Cancer-Derived Exosomal LINC01615 Induces M2 Polarization of Tumor-Associated Macrophages via RBMX-EZH2 Axis to Promote Colorectal Cancer Progression by Li A, Hong J, Ma X, Huang Y, Jiang Q, Zhang C, Wang Y, Huang Y

“…However, the specific role of cancer derived exosomal lncRNA in the M2 polarization of macrophages remains largely unknown.Methods: Bioinformatic analysis was used to screen out the differentially expressed lncRNAs in colorectal cancer (CRC). …”
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Auxiliary Diagnosis of Pulmonary Nodules’ Benignancy and Malignancy Based on Machine Learning: A Retrospective Study by Wang W, Yang B, Wu H, Che H, Tong Y, Zhang B, Liu H, Chen Y

“…Its nonspecific clinical presentation and heterogeneous imaging characteristics hinder accurate differentiation between benign and malignant lesions, while biopsy’s invasiveness and procedural constraints underscore the critical need for non-invasive early diagnostic approaches.Methods: In this retrospective study, we analyzed outpatient and inpatient records from the First Medical Center of Chinese PLA General Hospital between 2011 and 2021, focusing on pulmonary nodules measuring 5– 30mm on CT scans without overt signs of malignancy. …”
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Prediction of Abnormal Functional Performance in Chronic Obstructive Pulmonary Disease Using Respiratory Models: A Pilot Study by Ribeiro CO, Lopes AJ, de Melo PL

“…Caroline Oliveira Ribeiro,1,* Agnaldo José Lopes,2,* Pedro Lopes de Melo1,3,* 1Biomedical Instrumentation Laboratory - Institute of Biology and Faculty of Engineering, State University of Rio de Janeiro, Rio de Janeiro, Brazil; 2Pulmonary Function Laboratory, State University of Rio de Janeiro, Rio de Janeiro, Brazil; 3BioVasc Research Laboratory - Institute of Biology, State University of Rio de Janeiro, Rio de Janeiro, Brazil*These authors contributed equally to this workCorrespondence: Pedro Lopes de Melo, Email plopes@uerj.brIntroduction: The contribution of respiratory models to understanding and predicting functional capacity abnormalities in chronic obstructive pulmonary disease (COPD) has not yet been investigated.Purpose: The aims of this study were: (1) To investigate the associations between the extended Resistance-Inertance-Compliance (eRIC) and the fractional-order (FrOr) models with changes in Glittre-ADL and handgrip tests and; (2) To evaluate the accuracy of these models in predicting abnormal functional capacity in COPD.Patients and Methods: The study was carried out in a group of 40 adults with COPD and a control group of 40 healthy individuals, both evaluated by respiratory oscillometry, spirometry, Glittre-ADL test and handgrip test. eRIC and fractional order models were also used to quantify biomechanical changes and obtain physiological information. …”
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Prevalence of Urinary Incontinence, Risk Factors and Its Impact: Multivariate Analysis from Indonesian Nationwide Survey by Rochani Sumardi, Chaidir A Mochtar, Junizaf Junizaf, Budi I Santoso, Siti Setiati, Siti A Nuhonni, Partini P Trihono, Harrina E Rahardjo, Firtantyo A Syahputra

“… Aim: to describe the profile of urinary infection (UI) and to analyze its risk factors and impacts. Methods: subjects were enrolled consecutively from pediatric, urology, obstetrics & gynecology, and geriatric outpatient clinics at six teaching hospitals in various regions of Indonesia. …”
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Exploring Mechanisms of Lang Qing Ata in Non-Alcoholic Steatohepatitis Based on Metabolomics, Network Pharmacological Analysis, and Experimental Validation by Li S, Zhu H, Zhai Q, Hou Y, Yang Y, Lan H, Jiang M, Xuan J

“…However, the therapeutic effects and potential mechanisms of Lang Qing Ata (LQAtta) against NASH remain elusive.Materials and Methods: The components of LQAtta were identified using Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry (UHPLC-MS/MS). …”
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Impact of Radiation Therapy Techniques on Hippocampal Doses and Psychological Status in Patients With Nasopharyngeal Carcinoma by Gai X, Huang S, Zeng J, Chen J, Liu F, Li S, Lv W, Guo F, Cai C, Hong J, Su L

