Outperforming Traditional Staging: A Novel Nomogram for HR-Positive Breast Cancer by Liu C, Ding J, Xu J, Fang C, Zhang G, Shi C, Qiu F

“…Improved prognostic tools are needed to enhance individualized risk stratification.Materials and Methods: Clinical information from the Surveillance, Epidemiology, and End Results (SEER) database and the First Affiliated Hospital of Nanchang University were analyzed to evaluate outcomes across HR-positive BC subtypes. …”
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Effect of Machine Learning on Risk Stratification for Antiretroviral Treatment Failure in People Living with HIV by Zhang W, Ren L, Yang K, Yan J, Yu Q, Qi S, Ruan H, Zhao D, Ruan L

“…This study aims to develop and validate a nomogram-based scoring system to predict the incidence and determinants of virologic failure in people living with HIV (PLWH), facilitating timely interventions and reducing unnecessary transitions to second-line regimens.Methods: A total of 9879 patients with HIV/AIDS were included. …”
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The in vitro Activity of Omadacycline Alone and in Combination Against Carbapenem-Resistant Klebsiella pneumoniae by Du Y, Liu Y, Liu T, Pan F, Mu S, Zhu Y, Gao H, Jing X, Wang X, Liu Y, Wang S

“…Yingying Du,1– 3,* Yan Liu,4,* Tong Liu,1 Fen Pan,5 Shikui Mu,2 Yunlou Zhu,2 Hanlu Gao,2 Xin Jing,2 Xing Wang,6 Yuhao Liu,2 Sheng Wang1– 3 1Intensive Care Medical Center, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, People’s Republic of China; 2Department of Critical Care Medicine, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, 200072, People’s Republic of China; 3Key Laboratory of Pathogen-Host Interaction, Ministry of Education, Shanghai, 200092, People’s Republic of China; 4Department of Clinical Microbiology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, 200072, People’s Republic of China; 5Department of Laboratory Medicine, Children’s Hospital of Fudan University, National Children’s Medical Center, Shanghai, 200032, People’s Republic of China; 6Department of Laboratory Medicine, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yuhao Liu; Sheng Wang, Email lyh-7906@163.com; wangsheng@tongji.edu.cnObjective: This study aimed to evaluate the in vitro activity of omadacycline (OMC) and OMC-based combination therapy against carbapenem-resistant Klebsiella pneumoniae (CRKP).Methods: The broth microdilution assay assessed the in vitro susceptibility of CRKP to OMC. …”
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Nasal Symptoms Among Allergic Rhinitis Patients Could Contribute to Sexual Dysfunction by Zhang H, Zhang H, Jin P, Yu K, Zi X, Liang X, Zhang H, Zhao L

“…This study aimed to explore the relationship between the severity of nasal symptoms and sexual function in AR patients.Methods:  A case-control study involving 1034 AR patients and 422 healthy controls was conducted. …”
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Simulation-Based Evaluation of Large Language Models for Comorbidity Detection in Sleep Medicine – a Pilot Study on ChatGPT o1 Preview by Seifen C, Bahr-Hamm K, Gouveris H, Pordzik J, Blaikie A, Matthias C, Kuhn S, Buhr CR

“…Here, we investigate whether the novel LLM ChatGPT o1 preview can identify individual health risks or potentially existing comorbidities from the medical data of fictitious sleep medicine patients.Methods: We conducted a simulation-based study using 30 fictitious patients, designed to represent realistic variations in demographic and clinical parameters commonly seen in sleep medicine. …”
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A Longitudinal Dynamic Change in LMR Can Be a Biomarker for Recurrence in Fusobacterium Nucleatum-Positive Colorectal Cancer Patients by Chen S, Chang WH, Zhang J, Liu XY, Gao T, Qi XW, Cai DY, Mao Y, Lu TX

“…Shan Chen,1,* Wan-Hua Chang,2,* Jie Zhang,1,* Xiao-Yuan Liu,3,* Ting Gao,1 Xiao-Wei Qi,4 Dong-Yan Cai,1 Yong Mao,1 Ting-Xun Lu1 1Department of Oncology, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu Province, People’s Republic of China; 2Department of Gastroenterology, Huaian Hospital of Huaian City, Huai’an, Jiangsu Province, People’s Republic of China; 3Department of Clinical Pharmacy, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu Province, People’s Republic of China; 4Department of Pathology, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ting-Xun Lu, Department of Oncology, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu Province, People’s Republic of China, Email lutingxun@163.comPurpose: This study assessed lymphocyte-to-monocyte ratio (LMR) changes to predict postoperative recurrence in Fusobacterium nucleatum-positive (Fn-positive) CRC patients.Patients and Methods: Clinical information and paraffin tissue specimens were collected from a retrospective cohort of 332 patients. …”
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One- versus two-stage septic hip and knee revision surgery: a comparative cohort outcome study with short- to mid-term follow-up by M. M. J. Jacobs, P. J. C. Heesterbeek, K. Veerman, J. H. M. Goosen

