Trends in Global Burden of Alzheimer’s Disease and Other Dementias Attributable to High Fasting Plasma Glucose, 1990–2021 by Irena Ilic, Vladimir Jakovljevic, Ivana Zivanovic Macuzic, Ana Ravic-Nikolic, Milena Ilic, Marija Sorak, Vesna Milicic

“…This study aimed to assess the global burden of Alzheimer’s disease and other dementias attributable to high fasting plasma glucose in the last decades. <i>Materials and Methods</i>: A descriptive epidemiological study was conducted. …”
Get full text

miR-21-5p Enriched Exosomes from Human Embryonic Stem Cells Promote Osteogenesis via YAP1 Modulation by Huang X, Zhao Z, Zhan W, Deng M, Wu X, Chen Z, Xie J, Ye W, Zhao M, Chu J

“…Xinqia Huang,1,&ast; Ziquan Zhao,1,&ast; Weiqiang Zhan,1 Mingzhu Deng,1 Xuyang Wu,1 Zhoutao Chen,1 Jiahao Xie,2 Wei Ye,3 Mingyan Zhao,1,4 Jiaqi Chu3,4 1Orthopaedic Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, 524001, People’s Republic of China; 2Department of Dermatology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, 524001, People’s Republic of China; 3Department of Obstetrics and Gynecology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, 524001, People’s Republic of China; 4Stem Cell Research and Cellular Therapy Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, 524001, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Jiaqi Chu; Mingyan Zhao, Affiliated Hospital of Guangdong Medical University, No. 57 Renmin Avenue South Road, Zhanjiang, Guangdong, 524001, People’s Republic of China, Email chujiaqi@gdmu.edu.cn; mingyan.zhao@gdmu.edu.cnPurpose: To investigate the osteogenic potential of human embryonic stem cell-derived exosomes (hESC-Exos) and their effects on the differentiation of human umbilical cord mesenchymal stem cells (hUCMSCs).Methods: hESC-Exos were isolated and characterized using transmission electron microscopy (TEM), nanoparticle tracking analysis (NTA), and Western blotting. hUCMSCs were cultured with hESC-Exos to assess osteogenic differentiation through alizarin red staining, quantitative PCR (qPCR), and Western blotting. miRNA profiling of hESC-Exos was performed using miRNA microarray analysis. …”
Get full text

The Impact of Exercise Training on the Brain and Cognition in Type 2 Diabetes, and its Physiological Mediators: A Systematic Review by Jitske Vandersmissen, Ilse Dewachter, Koen Cuypers, Dominique Hansen

“…Resistance and endurance exercise were found to be equally effective for achieving cognitive improvement. …”
Get full text

Ethyl Acetate Extract of Elsholtzia bodinieri Vaniot Attenuates Oxidative Stress in ALI Mice by Yin H, Hu J, Li Y, Feng Y, Li Z, Sun R, Tian L, Li Y

“…This study was carried to investigate the role and mechanisms of EBE ethyl acetate extract (EBEE) against oxidative stress in ALI.Methods: By multiple bioinformatics analysis, AGER and ITGB2 were found to be the potential target genes of EBEE against oxidative stress in ALI. …”
Get full text

NLRP3 Mediates NOXs-Induced Iron Overload and Inflammation but Not Oxidative Damage in Colons of DSS-Treated Mice by Yu L, Wang M, Zhou Y, Qi J, Zheng Q, Song Z

“…Here, we investigated the effects of chemical inhibition of NOXs and NLRP3 activity on colonic iron metabolism and inflammatory reactions in a murine model of dextran sodium sulfate (DSS)-induced ulcerative colitis.Methods: The mice were randomly divided into five groups: normal control group, DSS-induced ulcerative colitis model group (DSS), DSS + Dapansutrile group, DSS + Diphenyleneiodonium chloride group, and DSS + Dapansutrile + Diphenyleneiodonium chloride group. …”
Get full text

Intrathecal Morphine and Ropivacaine for Quality of Recovery After Laparoscopic Colorectal Surgery: A Randomized Controlled Trial by Yang Y, Lin W, Zhuo Y, Luo Y, Wu X, Li J, Yao Y

“…This study aimed to evaluate this combination’s effect on recovery outcomes after laparoscopic colorectal surgery.Patients and Methods: In this randomized, double-blind, placebo-controlled trial, 78 patients undergoing laparoscopic colorectal surgery received either preservative-free intrathecal morphine 250 μg with ropivacaine 15 mg (Intrathecal group) or a sham subcutaneous saline injection (Control group). …”
Get full text