“…Xiujuan Gai,1– 3,* Shiqi Huang,1,2,* Jiang Zeng,1,2,4 Jun Chen,1,2,4 Feng Liu,1,2,4 Shan Li,1,2,4 Wenlong Lv,1,2,4 Feibao Guo,1,2,4 Chuanshu Cai,1,2,4 Jinsheng Hong,1,2,4 Li Su1,2,4 1Department of Radiotherapy, Cancer Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, People’s Republic of China; 2Department of Radiotherapy, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical Universisty, Fuzhou, Fujian, 350212, People’s Republic of China; 3Department of Oncology, Laiyang Central Hospital of Yantai, Yantai, 265200, People’s Republic of China; 4Key Laboratory of Radiation Biology of Fujian Higher Education Institutions, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, People’s Republic of China*These authors contributed equally to this workCorrespondence: Li Su; Jinsheng Hong, Department of Radiotherapy, Cancer Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, People’s Republic of China, Email lily2230@126.com; 13799375732@163.comPurpose: To investigate the impact of Intensity-Modulated Radiation Therapy (IMRT) and Volumetric Modulated Arc Therapy (VMAT) on hippocampal radiation dosage and psychological status in patients newly diagnosed with nasopharyngeal carcinoma (NPC).Patients and Methods: A retrospective analysis was conducted on 269 NPC patients who received initial treatment between January 2013 and April 2022. …”
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Phytosomes Loaded with Mastoparan-M Represent a Novel Strategy for Breast Cancer Treatment by Zhao H, Bao S, Chen S, Yang Q, Lou K, Gai Y, Lin J, Liu C, Liu H, Zhang C, Yang R

“…Furthermore, we investigated the underlying anti-tumor mechanisms of Mast-M.Methods: The synthesis of Phy-Mast-M involved a co-solvent technique, followed by solvent evaporation. …”
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Age, Sex, and Symptom-Dependent Variations in Total IgE and Eosinophils in Atopic Patients: A Five-Year Retrospective Study by Zhao L, Wu Y, Zhu H, Lin Y, Su H, Hu J, Zhang M, Bao W

“…Age, sex and allergic symptoms may influence these biomarkers and the relationship among t-IgE, eosinophils, and atopic diseases remained unknown.Methods: A five-year retrospective study enrolled 7654 patients with allergic symptoms underwent allergen testing. …”
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Anatomical Location of the Segmental Spinal Arteries in the Cervical Intervertebral Foramina: 3D-Micro CT Findings Relevant to Transforaminal Epidural Injection by Jun B, Yang HM, Shin DA, Jung HH, Cho TH, Kim SH

“…This study analyzed the precise anatomical location of the segmental spinal artery (SSA) within the cervical IVF using 3D micro-CT imaging to provide guidance for safer TFESI procedures.Participants and Methods: Fourteen embalmed cadavers were used in this study: three for serial sectional dissection, two for histological examination, and nine for micro-CT analysis. …”
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Comparison of Effects of Glucagon-Like Peptide-1 Receptor Agonists Compared to Long-Acting Insulin, Added to Oral Anti-Diabetic Agents on Self-Management Behaviors, Anxiety, and Sl... by Song X, Yang X, Liu Q, Bian X, Gao L, Tao J

“…Xiaoqing Song,1– 3,* Xueke Yang,1– 4,* Qinghua Liu,1– 4 Xuna Bian,1– 4 Lianlian Gao,1– 4 Jing Tao1– 4 1Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, People’s Republic of China; 2Hubei Clinical Medical Research Center for Endocrinology and Metabolic Diseases, Wuhan, Hubei Province, People’s Republic of China; 3Branch of National Clinical Research Center for Metabolic Disease, Wuhan, Hubei Province, People’s Republic of China; 4Department of Nursing, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lianlian Gao; Jing Tao, Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Road, Wuhan, Hubei, 430030, People’s Republic of China, Email gll821991@163.com; tjskc@126.comAim: This study aimed to investigate the impact of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on individuals with type 2 diabetes (T2DM) by comparing self-management behaviors, anxiety, and sleep quality in T2DM patients.Methods: This is a single-center prospective study. …”
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Global, Regional and National Burden of Low Back Pain in Adolescents Aged 10–19 years, 1990–2021: A Systematic Analysis of the Global Burden of Disease Study 20... by Wang S, Zhang S, Li M, Chen S, Chen Y, Song Y, Zhang X

