism of MST in treating schizophrenia is still unclear.Methods: This study centered on the key question of “the efficacy of magnetic stunning therapy for patients with schizophrenia and the combined fMRI-EEG to explore the regulatory mechanisms of brain networks”. …”
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Structural-Functional Correlation in Non-Arteritic Acute Ischemic Optic Neuropathy by Wei J, Zhang L, Wang H, Wang Q, Jia W, Wang R, Wang R, Cui Z

“…Junhan Wei,1,&amp;ast; Lei Zhang,1,&amp;ast; Haiyan Wang,1 Qianfeng Wang,2 Wei Jia,1 Ru Wang,1 Runsheng Wang,1 Zhili Cui1 1Shaanxi Eye Hospital, Xi’an People’s Hospital (Xi’an Fourth Hospital), Affiliated People’s Hospital of Northwest University, Xi’an, People’s Republic of China; Xi’an Key Laboratory of Digital Medical Technology of Ophthalmologic Imaging, Xi’an, 710004, People’s Republic of China; 2Medical College of Optometry and Ophthalmology, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, 250000, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Haiyan Wang, Email haiyanwang@med.nwu.edu.cnPurpose: This study investigated the relationships between structural and functional parameters in non-arteritic ischemic optic neuropathy (NAION).Methods: This retrospective study enrolled 29 patients (58.2 ± 10.4 years old) with unilateral NAION. …”
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Association of Conventional and Unconventional Lipid Profiles with Visceral Fat Area in Overweight/Obese Individuals with Type 2 Diabetes Mellitus by Ma X, Jiang X, Gao G, Ban B, Sheng J, Shi S, Zhao H, Ji B

“…Emphasizing the overall relationship between lipid metabolism and visceral fat accumulation.Methods: This cross-sectional study included 1288 overweight/obese T2DM patients, with VFA measured using bioelectrical impedance analysis and visceral fat obesity (VFO) was defined as VFA ≥ 100 cm². …”
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Identification of Specific Abnormal Brain Functional Activity and Connectivity in Cancer Pain Patients: A Preliminary Resting-State fMRI Study by Hua Y, Geng Y, Liu S, Xia S, Liu Y, Cheng S, Chen C, Pang C, Zhao Z, Peng B, Dai Y, Ji J, Wu D

“…The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, Zhejiang Province, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Jiansong Ji; Dan Wu, Email jjstcty@wmu.edu.cn; 215066083@qq.comObjective: This study investigates the differences in brain functional activity and connectivity patterns between Cancer Pain (CP) patients and Healthy Controls (HCs) using resting-state functional magnetic resonance imaging (rs-fMRI) to identify potential neuroimaging biomarkers.Methods: This study collected rs-fMRI data from 25 CP patients and 25 hCs, processed the functional MRI images, and calculated metrics such as amplitude of low-frequency fluctuation (ALFF), Regional Homogeneity (ReHo), and FC. …”
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The Effect of Laser Biostimulation at Sensitized Acupoints on Chronic Pelvic Pain and Quality of Life in Women with Pelvic Inflammatory Disease: A Randomized Controlled Trial by Marwa Esmael Hasanin, Sobhy Mahmoud Aly, Mona Mohamed Taha, Lama Saad El-Din Mahmoud, Monira I. Aldhahi

“…This study aimed to investigate the effects of laser on sensitized acupoints on pelvic pain perception and quality of life in women with pelvic inflammatory disease. <i>Materials and Methods</i>: Thirty-six women with CPP caused by chronic pelvic inflammatory disease were randomly divided into two equal groups. …”
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Genomic Epidemiology of Clostridioides difficile ST81 in Multiple Hospitals in China by Xia X, Lv T, Zheng L, Zhao Y, Shen P, Zhu D, Chen Y

“…However, given the potential for C. difficile ST81 transmission, research into the epidemiological characteristics of this type of ST remain limited.Methods: We conducted a genomic epidemiology study addressing the genetic characteristics of C. difficile ST81 in five tertiary hospitals covering different regions in China between January 2010 and January 2021. …”
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Upregulation of ARHGAP18 by miR-613 Inhibits Cigarette Smoke Extract-Induced Apoptosis and Epithelial-Mesenchymal Transition in Bronchial Epithelial Cells by Fu H, Liu K, Zheng Y, Zhao J, Xie T, Ding Y