Involvement in Parasocial Relationships among Middle-Aged Women by A.M. Molokostova, M.N. Kosmacheva

“…Women who feel lonely, as well as those who do not feel lonely, are equally prone to becoming involved in parasocial relationships. …”
Get full text

Risk Factors for Pleural Reaction in CT-Guided Percutaneous Lung Nodule Localization: A Single-Center Retrospective Study by Zhou N, Feng N, Jiao Z, Shi X, Wang T, Zhao G

“…This study aims to identify the risk factors associated with PR in CT-guided percutaneous lung nodule localization (CT-PLNL) procedures.Methods: This retrospective study included 467 patients who underwent video-assisted thoracic surgery (VATS) at Nanjing Drum Tower Hospital between January 2022 and December 2023, all of whom had received CT-PLNL. …”
Get full text

Biometry and Intraocular Lens Power Calculation by Combined Scheimpflug-Placido Disc versus Optical Interferometry Devices by Mehlan Juliane, Lehman Anne-Isabel, Cichocki Myriam, Druchkiv Vasyl, Katz Toam, Stephan J Linke

“…Abstract Purpose: To compare the results of the current gold standard, laser interferometry, and keratometry by the IOL-Master, with a newly developed Galilei G6 using raytracing software Okulix for intraocular lens (IOL) power calculations. Methods: For comparison of the IOL-power calculation of both devices, we analyzed the difference between the actual one-month postoperative subjective refraction and the theoretically calculated target refraction before cataract surgery. …”
Get full text

Correlation Between Serum Creatinine-to-Cystatin C Ratio and Prognosis of Patients with Hip Fracture by Lu W, Rao M, Jia F, Chen W, Li B, Bian J, Wang J

“…Wenbin Lu,&amp;ast; Miaomiao Rao,&amp;ast; Fan Jia,&amp;ast; Wubin Chen, Bin Li, Jinjun Bian, Jiafeng Wang Faculty of Anesthesiology, Changhai Hospital, Naval Military Medical University, Shanghai, 200433, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Jinjun Bian; Faculty of Anesthesiology, Changhai Hospital, Naval Military Medical University, 168, Changhai Road, Shanghai, 200433, People’s Republic of China, Tel/Fax +86-021-31161841, Email jinjunbicu@163.com Jiafeng Wang, Faculty of Anesthesiology, Changhai Hospital, Naval Military Medical University, 168, Changhai Road, Shanghai, 200433, People’s Republic of China, Tel/Fax +86-021-31161886, Email jfwang@smmu.edu.cnObjective: This study aimed to investigate the association between the serum creatinine-to-cystatin C ratio (CCR) and the prognosis of patients with hip fracture.Methods: This retrospective cohort study included patients who underwent hip fracture surgery at a tertiary hospital in China between January 2018 and December 2023. …”
Get full text

Decreased risk of chronic fatigue syndrome following influenza vaccine: a 20-year population-based retrospective study by Hsun Chang, Wei-Cheng Yao, Teng-Shun Yu, Heng-Jun Lin, Fuu-Jen Tsai, Shinn-Ying Ho, Chien-Feng Kuo, Shin-Yi Tsai

“…An equal number of participants without influenza were also identified. …”
Get full text

Impact of Laboratory-Derived Frailty Index on Clinical Outcomes in Critical Care Patients with COPD: A Retrospective Analysis Using the MIMIC-IV Database by Zhou Z, He Y, Wang Q, Li J, Yu Y

“…This research aims to investigate the relationship between the physiological and laboratory - based frailty index (FI - Lab) and mortality among critical care patients with COPD.Methods: The FI-Lab was constructed using 33 items. …”
Get full text

Enhanced in vivo Stability and Antitumor Efficacy of PEGylated Liposomes of Paclitaxel Palmitate Prodrug by Wu X, Wang X, Zhang H, Chen H, He H, Lu Y, Tai Z, Chen J, Wu W

“…This study aimed to propose a straightforward and efficient approach to enhance PTX loading and stability, thereby offering insights for targeted therapy against tumors.Patients and Methods: We synthesized a paclitaxel palmitate (PTX-PA) prodrug by conjugating palmitic acid (PA) to PTX and encapsulating it into liposomal vehicles using a nano delivery system. …”
Get full text