“…Shuang Wang,1,* Shouyao Zhang,1,* Min Li,1 Suyu Chen,1 Yiping Chen,1 Yongli Song,2 Xinghe Zhang1 1Second Clinical Medical College/Second Affiliated Hospital, Yunnan University of Chinese Medicine, Kunming, 650000, People’s Republic of China; 2School of Basic Medicine, Yunnan University of Chinese Medicine, Kunming, 650000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xinghe Zhang, Second Clinical Medical College/Second Affiliated Hospital, Yunnan University of Chinese Medicine, Kunming, 650000, People’s Republic of China, Tel +86 0871 6595 4563, Email doczhangxh@163.comObjective: To comprehensively analyze the levels and trends of low back pain (LBP) prevalence, incidence, and years lived with disability (YLDs) among adolescents aged 10– 19 globally from 1990 to 2021, stratified by sex and the Socio - Demographic Index (SDI), and analyze the risk factors.Summary of Background Data: LBP affects adolescents, but its global burden and trends among this age group need exploration.Methods: Estimations were carried out using the Bayesian meta-regression tool, DisMod-MR(Disease Modeling Meta-Regression) 2.1. …”
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Application of Impulse Oscillometry Combined with Fractional Exhaled Nitric Oxide in Monitoring Asthma Control Levels in Children by Hu J, Fan Y, Luo R, Li Q, Ai T, Wang L

“…Jie Hu, Yinghong Fan, Ronghua Luo, Qianqian Li, Tao Ai,* Li Wang* Department of Pediatric Respiratory Medicine, Chengdu Women’s and Children’s Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Tao Ai; Li Wang, Department of Pediatric Respiratory Medicine, Chengdu Women’s and Children’s Central Hospital, School of Medicine, University of Electronic Science and Technology of China, 1617 Riyue Avenue Section 1 Qingyang District, Chengdu, Sichuan, 610000, People’s Republic of China, Tel +8613981931891 ; +8618908015531, Email ait1108@163.com; 625664758@qq.comPurpose: To investigate whether Impulse Oscillometry (IOS) could more effectively monitor children with uncontrolled asthma and evaluate small airway function changes, while establishing a prediction model in combination with fractional exhaled nitric oxide (FeNO) to assist in clinical management and treatment of asthmatic children.Patients and Methods: A retrospective study was conducted on 203 asthmatic children who were followed up in our hospital from August 2023 to August 2024. …”
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Profiles of Deceased Patients with Coronavirus Disease 2019 (COVID-19) and Multidrug-Resistant Bacterial Coinfections at an Indonesian Tertiary Hospital by Joedhistira Bayu Firmansyah, Musofa Rusli, Juniastuti, Ratna Septyawati

“…Soetomo General Academic Hospital, Surabaya, Indonesia. Methods: We conducted a retrospective descriptive study of 120 deceased COVID-19 inpatients from January to December 2021. …”
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Comparison of treatment outcomes in severe personality disorder patients with or without substance use disorders: a 36-month prospective pragmatic follow-up study by Lana F, Sanchez-Gil C, Adroher N, Perez Sola V, Feixas G, Martí-Bonany J, Torrens Melich M

“…As a result, data on treatment outcomes in patients with concurrent PD/SUD are scarce.Methods: The study sample consisted of 51 patients diagnosed with severe PD and admitted for psychotherapeutic treatment as a part of routine mental health care. …”
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Craniofacial Development Characteristics in Children with Obstructive Sleep Apnea for Establishment and External Validation of the Prediction Model by Su Y, Wang Z, Chang H, Zhu S, Zhou Y, Cao Z, Ma L, Yuan Y, Xie Y, Niu X, Lu C, Zhang Y, Liu H, Shao N, Yin L, Si C, Ren X, Shi Y

“…Yonglong Su,1,* Zitong Wang,1,* Huanhuan Chang,2,* Simin Zhu,1 Yanuo Zhou,1 Zine Cao,1 Lina Ma,1 Yuqi Yuan,1 Yushan Xie,1 Xiaoxin Niu,1 Chendi Lu,1 Yitong Zhang,1 Haiqin Liu,1 Na Shao,1 Libo Yin,3 Chao Si,2 Xiaoyong Ren,1 Yewen Shi1 1Department of Otorhinolaryngology Head and Neck Surgery, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of China; 2Department of Otorhinolaryngology Head and Neck Surgery, Xi’an Children’s Hospital, Xi’an, People’s Republic of China; 3Department of Otorhinolaryngology Head and Neck Surgery, Xi’an Central Hospital, Xi’an, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaoyong Ren; Yewen Shi, Department of Otorhinolaryngology Head and Neck Surgery, the Second Affiliated Hospital of Xi’an Jiaotong University, 157 Xi Wu Road, Xi’an, Shaan’xi Province, 710004, People’s Republic of China, Email cor_renxiaoyong@126.com; shiyewen59@outlook.comPurpose: Aimed to analyze the developmental characteristics of craniofacial structures and soft tissues in children with obstructive sleep apnea (OSA) and to establish and evaluate prediction model.Methods: It’s a retrospective study comprising 747 children aged 2– 12 years (337 patients and 410 controls) visited the Department of Otolaryngology-Head and Neck Surgery, the Second Affiliated Hospital of Xi’an Jiaotong University (July 2017 to March 2024). …”
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Correlations Between Leadership, Self-Efficacy, and Evidence-Based Practice Competency in Nursing in a Chinese Tertiary Hospital by Li J, Liu YQ, Song J, Huang XF, Chen MF