“…</p> <p><strong>Materials and methods</strong>: We performed a retrospective cohort study, where equal numbers of one-stage and two-stage patients (knee: <span class="inline-formula"><i>n</i>=24</span>; hip: <span class="inline-formula"><i>n</i>=40</span>) were randomly included with the same inclusion and exclusion criteria. …”
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Predictors of diplopia following orbital fractures based on anatomical location, a retrospective cohort study by Honglin Chen, Yiqing Bao, Yuxin Chen, Yiqun Li, Peng Wu, Guohua Fan, Ji Zhang

“…Abstract Purpose This study aimed to identify predictors of diplopia following orbital fractures. Methods We retrospectively analyzed clinical and imaging data from 155 patients who experienced orbital fractures at our center between 2021 and 2023. …”
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Comparison of Ultrasound-Guided Thoracic Paravertebral Block Versus Thoracic Paravertebral Block Combined With Serratus Anterior Plane Block or Erector Spinae Block Following Video... by Zheng MM, Xie J, Tan W, Yuan CW, Qi DY, Sun J

“…Meng-Meng Zheng,1,&ast; Jue Xie,1,&ast; Wei Tan,2 Cong-Wang Yuan,1 Dun-Yi Qi,3 Jie Sun1,&ast; 1Department of Anesthesiology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, People’s Republic of China; 2Department of Anesthesiology, Yancheng Third People’s Hospital, Yancheng, People’s Republic of China; 3Department of Anesthesiology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Jie Sun, Department of Anesthesiology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, People’s Republic of China, Email dgsunjie@hotmail.comPurpose: Compared the efficacy of ultrasound-guided thoracic paravertebral block (TPVB) and thoracic paravertebral combined with serratus anterior plane block (SAPB) or erector spinae block (ESPB) following video-assisted thoracoscopic lobectomy(VATL).Patients and Methods: This retrospective study analyzed the medical records of 295 patients who underwent VATL surgery between August 2021 and January 2023. …”
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Correlation Between Tear Film Stability and Myopia in Children by Huang PW, Kuo YK, Chen NN, Li JH, Wu CH, Chen HM, Su KW, Sun CC

“…Pei-Wei Huang,1,2,&amp;ast; Yu-Kai Kuo,2,&amp;ast; Nan-Ni Chen,3 Ju-Hsien Li,2 Cheng‐Hsiu Wu,2 Ho-Min Chen,2 Kuan-Wen Su,4,5 Chi-Chin Sun2,6 1Department of Ophthalmology, Lo-Hsu Medical Foundation, Lotung Poh-Ai Hospital, Yilan, Taiwan; 2Department of Ophthalmology, Keelung Chang Gung Memorial Hospital, Keelung City, Taiwan; 3Department of Ophthalmology, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan; 4Department of Paediatrics, Keelung Chang Gung Memorial Hospital, Keelung City, Taiwan; 5Department of Paediatrics, College of Medicine, Chang Gung University, Taoyuan, Taiwan; 6Department of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan&amp;ast;These authors contributed equally to this workCorrespondence: Chi-Chin Sun, Department of Ophthalmology, Chang Gung Memorial Hospital, 222 Mai Chin Road, An Leh District, Keelung, Taiwan, Email chichinsun@gmail.comPurpose: To investigate the correlation between dry eye and myopia in Taiwanese school children.Methods: This retrospective cohort study enrolled children aged 5– 14-years-old between January 2021 and April 2022. …”
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Association of MTMR3 rs12537 at miR-181a Binding Site with Ischemic Stroke in Southern Chinese Han Population by Chen L, Wei S, Zhang Y, Li Y, Li Z, Huang P, Xiao C, Zhang Y