The Predictive Value of Absolute Lymphocyte Count and T Cell Subpopulations for Sepsis Prognosis by Jia X, Li X, Miao L, Bao R, Xiong H, You R, Lu Y, Gui X, Qu C

“…This study aims to explore immunologic parameters associated with sepsis prognosis, potentially identifying patients who may benefit from immunotherapy, improving intensive care survival.Methods: A total of 65 patients with sepsis from the Department of Emergency Medicine were divided based on survival at 28 days (47 in the survival group, 18 in the non-survival group). …”
Get full text

Mucoadhesive Mini-Containers with Unidirectional Drug Release Capacity for Macromolecular Therapeutics by Han CS, Choi YR, Jung WY, Kang JH, Kim DW, Park CW

“…To address these barriers, we have designed a novel mini-container system with unidirectional drug release and enhanced mucoadhesion capacities.Methods: Mini-containers composed of ethyl cellulose shells of varying degrees of viscosity were fabricated using a simple molding process and integrated with catechol-conjugated chitosan (CC) to improve their mucosal adhesion capacity and structural stability.Results: The catechol substitution levels were optimized (CC-A, CC-B, and CC-C), with the CC-C formulation exhibiting the highest degree of substitution (20.93%) and superior adhesion capacity, maintaining 80% attachment on porcine small intestinal mucosa after 72 h. …”
Get full text

Effects of Various Transfer Strategies of Frozen-Thawed Cleavage-Stage and Blastocyst Embryos on Pregnancy and Neonatal Outcomes in Different Age Groups by Jiang J, Wu X, Sun H, Han L, Zhang X, Liu C, Wang Y, Li Q

“…Jianxi Jiang,&ast; Xiaohan Wu,&ast; Hongliang Sun, Lei Han, Xianghui Zhang, Chunjiao Liu, Yanlin Wang, Qingchun Li Department of Reproductive Medicine, Binzhou Medical University Hospital, Binzhou, Shandong, 256603, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Qingchun Li, Department of Reproductive Medicine, Binzhou Medical University Hospital, Binzhou, Shandong, 256603, People’s Republic of China, Tel +05433258715, Email liqc1@126.com Yanlin Wang, Department of Reproductive Medicine, Binzhou Medical University Hospital, Binzhou, Shandong, 256603, People’s Republic of China, Tel +05433258713, Email docylwang2003@126.comObjective: The aim of this study is to assess the impact of different embryo transfer strategies, focusing on cleavage-stage embryos and blastocysts, on pregnancy and neonatal outcomes in frozen-thawed embryo transfer (FET) cycles among women < 35 years old and ≥ 35 years old.Methods: A retrospective cohort analysis of 3,065 FET cycles performed between April 2015 and October 2022 categorized patients into seven groups by embryo morphology, quality, and quantity: single/double high-quality cleavage (A/B), single/double high-quality blastocyst (C/D), single/double poor-quality blastocyst (E/F), and mixed-quality blastocyst (G). …”
Get full text

Varenicline Solution Nasal Spray for the Treatment of Dry Eye Disease in Sjogren&rsquo;s Disease: A Pilot Study by Gupta AS, Linaburg TJ, Iacobucci E, Augello PA, Qin VL, Ying GS, Bunya VY, Massaro M

“…Angela S Gupta,1,&ast; Taylor J Linaburg,1,&ast; Emma Iacobucci,1 Patrick A Augello,2 Vivian L Qin,3 Gui-Shuang Ying,1,2 Vatinee Y Bunya,1 Mina Massaro1 1Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA, USA; 2Department of Ophthalmology, Center for Preventive Ophthalmology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; 3Department of Ophthalmology, University of California Los Angeles, Los Angeles, CA, USA&ast;These authors contributed equally to this workCorrespondence: Taylor J Linaburg, Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania, 51 N. 39th St, Philadelphia, PA, 19104, USA, Tel +1 412 576 – 7668, Email Taylor.Linaburg@pennmedicine.upenn.eduPurpose: We evaluated the efficacy of varenicline solution nasal spray (VNS) in treating dry eye disease (DED) associated with moderate to severe Sjogren’s disease and analyzed tear film cytokine levels of patients with DED and Sjogren’s disease before and after VNS use.Methods: This was a pilot study involving a single-center, single-arm investigator-initiated trial. …”
Get full text

Development of a Ferritin-Based Nano-Allergen and Its Immunological Effects in vitro and in vivo by Zhou D, Ren Y, Zhou Y, Liao Y, Cheng Q, Chen J, Yuan C, Zeng D, Cui Y

