Artificial Intelligence Enabled Fully Automated CMR Function Quantification for Optimized Risk Stratification in Patients Undergoing Transcatheter Aortic Valve Replacement by Ruben Evertz, Torben Lange, Sören J. Backhaus, Alexander Schulz, Bo Eric Beuthner, Rodi Topci, Karl Toischer, Miriam Puls, Johannes T. Kowallick, Gerd Hasenfuß, Andreas Schuster

“…Novel fully automated analyses may facilitate data analyses but have not yet been compared against conventional manual data acquisition in patients with severe aortic stenosis (AS). Methods. Fully automated and manual biventricular assessments were performed in 139 AS patients scheduled for TAVR using commercially available software (suiteHEART®, Neosoft; QMass®, Medis Medical Imaging Systems). …”
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Exploring the Validity of an Instrument That Measures Final Year Medical Students’ Career Choice Preferences by Guru A, Henning MA, Webster CS, Kool B, Wilkinson TJ, Bagg W

“…This study aimed to explore the validity of an instrument that measures the factors that influence Aotearoa New Zealand (NZ) medical students’ career choices.Methods: The Medical Schools Outcomes Database (MSOD) questionnaire containing 24 question items entitled “Factors Influencing Career Choice” (FICC) section was psychometrically analyzed. …”
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Functional Connectivity Alterations Associated with COVID-19-Related Sleep Problems: A Longitudinal Resting-State fMRI Study by Chen HB, Li L, Sun YK, Liu Y, Chen W, Liu P, Liao YH, Xie A

“…Purpose: This study investigated SP-related brain functional connectivity (FC) alterations.Patients and methods: Fifty-five COVID-19 survivors with SP (COVID_SP) and 33 without SP (COVID_NSP), matched for demographics, completed PSQI and underwent rs-fMRI at baseline and 2-month follow-up. …”
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Clinical Features, Outcomes, and Antifungal Susceptibility Profiles of Invasive Candida Infections in a Tertiary Care Hospital in China by Yao D, Chen J, Zhang G

“…Dongting Yao,1,2,* Jia Chen,3,* Guanyi Zhang3 1Department of Laboratory Medicine, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200030, People’s Republic of China; 2Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, 200030, People’s Republic of China; 3Department of Laboratory Medicine, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200030, People’s Republic of China*These authors contributed equally to this workCorrespondence: Guanyi Zhang, Department of Laboratory Medicine, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200030, People’s Republic of China, Tel/Fax +86-021-64385700, Email zhangguanyi1233@163.com Dongting Yao, Department of Laboratory Medicine, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200030, People’s Republic of China, Tel/Fax +86-021-64070434, Email yaodongting@126.comPurpose: Given the increasing incidence of invasive Candida infection worldwide, particularly among immunocompromised and critically ill patients, we aimed to assess the distribution of Candida species as well as their clinical features and responses to common antifungal agents through a retrospective analysis of patient data in a Chinese traditional medicine hospital.Patients and Methods: In this retrospective single-center study, we analyzed data from 301 patients with invasive Candida infection at our hospital between 2020 and 2022, We report the clinical characteristics, species distribution, and in-vitro susceptibility profiles of Candida isolates to eight antifungal agents. …”
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Procyanidin Improves Erectile Function in Rats by Inhibiting PDE5A Activity by Su Y, Shui J, Qi D, Bai J, Xu X, Huang Y, Li R, Wu Q, Wang H, Cao C, Su Z, Zhang S

“…This study aims to validate the efficacy of procyanidin as a treatment for ED.Methods: The binding affinity of procyanidin for PDE5A was assessed by molecular docking, molecular dynamics (MD) simulations, and microscale thermophoresis (MST) assay. …”
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Identification and Validation of circDOCK1/miR-138-5p/GRB7 Axis for Promoting Breast Cancer Progression by Zhang Y, Yang M, Wang Y, Zhao J, Lee PY, Ma Y, Qu S