“…This research examined the potential association between the SNP rs12537 in the miRNA-181a binding location within the 3′ untranslated region (3′-UTR) of MTMR3 and the incidence and prognosis of IS.Methods: An improved multitemperature ligase detection reaction assay was used to perform genotyping analysis in two independent case-control datasets consisting of 1128 subjects with IS and 1140 healthy controls with matched ages.Results: The distribution frequencies of the T allele (p = 5.2× 10− 4) of SNP rs12537 in MTMR3 were elevated significantly in IS patients as compared to healthy controls. …”
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Cholinesterase Inhibitor Reveals Synergistic Potential for Neural Stem Cell-Based Therapy in the 5xFAD Mouse Model of Alzheimer&rsquo;s Disease by Wu CC, Lee YK, Tsai JK, Su YT, Ho YC, Chu TH, Chen KT, Chang CL, Chen JS

“…This study aimed to determine if combining ChEI treatment with stem cell therapy could improve therapeutic outcomes.Methods: Neural stem cells (NSCs) were injected into the hippocampus of the 5xFAD AD mice using a stereotactic technique. …”
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Establishing a Prediction Model for Weight Loss Outcomes After LSG in Chinese Obese Patients with BMI &amp;ge; 32.5 Kg/m2 Using Body Composition Data by Wang L, Sun Y, Sang Q, Wang Z, Yu C, Li Z, Shang M, Zhang N, Du D

“…However, suboptimal results are observed in certain patients.Objective: Drawing from body composition data at our center, clinically accessible predictive factors for weight loss outcomes were identified, leading to the development and validation of a preoperative predictive model for weight loss following LSG.Methods and Materials: A retrospective analysis was conducted on the general clinical baseline and body composition data of obese patients (body mass index [BMI] ≥ 32.5 kg/m2) who underwent LSG between December 2016 and December 2022. …”
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Increment of Skeletal Muscle Mass Predicts Survival Benefit for Hepatocellular Carcinoma Treated with Transarterial Chemoembolization Combining Molecular Targeted Agents and Immune... by Chen W, Yan HT, Zhang JX, Shen X, Liu J, Liu S, Shi HB, Ding Y, Zu QQ

“…Wen Chen,1,&ast; Hai-Tao Yan,1,&ast; Jin-Xing Zhang,1 Xiao Shen,1 Jin Liu,2 Sheng Liu,1 Hai-Bin Shi,1 Ye Ding,3 Qing-Quan Zu1 1Department of Interventional Radiology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, People’s Republic of China; 2Department of Clinical Medicine Research Institution, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, People’s Republic of China; 3Department of Maternal, Child and Adolescent Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Ye Ding, Department of Maternal, Child and Adolescent Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, People’s Republic of China, Tel +86-025-8686-8459, Email dingye@njmu.edu.cn Qing-Quan Zu, Department of Interventional Radiology, The First Affiliated Hospital with Nanjing Medical University, No. 300, Guangzhou Road, Nanjing, 210029, People’s Republic of China, Tel +86-13913807470, Email zuqingquan@njmu.edu.cnPurpose: To assess the relationship between clinical prognosis and changes of skeletal muscle mass for unresectable hepatocellular carcinoma (uHCC) patients who received transarterial chemoembolization (TACE) with molecular-targeted agents and immune checkpoint inhibitors (TACE-MTAs-ICIs).Methods: From June 2019 to June 2023, a total of 92 uHCC patients who received TACE-MTAs-ICIs therapy were included. …”
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Feasibility and Safety of Anlotinib Plus Docetaxel versus Docetaxel Monotherapy in Patients with Previously Immunotherapy-Treated NSCLC: A Retrospective Exploratory Study by Li DW, Li YD, Jin H

“…Da-Wei Li,1,&ast; Ying-Dong Li,2,&ast; Hong Jin3 1Department of Prescription Teaching and Research, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, 150006, People’s Republic of China; 2Department of Intensive Care Rehabilitation, The Fourth Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, 150070, People’s Republic of China; 3Department of Acupuncture, The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, 150040, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Hong Jin, Department of Acupuncture, The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, No. 26, He Ping Street, Xiang Fang District, Harbin, Heilongjiang, 150040, People’s Republic of China, Tel +86 13836129681, Email 9937200@qq.comObjective: This study aims to evaluate the efficacy and safety of anlotinib plus docetaxel in patients with advanced non-small cell lung cancer (NSCLC) who have previously treated with immunotherapy.Methods: This retrospective analysis was conducted on 86 previously immunotherapy-treated patients with advanced NSCLC from December 2018 to October 2024 in clinical practice. …”
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Time-Course Renal and Pulmonary Injury Analysis and Bioinformatics Screening of Core Pathogenic Genes and Immune Cell Infiltration Patterns in a Sepsis by Apizi A, Li J, Kamilijiang P, Yang CB, Wang ZK, Chai RF, Yu ZX