“…Dongmei Zhou,1,&amp;ast; Yaning Ren,1,&amp;ast; Ying Zhou,2 Yuanfen Liao,1 Qi Cheng,1 Jinni Chen,3 Cunyin Yuan,1 Dan Zeng,4 Yubao Cui1 1Clinical Research Center, The Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi, 214023, People’s Republic of China; 2Department of Pediatrics Laboratory, The Affiliated Children´s Hospital of Jiangnan University, Wuxi, 214023, People’s Republic of China; 3Department of Respiratory, Hainan Women and Children’s Medical Center, Affiliated Pediatrics Clinical College of Hainan Medical University, Haikou, 570100, People’s Republic of China; 4Department of Allergy, Chongqing General Hospital, Chongqing University, Chongqing, 401147, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Yubao Cui; Dan Zeng, Email ybcui1975@hotmail.com; zengdan@cqu.edu.cnIntroduction: We aimed to develop recombinant allergens on the nanoscale by using self-assembly property of ferritin and to investigate their immune response and protective effect.Methods: The cDNA encoding Ftn-Blo t 2 was synthesized and cloned into pET-21a (+) vector, then expressed in E. coli BL21 (DE3). …”
Get full text

Neonatal Hearing Loss Risk Factors and miRNA Biomarkers Identified Through AABR Screening by Huang M, Jing Y, Peng X, Xie J, Zhao Q, Yin JL, Xiao WD, Zhao SJ, Tian HJ

“…Min Huang,1,&amp;ast; Yunlong Jing,1,&amp;ast; Xiangyue Peng,1 Jiang Xie,1 Qin Zhao,1 Jiang-Long Yin,1 Wen-Du Xiao,1 Si-Jun Zhao,1 Hong-Ju Tian2 1Department of Otorhinolaryngology, Head and Neck Surgery, The Affiliated Children’s Hospital, Xiangya School of Medicine, Central South University (Hunan Children’s Hospital), Changsha, Hunan, 410007, People’s Republic of China; 2Obstetrics and Gynecology Center of Hunan Occupational Disease Prevention and Control Institute, Changsha, 410007, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Si-Jun Zhao, Department of Otorhinolaryngology, Head and Neck Surgery, The Affiliated Children’s Hospital, Xiangya School of Medicine, Central South University (Hunan Children’s Hospital), Yuhua District, Changsha, 410007, People’s Republic of China, Tel +86 073185356311, Fax +86073185356666, Email zhao_sijun@126.com Hong-Ju Tian, Obstetrics and Gynecology Center of Hunan Occupational Disease Prevention and Control Institute, Yuhua District, Changsha City, Hunan Province, 410007, People’s Republic of China, Tel +86 85303109, Fax +86 85534673, Email tianhongju713@outlook.comObjective: To determine the prevalence of hearing impairment in neonates and identify associated risk factors through auditory brainstem response (ABR) screening.Study Design: A prospective observational longitudinal study was conducted involving 158 infants, with Automated Auditory Brainstem Response (AABR) evaluations performed by 6 months of age.Setting: The study was undertaken in a hospital-based neonatal care unit.Methods: Infants with significant hearing loss in one or both ears were referred for further assessment and rehabilitation. …”
Get full text

Comprehensive Analysis of Pathogen Diversity and Diagnostic Biomarkers in Patients with Suspected Pulmonary Tuberculosis Through Metagenomic Next-Generation Sequencing by Li Y, Li C, Fang Y, Zhang L, Ying X, Ren R, Zang Y, Ying D, Zhu S, Liu J, Cao X

“…., Ltd, Hangzhou, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Yuecui Li, Department of Infectious Disease, The First People’s Hospital of Yongkang, affiliated to Hangzhou Medical College, 599 Jinshan West Road, Jinhua, 321300, People’s Republic of China, Email yklycwh@126.com Xuefang Cao, MatriDx Biotechnology Co., Ltd, Hangzhou, 311112, People’s Republic of China, Email xfczju@163.comBackground: This study aimed to investigate the co-infecting pathogens and lung microbiomes in patients with clinically confirmed pulmonary tuberculosis (TB) and explore potential diagnostic biomarkers to differentiate between varied infection patterns.Methods: We conducted a retrospective cohort study by analyzing 198 bronchoalveolar lavage fluid (BALF) samples collected from patients with suspected pulmonary TB. …”
Get full text