“…This study is intended to explore the function and molecular mechanism of ARHGAP18 and miR-613 in COPD pathogenesis.Methods: We initially identified the marker gene closely related to epithelial dysfunction in COPD by integrating bioinformatic analyses. …”
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Integrated Bioinformatics and Experimental Validation Reveal Macrophage Polarization-Related Biomarkers for Osteoarthritis Diagnosis by He Q, Liu L, Hu X, Lin L, Song Z, Xia Y, Lin Q, Wei J, Li S

“…In this study, we identified crucial genes associated with macrophage polarization in OA and constructed a diagnostic model to provide novel insights for diagnostic and therapeutic strategies.Methods: The GSE55235 and GSE55457 datasets were merged through the GEO database to identify genes related to macrophage polarization by conducting weighted gene co-expression network analysis (WGCNA) and differential expression analysis. …”
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Multimodal Magnetic Resonance Findings in Parkinson&rsquo;s Disease With &ldquo;Antecedent Essential Tremor&rdquo;: A Case Series of a Large Kindred by Kong Y, Yao L, Xiao X, Chen A, Wang K, Yan H, Sun R, Liu R, Kong Q

“…This study aimed at determining the morphological, microstructural and iron-related changes in these patients’ brains using multimodal magnetic resonance imaging (MRI).Methods: We reviewed a kindred with ET and PD with “antecedent ET” recruited at our hospital in May 2023. …”
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Heme Oxygenase-1 Modulates Macrophage Polarization Through Endothelial Exosomal miR-184-3p and Reduces Sepsis-Induce Lung Injury by Chen W, Zhang Y, Chen J, Dong S, Wu X, Wu Y, Du Z, Yang Y, Gong L, Yu J

“…But research on the mechanism of HO-1 in macrophage polarization via PMVEC exosomes in sepsis-induced lung injury is lacking.Methods: To investigate the role of HO-1 in the interaction between endothelial cells and macrophages, HO-1 knockout mouse model were established. …”
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Unveiling Theranostics: Nanocomplex-Assisted Photodynamic Eradication of Aggressive Cancer Cells and Modulation of Tumor-Associated Macrophages by Butkute A, Kazlauske E, Mlynska A, Peciukaityte E, Karabanovas V, Rotomskis R, Steponkiene S

“…Moreover, diagnostics and treatment are activated simultaneously, without the possibility of switching between two processes.Methods: We used photosensitizer chlorin e6 (Ce6) and luminescent quantum dots (QDs) to create a theranostic nanocomplex. …”
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Butyrylcholinesterase and 24 h-urinary copper excretion as compliance assessment in long-term treated Wilson’s disease by Harald Hefter, Max Novak, Dietmar Rosenthal, Sven G. Meuth, Tom Luedde, Philipp Albrecht, Philipp Albrecht, Christian J. Hartmann, Sara Samadzadeh, Sara Samadzadeh, Sara Samadzadeh, Sara Samadzadeh

“…Evidence is presented that butyrylcholinesterase (CHE) can be used as a sensitive biomarker to detect compliance problems in long-term treated WD-patients.MethodsFor the present retrospective, monocentric study demographical and treatment related data of 108 WD-patients (who had been treated at the Clinic of Neurology of the university hospital in Düsseldorf (Germany) between 2/2005 and 1/2021) were extracted from the charts. …”
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Qing-Luo-Yin Eases T Cells-Mediated Angiogenesis in Adjuvant-Induced Arthritis Rats by Activating PPAR&gamma; by Song MK, Wang MQ, Ruan YQ, Cui C, Chen WG, Olatunji OJ, Li Y, Zuo J

“…The study investigated if and how this property contributes to its anti-angiogenesis effects.Methods: Adjuvant-induced arthritis (AIA) rats were orally treated by QLY or rosiglitazone (a PPARγ agonist), and their monocytes and lymphocytes were co-cultured reciprocally in vitro with different sera. …”
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