“…Jing Li,1,* Ya-Qi Liu,2,* Jia Song,3 Xu-Fang Huang,1 Mei-Fen Chen1 1Department of Nursing, The Fifth Hospital Affiliated to Wenzhou Medical University, Lishui Central Hospital, Lishui, Zhejiang, 323000, People’s Republic of China; 2School of Nursing, Wenzhou Medical University, Wenzhou, 325000, People’s Republic of China; 3Phase I Clinical Research Ward, The Fifth Hospital Affiliated to Wenzhou Medical University, Lishui Central Hospital, Lishui, Zhejiang, 323000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Mei-Fen Chen, Department of Nursing, The Fifth Hospital Affiliated to Wenzhou Medical University, Lishui Central Hospital, No. 289 Kuocang Road, Liandu District, Lishui, 323000, Zhejiang, People’s Republic of China, Tel +8613567618608, Email chenmeifangcmf@126.com Xu-Fang Huang, Department of Nursing, The Fifth Hospital Affiliated to Wenzhou Medical University, Lishui Central Hospital, No. 289 Kuocang Road, Liandu District, Lishui, 323000, Zhejiang, People’s Republic of China, Tel +86159 9086 0585, Email huangxunfanghxf6k@126.comObjective: This study evaluates the interplay between nursing leadership, innovative self-efficacy, and evidence-based practice competencies, aiming to identify predictive factors for enhancing nursing performance in evidence-based care.Methods: A convenience sampling strategy was employed to enlist 1104 clinical nurses from a tertiary A-level general hospital in Lishui city. …”
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Probability of Breech Presentation in Fetuses with Sirenomelia at Birth by Mina Maričić, Jelena Podgorac, Srđan Kesić, Branka Petković, Aleksandra Vejnović, Ivan Čapo, Slobodan Sekulić

“…The aim of the study is to investigate the probability of BP at delivery in sirenomelic singleton gestations to confirm the rule that the maximum probability for BP is 50%. Methods: A systematic retrospective literature search using the keywords: sirenomelia, sympus apus, sympus monopus, and sympus dipus, in the SCOPUS database. …”
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Efficacy of USG-guided Supraclavicular Block with Plain Bupivacaine, Bupivacaine-Dexamethasone and Bupivacaine-Sodium Bicarbonate: A Prospective Interventional Study by Anjum Rashid, Basharat Ahad, Rohey Jan, Waquar Amin, Raja Suhail Shountoo, Samreen Azim, Tazeem Ayub

“…Aim: To compare the efficacy of the Supraclavicular Block (SCB) using plain bupivacaine versus bupivacaine combined with either dexamethasone or sodium bicarbonate. Materials and Methods: This was a prospective interventional study at the Department of Anaesthesia and Critical Care, SKIMS Medical College and Hospital, Bemina, Srinagar, India, over a period of 24 months, from January 2021 to December 2023 involving 99 patients (aged 18-80, ASA I/II, BMI ≤35 kg/m²) who were randomly divided into three equal groups of 33 each: Group-PB (plain bupivacaine), group-BD (bupivacaine+dexamethasone), and group-BB (bupivacaine+sodium bicarbonate). …”
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Comparison of Magnesium Sulphate versus Clonidine as Adjuvants to Ropivacaine in Ultrasound-guided Bilateral Transversus Abdominis Plane Block for Postoperative Analgesia in Lower... by S Mercy Saghana, Joshiah Jeyakumar, B Balamurugan

“…Both magnesium sulphate and clonidine are equally effective in enhancing postoperative analgesia in patients undergoing LSCS.…”
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Influence of Type 2 Diabetes Mellitus on the Clinical Outcomes in Hospitalized Patients with Active Pulmonary Tuberculosis: A Retrospective, Single-Center, Real-World Study in Chin... by Shi C, Shen X, Liu J, Huang L, Ni H, Tang P, Feng Y, Wu M, Zhang J

“…In addition, the treatment regimens of active pulmonary TB patients with or without T2DM were described.Methods: This is a retrospective, single-center, real-world study conducted in the Fifth People’s Hospital of Suzhou (China), an urban hospital. …”
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