“…This study aims to explore novel circular RNAs and their mechanisms of biological function in breast cancer.Methods: Six HER2-positive breast cancer tissues and paired normal tissues were obtained for the whole transcriptome RNA sequencing. …”
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Etiological Factors and Development of a Predictive Model for Urinary Tract Infections in Cervical Cancer Patients Undergoing Intensity-Modulated Radiotherapy by Yao Y, Tao L, Ma L, Fan Y, Zheng D, Wang J, Chen W

“…Furthermore, to explore the risk factors and predictive factors associated with urinary tract infections, and to establish a personalized risk prediction model.Methods: A retrospective study analyzed 160 cervical cancer patients undergoing intensity-modulated radiotherapy at the People’s Hospital of Ningxia Hui Autonomous Region from 2020 to 2023. …”
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Association Between Serum Uric Acid to High-Density Lipoprotein Cholesterol Ratio and Pneumonia After Endovascular Treatment of Vertebrobasilar Artery Occlusion by Lan W, Yuan K, Xiao L, Qiu F, Sun W, Xu L, Cao H, Zhu W, Du M, Liu X

“…We aimed to explore the association of UHR with pneumonia after endovascular thrombectomy (EVT) in patients with vertebrobasilar artery occlusion (VBAO).Methods: We retrospectively enrolled participants diagnosed with acute VBAO treated with EVT within 24 hours of estimated occlusion time from the multicenter PERSIST study. …”
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Identifying cross-tissue molecular targets of lung function by multi-omics integration analysis from DNA methylation and gene expression of diverse human tissues by Shisheng Peng, Jinlong Fang, Weiliang Mo, Guodong Hu, Senquan Wu

“…In this research, we used a cross-tissue multi-omics post-GWAS analysis to explain the associations between DNA methylation, gene expression, and lung function. Methods We conducted integration analyses of lung function traits using genome-wide association study (GWAS) summary data alongside expression quantitative trait loci (eQTLs) and DNA methylation quantitative trait loci (mQTLs) derived from whole blood, utilizing multi-omics SMR and Bayesian colocalization analysis. …”
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Ciprofol Ameliorates Myocardial Ischemia/Reperfusion Injury by Inhibiting Ferroptosis Through Upregulating HIF-1α by Ding J, Wang BY, Yang YF, Kuai LY, Wan JJ, Zhang M, Xia HY, Wang Y, Zheng Z, Meng XW, Peng K, Ji FH

“…Herein, we assessed the effects of ciprofol on ferroptosis during myocardial I/R injury.Methods: Experimental models of myocardial I/R injury in mice (ischemia for 30 min and reperfusion for 24 h) and hypoxia/reoxygenation (H/R) injury in H9c2 cardiomyocytes (hypoxia for 6 h followed by 6 h of reoxygenation) were established. …”
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Serum Lipid Biomarkers for the Diagnosis and Monitoring of Neuromyelitis Optica Spectrum Disorder: Towards Improved Clinical Management by Li R, Wang J, Wang J, Xie W, Song P, Zhang J, Xu Y, Tian D, Wu L, Wang C

“…This study aimed to identify serum lipid biomarkers for the diagnosis and monitoring of NMOSD and to assess their potential to improve clinical decision-making.Methods: We conducted a comprehensive serum proteomic analysis in a discovery cohort of NMOSD patients and controls to identify lipid-related proteins associated with NMOSD. …”
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Identification of Anoikis-Related Genes in Chronic Kidney Disease Based on Bioinformatics Analysis Combined with Experimental Validation by Liu H, Mei M, Zhong H, Lin S, Luo J, Huang S, Zhou J

“…We aimed to establish the Anoikis-related gene signature in CKD by bioinformatics analysis.Methods: We retrieved 3 datasets from the Gene Expression Omnibus (GEO) database to obtain differentially expressed genes (DEGs), followed by Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, Gene Set Enrichment Analysis (GSEA) and Gene Set Variation Analysis (GSVA) of them, which were intersected with Anoikis-related genes (ARGs) to derive Anoikis-related differentially expressed genes (ARDEGs). …”
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Irisin Mitigates Doxorubicin-Induced Cardiotoxicity by Reducing Oxidative Stress and Inflammation via Modulation of the PERK-eIF2α-ATF4 Pathway by Zhang Z, Yu X, Li J, Shen X, Fu W, Liu Y, Dong X, Wang Z