“…Anwaier Apizi,&amp;ast; Jian Li,&amp;ast; Paiheriding Kamilijiang, Chun-Bo Yang, Zheng-Kai Wang, Rui-Feng Chai, Zhao-Xia Yu Department of Intensive Care Unit, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Zhao-Xia Yu, Department of Intensive Care Unit, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, People’s Republic of China, Tel +86 13899858397, Email zhaoxia_yu01@126.com Rui-Feng Chai, Department of Intensive Care Unit, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, People’s Republic of China, Tel +86 13999819217, Email chairuifeng_chai@126.comObjective: This study aimed to evaluate the extent of organ damage associated with sepsis and to identify key genes implicated in its pathogenesis.Methods: Eighteen rats were randomized into experimental and control groups. …”
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Diabetes mellitus as an economic problem in Russian Federation by Ivan Ivanovich Dedov, Vitaliy Vladimirovich Omelyanovskiy, Marina Vladimirovna Shestakova, Maria Vladimirovna Avksentieva, Viktoria Igorevna Ignatieva

“…Objective.To estimate annual expenditures attributed to diabetes mellitus (DM) per patient in Russia based on data from epidemiologic studies and to analyse DM cost drivers.Methods.The expenditures per diabetic patient were calculated as the sum of medical costs (outpatient and emergency room visits, inpatient care and medications provided during outpatient care), payments for sick leaves, disability pensions and gross domestic production (GDP) losses due to temporary disability (indirect costs). …”
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Therapeutic Innovations in Nanomedicine: Exploring the Potential of Magnetotactic Bacteria and Bacterial Magnetosomes by Yadav VK, Pramanik S, Alghamdi S, Atwah B, Qusty NF, Babalghith AO, Solanki VS, Agarwal N, Gupta N, Niazi P, Patel A, Choudhary N, Zairov R

“…Further authors have reviewed the various functionalization methods of the magnetosomes for cancer treatment. …”
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Trends and Hospitalization Outcomes of Tetanus Cases: A Multicenter Retrospective Study in Suzhou, 2013&ndash;2023 by Yu J, Zheng B, Liu N, Zhu Y, Hui F, Zhang J, Luan L

“…Jiangtao Yu,1,&ast; Benfeng Zheng,2,&ast; Na Liu,2,3 Yiheng Zhu,4 Fen Hui,5 Jin Zhang,5 Lin Luan1,2 1Department of Epidemiology, School of Public Health, National Vaccine Innovation Platform, Nanjing Medical University, Nanjing, 210000, People’s Republic of China; 2Department of Immunization Program, Suzhou Center for Disease Control and Prevention, Suzhou, 215000, People’s Republic of China; 3Center for Immunization Planning, Chinese Center for Disease Control and Prevention, Beijing, 100050, People’s Republic of China; 4Suzhou Municipal Health Commission, Suzhou, 215000, People’s Republic of China; 5The Fifth People’s Hospital of Suzhou, Suzhou, 215000, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Lin Luan, Email szluanlin@163.comObjective: To investigate the epidemiology, and hospitalization of tetanus in Suzhou, Jiangsu Province, China, focusing on the severity of the disease, treatment, outcomes and hospitalization costs, and to explore the risk factors for severe tetanus.Methods: This retrospective, multicenter observational study analyzed tetanus patients admitted to various medical institutions between 2013 and 2023. …”
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Clinicopathological Features and Prognostic Factors of Renal Cell Carcinoma in Young Patients Under 45 Years: A Single-Center Retrospective Study by Gao Y, Yan H, Zhang T, Lu G, Ma L

“…Yu Gao,1,&amp;ast; Haisheng Yan,2,&amp;ast; Tao Zhang,2 Guanjun Lu,1 Lianghong Ma1,3 1Urology Department of General Hospital of Ningxia Medical University, Yinchuan, 750004, People’s Republic of China; 2The First Clinical Medical College, Ningxia Medical University, Yinchuan, 750004, People’s Republic of China; 3Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, 750004, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Lianghong Ma, Email mmm1770@163.comObjective: To explore the clinicopathological characteristics, diagnostic approaches, and therapeutic strategies for renal cell carcinoma (RCC) in young patients under 45 years of age, aiming to provide insights for early detection and improved prognosis.Methods: We retrospectively analyzed the clinical data of 150 RCC patients aged 18 to 45 years treated at the General Hospital of Ningxia Medical University from 2011 to 2023. …”
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