“…This study investigates the potential cardioprotective function of irisin in reducing the cardiac injury induced by DOX.Methods: In vitro, H9c2 cells were pretreated with irisin (20 nM) for 24 hours before exposure to DOX (1 μM). …”
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University Students’ Knowledge, Attitudes, and Practices Regarding Cervical Spine Health by Liu Y, Wang H, Liu H, Li L

“…This study investigated their knowledge, attitudes, and practices (KAP) concerning cervical spine health.Methods: From May 25 to June 16, 2023, a cross-sectional survey was conducted among students at various Chinese universities. …”
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Retrospective Analysis of Gut Microbiota and Metabolomic Profiles in Pregnant Women: Association with Cesarean Section Risk by Yuan J, Wang Y, Liu L

“…This study aimed to investigate gestation-specific alterations in gut microbiota and serum metabolomes and evaluate their association with CS risk.Methods: We conducted a retrospective analysis of 80 healthy pregnant women with singleton pregnancies who delivered at our hospital between January 2022 and December 2023. …”
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Comparison of the effect of Tabata training on soft and hard surfaces on left ventricular structure and function and some physical fitness factors in elite beach soccer players by Hamed Mohamadi Bazneshin, Arsalan Damirchi, Hamid Arazi

“…Thus, the aim of the present study was to compare the effect of six weeks of Tabata training on indoor hardcourt vs. sand on some physical fitness factors and the structure and function of the left ventricle in elite beach soccer players.Materials and Methods: Sixteen players from one of the Iran Premier Beach Soccer League teams were randomly divided into two equal groups including the sand group and the indoor group. …”
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Ultrasmall Antioxidant Copper Nanozyme to Enhance Stem Cell Microenvironment for Promoting Diabetic Wound Healing by Hou B, Li C, Yang F, Deng W, Hu C, Liu C, Chen Y, Xiao X, Huang X, Deng J, Xie S

“…Strategies to overcome these challenges are essential to enhance the therapeutic potential of stem cell therapy.Methods: Cu5.4O ultrasmall nanoparticles (Cu5.4O-USNPs), known for their excellent reactive oxygen species (ROS) scavenging properties, were utilized to protect adipose-derived stem cells (ADSCs) from oxidative stress injury. …”
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Parametric Population Pharmacokinetics Model Repository of Rifampicin: Model-Informed Individualized Therapy by Ju G, Liu X, Gu M, Chen L, Wang X, Li C, Yang N, Zhang G, Zhang C, Zhu X, He Q, Ouyang D

“…This study aims to construct a comprehensive rifampicin popPK model repository to support model-informed individualized therapy.Methods: A systematic review was conducted using PubMed, Web of Science, and Embase databases up to September 2023 to retrieve popPK model articles on rifampicin. …”
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Beam hardening of K-edge contrast agents: a phantom study comparing clinical energy-integrating detector and photon-counting detector CT systems by Amir Pourmorteza, Arnaud Richard Choux, Thomas Wesley Holmes, U. Joseph Schoepf, Marly van Assen, Carlo De Cecco, Tilman Emrich, Akos Varga-Szemes

“…We quantified the BH effect of different materials comparing energy-integrating detector (EID)-CT and PCD-CT. Methods Pairs of test tubes were filled with dense CA (iodine-, gadolinium-, and bismuth-based) and placed inside a water phantom. …”
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Real-World Effectiveness of Nirmatrelvir/Ritonavir in Hospitalized Older Adults with Severe Omicron COVID-19: A Retrospective Cohort Study from China by Chen Y, Liu L, Liu Y, Huang F, Guo L, Wan W, Jiang H

“…We aimed to estimate the effectiveness in older patients aged 80 and above with severe COVID-19.Methods: A retrospective study analyzed 263 COVID-19 patients aged 80 and above, admitted to the Department of Geriatrics at Jinling Hospital, affiliated with Nanjing University, between December 15, 2022, and January 15, 2023. …”
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